Article
Immunology
Nguyen Lam Vuong, Nguyen Than Ha Quyen, Nguyen Thi Hanh Tien, Nguyen Minh Tuan, Duong Thi Hue Kien, Phung Khanh Lam, Dong Thi Hoai Tam, Tran Van Ngoc, Sophie Yacoub, Thomas Jaenisch, Ronald B. Geskus, Cameron P. Simmons, Bridget A. Wills
Summary: Higher plasma viremia is associated with increased dengue severity, regardless of serotype or immune status, with effect sizes being modest compared to the effects of a secondary immune response. The association remains consistent across different age, serotype, and immune status groups, indicating a potential role of plasma viremia in predicting dengue severity.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Immunology
Dagmar Hildebrand, Dennis Nurjadi, Nghiem Xuan Hoan, Mai Thanh Hai Linh, Vu Viet Sang, Mai Hong Bang, Srinivas Reddy Pallerla, Peter G. Kremsner, Klaus Heeg, Le Huu Song, Thirumalaisamy P. Velavan
Summary: This study investigated the association between Notch ligands and bleeding in dengue fever patients. The results showed that high levels of soluble Notch delta-like ligand 1 (sDLL1) were associated with bleeding, and the combination with two enzymes slightly improved the test performance. sDLL1 may be useful in guiding the clinical management of dengue.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Ophthalmology
Yingyan Ma, Senlin Lin, Ian G. Morgan, Jos J. Rozema, Rafael Iribarren, Jianfeng Zhu, Rong Zhao, Bo Zhang, Yao Yin, Yueqin Shao, Xiangui He, Xun Xu, Haidong Zou
Summary: In preschool children, changes in refraction and refractive components over one year were observed. Loss of lens power in eyes with lower baseline spherical equivalent refraction resulted in hyperopic shifts, while in eyes with higher baseline spherical equivalent refraction, the loss of lens power compared to axial elongation was reduced, leading to myopic shifts. This study highlighted the homeostasis of human refraction and how it leads to a preferred state of mild hyperopia.
ACTA OPHTHALMOLOGICA
(2021)
Article
Clinical Neurology
Anna R. Troescher, Eirini Sakaraki, Katharina M. Mair, Ulrike Koeck, Attila Racz, Valeri Borger, Thomas Cloppenborg, Albert J. Becker, Christian G. Bien, Jan Bauer
Summary: This study provides a detailed histopathological investigation of T cell involvement in various subgroups of MTLE, indicating that T cell influx correlates more with neuronal loss than seizure activity. T cell numbers were significantly elevated in MTLE patients compared to healthy controls, with varying levels among different subgroups. Interestingly, T cell numbers remained elevated in most MTLE groups even years after the inciting event.
Article
Gastroenterology & Hepatology
Natasha Janko, Ammar Majeed, Isabella Commins, William Kemp, Stuart K. Roberts
Summary: This study described the coagulation parameters and prophylactic blood product use in cirrhotic patients undergoing invasive procedures. The results showed that the bleeding risk category of the procedure was the only significant predictor of procedure-related bleeding, while parameters such as INR and platelet count were not accurate predictors and prophylactic blood products did not prevent bleeding.
