Article
Pharmacology & Pharmacy
Friederike Holze, Livio Erne, Urs Duthaler, Matthias E. Liechti
Summary: This study investigated the pharmacokinetics, pharmacokinetic-pharmacodynamic relationship, and urinary recovery of LSD in healthy participants. The results showed that LSD exhibits dose-proportional pharmacokinetics and first-order elimination kinetics, with the duration and intensity of its subjective effects being dose-dependent. The study also found that LSD is extensively metabolized and shows dose-proportional urinary recovery. Evaluation: 8 out of 10.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
Qi Pan, Xiaoxia Wang, Wenjia Li, Xiaofeng Chen, Yulei Zhuang, Qinghong Zhou, Yuhui Huang, Yijie Zhou, Li Lan, Zhijie Wang, Wenjia Wang, Juan Hong, Wei-Hua Hao, Yu-Tsai Yang, Lixin Guo
Summary: This study aimed to verify whether the oral insulin N11005 is used as a prandial insulin by comparing its pharmacokinetics (PK), pharmacodynamics (PD), and safety profiles with a short-acting biosynthetic human insulin (Novolin R). A total of 12 healthy Chinese male subjects were enrolled in the study, and the results showed that N11005 has similar PD characteristics to prandial insulins, with a faster onset of action and comparable duration of action to the reference insulin. The study also demonstrated the safety and tolerability of N11005.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Veterinary Sciences
Heather K. K. Knych, Daniel Weiner, Linda Harrison, Daniel S. S. McKemie
Summary: This study investigated the pharmacokinetics and pharmacodynamic effects of isoflupredone acetate following intra-articular administration in an acute synovitis model in horses. Results showed rapid decrease in concentrations of isoflupredone in blood, urine, and synovial fluid over time, with short-term effects on joint circumference and pain free joint flexion.
BMC VETERINARY RESEARCH
(2022)
Article
Chemistry, Medicinal
Inseung Jeon, Jaeseong Oh, Yu-Kyung Kwon, Seo Hyun Yoon, Joo-Youn Cho, In-Jin Jang, Kyung-Sang Yu, SeungHwan Lee
Summary: The study compared the pharmacokinetic (PK), pharmacodynamic (PD), and tolerability profiles of CKD-11101 with those of the reference drug in healthy subjects. Results showed that CKD-11101 was well tolerated and exhibited comparable PK and PD characteristics with the reference drug after a single intravenous (IV) or subcutaneous (SC) dose.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Agriculture, Dairy & Animal Science
Kamil Uney, Ertugrul Terzi, Duygu Durna Corum, Rahmi Can Ozdemir, Soner Bilen, Orhan Corum
Summary: The pharmacokinetic/pharmacodynamic studies revealed non-linear and dose-disproportional pharmacokinetics of enrofloxacin in brown trout. Single oral administration of 10 and 20 mg/kg of enrofloxacin provided long duration of action, potentially reducing handling and stress in brown trout. Further research is needed for successful treatment of infections caused by Aeromonas hydrophila and A. sobria in brown trout.
Article
Infectious Diseases
Yaxin Fan, Yi Li, Yuancheng Chen, Jicheng Yu, Xiaofen Liu, Wanzhen Li, Beining Guo, Xin Li, Jingjing Wang, Hailan Wu, Yu Wang, Jiali Hu, Yan Guo, Fupin Hu, Xiaoyong Xu, Guoying Cao, Jufang Wu, Yingyuan Zhang, Jing Zhang, Xiaojie Wu
Summary: This study evaluated the pharmacokinetic/pharmacodynamic profiles and safety of CMS in Chinese subjects following a recommended dosage. The results showed that CMS may be effective against most carbapenem-resistant organisms, but inadequate for some carbapenem-resistant Acinetobacter baumannii.
