Article
Immunology
Biraj Shrestha, Zalak Shah, Andrew P. Morgan, Piyaporn Saingam, Chaiyaporn Chaisatit, Suwanna Chaorattanakawee, Chantida Praditpol, Nonlawat Boonyalai, Paphavee Lertsethtakarn, Mariusz Wojnarski, Molly Deutsch-Feldman, Matthew Adams, Darapiseth Sea, Soklyda Chann, Stuart D. Tyner, Charlotte A. Lanteri, Michele D. Spring, David L. Saunders, Philip L. Smith, Chanthap Lon, Panita Gosi, Somethy Sok, Prom Satharath, Huy Rekol, Dysoley Lek, Brian A. Vesely, Jessica T. Lin, Norman C. Waters, Shannon Takala-Harrison
Summary: This study estimated the prevalence of piperaquine resistance mutations in Plasmodium falciparum isolates collected in northern Cambodia from 2009 to 2017. The results showed a significant increase in newly emerged PfCRT mutations after the change to dihydroartemisinin-piperaquine in 2010, with a decline in PfCRT F145I prevalence after 2014. Additionally, there was a decrease in parasites with amplified pfpm2 after the switch to artesunate-mefloquine.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Irene Molina-de la Fuente, Maria Jose Sagrado Benito, Laurence Flevaud, Janet Ousley, Harriet Akello Pasquale, Ahmed Julla, Abdirashid M. Abdi, Buai Tut Chol, Bakri Abubakr, Agustin Benito, Cristian Casademont, Carolina Nanclares, Pedro Berzosa
Summary: Deletions of pfhrp2 and pfhrp3 genes pose a threat to the global use of Plasmodium falciparum malaria rapid diagnostic tests. In South Sudan, the frequencies of pf-hrp2 deletion, pfhrp3 deletion, and double deletions were 15.6%, 20.0%, and 7.5% respectively. Deletions were approximately twice as prevalent in monoclonal infections compared to polyclonal infections.
EMERGING INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Joseph A. Lewnard, Ayesha Mahmud, Tejas Narayan, Brian Wahl, T. S. Selvavinayagam, Chandra B. Mohan, Ramanan Laxminarayan
Summary: Mortality in Chennai substantially increased during the COVID-19 pandemic, with the greatest burden falling on disadvantaged communities. Reported COVID-19 deaths greatly underestimated the true pandemic-associated mortality.
LANCET INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Guoming Li, Yueming Yuan, Shaoqin Zheng, Chenguang Lu, Mingqiang Li, Ruixiang Tan, Hongying Zhang, Rahamatou Silai, Ruimei Liu, Kamal Said Abdallah, Affane Bacar, Qin Xu, Jianping Song, Wanting Wu, Changsheng Deng
Summary: The study found that artemisinin-piperaquine and artemether-lumefantrine maintained high efficacy and tolerance in treating uncomplicated falciparum malaria in the Comoros. However, asymptomatic malaria infections may pose new challenges to malaria control.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
Article
Chemistry, Medicinal
Benjamin R. Taft, Fumiaki Yokokawa, Tom Kirrane, Anne-Catherine Mata, Richard Huang, Nicole Blaquiere, Grace Waldron, Bin Zou, Oliver Simon, Subramanyam Vankadara, Wai Ling Chan, Mei Ding, Sandra Sim, Judith Straimer, Armand Guiguemde, Suresh B. Lakshminarayana, Jay Prakash Jain, Christophe Bodenreider, Christopher Thompson, Christian Lanshoeft, Wei Shu, Eric Fang, Jafri Qumber, Katherine Chan, Luying Pei, Yen-Liang Chen, Hanna Schulz, Jessie Lim, Siti Nurdiana Abas, Xiaoman Ang, Yugang Liu, Inigo Angulo-Barturen, Maria Belen Jimenez-Diaz, Francisco Javier Gamo, Benigno Crespo-Fernandez, Philip J. Rosenthal, Roland A. Cooper, Patrick Tumwebaze, Anna Caroline Campos Aguiar, Brice Campo, Simon Campbell, Jurgen Wagner, Thierry T. Diagana, Christopher Sarko
Summary: A highly potent antimalarial compound, INE963 (1), with favorable pharmacological properties, has been identified through high-throughput screening and shows potential for curing uncomplicated malaria.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Microbiology
Makoto Saito, Widi Yotyingaphiram, Zillah Cargill, Mary Ellen Gilder, Aung Myat Min, Aung Pyae Phyo, Thi Dar San, Hilda Poe, Cindy Chu, Nicholas J. White, Francois Nosten, Rose McGready
Summary: Quinoline antimalarials can cause drug-induced QT prolongation, with different effects observed for different antimalarial drugs in pregnant women with malaria. However, none of the antimalarial drug treatments exceeded conventional thresholds for an increased risk of torsade de pointes in pregnant women.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Infectious Diseases
Mulebeke Ronald, Wanzira Humphrey, Yeka Adoke, Van Geertruyden Jean-Pierre
Summary: This study evaluated the impact of combining mass drug administration and indoor residual spraying compared to indoor residual spraying alone in a high transmission area in Eastern Uganda.
