Article
Environmental Sciences
Congcong Gu, Xuewen Li, Huiyun Zou, Ling Zhao, Chen Meng, Chengxia Yang, Hui Zhang, Bjorn Berglund
Summary: The emergence and dissemination of carbapenem-resistant Enterobacteriaceae (CRE) is a major global health problem. This study investigates the occurrence and environmental transmission of CRE in groundwater in large animal breeding areas in northern China, suggesting that groundwater may be an underappreciated reservoir and source of CRE dissemination.
ENVIRONMENTAL POLLUTION
(2022)
Article
Infectious Diseases
Adel Azour, Charbel Al-Bayssari, Tania Nawfal Dagher, Faraj Fajloun, Mark Fajloun, Jean-Marc Rolain
Summary: The study found that Syrian refugees in Lebanon carried carbapenem and colistin-resistant bacteria, with multidrug-resistant phenotypes. Urgent strategies are needed to prevent the spread of such resistance in highly crowded communities.
Article
Infectious Diseases
Parnrada Nulsopapon, Manat Pongchaidecha, Worapong Nasomsong, Pitimon Polwichai, Sirilada Suphankong, Pantip Sirichote, Siriwan Chaisomboonpan, Wichai Santimaleeworagun
Summary: The spread of carbapenem-resistant Enterobacterales (CRE) is a global health burden, with variations in antimicrobial susceptibility and carbapenemase types among different geographic regions. This study collected clinical CRE isolates from hospitals in western Thailand and found high proportions of CRKP and regional hospitals reporting higher rates of resistance. The isolates were resistant to most antibiotics but susceptible to aminoglycosides. High-dose tigecycline was identified as the optimal regimen against CRE isolates.
Article
Infectious Diseases
Fakhur Uddin, Syed Hadi Imam, Saeed Khan, Taseer Ahmed Khan, Zulfiqar Ahmed, Muhammad Sohail, Ashraf Y. Elnaggar, Ahmed M. Fallatah, Zeinhom M. El-Bahy
Summary: The worldwide spread and increasing prevalence of carbapenem-resistant Enterobacteriaceae (CRE) is of utmost concern and a problem for public health, as determined by this study that aimed to determine the dominance of NDM-producing Enterobacteriaceae at a teaching hospital in Karachi.
Article
Biochemistry & Molecular Biology
Juan Xu, Hao Guo, Lirong Li, Fang He
Summary: This study identified 27 carbapenem-resistant Escherichia coli (CREC) strains, of which 17 carried the blaNDM-5 gene. All 23 NDM-producing E. coli strains were resistant to all antibiotics except tigecycline, colistin, and cefiderocol. Furthermore, two copies of the blaNDM-5 gene were found on a single plasmid, highlighting the need for attention.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Infectious Diseases
M. Biedrzycka, P. Urbanowicz, A. Guzek, S. Brisse, M. Gniadkowski, R. Izdebski
Summary: The study assessed the spread of NDM-1-producing Klebsiella pneumoniae ST147 organisms in Poland since 2015, demonstrating a high degree of homogeneity and close relatedness to organisms spreading in the Mediterranean region. The isolates showed a strict outbreak cluster with minor variations in resistome and plasmid replicon profiles, indicating continuous spread in Poland.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Microbiology
Min Yi Lau, Fui Enn Teng, Kek Heng Chua, Sasheela Ponnampalavanar, Chun Wie Chong, Kartini Abdul Jabar, Cindy Shuan Ju Teh
Summary: The study reported the epidemiology of carbapenem-resistant Klebsiella pneumoniae (CRKP) in a Malaysian teaching hospital, with bla(OXA-48) identified as the predominant carbapenemase gene. Infection or colonization by CRKP, especially NDM-producers, central venous catheter usage, and stoma were associated with higher in-hospital mortality. Early detection of CRKP isolates was crucial due to the potential high mortality rate associated with infection.
Article
Multidisciplinary Sciences
Mislav Acman, Ruobing Wang, Lucy van Dorp, Liam P. Shaw, Qi Wang, Nina Luhmann, Yuyao Yin, Shijun Sun, Hongbin Chen, Hui Wang, Francois Balloux
Summary: Acman et al. investigate the dynamics of bla(NDM) dissemination across the globe and identify the mobile genetic elements and specific mobilization events involved in the gene's global spread.