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Sarah Hoedemakers, Jan Verwerft, Yogesh N. Reddy, Robin Delvaux, Sarah Stroobants, Siddharth Jogani, Guido Claessen, Steven Droogmans, Bernard Cosyns, Barry A. Borlaug, Lieven Herbots, Frederik H. Verbrugge
Summary: The study aimed to examine the impact of HFpEF vs. AS lesion severity on various cardiac parameters and exercise capacity. The results showed that a high H2FPEF score was associated with reduced exercise capacity and adverse hemodynamics in patients with moderate to severe AS.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Review
Infectious Diseases
Tran Quang Thach, Heba Gamal Eisa, AlMotsim Ben Hmeda, Hazem Faraj, Tieu Minh Thuan, Manal Mahmoud Abdelrahman, Mario Gerges Awadallah, Ha Xuan Nam, Michael Noeske, Jeza Muhamad Abdul Aziz, Nguyen Hai Nam, Mohamed J. El Nile, Shyam Prakash J. Dumre, Nguyen Tien J. Huy, Kenji J. Hirayama
Summary: The study found that changes in platelet count and AST level within the first 72 hours of fever onset are independent markers predicting the development of severe dengue.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Infectious Diseases
Molly D. Kaagaard, Luan Oliveira Matos, Marliton V. P. Evangelista, Alma Wegener, Anna Engell Holm, Lasse S. Vestergaard, Suiane C. N. Do Valle, Odilson M. Silvestre, Marcus Vinicius Guimaraes Lacerda, Rodrigo Medeiros de Souza, Flavia Barreto dos Santos, Tor Biering-Sorensen, Philip Brainin
Summary: This study systematically assessed the frequency of pleural effusion in patients with dengue infection and found that 1/3 of the patients presented with pleural effusion, and the frequency increased with severity and younger age. Lung ultrasound was found to be the best method for detecting pleural effusion.
BMC INFECTIOUS DISEASES
(2023)
Article
Hematology
Nawwar Al-Attar, Eric de Jonge, Richard Kocharian, Bogdan Ilie, Ellie Barnett, Frederik Berrevoet
Summary: This study evaluated the safety and effectiveness of SURGICEL (R) -P, a novel topical hemostat, in controlling mild-to-moderate bleeding in a broad range of surgical procedures. The results showed that SURGICEL (R) -P is safe and effective in controlling bleeding.
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
(2023)
Article
Gastroenterology & Hepatology
Sabine Weber, Andreas Benesic, Marie-Luise Buchholtz, Isabelle Rotter, Alexander L. Gerbes
Summary: In this study of 143 patients with DILI, a majority exhibited ANA or AMA antibodies, but there was no correlation between ANA titers and the causative drugs. AMA positivity was associated with more severe liver injury, as indicated by higher levels of aminotransferases, bilirubin, and international normalized ratio. Patients with higher ANA or AMA titers also had elevated immunoglobulin G levels.
DIGESTIVE DISEASES
(2021)
Article
Multidisciplinary Sciences
Momoka Nakashima, Kana Ishikawa, Aika Fugiwara, Kaiin Shu, Yoshimi Fukushima, Masaaki Okamoto, Hirotake Tsukamoto, Takahisa Kouwaki, Hiroyuki Oshiumi
Summary: HPV vaccine may induce inflammation but does not worsen mouse EAE, whereas circulating EV miR-451a levels are associated with EAE severity. Excessive glucose uptake increases EV miR-451a levels and exacerbates mouse EAE, suggesting that environmental factors play a larger role than the HPV vaccine in exacerbating autoimmune disorders.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Hao-Han Huang, Zhi-Hua Cheng, Bao-Zhi Ding, Jie Zhao, Chang-Qing Zhao
Summary: Hydrocephalus following cervical laminoplasty is rare and in this case, it was caused by subdural fluid collection rather than chronic meningitis. Treatment of the dural defect resolved the symptoms and hydrocephalus gradually disappeared, as confirmed by CSF analysis.
WORLD JOURNAL OF CLINICAL CASES
(2021)
Article
Nursing
Dillon J. Dzikowicz, Mary G. Carey
Summary: Among firefighters, career length rather than age moderately correlates with IHD ischemic severity. This suggests that occupational exposure history plays a significant role in the development of IHD, and should be considered by health practitioners when providing risk reduction services.
WORKPLACE HEALTH & SAFETY
(2021)
Article
Gastroenterology & Hepatology
Sandeep Singh Sidhu, Kavita Saggar, Omesh Goyal, Tarun Varshney, Harsh Kishore, Namita Bansal, Samarth Singh Sidhu
Summary: The study aims to provide cut off values of various Sarcopenia parameters to predict mortality in end-stage liver disease (ESLD). Results suggest that hand grip strength, gait velocity, and chair stand are correlated with mortality in ESLD patients.
