Article
Infectious Diseases
Sotiria Fergadaki, Georgios Renieris, Nikolaos Machairas, Labros Sabracos, Dionyssia-Irene Droggiti, Evangelos Misiakos, Evangelos J. Giamarellos-Bourboulis
Summary: Experimental studies demonstrated that tigecycline alone or in combination effectively prolongs survival and reduces bacterial load in KPC-Kp infections in mice.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2021)
Article
Infectious Diseases
Wenli Liao, Lingbo Wang, Xiangkuo Zheng, Ying Zhang, Tao Chen, Cui Zhou, Ye Xu, Lijiang Chen, Tieli Zhou
Summary: This study investigated the mechanism of tigecycline resistance evolution in a patient infected with Klebsiella pneumoniae harbouring bla(KPC-2). By isolating and analyzing bacterial strains, the authors found the process of tigecycline resistance evolution in the patient during treatment.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2022)
Article
Allergy
Jose A. Cespedes, Ruben Fernandez-Santamaria, Adriana Ariza, Gador Bogas, Inmaculada Dona, Carmen Rondon, Maria Salas, Marina Labella, Cecilia Frecha, Cristobalina Mayorga, Maria J. Torres, Tahia D. Fernandez
Summary: This study evaluated the use of BAT with CD63 and CD203c as activation markers for diagnosing immediate reactions to amoxicillin and amoxicillin-clavulanic acid. The results showed that CD203c had higher sensitivity and specificity in amoxicillin allergic patients. Using BAT as a first step in the diagnostic procedure can reduce the need for a complete allergological work-up in a significant percentage of patients, reducing the risk of reinducing allergic reactions.
Article
Infectious Diseases
Eva Greibe, Claus Ernst Moser, Niels Eske Bruun, Elke Hoffmann-Lucke
Summary: We developed simple and rapid HPLC methods for quantification of amoxicillin and clindamycin in human plasma. The methods showed good linearity, precision, and accuracy, making them suitable for routine use and clinical studies.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Immunology
Lilan Sun, Lang Sun, Xue Li, Xinxin Hu, Xiukun Wang, Tongying Nie, Youwen Zhang, Xuefu You
Summary: ML-7 hydrochloride (ML-7) has been identified as a potential novel tigecycline adjuvant to combat tigecycline-resistant Klebsiella pneumoniae. ML-7 exhibits synergistic bactericidal activities with tigecycline, inhibits efflux pump function, disrupts proton motive force, reduces intracellular ATP levels, and leads to accumulation of ROS. Furthermore, transcriptomic analysis reveals the enrichment of ML-7-related genes in ABC transporters.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Infectious Diseases
Constantinos Tsioutis, Vanessa M. Eichel, Nico T. Mutters
Summary: This critical review aimed to evaluate the effectiveness of measures to control the spread of KPC-KP in healthcare settings, finding that successful control during outbreaks doesn't necessarily indicate the effectiveness of individual infection control measures, due to low-quality evidence and lack of controlled intervention studies. The distribution of studies, reported cases, and high mortality rates highlight that KPC-KP remains a major healthcare problem globally.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Infectious Diseases
Laura Campogiani, Pietro Vitale, Alessandra Lodi, Alessandra Imeneo, Carla Fontana, Cartesio D'Agostini, Mirko Compagno, Luigi Coppola, Ilaria Spalliera, Vincenzo Malagnino, Elisabetta Teti, Marco Iannetta, Massimo Andreoni, Loredana Sarmati
Summary: This study aimed to collect and describe real-life data on CAZ-AVI-resistant Klebsiella pneumoniae isolates in a University Hospital. The results showed that prior use of CAZ-AVI was associated with the emergence of drug resistance.
Article
Cell Biology
Suyeon Park, Hyunkeun Kim, Kwan Soo Ko
Summary: In hypervirulent Klebsiella pneumoniae strains, tigecycline resistance is associated with decreased virulence due to reduced production of capsular polysaccharides (CPS). Transcriptomic analyses revealed downregulation of ompK35 expression in tigecycline-resistant mutants, which overexpressed ompR and negatively regulated ompK35 expression. Tigecycline-resistant and ompR-overexpressed mutants exhibited reduced hypermucoviscosity and virulence, while deletion of ompR restored these phenotypes in tigecycline-resistant mutants.
