Article
Immunology
Jaideep Vazirani, David Routledge, Greg Snell, Doug Watson, Miranda Paraskeva, Glen P. Westall, Simon J. Harrison
Summary: In a retrospective audit of 12 LTx recipients with CLAD receiving rescue ECP, 67% responded positively to therapy. Factors such as sex, pre-ECP neutrophil count, and prior exposure to anti-thymocyte globulin may impact the response to ECP in CLAD patients, highlighting the need for further clinical trials to confirm efficacy and guide treatment decisions.
TRANSPLANTATION PROCEEDINGS
(2021)
Article
Medicine, Research & Experimental
Aaditya Khatri, Jamie L. . Todd, Fran L. . Kelly, Andrew Nagler, Zhicheng Ji, Vaibhav Jain, Simon G. Gregory, Kent J. Weinhold, Scott M. Palmer
Summary: Chronic lung allograft dysfunction (CLAD), characterized by decline in pulmonary function and bronchiolitis obliterans, lacks approved therapies. Single-cell RNA-Seq and spatial transcriptomic analysis identified the important role of JAK-STAT signaling in airway epithelial cells in CLAD. Activation of JAK-STAT signaling leads to upregulation of MHC-I in airway basal cells, resulting in cytotoxic T cell-mediated basal cell death. This study provides mechanistic insight and potential therapeutic strategy for CLAD.
Article
Medicine, General & Internal
Jesper Romhild Davidsen, Christian B. Laursen, Mikkel Hojlund, Thomas Kromann Lund, Klaus Nielsen Jeschke, Martin Iversen, Anna Kalhauge, Elisabeth Bendstrup, Jorn Carlsen, Michael Perch, Daniel Pilsgaard Henriksen, Hans Henrik Lawaetz Schultz
Summary: This study found that pleural thickening identified by lung ultrasound may serve as a potential surrogate marker to distinguish restrictive allograft syndrome (RAS) from bronchiolitis obliterans syndrome (BOS) in chronic lung allograft dysfunction (CLAD) patients after lung transplant. This discovery provides a new method for clinical diagnosis of CLAD patients post lung transplant.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Hematology
Yifan Pang, Ananth Charya, Michael B. Keller, Arlene Sirajuddin, Yi-Ping Fu, Noa G. Holtzman, Steven Z. Pavletic, Sean Agbor-Enoh
Summary: This study adapted the 2019 International Society for Heart and Lung Transplantation criteria to define novel phenotypes of pulmonary chronic graft-versus-host disease (PcGVHD) and compared its performance with the NIH criteria in identifying high-risk PcGVHD patients. The adapted criteria were found to be effective in identifying high-risk PcGVHD patients that were missed by the NIH criteria.
Article
Surgery
Naofumi Miyahara, Alberto Benazzo, Felicitas Oberndorfer, Akinori Iwasaki, Viktoria Laszlo, Balasz Dome, Mir Ali Hoda, Peter Jaksch, Walter Klepetko, Konrad Hoetzenecker
Summary: miR-21 expression was higher in restrictive allograft syndrome (RAS) than in bronchiolitis obliterans syndrome (BOS) specimens, with a significant increase in serum concentration over time in RAS patients. Vimentin, NICD, and p-SMAD 2/3 were positive in a higher proportion of BOS patients compared to RAS cases.
TRANSPLANT INTERNATIONAL
(2022)
Review
Medicine, General & Internal
Christophe Pison, Adrien Tissot, Eric Bernasconi, Pierre-Joseph Royer, Antoine Roux, Angela Koutsokera, Benjamin Coiffard, Benjamin Renaud-Picard, Jerome Le Pavec, Pierre Mordant, Xavier Demant, Thomas Villeneuve, Jean-Francois Mornex, Simona Nemska, Nelly Frossard, Olivier Brugiere, Valerie J. Siroux, Benjamin Marsland, Aurore Foureau, Karine Botturi, Eugenie Durand, Johann Pellet, Richard Danger, Charles Auffray, Sophie Brouard, Laurent Nicod, Antoine Magnan
Summary: SysCLAD is a research aiming to predict chronic lung allograft dysfunction (CLAD), which involves investigating various factors including clinical data, assessment of airway microbiota, air pollution studies, activation of immune cells, secretion of matrix metalloproteinase-9 by T cells, subpopulations of T and B cells, genome polymorphisms, blood transcriptome, plasma proteome studies, and MSK1 expression to develop predictors of CLAD.
