期刊
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
卷 91, 期 3, 页码 611-620出版社
AMER SOC TROP MED & HYGIENE
DOI: 10.4269/ajtmh.13-0600
关键词
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资金
- Global Emerging Infections Surveillance and Response System, a Division of the Armed Forces Health Surveillance Center [800000.82000.25GB.B0016]
- Military Infectious Diseases Research Program [6000 RAD1.S.B0302]
- National Center for Research Resources Grant [5P20RR016480-12]
- National Institute of General Medical Sciences Grant [8 P20 GM103451-12]
- Department of Pathology, University of Texas Medical Branch
- NIH [HHSN272201000040I/HHSN27200004/D04]
During 2010 and 2011, the Loreto region of Peru experienced a dengue outbreak of unprecedented magnitude and severity for the region. This outbreak coincided with the reappearance of dengue virus-2 (DENV-2) in Loreto after almost 8 years. Whole-genome sequence indicated that DENV-2 from the outbreak belonged to lineage II of the southeast Asian/American genotype and was most closely related to viruses circulating in Brazil during 2007 and 2008, whereas DENV-2 previously circulating in Loreto grouped with lineage I (DENV-2 strains circulating in South America since 1990). One amino acid substitution (NS5 A811V) in the 2010 and 2011 isolates resulted from positive selection. However, the 2010 and 2011 DENV-2 did not replicate to higher titers in monocyte-derived dendritic cells and did not infect or disseminate in a higher proportion of Aedes aegypti than DENV-2 isolates previously circulating in Loreto. These results suggest that factors other than enhanced viral replication played a role in the severity of this outbreak.
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