Article
Immunology
Koko Vanda, Naveen Bobbili, Masako Matsunaga, John J. Chen, Ali Salanti, Rose F. G. Leke, Diane Wallace Taylor
Summary: The study found that high avidity antibodies to VAR2CSA increase with gravidity in women, especially during the second pregnancy. These antibodies are mainly directed against a specific region of VAR2CSA and have a positive impact on pregnancy outcomes for women in urban areas.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Melissa D. Conrad, Victor Asua, Shreeya Garg, David Giesbrecht, Karamoko Niare, Sawyer Smith, Jane F. Namuganga, Thomas Katairo, Jennifer Legac, Rebecca M. Crudale, Patrick K. Tumwebaze, Samuel L. Nsobya, Roland A. Cooper, Moses R. Kamya, Grant Dorsey, Jeffrey A. Bailey, Philip J. Rosenthal
Summary: This study identified multifocal emergence and spread of Plasmodium falciparum with partial resistance to artemisinins in Uganda. The emergence and spread of resistance were predominantly observed in areas where effective malaria control had been discontinued or transmission was unstable.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Infectious Diseases
Alistair R. D. McLean, Chanida Indrasuta, Zay Soe Khant, Aung Kyaw Phyo, Sai Maung Maung, James Heaton, Hein Aung, Ye Aung, Kyaw Soe, Myo Maung Maung Swe, Lorenz von Seidlein, Ni Ni Tun, Kyaw Myo Tun, Nicholas P. J. Day, Elizabeth A. Ashley, Thaung Hlaing, Thar Tun Kyaw, Arjen M. Dondorp, Mallika Imwong, Nicholas J. White, Frank M. Smithuis
Summary: In regions with artemisinin resistance, mass drug administration of dihydroartemisinin-piperaquine can effectively reduce Plasmodium falciparum prevalence. This study demonstrated a significant decrease in P falciparum prevalence in clusters receiving MDA intervention, highlighting the importance of community case management in accelerating malaria elimination.
LANCET INFECTIOUS DISEASES
(2021)
Article
Cardiac & Cardiovascular Systems
Molly D. Kaagaard, Luan O. Matos, Anna Engell Holm, Laura Cordeiro Gomes, Alma Wegener, Karine O. Lima, Isabelle V. M. Vieira, Rodrigo Medeiros de Souza, Claudio Romero Farias Marinho, Lars Hviid, Lasse S. Vestergaard, Helena Dominguez, Tor Biering-Sorensen, Philip Brainin, Odison M. Silvestre
Summary: Studies have shown that malaria can cause changes in electrocardiographic (ECG) patterns and pericardial inflammation. This study aimed to investigate the frequency of ECG alterations and pericardial effusion in patients with malaria infection. The results suggest that ECG changes can be useful in detecting pericardial effusion in malaria and that these changes decrease after antimalarial treatment.
AMERICAN JOURNAL OF CARDIOLOGY
(2022)
Article
Microbiology
Clifford G. Banda, Dumisile Nkosi, Elizabeth Allen, Lesley Workman, Mwayiwawo Madanitsa, Marumbo Chirwa, Mayamiko Kapulula, Sharon Muyaya, Steven Munharo, Joel Tarning, Kamija S. Phiri, Victor Mwapasa, Feiko O. ter Kuile, Gary Maartens, Karen I. Barnes
Summary: In pregnant women living with HIV, the use of efavirenz-based antiretroviral therapy significantly reduces the plasma exposure of piperaquine. However, coadministration of dihydroartemisinin-piperaquine and dolutegravir-based ART can increase the overall piperaquine exposure without affecting its maximum concentration. This finding suggests that the efficacy of dihydroartemisinin-piperaquine will be retained in pregnant women on dolutegravir.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Infectious Diseases
Nonlawat Boonyalai, Kirakarn Kirativanich, Chatchadaporn Thamnurak, Chantida Praditpol, Brian A. Vesely, Mariusz Wojnarski, John S. Griesenbeck, Norman C. Waters
Summary: The study generated transgenic parasite clones with the E415G mutation in PfEXO and found that this mutation did not lead to increased resistance to PPQ. However, the results still highlighted the importance of monitoring and evaluating genetic mutations in parasites in relation to drug resistance and fitness.
