Letter
Surgery
Pal-Dag Line, Silvio Nadalin, Deniz Balci
Summary: The case report discusses two patients who underwent auxiliary liver transplantation and two staged hepatectomy, highlighting the importance of careful hemodynamic monitoring and optimizing venous outflow for graft regeneration. The surgical technique was described as novel, but previous literature has also discussed similar procedures in the setting of chronic liver disease.
Article
Pediatrics
Sebastian Loos, Markus J. Kemper, Kaja Schmaeschke, Uta Herden, Lutz Fischer, Bernd Hoppe, Tanja Kersnik Levart, Enke Grabhorn, Raphael Schild, Jun Oh, Florian Brinkert
Summary: This study retrospectively analyzed the long-term outcomes of 18 pediatric patients with primary hyperoxaluria type 1 (PH1) who underwent combined or sequential liver and kidney transplantation (CLKT/SLKT). The results showed a patient survival rate of 94% and liver and kidney survival rates of 90% and 85%, respectively, after CLKT/SLKT. The outcomes tend to be less optimal in patients with infantile PH1 compared to patients with juvenile PH1.
FRONTIERS IN PEDIATRICS
(2023)
Article
Surgery
Samrat Ray, Alejandro Torres-Hernandez, Michael Sean Bleszynski, Catherine Parmentier, Ian McGilvray, Blayne Amir Sayed, Chaya Shwaartz, Mark Cattral, Anand Ghanekar, Gonzalo Sapisochin, Cynthia Tsien, Nazia Selzner, Leslie Lilly, Mamatha Bhat, Elmar Jaeckel, Markus Selzner, Trevor W. Reichman
Summary: This study reports the clinical outcomes of liver transplants using donors after medical assistance in dying (MAiD), donors after cardiac death (DCD), and deceased brain death (DBD). The study found that MAiD donors had a higher incidence of biliary complications, but there was no significant difference in short- and long-term graft outcomes among the three groups.
Article
Surgery
Guosheng Wu, Chaoxu Liu, Nan Ma, Xile Zhou, Long Zhao, Yuntao Zhang, Wentong Zhang, Tingbo Liang
Summary: Current desensitization therapies for highly sensitized intestinal transplant patients are limited and ineffective. However, a study has shown that an auxiliary partial liver transplant can effectively protect highly sensitized intestinal transplant recipients, suggesting it as a useful therapeutic adjunct.
CLINICAL TRANSPLANTATION
(2023)
Review
Gastroenterology & Hepatology
Daniel Azoulay, Cyrille Feray, Chetana Lim, Chady Salloum, Maria Conticchio, Daniel Cherqui, Antonio Sa Cunha, Rene Adam, Eric Vibert, Didier Samuel, Marc Antoine Allard, Nicolas Golse
Summary: This study analyzed the use of small-for-size liver grafts in patients with chronic liver disease and identified opportunities for auxiliary liver transplantation to address the shortage of liver grafts. The study found that despite high postoperative morbidity, the long-term results of auxiliary liver transplantation in these patients were good. However, further research and standardization of surgical techniques are needed for better outcomes.
Article
Medicine, General & Internal
Nader Abraham, Min Zhang, Paul Cray, Qimeng Gao, Kannan P. Samy, Ryan Neill, Greta Cywinska, JonCarlo Migaly, Riley Kahan, Arya Pontula, Samantha E. Halpern, Caroline Rush, Jude Penaflor, Samuel J. Kesseli, Madison Krischak, Mingqing Song, Matthew G. Hartwig, Justin J. Pollara, Andrew S. Barbas
Summary: Based on a rat model, this study shows that during SNMP, the biliary compartment is more sensitive in detecting graft injury compared to the perfusate compartment. Additionally, using acRTMP provides better graft preservation in DCD liver transplantation compared to SCS.
