Article
Immunology
Andrea A. Berry, Joshua M. Obiero, Mark A. Travassos, Amed Ouattara, Drissa Coulibaly, Matthew Adams, Rafael Ramiro de Assis, Aarti Jain, Omid Taghavian, Andrew Sy, Rie Nakajima, Algis Jasinskas, Matthew B. Laurens, Shannon Takala-Harrison, Bourema Kouriba, Abdoulaye K. Kone, Ogobara K. Doumbo, B. Kim Lee Sim, Stephen L. Hoffman, Christopher V. Plowe, Mahamadou A. Thera, Philip L. Felgner, Kirsten E. Lyke
Summary: This study assessed IgG and IgA antibody responses in adult sera collected during CHMI studies and in Malian children, and identified differences in the immunoproteome among naive individuals and exposed individuals. It also expanded the list of pre-erythrocytic antigens recognized by the immune system and highlighted the potential of IgA responses as vaccine candidates.
Article
Biochemistry & Molecular Biology
Ada da Silva Matos, Isabela Ferreira Soares, Barbara de Oliveira Baptista, Hugo Amorim dos Santos de Souza, Lana Bitencourt Chaves, Daiana de Souza Perce-da-Silva, Evelyn Kety Pratt Riccio, Letusa Albrecht, Paulo Renato Rivas Totino, Rodrigo Nunes Rodrigues-da-Silva, Claudio Tadeu Daniel-Ribeiro, Lilian Rose Pratt-Riccio, Josue da Costa Lima-Junior
Summary: In this study, a P. vivax recombinant modular chimeric protein (PvRMC-1) composed of important antigenic regions was designed and expressed. The antigenicity of PvRMC-1 was assessed in naturally exposed individuals, and it was recognized by IgG and IgM antibodies. The study also observed a predominant cytophilic response mediated by IgG1 and IgG3. IgM levels were inversely correlated with age and time of residence in endemic areas, while IgG and IgM reactivity indexes were positively correlated with each other and inversely correlated with the time of the last malaria episode.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Parasitology
Arturo Reyes-Sandoval
Summary: In 2019, an estimated 229 million cases of malaria occurred worldwide, with P. falciparum and P. vivax responsible for most of the disease burden. Despite progress in P. falciparum vaccine development, challenges remain for P. vivax due to the hypnozoite leading to relapse, highlighting the need for further research in this area.
PARASITOLOGY INTERNATIONAL
(2021)
Article
Immunology
Mohd Amirul Fitri A. Rahim, Mohd Bakhtiar Munajat, Nor Diyana Dian, Mohd Ikhwan Mukmin Seri Rakna, Wathiqah Wahid, Nuraffini Ghazali, Noor Wanie Hassan, Siti Nor Azreen Abdul Manap, Muhd Rafiq Mohd Kasri, Ahmad Imran Mohamed, Emelia Osman, Sriwipa Chuangchaiya, Inke Nadia D. Lubis, Paul C. S. Divis, Akira Kaneko, Kevin K. A. Tetteh, Zulkarnain Md Idris
Summary: Malaria control in Malaysia has made significant progress, but there is still a need to determine malaria exposure and transmission patterns in high-risk populations. This study used a serological method to measure the transmission levels of Plasmodium falciparum and Plasmodium vivax among indigenous communities. The findings showed a higher level of P. falciparum transmission and an association between living in a specific area and malaria infection. This approach can be an important tool for monitoring and surveillance in low malaria transmission settings.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Infectious Diseases
Jenni Hietanen, Anongruk Chim-ong, Jetsumon Sattabongkot, Wang Nguitragool
Summary: As individuals age, the level of anti-RBP2P1 IgG increases while IgM decreases. The main IgG subtypes against RBP2P1 are IgG1 and IgG3, with a higher IgG3 seropositive rate in asymptomatic carriers. Higher levels of IgG3 correlate with enhanced in vitro complement fixing activity, suggesting a potential role of anti-RBP2P1 antibodies in immunity against P. vivax.
