期刊
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
卷 84, 期 2, 页码 71-77出版社
AMER SOC TROP MED & HYGIENE
DOI: 10.4269/ajtmh.2011.10-0085
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资金
- National Institute of Allergy and Infectious Diseases through Tropical Medicine Research Centers NIAID/TMRC [49486]
- National Institute of Allergy and Infectious Diseases through an International Center of Excellence for Malaria Research NIAID/ICEMR [U 19AI089702]
- Instituto Colombiano para el Desarrollo de la Ciencia y Tecnologia 'Francisco Jose de Caldas' COLCIENCIAS [6124-05-17594]
- Ministry for Social Protection/Colciencias [2304-04-19524]
- Abess Center for Ecosystem Science and Policy, University of Miami
Malaria infection induces antibodies capable of suppressing the infectivity of gametocytes and gametes, however, little is known about the duration of the antibody response, the parasite specificity, and the role of complement. We report the analyses of the transmission-blocking (TB) activity of sera collected from 105 Plasmodium vivax-infected and 44 non-infected individuals from a malaria endemic region of Colombia, using a membrane feeding assay in Anopheles albimanus mosquitoes. In infected donors we found that TB activity was antibody dose dependent (35%), lasted for 2-4 months after infection, and in 70% of the cases different P vivax wild isolates displayed differential susceptibility to blocking antibodies. Additionally, in a number of assays TB was complement-dependent. Twenty-seven percent of non-infected individuals presented TB activity that correlated with antibody titers. Studies here provide preliminary data on factors of great importance for further work on the development of TB vaccines.
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