Article
Immunology
Suzanne Bezstarosti, Cynthia S. M. Kramer, Marry E. I. Franke-van Dijk, Manon Vergunst, Kim H. Bakker, Merve Uyar-Mercankaya, Rico Buchli, Dave L. Roelen, Johan W. de Fijter, Frans H. J. Claas, Sebastiaan Heidt
Summary: HLA-DQ donor-specific antibodies (DSA) play a significant role in renal transplantation, and this study focuses on isolating HLA-DQ specific memory B cells to generate monoclonal antibodies that can verify the recognition of eplets on HLA molecules. The findings provide valuable insights into the epitopes of HLA-DQ, contributing to the understanding of HLA-DQ alloantibody pathogenicity in transplantation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Urology & Nephrology
Hossein Mohammadhassanzadeh, Karim Oualkacha, Wenmin Zhang, William Klement, Amelie Bourdiec, Jennat Lamsatfi, Yang Yi, Bethany Foster, Paul Keown, Howard M. Gebel, Frans Claas, Ruth Sapir-Pichhadze
Summary: This study investigated the association between structurally defined HLA EMM and DCGF in kidney transplant recipients. Network analysis revealed both singleton EMM and profiles of simultaneously occurring EMM, with some EMM predictive of DCGF.
KIDNEY INTERNATIONAL REPORTS
(2021)
Article
Immunology
David San Segundo, Sandra A. Guiral-Foz, Adalberto Benito-Hernandez, Andre Renaldo Fernandez, Alvaro Arnau, Rosalia Valero, Maria Angeles Ramos-Barron, Maria Teresa Garcia-Unzueta, Jose Maria Gomez-Ortega, Marcos Lopez-Hoyos, Juan Carlos Ruiz, Emilio Rodrigo
Summary: The study revealed an association between urinary CXCL10 and HLA-DQ epitope mismatch load, which partly explains the relationship between CXCL10 excretion and graft inflammation. It highlights the importance of considering HLA molecular mismatch in the evaluation of potential non-invasive biomarkers like CXCL10.
TRANSPLANT IMMUNOLOGY
(2022)
Article
Immunology
Nicholas G. Larkins, Lloyd D'Orsogna, Anne Taverniti, Ankit Sharma, Aron Chakera, Doris Chan, Anoushka Krishnan, Germaine Wong, Wai H. Lim
Summary: High resolution HLA typing is crucial for eplet compatibility and specificity of DSA. NGS and LD typing show high concordance but significant differences. Inaccurate DSA assignment from LD typing may inappropriately exclude candidates.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Suzanne Bezstarosti, Soufian Meziyerh, Marlies E. J. Reinders, Kim Voogt-Bakker, Koen E. E. Groeneweg, Dave L. L. Roelen, Jesper Kers, Johan W. W. de Fijter, Sebastiaan Heidt
Summary: Recently, a randomized phase-II Triton study found that mesenchymal stromal cell (MSC) therapy could help living donor kidney transplant recipients withdraw tacrolimus early. This sub-study analyzed the formation of de novo donor-specific HLA antibodies (dnDSA) in relation to HLA eplet mismatches. Results showed that dnDSA occurred more frequently in the MSC group compared to the control group, but the long-term kidney function and rejection episodes were similar between the two groups. The study also suggested exploring HLA molecular mismatch load as a biomarker for personalized immunosuppression in kidney transplantation.
Article
Immunology
Marta Crespo, Laura Llinas-Mallol, Dolores Redondo-Pachon, Carrie Butler, Javier Gimeno, Maria Jose Perez-Saez, Carla Burballa, Anna Buxeda, Carlos Arias-Cabrales, Montserrat Folgueiras, Sara Sanz-Urena, Nicole M. Valenzuela, Elaine F. Reed, Julio Pascual
Summary: The relationship between HLA-DSA and ABMR in kidney transplant recipients is strong but imperfect. Pre-transplant HLA-DSA and AT(1)R-Ab are more common in ABMR, indicating their potential role in ABMR(h)DSA(pos) cases. HLA epitope mismatches are associated with ABMR(h)DSA(pos) cases, suggesting non-HLA factors may contribute to the development of ABMR.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Huaying Liu, Lan Huang, Li Li, Tingting Lu, Huiping Liang, Chunbin Liu
Summary: This study investigated the risk factors for IBS in college students of Guangxi Han nationality and found that HLA-DQ genes and alcohol consumption have an additive interaction in the occurrence of IBS.
SCIENTIFIC REPORTS
(2023)
Review
Cell Biology
Malte Ziemann, Barbara Suwelack, Bernhard Banas, Klemens Budde, Gunilla Einecke, Ingeborg Hauser, Falko Markus Heinemann, Teresa Kauke, Reinhard Kelsch, Martina Koch, Nils Lachmann, Stefan Reuter, Christian Seidl, Urban Sester, Daniel Zecher
Summary: This study reviewed and updated the previous recommendations from 2015, providing a general recommendation to assign HLA against which plausible antibodies are found as unacceptable antigen mismatches. It also discussed the risk stratification prior to kidney transplantation.
