期刊
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
卷 83, 期 4, 页码 873-875出版社
AMER SOC TROP MED & HYGIENE
DOI: 10.4269/ajtmh.2010.10-0158
关键词
-
资金
- U.S. President's Emergency Plan for AIDS Relief
- Department of Health and Human Services/Centers for Disease Control and Prevention, National Center for HIV, Viral Hepatitis, Si]) [U62P024421]
- TB Prevention, Global AIDS Program
- Doris Duke Charitable Foundation
- Puget Sound Partners in Global Health
- National Institutes of Health/National Institute of Allergy and Infectious Disease [K23-AI082553]
Artemether-lumefantrine (AL) and dihydroartemisinin-piperaquine (DP) are highly efficacious antimalarial therapies in Africa. However, there are limited data regarding the tolerability of these drugs in young children. We used data from a randomized control trial in rural Uganda to compare the risk of early vomiting (within one hour of dosing) for children 6-24 months of age randomized to receive DP (n = 240) or AL (n = 228) for treatment of uncomplicated malaria. Overall, DP was associated with a higher risk of early vomiting than AL (15.1% versus 7.1%; P = 0.007). The increased risk of early vomiting with DP was only present among breastfeeding children (relative risk [RR] = 3.35, P = 0.001) compared with children who were not breastfeeding (RR = 1.03, P = 0.94). Age less than 18 months was a risk factor for early vomiting independent of treatment (RR = 3.27, P = 0.02). Our findings indicate that AL may be better tolerated than DP among young breastfeeding children treated for uncomplicated malaria.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据