FRONTIERS IN MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Khalil Aburahma, Jawad Salman, Bastian Engel, Florian W. R. Vondran, Mark Greer, Dietmar Boethig, Thierry Siemeni, Murat Avsar, Nicolaus Schwerk, Carsten Mueller, Richard Taubert, Marius M. Hoeper, Tobias Welte, Hans H. Wedemeyer, Nicolas Richter, Gregor Warnecke, Igor Tudorache, Axel Haverich, Christian Kuehn, Gerrit Grannas, Fabio Ius
Summary: A combined lung and liver transplant in patients with cystic fibrosis did not impair lung graft function, and the liver graft showed tolerogenic effects against rejection.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2021)
Article
Medicine, Research & Experimental
Seung Hyuk Yim, Eun-Ki Min, Mun Chae Choi, Deok-Gie Kim, Dai Hoon Han, Dong Jin Joo, Jin Sub Choi, Myong Soo Kim, Gi Hong Choi, Jae Geun Lee
Summary: Unusual liver grafts, such as extended left liver plus caudate lobe, right anterior section, and right posterior section grafts, serve as alternatives to conventional left and right lobe grafts for living-donor liver transplantation. This study found that despite their complexity, unusual grafts can achieve feasible surgical outcomes with acceptable donor complications.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Review
Immunology
Sarah Bouari, Elsaline Rijkse, Herold J. Metselaar, Martijn W. F. van den Hoogen, Jan N. M. IJzermans, Jeroen de Jonge, Wojciech G. Polak, Robert C. Minnee
Summary: The study compared the clinical outcomes of CLKT and LTA in patients with renal dysfunction, finding that in the short term, CLKT and LTA have similar patient and graft survival rates, but more data is needed to determine which stage of KDIGO patients benefit the most from CLKT.
TRANSPLANTATION REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Yi-Chinn Weng, Yu-Ting Huang, I-Chen Chiang, Pei-Ju Tsai, Yu-Wen Su, Wen-Hai Chou
Summary: The study found that LCN2 has neurotoxic effects on engrafted neurons during neural transplantation and can also modulate neuroinflammatory responses. Inhibition of LCN2 may be useful in reducing rejection after neural transplantation.
Article
Surgery
Christina Dalzell, Paola A. Vargas, Kyle Soltys, Frank Dipaola, George Mazariegos, Jose Oberholzer, Nicolas Goldaracena
Summary: Split and LDLT in pediatric patients have the potential to decrease wait times and waitlist mortality. Using UNOS-STAR data, this study compared outcomes of pediatric patients undergoing LDLT and SLT using LLS grafts. The findings suggest that LDLT is associated with a lower rate of graft failure in pediatric patients, and the use of LLS is a safe way to facilitate access to transplantation with acceptable short and long-term outcomes.
TRANSPLANT INTERNATIONAL
(2022)
Article
Materials Science, Biomaterials
Tao Yang, Guangxu Li, Xifeng Li, Boyang Wei, Hengxian Su, Wenchao Liu, Shenquan Guo, Nan Yang, Tao Xu, Chuanzhi Duan
Summary: Previous research on tissue-engineered blood vessels mainly focused on one layer, neglecting the equal importance of both the intima and adventitia. This study developed a small-diameter graft that can gradually release growth factors and inhibitors to enhance tissue regeneration and remodeling in both layers.
REGENERATIVE BIOMATERIALS
(2023)
Article
Transplantation
Amith Kumar Pakkala, Gaurav Chaubal, Aditya Nanavati, Hunaid Hatimi, Rajeev Sinha, Ameet Mandot, Uday Sanglodkar, Alisha Chaubal, Harshit Chaksota, Samir Shah
Summary: Auxiliary partial orthotopic liver transplant is a complex surgical technique that has been proven to be effective in treating acute liver failure. Advancements in surgical techniques have led to improved outcomes with this procedure, making it increasingly accepted as a valid treatment option. Careful patient selection and surgical planning are essential for successful outcomes.
EXPERIMENTAL AND CLINICAL TRANSPLANTATION
(2023)
Article
Gastroenterology & Hepatology
Xiaoye Qu, Ping Wan, Mingxuan Feng, Bijun Qiu, Yi Luo, Tao Zhou, Jianjun Zhu, Dong Zhao, Guangxiang Gu, Jianjun Zhang, Qiang Xia
Summary: This study presented four cases of pediatric LDLT receiving RPS graft, sourced from mothers, without postoperative complications and with high survival rate and normal liver function in recipients.
BMC GASTROENTEROLOGY
(2021)
Article
Pediatrics
Cheng-Yen Chen, Yi-Ting Yeh, Chinsu Liu, Rheun-Chuan Lee, Shan-Su Huang, Che-Chuang Loong
Summary: The feasibility of procuring the medial segment graft (MSG) was successfully demonstrated through 3D printing and ex vivo procedures. Analysis showed potential livers that met the criteria for the medial segment graft, indicating a promising approach for pediatric liver transplantation.