Article
Immunology
William Lemieux, David Fleischer, Archer Yi Yang, Matthias Niemann, Karim Oualkacha, William Klement, Lucie Richard, Constantin Polychronakos, Robert Liwski, Frans Claas, Howard M. M. Gebel, Paul A. A. Keown, Antoine Lewin, Ruth Sapir-Pichhadze
Summary: This study aimed to investigate whether certain T-cell molecular mismatches (TcEMM) are highly predictive of death-censored graft failure (DCGF).
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Urology & Nephrology
Dylan Isaacson, Jesse D. Schold, Michael W. Gmeiner, Hannah C. Copley, Vasilis Kosmoliaptsis, Anat R. Tambur
Summary: This study found that HLA-DQ mismatches had the strongest association with donor-specific antibodies, particularly in African American and Hispanic recipients. The effect of HLA-DQ on calculated panel reactive antibody (cPRA) increase was equivalent or larger than any other HLA locus. Therefore, the effects of HLA-DQ should be considered in kidney allocation.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Medicine, General & Internal
Emil Grothgar, Nina Goerlich, Bjoern Samans, Christopher M. Skopnik, Diana Metzke, Jan Klocke, Luka Prskalo, Paul Freund, Leonie Wagner, Michael Duerr, Mareen Matz, Sven Olek, Klemens Budde, Alexander Paliege, Philipp Enghard
Summary: Early detection of kidney transplant rejection is challenging but important. This study identified T cells in urine as potential non-invasive biomarkers to monitor and detect rejection in kidney transplant patients. CD8+HLA-DR+ T cells were found to be the most distinctive subset.
FRONTIERS IN MEDICINE
(2022)
Article
Immunology
You-Seok Hyun, Hyeong-A Jo, Yong-Hun Lee, Sun-Mi Kim, In-Cheol Baek, Hyun-Jung Sohn, Hyun-Il Cho, Tai-Gyu Kim
Summary: Within an individual, CD4(+) T cell responses are predominantly restricted by a limited number of HLA class II allotypes, with specific highly responsive alleles identified in each HLA-DR, -DQ, and -DP locus.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Endocrinology & Metabolism
Antigoni Eleftheriou, Clive J. Petry, Ieuan A. Hughes, Ken K. Ong, David B. Dunger
Summary: The study found variable associations of DR3, DR4, and DQ8 alleles with growth measures and IGF-I levels in infants from the general population, which could explain the heterogeneous growth trajectories observed in genetically at-risk cohorts. These findings suggest distinct mechanisms involving endocrine pathways related to the HLA-conferred type 1 diabetes risk.
Article
Immunology
Aileen C. Johnson, Joan Zhang, H. Cliff Sullivan, Chris Wiebe, Robert Bray, Howard Gebel, Christian P. Larsen
Summary: Eplet mismatch has an impact on transplant recipient outcomes, and accurate assessment requires high-resolution HLA typing. To simplify eplet analysis, we developed a software tool that can impute high-resolution data from low-resolution data and calculate overall and single molecule eplet mismatch. Compared to existing tools, this tool shows high consistency in eplet mismatch and provides rapid and reproducible imputation and mismatch calculation.