JOURNAL OF BIOMEDICAL SCIENCE
(2023)
Article
Infectious Diseases
Lin Huang, Min Cao, Yanyan Hu, Rong Zhang, Yufei Xiao, Gongxiang Chen
Summary: The trend of fosfomycin resistance among KPC-KP strains is increasing in China, with the two major mechanisms of resistance being plasmid-mediated fosfomycin resistance gene fosA3 and mutation of the target gene glpT.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2021)
Article
Infectious Diseases
Jee Hong Kim, Yun Young Cho, Ji Young Choi, Yu Mi Wi, Kwan Soo Ko
Summary: This study investigated the characteristics of KPC-2-producing Klebsiella pneumoniae isolates from a hospital in South Korea. It identified two main clones, ST11 and ST307, with different resistance profiles and virulence levels. Continuous monitoring of these clones, which show different characteristics including resistance and virulence, is necessary.
Article
Immunology
Xinqian Ma, Shining Fu, Yifan Wang, Lili Zhao, Wenyi Yu, Yukun He, Wentao Ni, Zhancheng Gao
Summary: This study used proteomics analysis to investigate the impact and mechanism of tigecycline and aminoglycoside combination therapy on carbapenem-resistant Klebsiella pneumoniae (CRKP). The study found that the proteomic responses to tigecycline and aminoglycosides were different in monotherapy, with tigecycline dominating the proteomic alterations in combination therapy. Adaptive responses to tigecycline were associated with the upregulation of oxidative phosphorylation and translation-related proteins, while tigecycline might perturb adaptive responses to aminoglycosides through inhibition of heat shock response.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Microbiology
Hung-Jen Tang, Chi-Chung Chen, Ying-Chen Lu, Hui-Ling Huang, Hung-Jui Chen, Yin-Ching Chuang, Chih-Cheng Lai, Chien-Ming Chao
Summary: This study investigated the inhibitory effect of probiotic Lactobacillus strains, including LYC1154, LYC1322, and LYC1511, with prebiotics such as lactulose or isomalto-oligosaccharide, against KPC-2-producing Klebsiella pneumoniae. The results showed that a lower pH value in the cell-free supernatant of Lactobacillus strains was associated with a stronger inhibitory effect against KPC-2-producing Klebsiella pneumoniae. The addition of lactulose/isomalto-oligosaccharide/inulin and fructo-oligosaccharide enhanced the inhibitory effect of Lactobacillus strains. Furthermore, a combination of three different Lactobacillus species had a better effect in reducing the amount of KPC-2-producing Klebsiella pneumoniae compared to each species alone.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Microbiology
Xiangning Huang, Siquan Shen, Fan Chang, Xin Liu, Jinxi Yue, Ning Xie, Lin Yin, Fupin Hu, Daiwen Xiao
Summary: This study reports a ceftazidime-avibactam-resistant Klebsiella pneumoniae strain carrying a novel KPC variant, KPC-134. The isolate showed resistance to multiple antibiotics but sensitivity to certain others. Further experiments revealed that the resistance was primarily mediated by a plasmid carrying the bla(KPC-134) gene, which also harbored other common resistance genes.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
Xiangning Huang, Siquan Shen, Fan Chang, Xin Liu, Jinxi Yue, Ning Xie, Lin Yin, Fupin Hu, Daiwen Xiao
Summary: The emergence of new KPC variants leading to treatment failure with ceftazidime-avibactam presents a new challenge for clinical anti-infection treatment. In this study, a ceftazidime-avibactam-resistant K. pneumoniae strain carrying a novel KPC-134 variant was reported. The study highlights the importance of timely identification of KPC variants and effective anti-infective therapy for saving infected patients.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
Jacqueline Findlay, Laurent Poirel, Mario Juhas, Patrice Nordmann
Summary: This study evaluated the impact of KPC variants on CZA resistance, finding increased susceptibility to cephalosporins and carbapenems but increased resistance to ceftazidime and piperacillin-tazobactam. The KPC variants exhibited increased affinity towards ceftazidime and slightly decreased sensitivity to avibactam, impacting CZA resistance while concurrently negatively impacting carbapenemase activities.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Ophthalmology
Yu Xiao, Yijun Hu, Wuxiu Quan, Yahan Yang, Weiyi Lai, Xun Wang, Xiayin Zhang, Bin Zhang, Yuqing Wu, Qiaowei Wu, Baoyi Liu, Xiaomin Zeng, Zhanjie Lin, Ying Fang, Yu Hu, Songfu Feng, Ling Yuan, Hongmin Cai, Tao Li, Haotian Lin, Honghua Yu
Summary: This study successfully developed deep learning models for classification of macular hole etiology and prediction of postoperative macular hole status using a multimodal deep fusion network. The models showed high accuracy and sensitivity.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Environmental Sciences
Jingwen Wang, Shiye Cheng, Ning Liu, Na Lu, Kefeng Shang, Nan Jiang, Jie Li, Yan Wu
Summary: This paper investigates the power characteristics and power factor optimization in a coaxial tube-tube dielectric barrier discharge reactor. The effects of various parameters on discharge power and power factor were evaluated. The results show that increasing discharge voltage, discharge frequency, and electrode length can enhance discharge power. However, the power factor initially increases and then decreases with increasing discharge frequency. Response surface method and artificial neural network were used for power factor optimization, and their results were consistent. The degradation experiment of toluene in the reactor reveals a positive correlation between the toluene degradation rate and power factor, with discharge voltage, gas flow rate, and initial concentration playing key roles. The importance of these parameters is demonstrated when the power factor reaches 0.34 and the toluene degradation rate reaches 74.3% at a discharge voltage of 10 kV, gas flow rate of 70 mL/min, and initial concentration of 50 ppm.
