期刊
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
卷 91, 期 5, 页码 1057-1065出版社
AMER SOC TROP MED & HYGIENE
DOI: 10.4269/ajtmh.14-0145
关键词
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资金
- Instituto Cientifico Pfizer (Epidemiology Award)
- FOSISS Grant SSA-IMSS-ISSSTE [CONACYT-1385]
- James W. McLaughlin Fellowship Fund
- Department of Pathology
- Institute for Human Infection and Immunity, University of Texas Medical Branch
- National Institutes of Health [HHSN272201000040I/HHSN27200004/D04]
Humoral immune response against dengue virus (DENY) is an important component in dengue-endemic transmission. We conducted a cross-sectional nested cohort study to determine the seroprevalence and frequency of neutralizing antibodies against DENV serotypes in two endemic localities in the state of Morelos, Mexico. The cohort participants (N = 1,196) were screened to determine previous exposure to DENV. Overall seroprevalence was 76.6% (95% confidence interval [95% CI] = 73.6-79.2), and prevalence of neutralizing antibodies in the 5- to 9-year-old group was 82.5% (95% CI = 67.2-92.7), 45% (95% CI = 29.3-61.5), and 65% (95% CI = 48.3-79.4) for DENV-1, DENV-2, and DENV-3, respectively. For participants older than 10 years, the observed seroprevalence was above 60% for each serotype, except DENV-4 in the 10- to 25-year-old group (42.9%); 81% of humoral responses were multitypic. The outcomes of our study contribute to understanding the immune component of dengue transmission and provide focal information for the evaluation of vaccine candidates under development.
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