Review
Chemistry, Analytical
T. J. Wallington, M. P. Sulbaek Andersen, O. J. Nielsen
Summary: It is argued that a precise definition of PFAS is needed to focus technical and regulatory discussions on environmental impacts, excluding certain groups and compounds. The focus should be on long-chain perfluoroalkyl sulfonic acids and perfluoroalkyl carboxylic acids.
ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS
(2021)
Article
Immunology
Yi-Ling Cheng, Chiao-Hsuan Chao, Yen-Chung Lai, Kun-Han Hsieh, Jen-Ren Wang, Shu-Wen Wan, Hong-Jyun Huang, Yung-Chun Chuang, Woei-Jer Chuang, Trai-Ming Yeh
Summary: This study confirms the presence of antibodies related to SARS-CoV-2 in dengue virus patients, and these antibodies can cross-react with proteins of the dengue virus. These antibodies can inhibit the pathological reactions caused by dengue virus infection, potentially providing some level of protection against dengue virus.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Ophthalmology
Xinyuan Zhang, Sobha Sivaprasad
Summary: The pachychoroid disease spectrum includes various retinal conditions with a focus on Drusen and pachydrusen. While these conditions are related, there are still differences in terms of phenotype, genotype, and pathogenesis that need to be further explored for clinical significance.
Article
Multidisciplinary Sciences
Maria S. Lopez, Daniela I. Jordan, Evelyn Blatter, Elisabet Walker, Andrea A. Gomez, Gabriela V. Muller, Diego Mendicino, Michael A. Robert, Elizabet L. Estallo
Summary: This study investigates the spatio-temporal fluctuations of dengue cases in Santa Fe Province, Argentina from 2009 to 2020, providing valuable data for understanding the emergence of dengue in temperate regions and for future research on socio-ecological, climatic, and environmental factors associated with DENV transmission.
Review
Immunology
Yean Kong Yong, Won Fen Wong, Ramachandran Vignesh, Indranil Chattopadhyay, Vijayakumar Velu, Hong Yien Tan, Ying Zhang, Marie Larsson, Esaki M. Shankar
Summary: This study reviews the latest research progress in understanding the immunopathogenesis of dengue and provides suggestions for targeted strategies against dengue.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Huiqin Wang, Yantao Yang, Gang Pei, Zhenzhen Wang, Naihong Chen
Summary: Depression is a major neuropsychiatric disease that has a significant impact on individuals' psychosocial function and quality of life. Neurotrophic factors have been linked to the development of depression, but their exact role is still unclear. Phytotherapy offers an alternative to conventional antidepressants and may reduce unwanted side effects. Therefore, further research is needed to investigate the interaction between neurotrophic factors and depression, as well as the use of phytochemicals to address neurotrophic factor deficiencies.
FRONTIERS IN PHARMACOLOGY
(2023)
Editorial Material
Biochemistry & Molecular Biology
Barry S. Coller
Summary: This study discovered a mechanism to stabilize a key water molecule, preventing partial activation of integrin receptors, which may have implications for future therapeutic development.
Review
Microbiology
Puneet Bhatt, Sasidharan Pillai Sabeena, Muralidhar Varma, Govindakarnavar Arunkumar
Summary: The pathogenesis of dengue virus infection involves a complex interplay between virus, host genes, and host immune response, with major determinants including host factors and viral determinants. Host factors include antibody-dependent enhancement, memory cross-reactive T cells, while viral determinants include NS1 protein, genomic variation, among others.
CURRENT MICROBIOLOGY
(2021)
Article
Immunology
Enyue Fang, Miao Li, Xiaohui Liu, Kongxin Hu, Lijuan Liu, Zelun Zhang, Xingxing Li, Qinhua Peng, Yuhua Li
Summary: A genetically stable attenuated dengue virus strain was successfully constructed by changing amino acid sequences in the NS1 and NS2A glycoproteins. The virus strain showed significantly reduced virulence in mice during neurovirulence assay. This study provides a theoretical basis for understanding the pathogenesis of dengue virus and developing live attenuated vaccines through the deletion of amino acid residues at the N-glycosylation site.
