Article
Pediatrics
Ajaya Kumar Dhakal, Devendra Shrestha, Saurav Kumar Singh, Sharda Acharya
Summary: This study aimed to describe and analyze the clinical features, complications, and laboratory parameters of children diagnosed with APSGN. The study found that most patients had acute nephritic syndrome features, but some had unusual clinical presentations such as pulmonary edema. It also found that the majority of patients showed improvement in clinical symptoms within three months, but a small proportion experienced persistent hypertension, impaired kidney function, and proteinuria.
PEDIATRIC NEPHROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Sergio Veloso Brant Pinheiro, Victor Buchini de Freitas, Gustavo Valverde de Castro, Beatriz Cronemberger Rufino Madeiro, Stanley Almeida de Araujo, Thomas Felipe Silva Ribeiro, Ana Cristina Simoes e Silva
Summary: This article provides a review on acute post-streptococcal glomerulonephritis (APSGN) and discusses its epidemiology, pathogenesis, clinical and laboratory findings, histopathology, treatment, and prognosis.
CURRENT MEDICINAL CHEMISTRY
(2022)
Review
Immunology
Jesus Mosquera, Adriana Pedreanez
Summary: Increasing evidence suggests a critical role of the immune system in acute post-streptococcal glomerulonephritis (APSGN), with renal glomerular immune complex deposition being crucial in disease initiation. Different host factors and streptococcal factors may contribute to both the initial and late renal events associated with nephritis. The disease may not be solely attributed to a single streptococcal antigen and its antibody, but rather to a combination of factors related to both streptococcus and host factors.
INTERNATIONAL REVIEWS OF IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Sebastien Lamontagne, Axel Suckow, Christoph Gerber, Alec Deslandes, Cornelia Wilske, Steven Tickell
Summary: The study evaluated the source of groundwater in the Mataranka Springs Complex in northern Australia, finding that it is mainly influenced by groundwater from the Daly and Georgina basins, with implications for unconventional gas development in the Beetaloo Sub-basin.
SCIENTIFIC REPORTS
(2021)
Article
Pediatrics
Hae-Young C. Chong, Te-Yu Hung, Anja Hohls, Joshua R. Francis, Swasti Chaturvedi
Summary: Despite the declining incidence of APSGN in Australia, there is a significant burden of disease amongst Aboriginal and Torres Strait Islander children in the Northern Territory. This study aims to describe the clinical characteristics and outcomes of hospitalized children with APSGN in the Northern Territory.
JOURNAL OF PAEDIATRICS AND CHILD HEALTH
(2023)
Article
Pediatrics
William Wong, Chanel Prestidge, Jonathan Zwi, Dug Yeo Han
Summary: This study reviewed the clinical and laboratory factors of patients with acute post-streptococcal glomerulonephritis (APSGN) to identify high-risk patients. The calculation of eGFR was found to be helpful in determining the need for urgent kidney biopsy.
PEDIATRIC NEPHROLOGY
(2023)
Article
Pharmacology & Pharmacy
K. H. Han, K. H. Lee, S. J. Park, R. Yu, S. H. Kim, I. R. Lee, S. Y. Han, H. S. Kim, A. Kronbichler, H. Li, A. Koyanagi, L. Jacob, J. Shin, J. H. Kim, L. Smith
Summary: This study demonstrated favorable clinical manifestations and severity of APSGN over the past 30 years in South Korean children. Monitoring C3 levels could be used to assess disease severity and risk of complications, such as edema and oliguria, which have decreased in incidence.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
Article
Medicine, General & Internal
Natsumi Kamijo, Akiko Mii, Sae Aratani, Tetsuya Kashiwagi, Takashi Oda, Akira Shimizu, Yukinao Sakai
Summary: A 44-year-old woman was admitted with gross hematuria and progressive renal dysfunction, suspected of having poststreptococcal acute glomerulonephritis (PSAGN). However, she was diagnosed with ANCA-associated vasculitis superimposed on PSAGN, which was the main contributor to her progressive renal injury.