FRONTIERS IN MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Wai Wong, Brandy Johnson, Pi Chun Cheng, Maureen B. Josephson, Katsuhide Maeda, Robert A. Berg, Steven M. Kawut, Michael O. Harhay, Samuel B. Goldfarb, Nadir Yehya, Adam S. Himebauch
Summary: This study aimed to investigate the impact of grade 3 PGD within 48 or 72 hours on CLAD-free survival following pediatric lung transplantation. The study found that the occurrence of grade 3 PGD within 48 or 72 hours was associated with shorter CLAD-free survival, and gender may be a modifier of this association.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Article
Pharmacology & Pharmacy
Filippo Patrucco, Elias Allara, Massimo Boffini, Mauro Rinaldi, Cristina Costa, Carlo Albera, Paolo Solidoro
Summary: Chronic lung allograft dysfunction (CLAD) affects the survival of lung transplant patients and includes bronchiolitis obliterans syndrome (BOS) and restrictive allograft syndrome (RAS). This study evaluated the 12-month follow-up of renal and lung function in lung transplant patients treated with everolimus, showing improvements in renal function and sustained improvements in lung function for CLAD related to BOS subgroup results, while RAS confirmed a worsening trend over a year.
THERAPEUTIC ADVANCES IN CHRONIC DISEASE
(2021)
Article
Respiratory System
Micheal C. McInnis, Jin Ma, Gauri Rani Karur, Christian Houbois, Liran Levy, Jan Havlin, Eyal Fuchs, Jussi Tikkanen, Chung-Wai Chow, Ella Huszti, Tereza Martinu
Summary: In this study, a machine learning computed tomography (CT) lung texture analysis tool was used for phenotyping and prognostication of chronic lung allograft dysfunction (CLAD) in lung transplant recipients. The results showed that machine learning could effectively distinguish different CLAD phenotypes, and the associated parameters were able to predict the risk of graft failure.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Cell Biology
Sundaresh Ram, Stijn E. Verleden, Alexander J. Bell, Benjamin A. Hoff, Wassim W. Labaki, Susan Murray, Bart M. Vanaudenaerde, Robin Vos, Geert M. Verleden, Ella A. Kazerooni, Stefanie Galban, Charles R. Hatt, Meilan K. Han, Vibha N. Lama, Craig J. Galban
Summary: This study investigates the relationship between the distribution and arrangement of PRM-derived classifications of pulmonary abnormalities and structural and biological markers in lung transplant recipients.
Article
Immunology
Tatsuaki Watanabe, Christina Lam, Jillian Oliver, Hisashi Oishi, Grace Teskey, Samuel Beber, Kristen Boonstra, Juan Mauricio Umana, Hifza Buhari, Betty Joe, Zehong Guan, Miho Horie, Shaf Keshavjee, Tereza Martinu, Stephen C. Juvet
Summary: Chronic lung allograft dysfunction (CLAD) is a major obstacle in the survival of lung transplant patients. This study investigated the role of a specific type of dendritic cells (cDC1) in CLAD using a mouse lung transplant model. The results showed that cDC1s accumulated in the transplanted lungs and their activation was enhanced by airway inflammation. Furthermore, the absence of BATF3, a transcription factor essential for cDC1 development, had differential effects on acute rejection and T-cell expansion depending on the presence of airway inflammation.
MUCOSAL IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Robin Reschke, Stephanie Zimmerlich, Christine Doehring, Gerhard Behre, Mirjana Ziemer
Summary: This study provides real-life data on the use of extracorporeal photopheresis (ECP) in patients with steroid-refractory intestinal acute graft-versus-host disease (aGvHD) and bronchiolitis obliterans syndrome (BOS). The results show that ECP can lead to partial or complete clinical response and symptom reduction in these patients. Responding patients tend to stay on treatment longer. In particular, lung function and forced expiratory volume stabilize in BOS patients, while abdominal pain, diarrhea, and systemic corticosteroids decrease in patients with intestinal acute GvHD.