Article
Multidisciplinary Sciences
Eva Stadler, Mohamed Maiga, Lukas Friedrich, Vandana Thathy, Claudia Demarta-Gatsi, Antoine Dara, Fanta Sogore, Josefine Striepen, Claude Oeuvray, Abdoulaye A. Djimde, Marcus C. S. Lee, Laurent Dembele, David A. Fidock, David S. Khoury, Thomas Spangenberg
Summary: This study analyzes the propensity of the antimalarial agent cabamiquine to select for resistant Plasmodium falciparum parasites. Through various studies, resistant mutations at 11 amino acid positions were identified and found to be translatable across models. Mathematical modeling suggests pre-existence of resistant mutants prior to drug exposure, and structural modeling indicates a binding relationship between cabamiquine and mRNA at specific resistance mutations.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Brendan Fries, Carlos A. Guerra, Guillermo A. Garcia, Sean L. Wu, Jordan M. Smith, Jeremias Nzamio Mba Oyono, Olivier T. Donfack, Jose Osa Osa Nfumu, Simon Hay, David L. Smith, Andrew J. Dolgert
Summary: Different population layers performed differently in matching the gold standard distribution at different population densities. Choosing the appropriate population map has a significant impact on burden estimates in a malaria model.
Article
Pharmacology & Pharmacy
Xin Hui S. Chan, Palang Chotsiri, Rebecca A. Capel, James Pike, Borimas Hanboonkunupakarn, Sue J. Lee, Maryam Hanafiah, Yan Naung Win, Maegan A. Cremer, Jean-Rene Kiechel, Bernhards Ogutu, Walter R. J. Taylor, Rebecca-Ann B. Burton, Joel Tarning, Nicholas J. White
Summary: Amodiaquine and desethylamodiaquine have concentration-dependent effects on heart rate, blood pressure, and ventricular repolarization.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Correction
Microbiology
Clifford G. Banda, Dumisile Nkosi, Elizabeth Allen, Lesley Workman, Mwayiwawo Madanitsa, Marumbo Chirwa, Mayamiko Kapulula, Sharon Muyaya, Steven Munharo, Joel Tarning, Kamija S. Phiri, Victor Mwapasa, Feiko O. ter Kuile, Gary Maartens, Karen I. Barnes
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Review
Medicine, General & Internal
Makoto Saito, Rose McGready, Halidou Tinto, Toussaint Rouamba, Dominic Mosha, Stephen Rulisa, Simon Kariuki, Meghna Desai, Christine Manyando, Eric M. Njunju, Esperanca Sevene, Anifa Vala, Orvalho Augusto, Christine Clerk, Edwin Were, Sigilbert Mrema, William Kisinza, Josaphat Byamugisha, Mike Kagawa, Jan Singlovic, Mackensie Yore, Anna Maria van Eijk, Ushma Mehta, Andy Stergachis, Jenny Hill, Kasia Stepniewska, Melba Gomes, PhilippeJ Guerin, Francois Nosten, Feiko O. ter Kuile, Stephanie Dellicour
Summary: This study compared adverse pregnancy outcomes in the first trimester of pregnancy after artemisinin-based treatment (ABT) versus non-ABTs. The results showed no evidence of embryotoxicity or teratogenicity associated with ABT during the first trimester. Artemether-lumefantrine was found to be the preferred treatment for uncomplicated P falciparum malaria in the first trimester, with fewer adverse pregnancy outcomes compared to quinine.
Editorial Material
Medicine, General & Internal
Lindsey Baden, Flaminia Catteruccia, Abdoulaye Diabate, Cristina Donini, Francois Nosten, Scott O'Neill, Faith Osier, Aung Pyae Phyo, Nicholas White
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Review
Immunology
Cindy S. Chu, Marie Stolbrink, Daniel Stolady, Makoto Saito, Candy Beau, Kan Choun, Tha Gay Wah, Ne Mu, Klay Htoo, Be Nu, Arunrot Keereevijit, Jacher Wiladpaingern, Verena Carrara, Aung Pyae Phyo, Khin Maung Lwin, Christine Luxemburger, Stephane Proux, Prakaykaew Charunwatthana, Rose McGready, Nicholas J. White, Francois Nosten
Summary: This study reviewed all malaria cases managed by the Shoklo Malaria Research Unit along the Thailand-Myanmar border between 2000 and 2016. The results showed that Plasmodium falciparum and Plasmodium vivax malaria had higher incidence and mortality rates in this area compared to areas of low seasonal malaria transmission.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Eva Legendre, Laurent Lehot, Sokhna Dieng, Stanislas Rebaudet, Aung Myint Thu, Jade D. Rae, Gilles Delmas, Florian Girond, Vincent Herbreteau, Francois Nosten, Jordi Landier, Jean Gaudart
Summary: This research developed a dynamic clustering approach to improve the stratification of malaria transmission areas, providing more information for decision-making.