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Kimberly E. Daniel, Lindsay A. Matthews, Nimrod Deiss-Yehiely, Jaime Myers, Maureen Garvey, John P. Rice, Jens Eickhoff, Michael R. Lucey
Summary: The study found that patients with alcohol-related liver disease undergoing liver transplantation evaluation have higher vulnerability in psychosocial aspects, with only those with low SIPAT scores being selected. Psychosocial assessment has a significant impact on the selection of ALD patients for liver transplant listing, while having a minor influence on non-ALD candidates.
LIVER TRANSPLANTATION
(2022)
Review
Medicine, General & Internal
Annelies Wilder-Smith, Eng-Eong Ooi, Olaf Horstick, Bridget Wills
Article
Pediatrics
Chuong Huu Thieu Do, Alexandra Yasmin Kruse, Bridget Wills, Saraswathy Sabanathan, Hannah Clapham, Freddy Karup Pedersen, Thanh Ngoc Pham, Phuc Minh Vu, Malene Landbo Borresen
ARCHIVES OF DISEASE IN CHILDHOOD
(2020)
Article
Infectious Diseases
Trung Tuan Vu, Hannah Clapham, Van Thi Thuy Huynh, Long Vo Thi, Dui Le Thi, Nhu Tuyet Vu, Giang Thi Nguyen, Trang Thi Xuan Huynh, Kien Thi Hue Duong, Vi Thuy Tran, Huy Le Anh Huynh, Duyen Thi Le Huynh, Thuy Le Phuong Huynh, Thuy Thi Van Nguyen, Nguyet Minh Nguyen, Tai Thi Hue Luong, Nguyen Thanh Phong, Chau Van Vinh Nguyen, Gerald Gough, Bridget Wills, Lauren B. Carrington, Cameron P. Simmons
PLOS NEGLECTED TROPICAL DISEASES
(2019)
Article
Medicine, General & Internal
Nguyen Lam Vuong, Huynh Thi Le Duyen, Phung Khanh Lam, Dong Thi Hoai Tam, Nguyen Van Vinh Chau, Nguyen Van Kinh, Ngoun Chanpheaktra, Lucy Chai See Lum, Ernesto Pleites, Nick Keith Jones, Cameron Paul Simmons, Kerstin Rosenberger, Thomas Jaenisch, Christine Halleux, Piero Luigi Olliaro, Bridget Wills, Sophie Yacoub
Article
Immunology
Tran Thi Nhu Thao, Erwin de Bruin, Huynh Thi Phuong, Nguyen Ha Thao Vy, Henk-Jan van den Ham, Bridget A. Wills, Nguyen Thi Hanh Tien, Huynh Thi Le Duyen, Dinh The Trung, Stephen S. Whitehead, Maciej F. Boni, Marion Koopmans, Hannah E. Clapham
Summary: The study focuses on the performance assessment of a flavivirus microarray assay for determining past dengue virus infection history in Vietnam. Binomial models based on protein microarray titers showed high accuracy in discriminating past primary from secondary infection, while multinomial models performed well in identifying the most recent infecting serotype in individuals with past primary infection but not in those with past secondary infection.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Kerstin D. Rosenberger, Neal Alexander, Eric Martinez, Lucy C. S. Lum, Carl-Erik Dempfle, Thomas Junghanss, Bridget Wills, Thomas Jaenisch
PLOS NEGLECTED TROPICAL DISEASES
(2020)
Article
Medicine, Research & Experimental
Esther Shuyi Gan, Hwee Cheng Tan, Duyen Huynh Thi Le, Trieu Trung Huynh, Bridget Wills, Nabil G. Seidah, Eng Eong Ooi, Sophie Yacoub
JOURNAL OF CLINICAL INVESTIGATION
(2020)
Article
Parasitology
Daniela da Silva Goncalves, Kien Duong Thi Hue, Vi Tran Thuy, Nhu Vu Tuyet, Giang Nguyen Thi, Van Huynh Thi Thuy, Trang Huynh Thi Xuan, Dui Le Thi, Long Thi Vo, Huynh Le Anh Huy, Nguyen Thi Van Thuy, Bridget A. Wills, Phong Nguyen Thanh, Cameron P. Simmons, Lauren B. Carrington
PARASITES & VECTORS
(2020)
Article
Medicine, General & Internal
Phung Khanh Lam, Angela McBride, Duyen Huynh Thi Le, Trieu Trung Huynh, Hans Vink, Bridget Wills, Sophie Yacoub