Article
Immunology
Gabriela Maira Pereira de Assis, Denise Anete Madureira de Alvarenga, Matheus de Oliveira Costa Pereira, Juan Camilo Sanchez-Arcila, Anielle de Pina Costa, Julio Cesar de Souza Junior, Ana Julia Dutra Nunes, Alcides Pissinatti, Silvia Bahadian Moreira, Leticia de Menezes Torres, Helena Lott Costa, Herlandes da Penha Tinoco, Valeria do Socorro Pereira, Irene da Silva Soares, Tais Nobrega de Sousa, Francis Babila Ntumngia, John H. Adams, Flora Satiko Kano, Zelinda Maria Braga Hirano, Claudio Tadeu Daniel-Ribeiro, Joseli Oliveira Ferreira, Luzia Helena Carvalho, Cristiana Ferreira Alves de Brito
Summary: This study evaluated the humoral immune response against pre-erythrocytic and erythrocytic antigens of Neotropical primates in the Atlantic Forest, Brazil, to identify potential reservoirs of malaria. The results showed a high prevalence of antibodies against Plasmodium antigens in monkeys from different areas of the Atlantic Forest, suggesting a significant exposure to infected-mosquitoes bites. Monkeys from the Atelidae family showed higher levels of antibodies against P. vivax erythrocytic antigens, indicating a potential role as reservoirs of malaria in the Atlantic Forest.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Immunology
Iris Aparici-Herraiz, Melisa Gualdron-Lopez, Carlos J. Castro-Cavadia, Jaime Carmona-Fonseca, Maria Fernanda Yasnot, Carmen Fernandez-Becerra, Hernando A. del Portillo
Summary: In this study, we identified new candidate vaccine antigens for Plasmodium vivax by analyzing parasite proteins in circulating extracellular vesicles (EVs) of P. vivax patients. We also confirmed the antigenicity of the PHIST-c protein. This research represents a significant advancement in the development of vaccines against this human malaria parasite.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Sataporn Thongpoon, Wanlapa Roobsoong, Wang Nguitragool, Sadudee Chotirat, Takafumi Tsuboi, Eizo Takashima, Liwang Cui, Tomoko Ishino, Mayumi Tachibana, Kazutoyo Miura, Jetsumon Sattabongkot
Summary: This study aimed to investigate naturally acquired transmission-blocking immunity against Plasmodium vivax. The findings suggest that transmission-blocking immunity is primarily mediated by antibodies, with varying effectiveness against different parasite strains. These findings have implications for vaccine development.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Immunology
Surafel K. Tebeje, Wakweya Chali, Elifaged Hailemeskel, Jordache Ramjith, Abrham Gashaw, Temesgen Ashine, Desalegn Nebret, Endashaw Esayas, Tadele Emiru, Tizita Tsegaye, Karina Teelen, Kjerstin Lanke, Eizo Takashima, Takafumi Tsuboi, Nichole D. Salinas, Niraj H. Tolia, David Narum, Chris Drakeley, Benoit Witkowski, Amelie Vantaux, Matthijs M. Jore, William J. R. Stone, Ivo S. Hansen, Fitsum G. Tadesse, Teun Bousema
Summary: This study investigated the association between antibody prevalence and the infectivity of Plasmodium vivax to mosquitoes. The results showed that antibodies against Pvs47, Pvs230, and Pvs25 were significantly associated with a reduction in mosquito infection rates. Further research can help establish causality and contribute to our understanding of P. vivax transmission and vaccine development.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Medicine, Research & Experimental
Katja Mueller, Matthew P. Gibbins, Mark Roberts, Arturo Reyes-Sandoval, Adrian V. S. Hill, Simon J. Draper, Kai Matuschewski, Olivier Silvie, Julius Clemence R. Hafalla
Summary: Antigens from different origins, either from sporozoites or exo-erythrocytic forms, exhibit significant differences in immunogenicity. However, both types of antigens can be effectively targeted and recognized by vaccine-induced effector CD8(+) T cells, leading to high levels of protection. This finding has important implications for antigen prioritization in next-generation pre-erythrocytic malaria vaccines.
