期刊
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
卷 79, 期 4, 页码 485-494出版社
AMER SOC TROP MED & HYGIENE
DOI: 10.4269/ajtmh.2008.79.485
关键词
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资金
- Ministry of Health [50148920037]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo [04/00373-2]
- FAPESP
- Conselho Nacional de Desenvolvimento Cientffico a Tecnologico (CNPq), Brazil
A comparison of dengue virus (DENV) antibody levels in paired serum samples collected from predominantly DENV-naive residents in an agricultural settlement in Brazilian Amazonia (baseline seroprevalence, 18.3%) showed a seroconversion rate of 3.67 episodes/100 person-years at risk during 12 months of follow-up. Multivariate analysis identified male sex, poverty, and migration from extra-Amazonian states as significant predictors of baseline DENY seropositivity, whereas male sex, a history of clinical diagnosis of dengue fever, and travel to an urban area predicted subsequent seroconversion. The laboratory surveillance of acute febrile illnesses implemented at the study site and in a nearby town between 2004 and 2006 confirmed 11. DENV infections among 102 episodes studied with DENV IgM detection, reverse transcriptase-polymerise chain reaction, and virus isolation; DENV-3 was isolated. Because DENV exposure is associated with migration or travel, personal protection measures when visiting high-risk urban areas may reduce the incidence of DENV infection in this rural population.
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