Article
Immunology
Aleksandar Senev, Bryan Ray, Evelyne Lerut, Jayasree Hariharan, Christine Heylen, Dirk Kuypers, Ben Sprangers, Marie-Paule Emonds, Maarten Naesens
Summary: This study found that patients highly and broadly sensitized to non-HLA targets are at increased risk of ABMR histology after kidney transplantations in the absence of HLA-DSA. Additionally, some pretransplant non-HLA autoantibodies are individually associated with increased rates of ABMR histology. However, further studies are needed to determine whether these associations are clinically relevant and represent causality.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Urology & Nephrology
Ruth Sapir-Pichhadze, Kathryn J. Tinckam, Andreas Laupacis, Alexander G. Logan, Joseph Beyene, S. Joseph Kim
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2016)
Article
Surgery
J. M. Kaths, J. Y. Cen, Y. M. Chun, J. Echeverri, I. Linares, S. Ganesh, P. Yip, R. John, D. Bagli, I. Mucsi, A. Ghanekar, D. R. Grant, L. A. Robinson, M. Selzner
AMERICAN JOURNAL OF TRANSPLANTATION
(2017)
Article
Urology & Nephrology
Eun Hui Bae, Fei Fang, Vanessa R. Williams, Ana Konvalinka, Xiaohua Zhou, Vaibhav B. Patel, Xuewen Song, Rohan John, Gavin Y. Oudit, York Pei, James W. Scholey
KIDNEY INTERNATIONAL
(2017)
Editorial Material
Pediatrics
Mallory L. Downie, Jaap Mulder, Rayfel Schneider, Lillian Lim, Nasrin Tehrani, Jonathan D. Wasserman, Shai Fuchs, Rohan John, Damien G. Noone, Diane Hebert
PEDIATRIC NEPHROLOGY
(2018)
Article
Immunology
J. Moritz Kaths, Juan Echeverri, Yi Min Chun, Jun Yu Cen, Nicolas Goldaracena, Ivan Linares, Luke S. Dingwell, Paul M. Yip, Rohan John, Darius Bagli, Istvan Mucsi, Anand Ghanekar, David R. Grant, Lisa A. Robinson, Markus Selzner
Article
Immunology
Ben C. Reynolds, Kathryn J. Tinckam
TRANSPLANTATION REVIEWS
(2017)
Article
Urology & Nephrology
Moumita Barua, Rohan John, Lorenzo Stella, Weili Li, Nicole M. Roslin, Bedra Sharif, Saidah Hack, Ginette Lajoie-Starkell, Andrew L. Schwaderer, Brian Becknell, Matthias Wuttke, Anna Koettgen, Daniel Cattran, Andrew D. Paterson, York Pei
AMERICAN JOURNAL OF KIDNEY DISEASES
(2018)
Article
Surgery
J. A. McCaughan, R. K. Battle, S. K. S. Singh, J. M. Tikkanen, Y. Moayedi, H. J. Ross, L. G. Singer, S. Keshavjee, K. J. Tinckam
AMERICAN JOURNAL OF TRANSPLANTATION
(2018)
Editorial Material
Surgery
Laurie D. Snyder, Kathryn J. Tinckam
AMERICAN JOURNAL OF TRANSPLANTATION
(2018)
Editorial Material
Surgery
Anat R. Tambur, Patricia Campbell, Frans H. Claas, Sandy Feng, Howard M. Gebel, Annette M. Jackson, Roslyn B. Mannon, Elaine F. Reed, Kathryn Tinckam, Medhat Askar, Anil Chandraker, Patricia P. Chang, Monica Colvin, Anthony-Jake Demetris, Joshua M. Diamond, Anne I. Dipchand, Robert L. Fairchild, Mandy L. Ford, John Friedewald, Ronald G. Gill, Denis Glotz, Hilary Goldberg, Ramsey Hachem, Stuart Knechtle, Jon Kobashigawa, Deborah J. Levine, Joshua Levitsky, Michael Mengel, Edgar Milford, Kenneth A. Newell, Jacqueline G. O'Leary, Scott Palmer, Parmjeet Randhawa, John Smith, Laurie Snyder, Randall C. Starling, Stuart Sweet, Timucin Taner, Craig J. Taylor, Steve Woodle, Adriana Zeevi, Peter Nickerson
AMERICAN JOURNAL OF TRANSPLANTATION
(2018)
Review
Surgery
Jennifer A. McCaughan, Kathryn J. Tinckam
TRANSPLANT INTERNATIONAL
(2018)
Article
Surgery
Meghan Aversa, Tereza Martinu, Christopher Patriquin, Marcelo Cypel, David Barth, Rasheed Ghany, Jin Ma, Shaf Keshavjee, Lianne G. Singer, Kathryn Tinckam
Summary: The Toronto Lung Transplant Program has been using a desensitization regimen since 2008 for DSA-positive lung transplants, and long-term follow-up showed that allograft survival and CLAD-free survival of these patients were not significantly different from other lung transplant recipients.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Surgery
J. M. Kaths, J. Echeverri, I. Linares, J. Y. Cen, S. Ganesh, M. Hamar, P. Urbanellis, P. Yip, R. John, D. Bagli, I. Mucsi, A. Ghanekar, D. Grant, L. A. Robinson, M. Selzner
AMERICAN JOURNAL OF TRANSPLANTATION
(2017)
Article
Urology & Nephrology
Frank L. Ward, Rohan John, Joanne M. Bargman, Rory F. McQuillan
AMERICAN JOURNAL OF KIDNEY DISEASES
(2017)
Article
Cardiac & Cardiovascular Systems
Nicholas Jackson, Sigfus Gizurarson, Mohammed Ali Azam, Benjamin King, Andrew Ramadeen, Nima Zamiri, Andreu Porta-Sanchez, Abdul Al-Hesayen, John Graham, Marjan Kusha, Stephane Masse, Patrick F. H. Lai, John Parker, Rohan John, Tim-Rasmus Kiehl, Govind Krishna Kumar Nair, Paul Dorian, Kumaraswamy Nanthakumar
CIRCULATION-CARDIOVASCULAR INTERVENTIONS
(2017)