Article
Nutrition & Dietetics
Kao-Ming Hsu, Pei-Ru Lin, Ping-Fang Chiu, Yao-Peng Hsieh
Summary: This study investigated the subsequent renal function change following incident infectious diseases in living-donor liver transplant recipients. The results showed that hospitalization with major infections or pneumonia increased the risk of eGFR decline and adverse renal outcomes in these patients.
Article
Surgery
L. Ebony Boulware, Debra L. Sudan, Tara S. Strigo, Patti L. Ephraim, Clemontina A. Davenport, Jane F. Pendergast, Iris Pounds, Jennie A. Riley, Margaret Falkovic, Aviel Alkon, Felicia Hill-Briggs, Ashley N. Cabacungan, Tyler M. Barrett, Dinushika Mohottige, Lisa McElroy, Clarissa J. Diamantidis, Matthew J. Ellis
Summary: The study found limited effectiveness of a transplant social worker intervention and financial assistance in activating potential donors among African Americans on the transplant waiting list.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Surgery
Robin K. Avery, Jennifer D. Motter, Kyle R. Jackson, Robert A. Montgomery, Allan B. Massie, Edward S. Kraus, Kieren A. Marr, Bonnie E. Lonze, Nada Alachkar, Mary J. Holechek, Darin Ostrander, Niraj Desai, Madeleine M. Waldram, Shmuel Shoham, Seema Mehta Steinke, Aruna Subramanian, Janet M. Hiller, Julie Langlee, Sheila Young, Dorry L. Segev, Jacqueline M. Garonzik Wang
Summary: Desensitization for incompatible living donor kidney transplantation increases the risk of infections, especially in highly desensitized recipients, leading to prolonged hospitalization and graft loss. Strategies are needed to protect patients from recurrent infections and extend the survival benefit of ILDKT.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Medicine, General & Internal
Kai-Chieh Chang, Yao-Peng Hsieh, Huan-Nung Chao, Chien-Ming Lin, Kuo-Hua Lin, Chun-Chieh Tsai, Chia-En Heish, Pei-Ru Lin, Chew-Teng Kor, Yao-Li Chen, Ping-Fang Chiu
Summary: The presence of hematuria and preoperative use of NSAIDs in patients who undergo liver transplantation are associated with worse long-term renal function and survival.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Urology & Nephrology
Takahisa Hiramitsu, Toshihide Tomosugi, Kenta Futamura, Manabu Okada, Yutaka Matsuoka, Norihiko Goto, Toshihiro Ichimori, Shunji Narumi, Asami Takeda, Takaaki Kobayashi, Kazuharu Uchida, Yoshihiko Watarai
Summary: This study investigated the impact of age differences between older adult living donors and recipients on kidney transplantation outcomes. The results showed that kidney transplants from older adult donors to older adult recipients had the highest risk of graft loss and mortality, with recipients having lower estimated glomerular filtration rates.
KIDNEY INTERNATIONAL REPORTS
(2021)
Article
Biochemistry & Molecular Biology
G. J. Julia Huisman, Nora A. Spraakman, Jeroen V. Koomen, A. Marrit Talsma, Robert A. Pol, Stefan P. Berger, Henri G. D. Leuvenink, Michel M. R. F. Struys, Gertrude J. Nieuwenhuijs-Moeke
Summary: Early non-invasive detection and prediction of graft function after kidney transplantation is important. The study analyzed four urinary biomarkers and found that KIM-1 and NAG at early timepoints after transplantation were significant predictors for eGFR, while NGAL and NAG at day 1 after transplantation were negative predictors. Including these biomarkers improved the prediction models for graft outcome. Factors such as timing of measurement and transplantation factors need to be considered when using urinary biomarkers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Melissa Grigorescu, Stephan Kemmner, Ulf Schoenermarck, Isidora Sajin, Wolfgang Guenther, Tiago Lemos Cerqueira, Ben Illigens, Timo Siepmann, Bruno Meiser, Markus Guba, Michael Fischereder, Manfred Johannes Stang
Summary: The study found that in a transplant center in Germany, medical reasons are the main cause for potential living kidney donors to be disqualified, with potentially severe consequences for potential recipients. However, only a small number of disqualified end-stage kidney disease patients subsequently received kidney transplants, leaving others at higher risk of death.