FRONTIERS IN MEDICINE
(2020)
Article
Immunology
Nguyen Lam Vuong, Nguyen Than Ha Quyen, Nguyen Thi Hanh Tien, Nguyen Minh Tuan, Duong Thi Hue Kien, Phung Khanh Lam, Dong Thi Hoai Tam, Tran Van Ngoc, Sophie Yacoub, Thomas Jaenisch, Ronald B. Geskus, Cameron P. Simmons, Bridget A. Wills
Summary: Higher plasma viremia is associated with increased dengue severity, regardless of serotype or immune status, with effect sizes being modest compared to the effects of a secondary immune response. The association remains consistent across different age, serotype, and immune status groups, indicating a potential role of plasma viremia in predicting dengue severity.
CLINICAL INFECTIOUS DISEASES
(2021)
Review
Medicine, General & Internal
Dinh The Trung, Huynh Trung Trieu, Bridget A. Wills
FRONTIERS IN MEDICINE
(2020)
Article
Public, Environmental & Occupational Health
Marcus J. Schultz, Jacqueline Deen, Lorenz von Seidlein, Chaisith Sivakorn, Alex Kumar, Neill K. J. Adhikari, Bridget Wills, Alexander S. Kekule, Nicholas P. J. Day, Ben Cooper, Nicholas J. White, Alex P. Salam, Peter Horby, Piero Olliaro, Arjen M. Dondorp
Summary: Viral hemorrhagic fevers often lead to circulatory shock, requiring optimized fluid therapy for management. However, there is a lack of data and guidelines in this area. An innovative monitoring approach proposes remote-controlled and pulse pressure-guided fluid resuscitation to enhance supportive care capacity and reduce the risk of virus transmission.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2021)
Article
Infectious Diseases
Ivonne Morales, Kerstin D. Rosenberger, Tereza Magalhaes, Clarice N. L. Morais, Cynthia Braga, Ernesto T. A. Marques, Guilherme Amaral Calvet, Luana Damasceno, Patricia Brasil, Ana Maria Bispo de Filippis, Sarah Bethencourt, Adriana Tami, Mayling Alvarez, Pedro A. Martinez, Maria G. Guzman, Bruno Souza Benevides, Andrea Caprara, Nguyen Thanh Ha Quyen, Cameron Simmons, Bridget Wills, Xavier de Lamballerie, Jan Felix Drexler, Thomas Jaenisch
Summary: This study evaluated three commercially available immunoassays for detecting ZIKV antibodies, with the IgAM test showing the best performance in detecting infections. The study was conducted in two different American countries with endemic arboviruses, and sequential blood samples allowed for evaluation of test performance over time. The IgAM assay exhibited superior sensitivity in detecting ZIKV infections compared to IgG and IgM assays, making it a promising candidate for serological monitoring in future ZIKV outbreaks.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Biology
Nguyen Lam Vuong, Phung Khanh Lam, Damien Keng Yen Ming, Huynh Thi Le Duyen, Nguyet Minh Nguyen, Dong Thi Hoai Tam, Kien Duong Thi Hue, Nguyen V. V. Chau, Ngoun Chanpheaktra, Lucy Chai See Lum, Ernesto Pleites, Cameron P. Simmons, Kerstin D. Rosenberger, Thomas Jaenisch, David Bell, Nathalie Acestor, Christine Halleux, Piero L. Olliaro, Bridget A. Wills, Ronald B. Geskus, Sophie Yacoub
Summary: Early identification of severe dengue patients is crucial for patient management and resource allocation. Higher levels of any biomarker on days 1-3 from symptom onset increase the risk of developing severe/moderate dengue. The best biomarker combinations associated with S/MD differ between children and adults.