JOURNAL OF PEDIATRIC SURGERY
(2021)
Article
Gastroenterology & Hepatology
Theodoros Michelakos, Filippos Kontos, Yurie Sekigami, Motaz Qadan, Lei Cai, Onofrio Catalano, Vikram Deshpande, Madhukar S. Patel, Teppei Yamada, Nahel Elias, Leigh Anne Dageforde, Shoko Kimura, Tatsuo Kawai, Kenneth K. Tanabe, James F. Markmann, Heidi Yeh, Cristina R. Ferrone
Summary: This study found that in patients with solitary hepatocellular carcinoma, different hepatic resection margin widths did not have a significant impact on overall survival, recurrence-free survival, and liver-specific recurrence-free survival.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Biochemistry & Molecular Biology
Yuchen Wang, Yanna Liu, Wenfeng Deng, Fangxiang Fu, Susha Yan, Hongwei Yang, Rumin Liu, Jian Geng, Jian Xu, Yihan Wu, Junfeng Ma, Jiapeng Zhou, Na Liu, Yu Jin, Renfei Xia, Nahel Elias, Richard J. Lee, Adam S. Feldman, Michael L. Blute, Robert B. Colvin, Chin-Lee Wu, Yun Miao
Article
Immunology
Alex G. Cuenca, Ivy Rosales, Richard J. Lee, Chin-Lee Wu, Robert Colvin, Adam S. Feldman, Jason A. Efstathiou, Nina Tolkoff-Rubin, Nahel Elias
TRANSPLANTATION PROCEEDINGS
(2020)
Review
Medicine, General & Internal
Stepan M. Esagian, Ioannis A. Ziogas, Dimitrios Giannis, Muhammad H. Hayat, Nahel Elias, Georgios Tsoulfas
FRONTIERS IN MEDICINE
(2020)
Article
Urology & Nephrology
Meghan E. Sise, David S. Goldberg, Jens J. Kort, Douglas E. Schaubel, Rita R. Alloway, Christine M. Durand, Robert J. Fontana, Robert S. Brown, John J. Friedewald, Stacey Prenner, J. Richard Landis, Melissa Fernando, Caitlin C. Phillips, E. Steve Woodle, Adele Rike-Shields, Kenneth E. Sherman, Nahel Elias, Winfred W. Williams, Jenna L. Gustafson, Niraj M. Desai, Brittany Barnaba, Silas P. Norman, Mona Doshi, Samuel T. Sultan, Meredith J. Aull, Josh Levitsky, Dianne S. Belshe, Raymond T. Chung, Peter P. Reese
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2020)
Article
Biochemistry & Molecular Biology
Yu Jin, Yi Zhou, Wenfeng Deng, Yuchen Wang, Richard J. Lee, Yanna Liu, Nahel Elias, Yangcheng Hu, Min-Hua Luo, Rumin Liu, Bowen Guan, Jian Geng, Jian Xu, Junfeng Ma, Jiapeng Zhou, Na Liu, Michael L. Blute, Robert B. Colvin, Chin-Lee Wu, Yun Miao
Summary: Chronic BK polyomavirus (BKPyV) infection is considered a potential oncogenic factor for urothelial carcinoma (UC) in renal transplant recipients. Integration sites between human and BKPyV genomes were enriched with microhomologies, and viral insertional integration led to fusion sequences of 75 human genes, with 15 genes showing statistical association with UC based on expression analysis. These findings suggest a potential mechanism of viral-driven carcinogenesis in BKPyV-related UC.
Review
Oncology
Ioannis A. Ziogas, Alexandros P. Evangeliou, Dimitrios Giannis, Muhammad H. Hayat, Konstantinos S. Mylonas, Samer Tohme, David A. Geller, Nahel Elias, Lipika Goyal, Georgios Tsoulfas
Summary: This study reviewed the outcomes of 2402 patients with advanced-stage hepatocellular carcinoma (HCC), of whom 2376 had unresectable HCC, treated with immune checkpoint inhibitors (ICIs). The overall objective response rate was 22.7%, with a mean overall survival of 15.8 months. The study also found a high graft rejection rate of 40.0% in patients receiving ICIs in the liver transplant setting.
Article
Surgery
Qing Yuan, Omar Haque, Shanjuan Hong, Andric Ortiz, Emily D. Bethea, Meghan E. Sise, James F. Markmann, Nahel Elias
Summary: The study found that HBsAg-positive status in kidney transplant donors or recipients did not significantly impact long-term survival outcomes. In 2019, discard rates for kidneys from HBsAg-positive donors were 15% higher, indicating the need for further research on tolerance.