Review
Public, Environmental & Occupational Health
Ahmar Hashmi, Mu Chae Darakamon, Ko Ko Aung, Mu Mu, Prapatsorn Misa, Podjanee Jittamala, Cindy Chu, Aung Pyae Phyo, Claudia Turner, Francois Nosten, Rose McGready, Verena I. I. Carrara
Summary: This study examined the care and outcomes of preterm neonates in a special care baby unit (SCBU) along the Myanmar-Thailand border. The study found significant reductions in neonatal mortality rates and identified implementation factors that impact the delivery of evidence-based care, such as financial issues and social support systems.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Medicine, General & Internal
Makoto Saito, Aung Pyae Phyo, Cindy Chu, Stephane Proux, Marcus J. Rijken, Candy Beau, Htun Htun Win, Laypaw Archasuksan, Jacher Wiladphaingern, Nguyen H. Phu, Tran T. Hien, Nick P. Day, Arjen M. Dondorp, Nicholas J. White, Francois Nosten, Rose Mcgready
Summary: This study aimed to identify factors predicting higher maternal mortality and describe the fetal mortality and morbidity associated with severe falciparum malaria in pregnancy. Coma, hypotension, and respiratory failure were associated with maternal mortality. Maternal death, fetal loss, and preterm birth commonly occurred within a week of severe malaria diagnosis.
Article
Pharmacology & Pharmacy
Ali Haghiri, David J. Price, Phoebe Fitzpatrick, Saber Dini, Megha Rajasekhar, Caterina Fanello, Joel Tarning, James Watson, Nicholas J. White, Julie A. Simpson
Summary: The majority of deaths from malaria occur in young African children, so it is important to determine the appropriate dosage of medication for them. The US FDA has challenged the World Health Organization's recommendation of a lower dose for younger children, but a study showed that younger children given the lower dose did not reach the same drug exposures as older children. Therefore, it is suggested to withdraw the FDA's recent lower dose recommendation.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Infectious Diseases
Navaporn Posayapisit, Jutharat Pengon, Philip J. Shaw, Chairat Uthaipibull, Darin Kongkasuriyachai, Aung Pyae Phyo, Francois Nosten, Yongyuth Yuthavong, Sumalee Kamchonwongpaisan
Summary: The effectiveness of antimalarial drug P218 against artemisinin-resistant Plasmodium falciparum is still uncertain, despite its efficacy against other drug-resistant parasites.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Immunology
Aude Mondeilh, Emmanuel Yovo, Manfred Accrombessi, Cornelia Hounkonnou, Gino Agbota, William Atade, Olaiitan T. Ladikpo, Murielle Mehoba, Auguste Degbe, Bertin Vianou, Dariou Sossou, Nicaise Tuikue Ndam, Achille Massougbodji, Rose McGready, Nadine Fievet, Marcus J. Rijken, Gilles Cottrell, Valerie Briand
Summary: This study evaluated the effect of malaria in pregnancy on uterine artery and umbilical artery blood flow. The results showed that malaria infections in the early stages of pregnancy can impair placental blood flow, highlighting the need to prevent malaria from the very beginning of pregnancy.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Article
Health Care Sciences & Services
Amy Ibrahim, Emilia Manko, Jamille G. Dombrowski, Monica Campos, Ernest Diez Benavente, Debbie Nolder, Colin J. Sutherland, Francois Nosten, Diana Fernandez, Gabriel Velez-Tobon, Alberto Tobon Castano, Anna Caroline C. Aguiar, Dhelio Batista Pereira, Simone da Silva Santos, Martha Suarez-Mutis, Silvia Maria Di Santi, Andrea Regina de Souza Baptista, Ricardo Luiz Dantas Machado, Claudio R. F. Marinho, Taane G. Clark, Susana Campino
Summary: Through whole genome sequencing of P. vivax isolates from 7 Brazilian states, researchers have identified distinct genetic diversity of P. vivax parasites in Brazil compared to other global regions. They have also discovered mutations in genes under selective pressure linked to antimalarial drugs and mosquito vectors. This study provides important insights into the population structure of P. vivax in Brazil and can inform future research and control measures.
LANCET REGIONAL HEALTH-AMERICAS
(2023)
Article
Multidisciplinary Sciences
Sean Cavany, Stella Nanyonga, Cathrin Hauk, Cherry Lim, Joel Tarning, Benn Sartorius, Christiane Dolecek, Celine Caillet, Paul N. Newton, Ben S. Cooper
Summary: Approximately 10% of antimicrobials used in low- and middle-income countries are substandard or falsified, which can potentially impact antimicrobial resistance levels. Our understanding of this relationship is limited, and further research is needed to understand how different drug exposures affect resistance emergence and spread, as well as the distribution of active pharmaceutical ingredients in substandard and falsified medicines.
NATURE COMMUNICATIONS
(2023)
