期刊
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
卷 87, 期 3, 页码 504-510出版社
AMER SOC TROP MED & HYGIENE
DOI: 10.4269/ajtmh.2012.11-0477
关键词
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资金
- French Agency of National Research grant (ANR-Epi-Dengue project)
- Institut de Recherche pour le Developpement
- CGG-Veritas Company
- Centre National de la Recherche Scientifique Interdisciplinaire MIE grant
- Infectiopole Sud' Fundation (Marseille, France)
Aedes mosquitoes are important vectors of re-emerging diseases in developing countries, and increasing exposure to Aedes in the developed world is currently a source of concern. Given the limitations of current entomologic methods, there is a need for a new effective way for evaluating Aedes exposure. Our objective was to evaluate specific antibody responses to Aedes aegypti saliva as a biomarker for vector exposure in a dengue-endemic urban area. IgG responses to saliva were strong in young children and steadily waned with age. Specific IgG levels were significantly higher in persons living in sites with higher Ae. aegypti density, as measured by using entomologic parameters. Logistic regression showed a significant correlation between IgG to saliva and exposure level, independently of either age or sex. These results suggest that antibody responses to saliva could be used to monitor human exposure to Aedes bites.
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