Article
Cardiac & Cardiovascular Systems
Liran Levy, Sajad Moshkelgosha, Ella Huszti, Sarah Hunter, Benjamin Renaud-Picard, Gregory Berra, Mitsuaki Kawashima, Juan Fernandez-Castillo, Eyal Fuchs, Milagros Dianti, Rasheed Ghany, Shaf Keshavjee, Lianne G. Singer, Jussi Tikkanen, Tereza Martinu
Summary: This study found that markers of epithelial activity and injury in bronchoalveolar lavage fluid (BAL) are associated with the diagnosis of chronic lung allograft dysfunction (CLAD) and different phenotypes of CLAD. The abnormal expression of airway mucins and epithelial cell death may be involved in the pathogenesis of CLAD, and their detection could assist in the development of targeted therapies.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Review
Surgery
Rickey A. Evans, Krysta S. Walter, Leonard Jason Lobo, Raymond Coakley, Christina T. Doligalski
Summary: Chronic lung allograft dysfunction (CLAD) remains the leading cause of death in lung transplant recipients (LTRs) despite improvements in immunosuppression management. Treatments for CLAD are usually ineffective and there are currently no evidence-based guidelines.
CLINICAL TRANSPLANTATION
(2022)
Article
Biochemistry & Molecular Biology
Martin Reichert, Srebrena Atanasova, Kathrin Petri, Marian Kampschulte, Baktybek Kojonazarov, Gabriele Fuchs-Moll, Gabriele A. Krombach, Winfried Padberg, Veronika Grau
Summary: Alloreactive and autoreactive antibodies have been associated with chronic lung allograft dysfunction, with lipopolysaccharide-induced infiltration of B cells and accumulation of immunoglobulins potentially contributing to the pathogenesis of this condition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Public, Environmental & Occupational Health
Benjamin Seeliger, Moritz Z. Kayser, Nora Drick, Jan Fuge, Christina Valtin, Mark Greer, Jens Gottlieb
Summary: This study investigated the effects of supplementing standard informed consent with a graphic narrative on patient satisfaction, periprocedural anxiety, and experience. The results showed that the addition of a graphic narrative improved patient satisfaction with informed consent but did not influence pre-procedural anxiety and adverse experience during the procedure.
PATIENT EDUCATION AND COUNSELING
(2022)
Article
Immunology
Moritz Z. Kayser, Benjamin Seeliger, Christina Valtin, Jan Fuge, Stefan Ziesing, Tobias Welte, Mathias W. Pletz, Patrick Chhatwal, Jens Gottlieb
Summary: The study showed that BFPPp offered faster test results compared to conventional tests, which led to quicker clinical decisions. BFPPp demonstrated high accuracy in diagnosing viral LRTI, non-viral LRTI, and combined viral and non-viral LRTI. Additionally, preliminary therapies based on BFPPp results were upheld in 90% of cases.
TRANSPLANT INFECTIOUS DISEASE
(2022)
Article
Multidisciplinary Sciences
Julian Doricic, Robert Greite, Vijith Vijayan, Stephan Immenschuh, Andreas Leffler, Fabio Ius, Axel Haverich, Jens Gottlieb, Hermann Haller, Irina Scheffner, Wilfried Gwinner
Summary: This study confirms the importance of AKI in lung transplant patients. However, a simple and pragmatic indicator of renal function, d7/preHD-sCr, can predict long-term mortality equally reliably as more complex AKI definitions like KDIGO and ADQI.
Article
Medicine, General & Internal
Oana Joean, Maria Petronella Van't Klooster, Moritz Z. Kayser, Christina Valtin, Raphael Ewen, Heiko Golpon, Thomas Fuehner, Jens Gottlieb
Summary: Background Oxygen therapy is widely used in German hospitals and rescue services, but there is a lack of reliable data on its use, documentation, and surveillance. In a study conducted in three hospitals in Hannover, Germany, it was found that 20% of patients received oxygen therapy, with 29% of them at risk of hypercapnia. Only 68% of patients had a standard operating procedure for oxygen therapy, and only 22% received appropriate therapy based on documented vital parameters. Complete documentation of vital parameters was conducted in only 30% of all patients and 41% of patients receiving oxygen therapy.
DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT
(2022)
Letter
Medicine, General & Internal
Jens Gottlieb, Heinrich Worth, Thomas Volk, Thomas Fuehner
DEUTSCHES ARZTEBLATT INTERNATIONAL
(2022)
Article
Infectious Diseases
Nikolaus Kneidinger, Matthias Hecker, Vasiliki Bessa, Ina Hettich, Alexandra Wald, Sabine Wege, Anna-Barbara Nolde, Maike Oldigs, Zulfiya Syunyaeva, Heinrike Wilkens, Jens Gottlieb
Summary: This study aims to assess the outcome and associated factors in lung transplant recipients during the Omicron era of COVID-19, and found that age and glomerular filtration rate < 30 ml/min/1.73m(2) were independent risk factors for severe or critical COVID-19.