ENVIRONMENTAL TECHNOLOGY
(2023)
Article
Development Studies
Yingzhi Xu, Ruijie Zhang, Biying Dong, Jingjing Wang
Summary: This study examines the impact of low-carbon city construction on haze pollution in China using the VAR model and DID-PSM method. The results show that the construction of low-carbon cities has not effectively reduced haze pollution, and the ineffectiveness of technical innovation effect, industrial structure effect, and population quality effect, as well as regional heterogeneity, may be the reasons. Several recommendations for alleviating China's haze pollution through low-carbon city construction are proposed.
JOURNAL OF ENVIRONMENTAL PLANNING AND MANAGEMENT
(2023)
Article
Environmental Sciences
Bin Zhao, Yanping Yang, Chen Zhao, Chunchun Zhang, Zhaohui Zhang, Liang Wang, Shang Wang, Jingfeng Wang
Summary: This study investigates the metabolic mechanisms of glycogen accumulating organisms (GAOs) and reveals the crucial metabolic pathways in a GAOs enrichment system. It also provides insights into the potential application of Ca. Contendobacter for wastewater treatment.
JOURNAL OF ENVIRONMENTAL SCIENCES
(2023)
Article
Management
Jingyu Yu, Anying Chan, Bo Wang, Yong Liu, Jingfeng Wang
Summary: This study investigates the critical success factors for the adoption of assembled buildings with the steel structure (ABSS) method in China. The results identify six critical success factors: market, organization, government, project, professional, and social factors. The government factor is found to be the most important influence on the use of the ABSS method.
INTERNATIONAL JOURNAL OF CONSTRUCTION MANAGEMENT
(2023)
Article
Meteorology & Atmospheric Sciences
Jingzhi Wang, Xiao-Feng Li, Shaofeng Liu, Ting Liu, Yongjiu Dai, Song Yang, Hayley J. Fowler
Summary: This study identifies the dominant wind patterns over the western Tibet Plateau using MV-EOF analysis. It finds that the wind field in most seasons over the plateau shows high similarity to the Western Tibetan Vortex.
Article
Biochemistry & Molecular Biology
Fengyi Chen, Yanping Wang
Summary: Neuromyelitis optica (NMO) is an inflammatory demyelinating disorder associated with upregulated osteopontin (OPN). This study found that downregulation of OPN alleviated demyelination and other pathological features, while increasing neurotrophic factors levels. Furthermore, OPN was shown to activate the IFN-γ/NF-kB/IL-12 signaling pathway, promoting microglia activation and contributing to the pathogenesis of NMO.
MOLECULAR & CELLULAR TOXICOLOGY
(2023)
Article
Psychology, Developmental
Zhongjie Wang, Xuezhen Wang, Ying Peng, Cuijing Liu, Jingke He
Summary: This study aims to investigate whether psychache mediates the relationship between recalled childhood maltreatment and suicide risk among college students, as well as whether meaning in life moderates this indirect path. The findings reveal that recalled childhood maltreatment is positively associated with suicide risk, with psychache partially mediating this relationship. Moreover, meaning in life moderates the association between psychache and suicide risk, indicating that higher levels of meaning in life weaken the impact of psychache on suicide risk. These findings highlight the importance of considering these risk and protective factors when assessing suicide risk and developing prevention and intervention strategies.
