Article
Medicine, General & Internal
Dela Akpokavie, Capucine Gubert, Imene Abdelli, Alix O'Meara Stern, Herve Zender
Summary: This report examines the case of a 66-year-old patient with metastatic prostate cancer. Treatment with abiraterone acetate and corticosteroid co-administration as well as LH-RH analog hormone therapy was initiated. The patient developed fulminant hepatitis, attributing it to the abiraterone acetate treatment. Regular monitoring of liver tests on this therapy is important.
FRONTIERS IN MEDICINE
(2023)
Review
Endocrinology & Metabolism
Shih-Chun Chang, Chun-Yi Tsai, Keng-Hao Liu, Shang-yu Wang, Jun-Te Hsu, Ta-Sen Yeh, Chun-Nan Yeh
Summary: This case report describes a fatal fulminant hepatitis B reactivation in a male patient with pancreatic neuroendocrine tumors who received everolimus and octreotide treatment. The patient did not receive hepatitis B virus prophylaxis treatment and ultimately died due to acute hepatitis B flare-up-related fulminant hepatic failure.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, General & Internal
Erika Peroni, Pierre Mora, Anne Motte, Rene Gerolami, Sarah Aherfi, Philippe Colson
Summary: Hepatitis E is commonly transmitted through consuming pig-derived products in developed countries. The infection is usually asymptomatic or self-limiting, but can lead to acute liver failure. This study reports a case of a diabetic patient in his 60s without chronic liver disease who developed coma and ultimately died from metformin overdose and fulminant hepatitis E. The study highlights the importance of HEV testing in diabetic patients.
Article
Immunology
Heli Harvala, Claire Reynolds, Su Brailsford, Katy Davison
Summary: In England, screening blood donations with nucleic acid test (NAT) has largely eliminated infectious HEV, but missed detection of low levels of HEV RNA can lead to severe infections. More sensitive screening methods are needed to prevent transmission risks.
EMERGING INFECTIOUS DISEASES
(2022)
Article
Immunology
Ayo S. Falade, Kerry L. Reynolds, Leyre Zubiri, Vikram Deshpande, Florian J. Fintelmann, Michael Dougan, Meghan J. Mooradian
Summary: Immune checkpoint inhibitors are an important treatment option for tumors, but can lead to immune-related adverse events. This case report presents a patient with widespread metastatic melanoma who developed rapid onset anasarca and transaminitis after treatment with dual anti-PD-1/CTLA-4 therapy. Further investigation revealed celiac disease, which resolved with a gluten-free diet. This case emphasizes the need for a broad differential diagnosis when managing suspected immune-related adverse events.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Guanglin Cui, Rui Li, Chunxia Zhao, Dao Wen Wang
Summary: This is the first report of two cases of fulminant myocarditis (FM) occurring after administration of the currently available inactivated SARS-CoV-2 vaccine. Cardiac magnetic resonance imaging revealed myocardial edema and necrosis, while pathological evaluation showed inflammatory cell infiltration, myocyte necrosis, and fibrosis. The patients recovered and were discharged after comprehensive treatment. These findings highlight the importance of paying more attention to the rare but lethal complications of COVID-19 vaccination.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Haider Malik, Hamza Malik, Muskan Uderani, Mefthe Berhanu, Cuauhtemoc Jeffrey Soto, Faraz Salee
Summary: Acute liver failure is a severe clinical condition with high mortality rates, and viral hepatitis, especially dual infection of HAV and HEV, can further exacerbate liver damage and increase the mortality rate. Prompt diagnosis, timely intervention, and organ transplantation are crucial for treating liver failure.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Medicine, General & Internal
Yoann Zerbib, Louis Gibert, Youssef Bennis, Kamel Masmoudi, Julien Maizel, Clement Brault
Summary: PRES is a rare neurological disorder caused by cerebral perfusion dysregulation. In this case, inappropriate self-medication with an oral decongestant triggered PRES in a patient with end-stage renal disease undergoing hemodialysis, along with a concurrent bloodstream infection. Prompt diagnosis and intervention are crucial in managing this life-threatening condition.