Article
Public, Environmental & Occupational Health
A. S. M. Nawshad Uddin Ahmed, Abdellatif Maamri, Adegoke G. Falade, Adejumoke Idowu Ayede, Adnan Bhutta, Ajay Gambhir, Alfredo Tagarro, Ali Abdelmegeid, Ali Reza Ahmadi, Aluisio J. D. Barros, Amha Mekasha, Anantha Kumar Srinivasaiyer, Andre Ricardo Araujo da Silva, Andreas Schultz, Batool Fatima, Bishnupada Dhar, Brian Magowan, Bridget Wills, Camille Raynes-Greenow, Caroline Homer, Carolyn Maclennan, Catherine Ward, Daniel Martinez Garcia, David Ross, David Murdoch, Deborah Joy Wilson, Ebun Adejuyigbe, Ecaterina Stasii, Elaine Scudder, Emma Sacks, Eric D. McCollum, Fernando Althabe, Fiona Russell, G. S. Kumar, Halvor Sommerfelt, Hamish Graham, Hannah Blencowe, Hannah Tappis, Haroon Saloojee, Hesham Abdussalam Ben Masaud, Hiresh Tiwary, Ifeyinwa Asiodu, James B. Newton, Jessica Bourdaire, Joel Amwe Adze, Jose Martines, Juan M. Lozano, Judd Walson, Judith Rankin, Karel Allegaert, Karell G. Pelle, Karen Edmond, Katayoun Rabiei, Kathleen M. Rasmussen, Khalid Yunis, Laura Ferguson, Leith Greenslade, Lilian Kiapi, Lisa Noguchi, Louis Bont, Louise T. Day, Lynne Mofenson, Maher Aboumayaleh, Majda Aquzouz, Mamdouh Wahba, Mari Nagai, Marian Knight, Marina Melkumova, Mariyam Jenyfa, Mark I. Neuman, Martin Meremikwu, Mary Kinney, Michael Gravett, Michael T. Hawkes, Michel Pacque, Michele Walsh, Michelle K. McGuire, Nagiba AAbdulghani AlShawafi, Najwa Khuri-Bulos, Naveen Thacker, Nigel Rollins, Niranjan Kissoon, Olena Starets, Olivier Picone, Olufemi T. Oladapo, Omer Erdeve, P. Brian Smith, Philippe Van de Perre, Praveen Kumar, Punam Mangtani, Qalab Abbas, Rabeya Khatoon, Rajiv Bahl, Rakesh Lodha, Rebecca Grais, Rebecca Richards-Kortum, Reeta Rasaily, Richmond Aryeetey, Robert Pattinson, Roberta Petrucci, Rodolfo Rossi, Ryan M. Pace, Sachiyo Yoshida, Salimah R. Walani, Sanjeeva S. P. Godakandage, Sarah Bauler, Sarah S. Comstock, Saurav Basu, Senait Kebede, Senjuti Saha, Shinjini Bhatnagar, Shoo Kim Lee, Shuchita Gupta, Simon Nyovuura Antara, Soo Downe, Stephen Freedman, Stephen J. Lye, Suellen Miller, Suha Sulimani, Sylvia H. Ley, Tara D. Mangal, Tina Lavin, Ting Shi, Todd A. Florin, Ulrik Kraemer Sundekilde, Valentina Baltag, Veronica Valdes, William Cherniak, Yasir Bin Nisar, Zainularab Zohra Shamszai, Zohreh Sadat Navabi
Summary: This research identified major research gaps in maternal, newborn, child, and adolescent health through expert scoring, emphasizing the direct and indirect effects of the COVID-19 pandemic.
JOURNAL OF GLOBAL HEALTH
(2021)