Article
Public, Environmental & Occupational Health
Carlos M. Baak-Baak, Nohemi Cigarroa-Toledo, Jose F. Pinto-Castillo, Rosa C. Cetina-Trejo, Oswaldo Torres-Chable, Bradley J. Blitvich, Julian E. Garcia-Rejon
Summary: Dengue cases and deaths in Mexico show geographical variation, with coastal states in cluster 3 identified as high-risk areas. Public health and vector control strategies should prioritize these areas in order to mitigate the burden of dengue.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2022)
Article
Public, Environmental & Occupational Health
Thekkumkara Surendran Anish, Mathew J. Valamparampil, Arya Rahul, Prasanta Saini, Kannamkottapilly Chandrasekharan Prajitha, Meenu Maheswari Suresh, Aravind Reghukumar, N. Pradeep Kumar
Summary: The study aims to study the test positivity rate of the World Health Organization's probable dengue case definition and suggest region-specific improvisations to it. The study also analyzes the sociodemographic and environmental risk factors of dengue fever in South Kerala, India. The results show that certain symptoms and environmental factors are associated with the occurrence of dengue.
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE
(2023)
Review
Microbiology
Victor Edgar Fiestas Solorzano, Raquel Curtinhas de Lima, Elzinandes Leal de Azeredo
Summary: This study systematically reviewed the role of growth factors (GFs) in the pathogenesis of dengue. The findings showed that in severe dengue, levels of vascular endothelial growth factor and hepatocyte growth factor were increased, while platelet-derived growth factor and epidermal growth factor levels were reduced. Furthermore, evidence suggested that the dengue virus can exploit the growth factor pathway to facilitate its entry into cells and promote viral replication.
Article
Immunology
Nguyen Lam Vuong, Ka-Wai Cheung, Balamurugan Periaswamy, Tran Thuy Vi, Huynh Thi Le Duyen, Yan Shan Leong, Zayanah Noor Binte Hamis, Michaela Gregorova, Eng Eong Ooi, October Sessions, Laura Rivino, Sophie Yacoub
Summary: Patients with severe dengue exhibit higher levels of inflammatory biomarkers, impaired NK cell function, and genetic variations in genes related to NK cell cytolytic function. These hyperinflammatory features are associated with dengue severity.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Pharmacology & Pharmacy
Mikael Feracci, Cecilia Eydoux, Veronique Fattorini, Lea Lo Bello, Pierre Gauffre, Barbara Selisko, Priscila Sutto-Ortiz, Ashleigh Shannon, Hongjie Xia, Pei-Yong Shi, Mathieu Noel, Francoise Debart, Jean-Jacques Vasseur, Steve Good, Kai Lin, Adel Moussa, Jean-Pierre Sommadossi, Aurelie Chazot, Karine Alvarez, Jean-Claude Guilemot, Etinne Decroly, Francois Ferron, Bruno Canard
Summary: AT-752 is a guanosine analogue prodrug that is active against dengue virus (DENV) by inhibiting RNA synthesis. It targets the RNA 2'-O-MTase and RNA-dependent RNA polymerase (RdRp) activities of NS5. The crystal structure and activities of the DENV 2 MTase domain in complex with AT-9010 show its binding to the GTP/RNA-cap binding site, resulting in the inhibition of 2'-O but not N7-methylation activity.
ANTIVIRAL RESEARCH
(2023)
Review
Genetics & Heredity
Yanzi Gao, Xiaohui Jiang, Zhi Wei, Hu Long, Wenli Lai
Summary: Non-syndromic tooth agenesis (NSTA) is a common dental developmental malformation affected by genetic factors. The EDA, EDAR, and EDARADD genes in the EDA/EDAR/NF-κB signaling pathway have been found to play essential roles in the pathogenesis of NSTA. This review provides an overview of the genetic basis of NSTA and highlights the importance of genetic analysis in diagnosing and managing NSTA and related ectodermal disorders.
FRONTIERS IN GENETICS
(2023)