FRONTIERS IN MEDICINE
(2022)
Article
Immunology
Dong Ying, Wenxia Niu, Yanling Chen, Yingbin Wang, Weikun Tian, Xiaoping Zhang, Chang Liu, Siling Wang, Zihao Chen, Yajie Lin, Shaoqi Guo, Zihao Yu, Xiuting Chen, Mujin Fang, Hongsheng Qiang, Yifan Yin, Zimin Tang, Zizheng Zheng, Lijuan Fu, Ningshao Xia
Summary: We report a case of chronic HEV infection of genotype 3a in an individual without evidence for immune deficiency. The patient presented hepatitis with significant HEV viremia and viral shedding. Despite the presence of HEV-specific immune responses, viral shedding persisted. Treatment with ribavirin combined with interferon led to complete suppression and clearance of HEV, suggesting that chronic HEV infection can occur in individuals without evidence of immunodeficiency.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Lu Zhang, Xiaohao Wang, Jing Zhang, Zhongrong Wang, Dachuan Cai
Summary: We report a rare case of co-infection with hepatitis E viruses, Clonorchis sinensis, and Escherichia coli. The patient was hospitalized due to fatigue, jaundice, and nausea. Laboratory tests confirmed the presence of hepatitis E virus, Clonorchis sinensis, and Escherichia coli. Treatment with praziquantel, imipenem, and hepatoprotective drugs was effective in relieving the clinical symptoms.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Immunology
Zihao Chen, Junfeng Wei, Li Jiang, Dong Ying, Weikun Tian, Mengyang Zhang, Guiping Wen, Siling Wang, Chang Liu, Yingbin Wang, Ting Wu, Zimin Tang, Zizheng Zheng, Li Yan, Ningshao Xia
Summary: This study reported a severe aplastic anemia patient who developed chronic hepatitis E after hematopoietic stem cell transplantation. The study suggests a risk of HEV infection in HSCT recipients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Mohammad Barary, Athena Sharifi-Razavi, Nasser Rakhshani, Terence T. Sio, Soheil Ebrahimpour, Mana Baziboroun
Summary: The common side effects of COVID-19 vaccination are usually self-restricted local reactions. However, rare cases of autoimmune hepatitis have been reported in individuals vaccinated with mRNA COVID-19 vaccines. This article presents a case of a young man who developed fulminant hepatitis a few days after receiving the first dose of the AstraZeneca COVID-19 vaccine. Despite ruling out other causes, it was confirmed that the fulminant hepatitis was secondary to the AstraZeneca COVID-19 vaccine in this patient. Unfortunately, the patient died three days later due to disseminated intravascular coagulopathy.
CLINICAL CASE REPORTS
(2022)
Article
Oncology
Yeong Jin Kim, Kang Hee Ahn, Kyung-Hwa Lee, Kyung-Sub Moon
Summary: This case report describes a rare occurrence of extraneural metastasis (ENM) in a patient with glioblastoma. The tumor invaded the venous sinus and eventually spread to the lymph nodes and multiple bones, leading to paralysis and death.
FRONTIERS IN ONCOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Madhusudan Samprathi, Faisal Mohammad, M. Sridhar, Prakash Ramachandra, Prakash Vemgal
Summary: Thiamine deficiency disorders are a serious public health issue in low- and middle-income countries. This study reports six infants with acute fulminant illness, with four of them showing dramatic recovery after empirical thiamine treatment, highlighting the importance of early recognition and treatment of infantile beriberi to save lives.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2021)
Article
Medicine, General & Internal
Meijuan Zhang, Penglong Yu, Jie Yuan, Tao Yu, Dan Sun
Summary: This is a case of gastric antral ulcer caused by drug overdose. The patient took 48 Ibuprofen Sustained-Release capsules and experienced severe abdominal pain and increased blood pressure. Symptoms disappeared after treatment.