Article
Veterinary Sciences
Carl Ekstrand, Peter Michanek, Ronette Gehring, Anna Sundell, Annika Kallse, Mikael Hedeland, Lena Strom
Summary: This study suggests that the use of atropine to treat equine uveitis may result in decreased intestinal motility and abdominal pain in horses. Different dosing regimens have varying effects on horses, with dosing every 6 hours predicted to be a safer approach.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Infectious Diseases
Mehmet Nihat Ural, Kamil Uney
Summary: This study aimed to investigate the pharmacokinetics and pharmacodynamics of danofloxacin in healthy lambs and lambs with respiratory infections. Co-administration with meloxicam was found to increase the AUC and peak concentration of danofloxacin, indicating a potential for enhanced antimicrobial effects in infected lambs.
Article
Endocrinology & Metabolism
Shanshan Chen, George F. Wohlford, Alessandra Vecchie, Salvatore Carbone, Sahzene Yavuz, Benjamin Van Tassell, Antonio Abbate, Francesco S. Celi
Summary: This study assessed the clinical relevance of transient increase of T3 levels on cardiovascular system and energy metabolism. The results showed that no measurable rapid effects on the cardiovascular system were observed following a high dose of liothyronine.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Sungpil Han, Yong-Soon Cho, Seok-Kyu Yoon, Kyoung Soo Lim, Sang-Heon Cho, JaeWoo Kim, Sangmin Choe, Jinah Jung, Jong-Lyul Ghim, SangKeun Choi, Minhee Lee, Seon Mi Kim, Hun-Taek Kim, Hyeong-Seok Lim, Jae Yoon Shim, Kyun-Seop Bae
Summary: The study evaluated the safety, pharmacokinetics, and pharmacodynamics of a novel GnRH antagonist, TU2670, in healthy female participants. Results showed that a single dose of TU2670 led to dose-dependent suppression of LH, FSH, and estradiol, indicating rapid and significant inhibition of pituitary and ovarian hormones.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Pharmacology & Pharmacy
Fanxi Guo, Dongying Liu, Yuqing Zhou, Yuanqian Yu, Yidan Xu, Yuanpeng Zou, Chongyang Li, Fengyichi Zhang, Zugong Yu
Summary: This study investigated the pharmacokinetics of orally administered glutamine tablets in Beagles. The results showed a linear relationship between dosage and certain pharmacokinetic parameters. Glutamine tablets were quickly absorbed and did not accumulate in Beagles after long-term administration.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Chang Hee Kim, Sol Ip Kang, Dongseong Shin
Summary: This study investigated the potential interactions between telmisartan and rosuvastatin/ezetimibe, finding that coadministration led to a slight increase in systemic exposure to telmisartan and rosuvastatin, with no significant change in exposure to total ezetimibe. Further large-scale clinical studies may be needed to assess the generalizability of the clinical effects in patients with hypertension and dyslipidemia.
ADVANCES IN THERAPY
(2021)
Article
Infectious Diseases
Richard J. Everts, Sharon J. Gardiner, Mei Zhang, Ronald Begg, Stephen T. Chambers, John Turnidge, Evan J. Begg
Summary: This study evaluated the effects of probenecid on the pharmacokinetics and pharmacodynamics of oral cephalexin in healthy volunteers. Results showed that probenecid increased cephalexin plasma concentrations and prolonged half-life, enhancing the likelihood of reaching PK/PD targets. Co-administration of probenecid may expand the clinical benefits of oral cephalexin.
JOURNAL OF INFECTION
(2021)
Article
Pharmacology & Pharmacy
Per O. Olsson Gisleskog, Juan Jose Perez Ruixo, Ake Westin, Anna C. Hansson, Paul A. Soons
Summary: This study evaluated the population pharmacokinetics of nicotine in healthy smoking subjects across various routes and formulations. Robust population pharmacokinetic models were developed for different types of nicotine replacement therapy products, providing useful information for product design and effectiveness analysis.
CLINICAL PHARMACOKINETICS
(2021)
Review
Infectious Diseases
Cornelia B. Landersdorfer, Amanda Gwee, Roger L. Nation
Summary: Traditionally, ongoing i.v. antibiotic therapy has been believed to be superior to early i.v. to oral switch for severe infections. However, this belief may not be based on robust data and contemporary clinical studies. This review examines the rationale for an early switch and discusses barriers and perceptions related to this practice.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)