FRONTIERS IN MEDICINE
(2022)
Article
Immunology
Fan Zhang, Saifu Yin, Yu Fan, Turun Song, Zhongli Huang, Jiayu Liang, Jiapei Wu, Youmin Yang, Tao Lin, Xianding Wang
Summary: This study found that the secretor status of both donors and recipients may have an impact on the outcomes of ABO incompatibility kidney transplantation. Recipients with weak secretor status may have better post-transplant renal function, while recipients from secretor donors had a lower incidence of graft rejection in the first year after transplantation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Surgery
Manuela Almeida, Goncalo Calheiros Cruz, Ciria Sousa, Catia Figueiredo, Sofia Ventura, Jose Silvano, Sofia Pedroso, La Salete Martins, Miguel Ramos, Jorge Malheiro
Summary: A predictive model was developed to estimate the eGFR and risk of CKD at 1-year post-donation, which showed a strong correlation with the observed eGFR. Retrospective analysis of living donor kidney transplants from 1998 to 2020 revealed a good agreement between predicted and observed eGFR at 1-year post-donation. The model demonstrated a good discriminative ability in predicting CKD at 1-year post-donation.
TRANSPLANT INTERNATIONAL
(2023)
Article
Medicine, General & Internal
Martina Cozzi, Paola Donato, Gabriele Ugolini, Rostand Emmanuel Nguefouet Momo, Francesco Nacchia, Zeno Ballarini, Pierluigi Piccoli, Maurizio Cantini, Chiara Caletti, Stefano Andreola, Giorgio Gandini, Giovanni Gambaro, Luigino Boschiero
Summary: AB0 incompatible living donor kidney transplantation (AB0i LDKT) is an effective therapeutic strategy with graft function and survival comparable to compatible living donor kidney transplantation (AB0c LDKT), despite higher rates of acute rejection and sepsis. It provides an additional opportunity for patients with blood group 0.
FRONTIERS IN MEDICINE
(2022)
Article
Surgery
Suhani S. Patel, Bonnie E. Lonze, Teresa Po-Yu Chiang, Fawaz Al Ammary, Dorry L. Segev, Allan B. Massie
Summary: Decreased postdonation eGFR is associated with a higher risk of ESRD after living kidney donation. The Toulouse-Rangueil model (TRM) overestimates postdonation renal function in US donors, especially among male, Black, and younger donors.
TRANSPLANT INTERNATIONAL
(2023)
Article
Medicine, General & Internal
Jun Young Lee, Sung Hwan Cha, Sung Hwa Kim, Kyung Hwan Jeong, Ku Yong Chung, Hong Rae Cho, Juhan Lee, Kyu Ha Huh, Jaeseok Yang, Myoung Soo Kim, Deok Gie Kim
Summary: The combination of ABO incompatibility and donor-recipient weight mismatch is an independent risk factor for graft and patient survival in living donor kidney transplantation, leading to an increased risk of pneumonia.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Yi-Chia Chan, Cheng-Hsi Yeh, Lung-Chih Li, Chao-Long Chen, Chih-Chi Wang, Chih-Chi Lin, Aldwin D. Ong, Ting-Yu Chiou, Chee-Chien Yong
Summary: Acute kidney injury (AKI) after liver transplantation (LT) is associated with major adverse cardiovascular events (MACE) and major adverse kidney events (MAKE). It is also an independent predictor and risk factor for cardiovascular disease and end-stage renal disease.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Surgery
Stijn C. van de Laar, Matthew L. Robb, Rachel Hogg, Lisa Burnapp, Vassilios E. Papalois, Frank J. M. F. Dor
Summary: The study found that LDKT performed within the UKLKSS had longer cold ischaemia time, higher incidence of delayed graft function, and lower graft function compared to the non-KEP group, but excellent 5-year graft survival similar to non-KEP was observed.
Article
Nursing
Ingrid Villadsen Kristensen, Regner Birkelund, Jette Henriksen, Annelise Norlyk
Summary: The study reveals that kidney transplant patients face multifaceted existential challenges in their everyday lives, including bodily vulnerability, gratitude and guilt, uncertain identity, and unknown future. This highlights the need for developing a rehabilitation program to address the individual and various existential challenges faced by these patients.
JOURNAL OF ADVANCED NURSING
(2021)