Article
Infectious Diseases
Ana Fuentes, Esther Serrano-Conde, Carolina Roldan, Rafael Benito-Ruesca, Gregoria Mejias, Antonio Sampedro, Gabriel March-Rosello, Isabel Fernandez-Natal, Juliana Esperalba, Mario Jose Rodriguez, Paula Martinez de Aguirre, Carlos Salas, Maria Lourdes Roc, Luis Miguel Soria, Monica Parra-Grande, Maria Dolores Montero, Ricardo Fernandez-Roblas, Francisco Franco-Alvarez de Luna, Carmen Lozano, Federico Garcia
Summary: The study evaluated the serological response against SARS-CoV-2 in Spanish COVID-19 patients and found that approximately half of the patients had antibodies as soon as 2 days after the first positive PCR result. Serological test positivity increased with time, with 91.5% presenting IgM + IgA antibodies and 88.0% presenting IgG antibodies 10 days after the first PCR result.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2021)
Letter
Dermatology
D. Ortega-Quijano, D. Fernandez-Nieto, J. Jimenez-Cauhe, J. L. Cortes-Cuevas, D. Marcos-Mencia, M. Rodriguez-Dominguez, G. Segurado-Miravalles, M. Fernandez-Guarino, P. Jaen-Olasolo
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Article
Infectious Diseases
Belen Gutierrez-Gutierrez, Maria Dolores del Toro, Alberto M. Borobia, Antonio Carcas, Inmaculada Jarrin, Maria Yllescas, Pablo Ryan, Jeronimo Pachon, Jordi Carratala, Juan Berenguer, Jose Ramon Arribas, Jesus Rodriguez-Bano
Summary: This study examined the clinical phenotypes of COVID-19 patients through clinical data, identifying three distinct phenotypes (A, B, C) that correlate with prognosis. A simplified probabilistic model was developed for phenotype assignment, which could aid in clinical management of patients.
LANCET INFECTIOUS DISEASES
(2021)
Article
Veterinary Sciences
Paula F. Navarro, Laura Gil, German Martin, Salceda Fernandez-Barredo
Summary: Reference intervals for urine protein fractions obtained by capillary electrophoresis in healthy dogs were established, which may be useful for clinical comparisons with pathological samples. Age and sex were found to have significant effects on certain protein fractions.
JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION
(2021)
Article
Integrative & Complementary Medicine
Sergio Montero Navarro, Sonia del Rio Medina, Jose Martin Botella Rico, Maria Isabel Rocha Ortiz, Maria Teresa Perez Gracia
Summary: Superficial or deep dry needling at MTrP 1 in the upper trapezius led to increased pain pressure threshold and changes in cervical range of motion. However, there were no statistically significant changes observed in PPT or goniometry measurements following a single intervention.
ACUPUNCTURE IN MEDICINE
(2022)
Review
Infectious Diseases
Antonio Tarin-Pello, Beatriz Suay-Garcia, Maria-Teresa Perez-Gracia
Summary: Antibiotic resistance is a major global health threat, with antibiotic-resistant bacteria causing 700,000 deaths annually. This review discusses current and emerging antimicrobial therapies and highlights the potential advantages of drug repurposing and mathematical prediction models in addressing antimicrobial resistance. The development of new antimicrobials remains necessary to combat this global threat.