EMBO MOLECULAR MEDICINE
(2021)
Article
Microbiology
Amed Ouattara, Ankit Dwivedi, Matthew Adams, Amadou Niangaly, Matthew B. Laurens, Myaing M. Nyunt, Christopher Plowe, Abdoulaye Djimde, Shannon Takala-Harrison, Joana C. Silva
Summary: Failure to account for genetic diversity of antigens during vaccine design may lead to vaccine escape. To evaluate the vaccine escape potential of antigens, this study analyzed the genetic diversity and T-cell epitopes of Plasmodium falciparum pre-erythrocytic-stage antigens using whole-genome sequence data from field isolates. The findings identified representative protein variants and potential immunogenic T-cell epitopes, providing insights for the rational design of a multivalent malaria vaccine.
Article
Multidisciplinary Sciences
Seong-Kyun Lee, Leanne M. Low, John F. Andersen, Lee M. Yeoh, Paola Carolina Valenzuela Leon, Damien R. Drew, Johannes S. P. Doehl, Eric Calvo, Louis H. Miller, James G. Beeson, Karthigayan Gunalan
Summary: This study used a transgenic parasite to investigate the invasion process mediated by PvAMA1. The findings showed that PfRON2 had no effect on the invasion of transgenic parasites expressing PvAMA1, while PvRON2p blocked the invasion of PvAMA1 transgenic parasites. Additionally, the study revealed that PvAMA1 directly interacts with erythrocytes during invasion, and the invasion blocking by PvRON2p may be due to its interference with PvAMA1 binding to erythrocytes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Infectious Diseases
Sanghyun Lee, Young-Ki Choi, Youn-Kyoung Goo
Summary: Natural antibody and cellular responses in P. vivax-infected Korean malaria patients are similar to those in other countries. VIR proteins elicit a high level of immune response, suggesting further studies are needed to elucidate the molecular mechanisms by which human immune response is elicited to the malaria parasite VIR antigens.
Article
Multidisciplinary Sciences
Li-Jin Chan, Anugraha Gandhirajan, Lenore L. Carias, Melanie H. Dietrich, Oscar Vadas, Remy Visentin, Camila T. Franca, Sebastien Menant, Dominique Soldati-Favre, Ivo Mueller, Christopher L. King, Wai-Hong Tham
Summary: The study shows that antibodies against Plasmodium vivax RBP2b can provide protection against infection and disease, and inhibit invasion of reticulocytes. Researchers have identified different mechanisms by which human antibodies can inhibit the invasion ability of P. vivax RBP2b.
NATURE COMMUNICATIONS
(2021)
Article
Parasitology
Edvige Perrotti, Mariangela L'Episcopia, Michela Menegon, Irene S. Soares, Angel Rosas-Aguirre, Niko Speybroeck, Alejandro LLanos-Cuentas, Didier Menard, Marcelo Urbano Ferreira, Carlo Severini
Summary: This study investigates the genetic diversity of the pvetramp11.2 gene in parasite populations from the Amazonian region and worldwide. The low variability of the sequence encoding PvETRAMP11.2 protein suggests its suitability as a marker in serodiagnostic assays and vaccine design. The study also explores B-cell epitopes and their polymorphisms.
