期刊
AMINO ACIDS
卷 38, 期 1, 页码 65-73出版社
SPRINGER WIEN
DOI: 10.1007/s00726-008-0205-8
关键词
Amino acids; Tubular handling; Metabonomics; Population studies
资金
- FP6-EUGIN-DAT
- Italian Ministry of Health (to PG)
- Regione Veneto
- Giunta Regionale-Ricerca Sanitaria Finalizzata [176/04]
- Spanish Project MEC [BFU2006-14600-C02-01-02/BMC]
The study of two different Italian isolated populations was combined with a metabonomic approach to better understand tubular handling of amino acids. Levels of amino acids and metabolites have been analyzed by Nucleic Magnetic Resonance and expressed as ratio vs urinary creatinine concentration (mmol/mol). For most of the amino acids there is an age-related U shape pattern of excretion, with the peaks during childhood and old age, and a significant reduction in the adult age. Hierarchical cluster analysis has clearly identified three groups clustering the same amino acids: His, Thr and Ala (group one); Gly and Phe (group two) and a third larger one. Results have been further confirmed by factor and regression analysis, and used to confirm and, in some cases, infer new amino acids networks. As a matter of facts, the identification of strong evidences for clustering of urine excretion of several neutral amino acids suggests the predominant impact of relevant and common transporters
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据