CLINICAL TRANSPLANTATION
(2021)
Letter
Urology & Nephrology
Eliot Heher, Nahel Elias
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Surgery
Christine M. Durand, Sander Florman, Jennifer D. Motter, Diane Brown, Darin Ostrander, Sile Yu, Tao Liang, William A. Werbel, Andrew Cameron, Shane Ottmann, James P. Hamilton, Andrew D. Redd, Mary G. Bowring, Yolanda Eby, Reinaldo E. Fernandez, Brianna Doby, Nazzarena Labo, Denise Whitby, Wendell Miley, Rachel Friedman-Moraco, Nicole Turgeon, Jennifer C. Price, Peter Chin-Hong, Peter Stock, Valentina Stosor, Varvara A. Kirchner, Timothy Pruett, David Wojciechowski, Nahel Elias, Cameron Wolfe, Thomas C. Quinn, Jonah Odim, Megan Morsheimer, Sapna A. Mehta, Meenakshi M. Rana, Shirish Huprikar, Allan Massie, Aaron A. R. Tobian, Dorry L. Segev
Summary: In this multicenter pilot study of HIV D+/R+ LT, patient and graft survival were better than historical cohorts, however, a potential increase in infections and cancer merits further investigation.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Surgery
Miklos Z. Molnar, Vishnu S. Potluri, Douglas E. Schaubel, Meghan E. Sise, Beatrice P. Concepcion, Rachel C. Forbes, Emily Blumberg, Roy D. Bloom, David Shaffer, Raymond T. Chung, Ian A. Strohbehn, Nahel Elias, Ambreen Azhar, Mital Shah, Deirdre Sawinski, Laura A. Binari, Manish Talwar, Vasanthi Balaraman, Anshul Bhalla, James D. Eason, Behdad Besharatian, Jennifer Trofe-Clark, David S. Goldberg, Peter P. Reese
Summary: HCV-positive donor kidney transplantation does not significantly increase the risk of primary BK polyomavirus viremia, but may elevate the risk of more severe BK polyomavirus viremia. However, one-year graft function for HCV-positive recipients is reassuring.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Surgery
Qing Yuan, Hanwen Cui, Greg A. Leya, Shanjuan Hong, Eve M. Roth, Meghan E. Sise, Emily D. Bethea, Heidi Yeh, Winfred W. Williams, Nahel Elias
Summary: The availability of direct-acting antivirals (DAA) has led to a significant increase in the willingness to accept organs from HCV+ donors, particularly benefiting kidney and liver candidates with improved transplantation success rates and shorter wait times.
TRANSPLANT INTERNATIONAL
(2021)
Article
Surgery
Tsukasa Nakamura, Kazunari Sasaki, Lisa Kojima, Richard Teo, Yosuke Inaba, Takayuki Yamamoto, Shoko Kimura, Leigh Anne Dageforde, Heidi Yeh, Nahel Elias, Adel Bozorgzadeh, Tatsuo Kawai, James F. Markmann
Summary: This study investigated the relationship between HCC recurrence risk and the combination of donor and recipient sexes in liver transplant. The results showed that pairing male donors with female recipients significantly reduced HCC recurrence rates.
CLINICAL TRANSPLANTATION
(2023)
Review
Gastroenterology & Hepatology
Srilakshmi Atthota, Anne Macdonald, James F. Markmann, David Kuter, Nahel Elias, Heidi Yeh, Walter H. Dzik, Leigh Anne Dageforde
Summary: OLT is associated with a precarious perioperative hemostatic state due to dysregulation of procoagulant and anticoagulant factors, endothelial injury, and inflammation. Transmission of inherited bleeding and clotting disorders from the liver donor may further complicate hemostasis during and after transplantation. However, there is currently no clear consensus regarding the selection of donors with known or suspected thrombophilia or bleeding disorders, and large-scale studies examining the frequency of transmission and clinical impact of donor hemostatic disorders are lacking.
LIVER TRANSPLANTATION
(2023)
Article
Immunology
Sapna A. Mehta, Meenakshi M. Rana, Jennifer D. Motter, Catherine B. Small, Marcus R. Pereira, Valentina Stosor, Nahel Elias, Brandy Haydel, Sander Florman, Jonah Odim, Megan Morsheimer, Mark Robien, Allan B. Massie, Diane Brown, Brian J. Boyarsky, Jacqueline Garonzik-Wang, Aaron A. R. Tobian, William A. Werbel, Dorry L. Segev, Christine M. Durand
Summary: Among kidney and liver transplant recipients with HIV, there was a 4% incidence rate of COVID-19 with high mortality. Most patients required hospitalization and aggressive treatment with high-dose steroids, tocilizumab, remdesivir, and convalescent plasma.