JOURNAL OF ADULT DEVELOPMENT
(2023)
Article
Chemistry, Physical
Anlian Zhu, Jingyi Wang, Mingyue Wang, Dongshuang Fan, Lingjun Li
Summary: A series of ionic liquids were synthesized and their synergetic effects on the Cu catalyzed one-pot A(3) coupling reactions were investigated for the synthesis of propargylamines. The combined catalytic system based on ionic liquid [MEA] [H2PO4 ] and CuI showed excellent catalytic activity and selectivity for propargylamine synthesis, achieving good to excellent yields for various aromatic and heteroaromatic aldehydes.
Review
Food Science & Technology
Lu Qiao, Jinhua Xu, Zhen Yang, Xingyang Li, Lu Chen, Huiwu Sun, Yingchun Mu
Summary: This paper provides an overview of the residual risk and toxicity of Avermectins (AVMs) in animal-derived food products, as well as summarizing the analytical methods used for their detection. It highlights the need for further research on the environmental impacts of AVMs and the potential toxicological significance of food contamination.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Engineering, Electrical & Electronic
Wei-Hua Shang-Guan, Rong-Bing Zhao, Jin-Qing Wang, Zhi-Chao Wang, Qing-Hui Liu, Xiao-Yu Hong, Guang-Li Wang, Wei-Min Zheng, Xiu-Zhong Zhang, Tao Shuai, Zhen Yan, Yi-Dan Huang, Xue-Jiang Lu, Lin-Feng Yu, Yong-Bin Jiang, Chao Zhang, Mao-Li Ma, Wei-Ye Zhong, Ren-Jie Zhu, Wen-Bin Wang, Juan Zhang, Bo Xia, Chu-Yuan Zhang
Summary: China plans to launch a relay satellite in the future to conduct lunar orbit very-long-baseline interferometry (LOVEX) experiments, aiming to improve the accuracy of spacecraft orbit determination and scientific observation capabilities. In order to verify the key technologies of the LOVEX system, a LOVEX ground validation system with similar performance has been established. Experimental results using this system show the feasibility of LOVEX time-delay calibration.
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
(2023)
Article
Biochemistry & Molecular Biology
Chongyang Huang, Wenjun Deng, Huan-zhou Xu, Chen Zhou, Fan Zhang, Junfei Chen, Qinjia Bao, Xin Zhou, Maili Liu, Jing Li, Chaoyang Liu
Summary: Short-chain fatty acids (SCFAs) have anticancer activity in colon cancer. Acetate, propionate, and butyrate are the major SCFAs produced from dietary fiber by gut microbiota fermentation and have beneficial effects on human health. This study systematically analyzed the effects of acetate, propionate, and butyrate on ROS levels and metabolic and transcriptomic signatures in human colorectal adenocarcinoma cells, showing elevated levels of ROS and regulated signatures in pathways related to ROS production.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Geochemistry & Geophysics
Rongqi Tang, Xiaodan Wu, Jingping Wang, Zheng Li, Qicheng Zeng, Jianguang Wen, Qing Xiao
Summary: Validation of satellite albedo products commonly uses reference values obtained within the validation pixel's nominal spatial extent. However, geometric errors can cause geolocation mismatch, leading to large uncertainty in validation results. This study proposes a geometric location matching method to accurately establish the position of the validation pixel on a coarse pixel scale. The method significantly reduces the uncertainty and improves the accuracy of satellite albedo products.