NATURE COMMUNICATIONS
(2022)
Article
Public, Environmental & Occupational Health
Fen Pan, Qi Xu, Hong Zhang
Summary: This study investigated the resistance profiles, dissemination mechanism, and molecular characteristics of carbapenem-resistant Klebsiella aerogenes (CRKA) strains isolated from children in a pediatric hospital in Shanghai. The majority of the isolates belonged to ST4, indicating the emergence of NDM-5 producing CRKA among children in Shanghai. Further attention should be paid to controlling the horizontal spread of Class B carbapenemases like NDM in children.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Microbiology
Feilong Zhang, Ziyao Li, Xinmeng Liu, Yanning Hu, Jiankang Zhao, Yulin Zhang, Yanyan Fan, Zichen Lei, Xinrui Yang, Zhihua Li, Chen Li, Yongli Wu, Binghuai Lu
Summary: Studying the transferability and potential dissemination of blaKPC-2- and blaNDM-1-coharboring carbapenem-resistant Citrobacter freundii (CRCF) is crucial due to the increase in clinical Enterobacteriaceae with dual carbapenemase. The research revealed clonal dissemination of ST523 blaKPC-2- and blaNDM-1-coharboring CRCF strains, and the first reported occurrence of blaKPC-2 and blaNDM-1 concomitantly located on one plasmid, which could be transferred with mediation by IS6100 via transposition.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Microbiology
Feilong Zhang, Ziyao Li, Xinmeng Liu, Guolan Luo, Yongli Wu, Chen Li, Jiankang Zhao, Yulin Zhang, Yanning Hu, Binghuai Lu
Summary: The carbapenem-resistant Klebsiella pneumoniae (CRKP) strain GX34, recovered from a patient with severe pneumonia, was found to be susceptible only to amikacin, tigecycline, and colistin. The strain belonged to K51-ST16 and carried plasmid-encoded NDM-4 and OXA-181, located on two different plasmids. The transferability and stability of these plasmids were confirmed, and comparative genomic analysis indicated a potential for dissemination of the bla(NDM-4) and bla(OXA-181) genes.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Microbiology
Chengxia Yang, Jingyi Han, Bjorn Berglund, Huiyun Zou, Congcong Gu, Ling Zhao, Chen Meng, Hui Zhang, Xianjun Ma, Xuewen Li
Summary: Animal farms are an important reservoir of carbapenem-resistant Klebsiella spp. (CRK), and One Health-studies are necessary to understand their dissemination. This study identified CRK strains in various samples collected from livestock and poultry farms in China. The strains carried carbapenemase-encoding genes and could spread through horizontal gene transfer and clonal expansion.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Microbiology
Xinmiao Jia, Peiyao Jia, Ying Zhu, Wei Yu, Xue Li, Jingyuan Xi, Xiaoyu Liu, Kang Liao, Yingchun Xu, Bin Cheng, Qiwen Yang
Summary: We identified a novel hybrid plasmid carrying both bla(NDM-1) and bla(IMP-4) genes, and characterized its genetic and phenotypic features. The plasmid showed potential for horizontal transfer and high stability, without exerting significant growth pressure on bacteria.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Microbiology
Zhou Liu, Xiubing Hang, Xiao Xiao, Wenwen Chu, Xin Li, Yangyang Liu, Xi Li, Qiang Zhou, Jiabin Li
Summary: The study identified a multidrug-resistant Klebsiella pneumoniae strain harboring a transferable plasmid co-encoding bla(NDM-1) and mcr-9, marking the first report of such plasmid spread in China. These findings highlight the importance of enhanced surveillance to assess the potential dissemination of this threat.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Infectious Diseases
Maria El Khoury, Tamara Salloum, Ibrahim Al Kodsi, Tamima Jisr, Mira El Chaar, Sima Tokajian, CREs Genome Diversity in Lebanon
Summary: The objective of this study was to characterize the plasmid content and resistome of clinical carbapenem-resistant Enterobacteriaceae (CRE) recovered from hospitalized patients in Lebanon from 2016 to 2019. The results showed that bla OXA-48 and bla OXA-48-like genes were among the detected resistance determinants. Carbapenem resistance determinants were linked to various incompatibility groups, with IncFIB(K) being the most prevalent. This study highlights the importance of tracking the spread and dominance of clinically relevant carbapenemase-encoding plasmids in healthcare settings.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2023)