Article
Pediatrics
Qianhuining Kuang, Xu He, Lili Jia, Zhiqiang Zhang, Chunhong Gui, Chunlin Gao, Zhengkun Xia
Summary: An 8-year-old girl presented with vomiting, gross hematuria, and renal dysfunction. Renal biopsy confirmed endocapillary proliferative glomerulopathy and crescent formation. Further tests revealed positive myeloperoxidase anti-neutrophil cytoplasmic antibody (MPO-ANCA), and the patient developed palisaded neutrophilic and granulomatous dermatitis (PNGD), as well as granulomatous neoplasms in the orbital and paranasal sinuses. She was diagnosed with MPO-ANCA-associated granulomatosis with polyangiitis (GPA) superimposed on post-streptococcal acute glomerulonephritis (PSAGN). Aggressive treatment including renal replacement therapy and immunosuppressive medications resulted in renal function improvement and alleviation of pain symptoms.
FRONTIERS IN PEDIATRICS
(2023)
Article
Medicine, General & Internal
Somshukla Ghosh, Kelli King-Morris, Joshua Shultz
Summary: Simultaneous occurrence of acute rheumatic fever and acute post Streptococcal glomerulonephritis is rare, highlighting the importance of maintaining a high clinical suspicion for the sequelae of GABHS infection, especially in adults and geographic locations with nearly undetectable burden of acute rheumatic fever.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Review
Immunology
Piotr Skrzypczyk, Anna Ofiara, Anna Zacharzewska, Malgorzata Panczyk-Tomaszewska
Summary: Acute post-streptococcal glomerulonephritis (APSGN) is an immunological complication of infection with group A beta-hemolytic streptococcus, with a favorable prognosis in children. The disease typically presents with macroscopic or microscopic hematuria, hypertension, edema, and acute kidney injury.
CENTRAL EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Clinical Neurology
Bazhu, Yanhui Shi, Shuang Ren, Liang Shu, Qiang Li
Summary: PRES is a rare but serious disease that affects the central nervous system. This case report describes a rare occurrence of PRES following APSGN in a 14-year-old child in a high-altitude environment. The hypoxic conditions of a high-altitude setting might lower the cerebral autoregulation threshold and amplify the endothelial inflammatory reaction, thus inducing PRES in patients with APSGN. Recognizing the clinical and radiologic features of PRES and adjuvant HBO therapy can promote rapid recovery from this condition in high-altitude areas.
Review
Medicine, General & Internal
Mustafa A. Alhamoud, Ibrahim Z. Salloot, Shamim S. Mohiuddin, Turki M. AlHarbi, Faisal Batouq, Naif Y. Alfrayyan, Ahmad Alhashem, Mohammad Alaskar
Summary: Post-streptococcal glomerulonephritis is an immune-complex mediated inflammation caused by nephritogenic strains of group A beta-hemolytic streptococci, leading to kidney injury and potential complications. Diagnosis relies on laboratory tests and imaging studies, with symptomatic management as the primary treatment approach and prevention focusing on treating group A streptococcal infections.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Infectious Diseases
Michael Nohrenberg, Alyson Wright, Vicki Krause
Summary: This study aimed to determine the current and historical incidence rates and organisms involved in skin and soft tissue (SST) infections caused by nontuberculous mycobacteria (NTM) in the Northern Territory (NT). A retrospective review of NTM cases reported from 1989 to 2021 was conducted. The results showed an increasing incidence of SST cases over the study period, with females being more commonly affected. The most common risk factor was localized skin trauma, and the most frequently identified organism was M. fortuitum. Diagnosis was often delayed, and most cases required surgical intervention and adjunctive anti-mycobacterial medical therapy.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Construction & Building Technology
Nikolas Mpilias, Ali Rajabipour, Bede Rodeghiero, Milad Bazli
Summary: This paper investigates the lateral load capacity and failure modes of a common SSWF braced bay configuration used in the Northern Territory, Australia, through full-scale experimental testing and finite element simulations. The common failure modes were found to be the tensile failure of the stud flange and failure of the weld between the tensile stud and bottom plate. The results provide a reliable evaluation of the lateral resistance of the common SSWF configurations in housing in the Northern Territory.