PARASITES & VECTORS
(2023)
Article
Public, Environmental & Occupational Health
Mary Lopez-Perez, Alvaro Alvarez, Juan B. Gutierrez, Alberto Moreno, Socrates Herrera, Myriam Arevalo-Herrera
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2015)
Article
Immunology
Pilar Requena, Diana Barrios, Leanne J. Robinson, Paula Samol, Alexandra J. Umbers, Regina Wangnapi, Maria Ome-Kaius, Anna Rosanas-Urgell, Alfredo Mayor, Marta Lopez, Elisa de Lazzari, Myriam Arevalo-Herrera, Carmen Fernandez-Becerra, Hernando del Portillo, Chetan E. Chitnis, Peter M. Siba, Stephen Rogerson, Ivo Mueller, Azucena Bardaji, Clara Menendez, Carlota Dobano
JOURNAL OF IMMUNOLOGY
(2015)
Article
Infectious Diseases
Myriam Arevalo-Herrera, Mary Lopez-Perez, Luz Medina, Alberto Moreno, Juan B. Gutierrez, Socrates Herrera
Article
Infectious Diseases
Andres F. Vallejo, Pablo E. Chaparro, Yoldy Benavides, Alvaro Alvarez, Juan Pablo Quintero, Julio Padilla, Myriam Arevalo-Herrera, Socrates Herrera
Article
Public, Environmental & Occupational Health
Temitope O. Alimi, Douglas O. Fuller, Socrates V. Herrera, Myriam Arevalo-Herrera, Martha L. Quinones, Justin B. Stoler, John C. Beier
Article
Infectious Diseases
Socrates Herrera Valencia, Ivan Dario Ocampo, Maria Isabel Arce-Plata, Judith Recht, Myriam Arevalo-Herrera
Article
Infectious Diseases
Pablo E. Chaparro-Narvaez, Mary Lopez-Perez, Lina Marcela Rengifo, Julio Padilla, Socrates Herrera, Myriam Arevalo-Herrera
Article
Infectious Diseases
Andres F. Vallejo, Nora L. Martinez, Alejandra Tobon, Jackeline Alger, Marcus V. Lacerda, Andrey V. Kajava, Myriam Arevalo-Herrera, Socrates Herrera
Article
Infectious Diseases
Juan M. Vasquez-Jimenez, Myriam Arevalo-Herrera, Juliana Henao-Giraldo, Karen Molina-Gomez, Maria Arce-Plata, Andres F. Vallejo, Socrates Herrera
Article
Infectious Diseases
Andres F. Vallejo, Jhon Garcia, Andres B. Amado-Garavito, Myriam Arevalo-Herrera, Socrates Herrera
Article
Infectious Diseases
Mary Lopez-Perez, M. Andreina Pacheco, Lucia Buritica, Ananias A. Escalante, Socrates Herrera, Myriam Arevalo-Herrera
Article
Infectious Diseases
Myriam Arevalo-Herrera, Mary Lopez-Perez, Emmanuel Dotsey, Aarti Jain, Kelly Rubiano, Philip L. Felgner, D. Huw Davies, Socrates Herrera
PLOS NEGLECTED TROPICAL DISEASES
(2016)
Article
Infectious Diseases
M. Andreina Pacheco, Mary Lopez-Perez, Andres F. Vallejo, Socrates Herrera, Myriam Arevalo-Herrera, Ananias A. Escalante
PLOS NEGLECTED TROPICAL DISEASES
(2016)
Article
Multidisciplinary Sciences
Michela Menegon, Azucena Bardaji, Flor Martinez-Espinosa, Camila Botto-Menezes, Maria Ome-Kaius, Ivo Mueller, Inoni Betuela, Myriam Arevalo-Herrera, Swati Kochar, Sanjay K. Kochar, Puneet Jaju, Dhiraj Hans, Chetan Chitnis, Norma Padilla, Maria Eugenia Castellanos, Lucia Ortiz, Sergi Sanz, Mireia Piqueras, Meghna Desai, Alfredo Mayor, Hernando del Portillo, Clara Menendez, Carlo Severini
Article
Health Care Sciences & Services
Monica L. Rojas-Pena, Meixue Duan, Dalia Arafat, Lina Rengifo, Socrates Herrera, Myriam Arevalo-Herrera, Greg Gibson
JOURNAL OF PERSONALIZED MEDICINE
(2018)