IEEE GEOSCIENCE AND REMOTE SENSING LETTERS
(2023)
Article
Medicine, Research & Experimental
Yintang Wang, Yu Geng, Ou Zhang, Qin Xu, Yajun Xue, Boda Zhou, Ping Zhang, Aihua Li, Bao Li, Biao Xu, Guangshu Han, Bin Li, Bin Liu, Bin Wang, Bing Fu, Bo Yu, Bosong Yang, Caidong Luo, Changqian Wang, Changyong Liu, Chuanliang Liang, Chuanyu Gao, Chunlin Lai, Chuntong Wang, Chunyan Zhang, Chunyang Wu, Congliang Zhang, Cui Bin, Lan Huang, Daoquan Peng, Dawen Xu, Di Wu, Dongmei Zhu, Dongsheng Chai, Dongyan Li, Fakuan Tang, Jun Xiao, Fang Zhao, Fangfang Huang, Fanju Meng, Fengwei Li, Fudong Gan, Gang Xu, Gengsheng Sang, Genshan Ma, Guixia Zhang, Guizhou Tao, Guo Li, Guoduo Chen, Guoqin Xin, Guoqing Li, Guosheng Fu, Guoxiong Chen, Hailong Lin, Haiping Guo, Haiyun Lin, Hong Jiang, Hong Liu, Hong Luan, Hong Zhang, Honghua Deng, Hongwei Li, Honhju Wang, Hualing Liu, Hui Dong, Hui Liu, Huifang Zhang, Huifeng Wang, Huimin Chu, Jiabin Xi, Jian Yang, Jianfeng Ye, Jianhao Li, Jianhong Tao, Jianwen Liu, JiaoMei Yang, Jiawang Ding, Jiayi Tong, Jie Chen, Jie Jiang, Jie Yang, Jifu Li, Jinchuan Yan, Jing Hu, Jing Xu, Jingfeng Wang, Jinglan Diao, Jingshan Zhao, Jinru Wei, Jinxing Yi, Jinzi Su, Jiong Tang, Jiyan Chen, Jiyan Yin, Juexin Fan, Jun Guan, Junbo Ge, Junming Liu, Junping Deng, Junping Fang, Junxia Li, Kaihong Chen, Kalan Luo, Keng Wu, Lang Ji, Lang Li, Li Jiang, Li Wei, Lijun Meng, Likun Ma, Lilong Tang, Lin Wang, Lin Wei, Ling Li, Ling Tao, Liqiong Yang, Lirong Wu, Man Zhang, Kaiming Chen, Meisheng Lai, Miao Tian, Mingcheng Bai, Minghua Han, Moshui Chen, Naiyi Liang, Nan Jia, Peiying Zhang, Peng Qu, Pengfei Zhang, Ping Chen, Ping Hou, Ping Xie, Pingshuan Dong, Qiang Wu, Qiang Xie, Qiaoqing Zhong, Qichun Wang, Qinfeng Su, Rong Chang, Rong Lin, Ruiping Zhao, Shaobin Jia, Shaoping Nie, Shaowu Ye, Shenghu He, Shengyong Chen, Shixin Ma, Shuangbin Li, Shuanli Xin, Shudong Xia, Shuhua Zhang, Shuqiu Qu, Shuren Ma, Siding Wang, Songbai Li, Suxin Luo, Tao Liu, Tao Zhang, Tian Tuo, Tianchang Li, Tianlun Yang, Tianmin Du, Tongguo Wu, Wei Liu, Wei Mao, Wei Tuo, Wei Wang, Weihong Jiang, Weijian Huang, Weijun Liu, Weiqing Fan, Weiting Xu, Wenhua Lin, Xi Su, Xia Chen, Xianan Zhang, Xianghua Fu, Xiangjun Yang, Xianxian Zhao, Xiaochuan Ma, Xiaofei Sun, Xiaojun Wang, Xiaolan Li, Xiaolei Li, Xiaoli Yang, Xiaoping Chen, Xiaoqin Zhang, Xiaoshu Cheng, Xiaowei Peng, Xiaowen Ma, Xiaoyong Qi, Xiaoyun Feng, Ximing Chen, Xin Tang, Xingsheng Tang, Xingsheng Zhao, Xiufeng Chen, Xudong Li, Xue Li, Xuebo Liu, Xuemei Peng, Yaling Han, Yan Wang, Yanbo Niu, Yang Yu, Yang Zheng, Yanli Wang, Yanlie Zheng, Yansong Guo, Yanzong Yang, Yi Huang, Yin Liu, Ying Guo, Yingchao Luo, Yinglu Hao, Yingxian Sun, Yingzhong Lin, Yitong Ma, Yong Guo, Yong Li, Yongdong Li, Yonglin Zhang, Yuanzhe Jin, Yue Li, Yuehua Huang, Yuemin Sun, Yuheng Yang, Yuhua Zhu, Yuhuan Shi, Yulan Zhao, Yuqing Hou, Zeqi Zheng, Zesheng Xu, Zewei Ouyang, Zeyuan He, Zhan Lv, Zhanquan Li, Zhaofa He, Zheng Ji, Zheng Zhang, Zhenguo Ji, Zhenqi Su, Zhenyu Yang, Zhihong Ou, Zhijian Yang, Zhiming Yang, Zhirong Wang, Zhiyuan Song, Zhongshan Wang, Zuyi Yuan
Summary: In patients with NSTEACS who were already taking P2Y12 receptor inhibitors, reloading of these inhibitors was associated with a decreased risk of in-hospital major adverse cardiac events (MACE) and all-cause death, without an increased risk of major bleeding.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Letter
Surgery
Binghao Zhao, Hao Xing, Wenbin Ma