CASE STUDIES IN CONSTRUCTION MATERIALS
(2022)
Article
Pediatrics
Ryan Lucas, Peta Dennington, Erica Wood, Audrey Dionne, Sarah D. de Ferranti, Jane W. Newburger, Nagib Dahdah, Allen Cheng, David Burgner, Davinder Singh-Grewal
Summary: There is general consensus among Australian and New Zealand clinicians on the management of Kawasaki disease, particularly on the use of intravenous immunoglobulin and aspirin. However, there are variations in other aspects of diagnosis and treatment which may impact patient outcomes, indicating the need for further research in this area.
JOURNAL OF PAEDIATRICS AND CHILD HEALTH
(2021)
Article
Medicine, General & Internal
Aidan J. C. Burrell, Breanna Pellegrini, Farhad Salimi, Husna Begum, Tessa Broadley, Lewis T. Campbell, Allen C. Cheng, Winston Cheung, D. James Cooper, Arul Earnest, Simon J. Erickson, Craig J. French, John M. Kaldor, Edward Litton, Srinivas Murthy, Richard E. McAllister, Alistair D. Nichol, Annamaria Palermo, Mark P. Plummer, Mahesh Ramanan, Benjamin A. J. Reddi, Claire Reynolds, Tony Trapani, Steve A. Webb, Andrew A. Udy
Summary: The study of COVID-19 patients admitted to ICUs in Australia revealed that patients mostly acquired the virus through overseas travel, with common comorbidities being obesity, diabetes, and hypertension. Patients requiring invasive ventilation had longer ICU stay and higher mortality rates.
MEDICAL JOURNAL OF AUSTRALIA
(2021)
Editorial Material
Medicine, General & Internal
Allen C. Cheng
MEDICAL JOURNAL OF AUSTRALIA
(2021)
Review
Infectious Diseases
Kelly A. Cairns, Matthew D. M. Rawlins, Sean D. Unwin, Fiona F. Doukas, Rosemary Burke, Erica Tong, Andrew J. Henderson, Allen C. Cheng
Summary: Antimicrobial stewardship is well established in Australian hospitals, but the implementation of electronic medical records (EMR) has been slow. EMR implementation has the potential to positively impact AMS teams through more efficient workflows and expanded activities, but there are inevitable limitations that must be considered.
INFECTIOUS DISEASES AND THERAPY
(2021)
Editorial Material
Medicine, General & Internal
Christopher C. Blyth, Katie L. Flanagan, Robyn A. Gibbs, Nigel W. Crawford, Allen C. Cheng
MEDICAL JOURNAL OF AUSTRALIA
(2021)
Editorial Material
Medicine, General & Internal
Cassie Nesbitt, Louise Rath, Michael Zhong, Allen C. Cheng, Helmut Butzkueven, Robb Wesselingh, Olga Skibina, Mastura Monif, Wei Yeh, Julia M. L. Brotherton, Stephen Reddel, Anneke Van der Walt
MEDICAL JOURNAL OF AUSTRALIA
(2021)
Editorial Material
Medicine, General & Internal
Samantha J. Carlson, Christopher C. Blyth, Frank H. Beard, Alexandra J. Hendry, Allen C. Cheng, Helen E. Quinn, Julie Leask, Kristine Macartney
MEDICAL JOURNAL OF AUSTRALIA
(2021)
Article
Microbiology
Ryan J. Farr, Christina L. Rootes, Louise C. Rowntree, Thi H. O. Nguyen, Luca Hensen, Lukasz Kedzierski, Allen C. Cheng, Katherine Kedzierska, Gough G. Au, Glenn A. Marsh, Seshadri S. Vasan, Chwan Hong Foo, Christopher Cowled, Cameron R. Stewart
Summary: This study analyzed the host miRNA response to COVID-19 and identified a three-miRNA signature that can independently classify COVID-19 cases with high accuracy. The findings suggest that miRNA profiling could potentially improve COVID-19 detection and patient management.