Article
Cardiac & Cardiovascular Systems
Mark Greer, Bin Liu, Jesper M. Magnusson, Thomas Fuehner, Bernhard Magnus Wilhelm Schmidt, David Deluca, Christine Falk, Fabio Ius, Tobias Welte
Summary: This study retrospectively analyzed the clinical course of CLAD patients who completed ECP treatment between 2007 and 2022. Five temporal phenotypes were identified, and their treatment response and survival outcomes were compared. The study found that timely intervention is important, and predicting survival before ECP treatment initiation is feasible.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Article
Surgery
Emma L. Heise, Evgeny Chichelnitskiy, Mark Greer, Maximilian Franz, Khalil Aburahma, Pavel Iablonskii, Nunzio D. de Manna, Stella Christoph, Murielle Verboom, Michael Hallensleben, Dietmar Boethig, Murat Avsar, Tobias Welte, Nicolaus Schwerk, Wiebke Sommer, Axel Haverich, Gregor Warnecke, Christian Kuehn, Christine Falk, Jawad Salman, Fabio Lus
Summary: This study presents a 9-year experience with lung transplant patients with preformed donor-specific antiHLA antibodies (pfDSA). The results show that these patients have similar graft survival and freedom from chronic lung allograft dysfunction rates compared to control patients, after a treatment protocol based on IgGAM.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Multidisciplinary Sciences
Jens Gottlieb, Bettina Fischer, Jonas Schupp, Heiko Golpon
Summary: This study investigated the effectiveness of CNI-free immunosuppression using mTOR inhibitors in lung transplant recipients. The results showed that the 1-year survival rate was 36% in patients with malignancy who were converted to CNI-free immunosuppression, while the 1-year survival rate was 100% in other patients. Additionally, patients who received this immunosuppression showed improvement in glomerular filtration rate.
Article
Respiratory System
Geert M. Verleden, Jens Gottlieb
EUROPEAN RESPIRATORY REVIEW
(2023)
Article
Cardiac & Cardiovascular Systems
Jens Gottlieb, Fernando Torres, Tarik Haddad, Gundeep Dhillon, Daniel F. Dilling, Christiane Knoop, Reinaldo Rampolla, Rajat Walia, Vivek Ahya, Romain Kessler, Marie Budev, Claus Neurohr, Allan R. Glanville, Robert Jordan, Danielle Porter, Matt McKevitt, Polina German, Ying Guo, Jason W. Chien, Timothy R. Watkins, Martin R. Zamora
Summary: This study evaluated the efficacy of the RSV fusion inhibitor presatovir in RSV-infected lung transplant recipients. The results showed that presatovir did not significantly improve nasal RSV load, symptoms, or lung function in lung transplant recipients.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Article
Respiratory System
Jens Gottlieb, Thomas Fuehner, Patrick Zardo
Summary: This study investigated the management and outcome of obstructive airway complications (OACs) after lung transplantation. The results showed that bilateral OACs impose a high burden on patients and are associated with early and late graft loss. Patients with bilateral OACs had reduced graft function and impaired quality of life.
THERAPEUTIC ADVANCES IN RESPIRATORY DISEASE
(2023)
Article
Cardiac & Cardiovascular Systems
Maximilian Franz, Khalil Aburahma, Murat Avsar, Dietmar Boethig, Mark Greer, Hani Alhadidi, Wiebke Sommer, Igor Tudorache, Gregor Warnecke, Axel Haverich, Fabio Ius, Jawad Salman
Summary: The study investigates whether age mismatch between lung transplant recipients and donors affects long-term outcomes. The results show that age mismatch does not have an impact on overall patient mortality, biopsy-confirmed rejection, and chronic lung allograft dysfunction.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
J. Sauer, K. Beushausen, J. Keil, L. Ruhl, J. Kuehne, M. Schael, T. Welte, A. Haverich, J. Gottlieb, A. Niehaus, C. S. Falk
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
J. Gottlieb, C. Valtin, B. Fischer, J. Schupp, H. Golpon.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)