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
(2022)
Article
Microbiology
Antonio Tarin-Pello, Beatriz Suay-Garcia, Elisa Marco-Crespo, Carolina Galiana-Rosello, Jose I. Bueso-Bordils, Maria-Teresa Perez-Gracia
Summary: Antimicrobial resistance (AMR) is a serious global health issue, and Spain ranks high in antibiotic consumption in Europe. Adequate training on AMR and rational use of antimicrobials is crucial to prevent a post-antibiotic era. The SWICEU project, an academic program about antibiotic discovery, has had a positive impact on pre-university students' knowledge of AMR and rational use of antibiotics. The project has also received high satisfaction from university and pre-university students.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Chemistry, Medicinal
Beatriz Suay-Garcia, Jose-Ignacio Bueso-Bordils, Gerardo Anton-Fos, Maria-Teresa Perez-Gracia, Antonio Falco, Pedro Aleman-Lopez
Summary: Quinolones are widely used antibiotics, but the rise in antibiotic resistance has diminished the effectiveness of many compounds. By utilizing a prediction model, two quinolones were selected and synthesized, along with the discovery of a new type of antibacterial zwitterionic quinolonate.
Review
Gastroenterology & Hepatology
Maria Teresa Perez-Gracia, Antonio Tarin-Pello, Beatriz Suay-Garcia
Summary: In May 2022, the UK reported 176 cases of severe acute hepatitis of unknown etiology in children under 10 years old. Similar cases were subsequently reported in other countries. As of June 17, 2022, a total of 991 cases had been reported globally, with 50 children requiring liver transplant and 28 patient deaths. The cause of these cases remains unknown, but adenovirus has been detected in 62.2% of analyzed samples.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2022)
Editorial Material
Microbiology
Anna Kramvis, Maria Teresa Perez-Gracia, Kavita Satish Lole, Manuel Rodriguez-Iglesias, None Shalimar
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Microbiology
Antonio Tarin-Pello, Elisa Marco-Crespo, Beatriz Suay-Garcia, Carolina Galiana-Rosello, Jose Bueso-Bordils, Maria-Teresa Perez-Gracia
Summary: This case study presents the strategies and actions taken by the SWICEU team at CEU Cardenal Herrera University in Spain over the past 5 years to educate and raise awareness about antimicrobial resistance and the correct use of antibiotics. The team has developed innovative gamification supports and utilized various digital communication platforms to successfully engage young people and increase their understanding of the issue.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Veterinary Sciences
Paula Fatima Navarro, Salceda Fernandez-Barredo, Laura Gil
Summary: Urinary capillary electrophoresis (UCE) is a laboratory technique that provides an easily interpretable electrophoretic pattern and can be useful in the early diagnosis of renal disease. This study found that UCE can detect changes in the electrophoretic patterns in dogs with kidney disease due to different pathologies, suggesting its potential as a diagnostic and follow-up tool.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Veterinary Sciences
Laura Montoro-Dasi, Laura Lorenzo-Rebenaque, Adrian Ramon-Moragues, Maria Teresa Perez-Gracia, Maria de Toro, Clara Marin, Arantxa Villagra
Summary: The study aimed to evaluate the effect of antibiotic feed supplementation on microbiota and productive performance in rabbits during the growing period. Results showed that antibiotic supplementation had no effect on microbiota composition and productive performance in the robust genetic line.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Biology
Paula F. Navarro, Laura Gil, Salceda Fernandez-Barredo
Summary: Capillary electrophoresis (CE) is a laboratory method for separating proteins in body fluids like urine, serum, and cerebrospinal fluid. It offers advantages over gel electrophoresis such as shorter separation times, reduced waste production, and the ability to obtain curves without additional staining.
Article
Dentistry, Oral Surgery & Medicine
Paula Maciel Pires, Andrei Cristian Ionescu, Maria Teresa Perez-Gracia, Elena Vezzoli, Igor Paulino Mendes Soares, Eugenio Brambilla, Aline de Almeida Neves, Salvatore Sauro
Summary: This study evaluated the ability of current ion-releasing materials to remineralize artificial caries lesions. The results showed that calcium silicate-based materials were able to induce apatite deposition and promote hardness recovery of the carious lesions.
CLINICAL ORAL INVESTIGATIONS
(2022)