Article
Pediatrics
Ryan Lucas, Peta Dennington, Erica Wood, Kevin J. Murray, Allen Cheng, David Burgner, Davinder Singh-Grewal
Summary: The diagnosis and hospitalization rates of Kawasaki disease (KD) have increased in the 0-4 year age group in Australia over the past 25 years. This rise may reflect a true increase in disease incidence, increasing recognition, or overdiagnosis. Further research is needed to determine the cause of these trends.
JOURNAL OF PAEDIATRICS AND CHILD HEALTH
(2022)
Article
Psychology, Multidisciplinary
Simon T. van Baal, Lukasz Walasek, Daniela Karanfilovska, Allen C. Cheng, Jakob Hohwy
Summary: This study examines the impact of different government communication strategies on people's attitudes towards staying home or going out during the COVID-19 pandemic. It also investigates how individuals perceive and process the risk of viral transmission in different scenarios. The results suggest that the level of risk and communication framings play a significant role in shaping attitudes towards going out. Additionally, age and gender were found to be associated with permissive attitudes. These findings suggest the importance of employing imperative communication strategies for increasing compliance with staying home.
BRITISH JOURNAL OF PSYCHOLOGY
(2022)
Review
Health Care Sciences & Services
Elizabeth Korevaar, Amalia Karahalios, Simon L. Turner, Andrew B. Forbes, Monica Taljaard, Allen C. Cheng, Jeremy M. Grimshaw, Lisa Bero, Joanne E. McKenzie
Summary: This study aimed to examine the statistical approaches, methods, and completeness of reporting in reviews that meta-analyze results from interrupted time series (ITS). The results showed that although most reviews used two-stage meta-analysis and fitted random effects models, reporting of the statistical methods and ITS characteristics was often incomplete. The study suggests that improvement is needed in the conduct and reporting of these reviews.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2022)
Editorial Material
Medicine, General & Internal
Allen C. Cheng, Jim P. Buttery
MEDICAL JOURNAL OF AUSTRALIA
(2022)
Article
Medicine, General & Internal
Husna Begum, Ary S. Neto, Patricia Alliegro, Tessa Broadley, Tony Trapani, Lewis T. Campbell, Allen C. Cheng, Winston Cheung, D. James Cooper, Simon J. Erickson, Craig J. French, Edward Litton, Richard McAllister, Alistair Nichol, Annamaria Palermo, Mark P. Plummer, Hannah Rotherham, Mahesh Ramanan, Benjamin Reddi, Claire Reynolds, Steven A. R. Webb, Andrew A. Udy, Aidan Burrell
Summary: This study compared the demographic characteristics, treatments, and outcomes of patients admitted to intensive care units (ICUs) with COVID-19 during different waves of the pandemic in Australia. The results showed that the characteristics and treatments of patients admitted during the third wave differed from the first two waves. Adjusted in-hospital mortality was highest during the third wave.
MEDICAL JOURNAL OF AUSTRALIA
(2022)
Editorial Material
Medicine, General & Internal
Sarah Allen, Celia M. Cooper, Ajay Taranath, Allen C. Cheng, Philip N. Britton
MEDICAL JOURNAL OF AUSTRALIA
(2023)
Article
Immunology
Bette Liu, Sandrine Stepien, Jiahui Qian, Heather Gidding, Katrina Nicolopoulos, Janaki Amin, Allen Cheng, Kristine Macartney
Summary: This study compared the effectiveness of different COVID-19 vaccines. The results showed that the BNT162b2 mRNA vaccine had higher effectiveness in preventing primary infections compared to mRNA-1273, ChAdOx-1 nCov-19, and NVX-CoV2373. For booster doses, the BNT162b2 mRNA vaccine also showed good effectiveness.
