4.5 Article

Travel and Travelers' Diarrhea in Patients with Irritable Bowel Syndrome

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出版社

AMER SOC TROP MED & HYGIENE
DOI: 10.4269/ajtmh.2010.09-0538

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资金

  1. Kelsey Research Foundation
  2. University of Texas School of Public Health
  3. Public Health Service [DK 56338]
  4. Texas Gulf Coast Digestive Diseases Center
  5. Salix Pharmaceuticals, Inc.
  6. McNeil Consumer Healthcare
  7. IOMAI Corporation
  8. Intercell Corporation
  9. Optimer Pharmaceuticals, Inc.

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This Study evaluated Occurrence of travel and travelers diarrhea in patients with irritable bowel syndrome (IBS). A survey was mailed to 591 patients of a clinical practice who had IBS. Based oil survey responses, patients were categorized as having IBS, post-infectious IBS (PI-IBS), Unclassified functional bowel disorder (UFBD), or post-infectious UFBD (PI-UFBD). Of 201 Persons Who returned questionnaires meeting inclusion criteria, 57.7%, 11.4%, 24.9%, and 6.0% had IBS, UFBD, PI-IBS, and PI-UFBD, respectively. Travel during six months before illness onset was more common in patients with PI-IBS or PI-UFBD than in persons with idiopathic IBS or UFBD (P = 0.006). Survey results demonstrated that 16.1% of post-infectious bowel disorder cases and 7.5% of overall IBS cases in a general medical population developed chronic disease within six months of ail international trip. Symptoms of established functional bowel disorder in each clinical category were shown to worsen after travel-related acute diarrhea.

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