Article
Oncology
Fei-Lin Qu, Rui Mao, Zhe-Bin Liu, Cai-Jin Lin, A-Yong Cao, Jiong Wu, Guang-Yu Liu, Ke-Da Yu, Gen-Hong Di, Jun-Jie Li, Zhi-Ming Shao
Summary: Background Loco-regional recurrences following breast-conserving surgery remain a heterogeneous class of disease with significant variation in biological behavior and prognosis. Different recurrence patterns after BCS are related to distinct clinical outcomes. Management of LRR should be individualized and tailored based on disease extent, molecular profile, and baseline clinical variables.
FRONTIERS IN ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Alexander Clevewood Ng
Summary: This article discusses the feasibility of adhering to the Brazil-Milan Criteria in determining liver transplantation for HCC patients, highlighting the potential risks of disregarding the number of tumor nodules in patients and its impact on disease recurrence potential.
ANNALS OF HEPATOLOGY
(2021)
Review
Gastroenterology & Hepatology
Jin Hean Koh, Darren Jun Hao Tan, Yuki Ong, Wen Hui Lim, Cheng Han Ng, Phoebe Wen Lin Tay, Jie Ning Yong, Mark D. Muthiah, Eunice X. Tan, Ning Qi Pang, Beom Kyung Kim, Nicholas Syn, Alfred Kow, Brian K. P. Goh, Daniel Q. Huang
Summary: Mortality after LR for HCC is nearly 50% higher compared to LT. Survival between LR and LT were similar in uninodular disease. The risk of recurrence after LR is threefold that of LT.
HEPATOBILIARY SURGERY AND NUTRITION
(2022)
Article
Oncology
Yang Li, Su Lu, Yuhan Zhang, Shuaibing Wang, Hong Liu
Summary: The study found that the rates of local recurrence and regional recurrence in young breast cancer patients showed a downward trend, and the proportion of early-stage breast cancer increased. HR-/HER2+ tumors were significantly associated with higher rates of local recurrence in young patients.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Benjamin V. Tran, Dimitrios Moris, Daniela Markovic, Hamed Zaribafzadeh, Ricardo Henao, Quirino Lai, Sander S. Florman, Parissa Tabrizian, Brandy Haydel, Richard M. Ruiz, Goran B. Klintmalm, David D. Lee, C. Burcin Taner, Maarouf Hoteit, Matthew H. Levine, Umberto Cillo, Alessandro Vitale, Elizabeth C. Verna, Karim J. Halazun, Amit D. Tevar, Abhinav Humar, William C. Chapman, Neeta Vachharajani, Federico Aucejo, Jan Lerut, Olga Ciccarelli, Mindie H. Nguyen, Marc L. Melcher, Andre Viveiros, Benedikt Schaefer, Maria Hoppe-Lotichius, Jens Mittler, Trevor L. Nydam, James F. Markmann, Massimo Rossi, Constance Mobley, Mark Ghobrial, Alan N. Langnas, Carol A. Carney, Jennifer Berumen, Gabriel T. Schnickel, Debra L. Sudan, Johnny C. Hong, Abbas Rana, Christopher M. Jones, Thomas M. Fishbein, Ronald W. Busuttil, Andrew S. Barbas, Vatche G. Agopian
Summary: The individual prediction of post-liver transplantation hepatocellular carcinoma (HCC) recurrence risk is important. By analyzing the data of 4981 HCC patients undergoing transplantation, a prediction score was developed to accurately discriminate the risk of HCC recurrence. The score was externally validated in another 1160 patients, showing consistent results in risk discrimination.
LIVER TRANSPLANTATION
(2023)
Review
Oncology
Riccardo Nevola, Augusto Delle Femine, Valerio Rosato, Loreta Anesti Kondili, Maria Alfano, Davide Mastrocinque, Simona Imbriani, Pasquale Perillo, Domenico Beccia, Angela Villani, Rachele Ruocco, Livio Criscuolo, Marco La Montagna, Antonio Russo, Aldo Marrone, Ferdinando Carlo Sasso, Raffaele Marfella, Luca Rinaldi, Nicolino Esposito, Giuseppe Barberis, Ernesto Claar
Summary: The treatment of hepatocellular carcinoma is hindered by high recurrence rates and lack of validated systemic therapy. Perioperative combination treatments can optimize radical treatment, reduce recurrence rates, and improve overall survival. Immunotherapy has the potential to revolutionize HCC treatment and predictive biomarkers can contribute to precision medicine.
Article
Oncology
Bianca Magro, Domenico Pinelli, Massimo De Giorgio, Maria Grazia Luca, Arianna Ghirardi, Alessandra Carrobio, Giuseppe Baronio, Luca Del Prete, Franck Nounamo, Andrea Gianatti, Michele Colledan, Stefano Fagiuoli
Summary: In the context of liver transplantation, predicting hepatocellular carcinoma (HCC) recurrence remains a significant challenge. This study identified that AFP levels >25.5 ng/mL at transplant and a dynamic increase in AFP >20.8% on the waitlist were strong predictors of HCC recurrence after transplantation in patients meeting Milan criteria. Further studies are needed to validate these findings.
Review
Oncology
Khalid Bzeizi, Maheeba Abdullah, Kota Vidyasagar, Saleh A. Alqahthani, Dieter Broering
Summary: This systematic and meta-analysis study examined the recurrence rate and risk factors of hepatocellular carcinoma after liver transplantation. The study found that the recurrence, overall survival, and mortality rates among HCC patients post-transplantation remain relatively high, with significant regional differences.
Article
Oncology
Hui-Zhou Li, Jie Tan, Tian Tang, Tian-Zhi An, Jun-Xiang Li, Yu-Dong Xiao
Summary: This study compared the treatment efficacy and down-staging rate of combined TACE-MWA and TACE alone in patients with unresectable HCC beyond the Milan criteria. The results indicate that TACE-MWA offers better overall survival and progression-free survival compared to TACE alone, as well as a higher downstaging rate, potentially increasing the chance of liver transplantation.
JOURNAL OF HEPATOCELLULAR CARCINOMA
(2021)
Review
Oncology
Antonio Facciorusso, Nicola Tartaglia, Rosanna Villani, Gaetano Serviddio, Daryl Ramai, Babu P. Mohan, Saurabh Chandan, Mohamed A. Abd El Aziz, Jessica Evangelista, Christian Cotsoglou, Antonio Ambrosi
Summary: In comparing lenvatinib and sorafenib as first-line treatments for advanced hepatocellular carcinoma patients, lenvatinib showed a significant improvement in progression-free survival, objective response rate, and disease control rate. However, there was no significant difference in overall survival between the two treatments and the rate of severe adverse events was similar.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Oncology
Jan-Paul Gundlach, Michael Linecker, Henrike Dobbermann, Felix Wadle, Thomas Becker, Felix Braun
Summary: Liver transplantation is the only definitive treatment for hepatocellular carcinoma in cirrhosis. The use of Milan-criteria and labMELD in selecting patients for transplantation has limitations. This study found that liver transplantation for patients with hepatocellular carcinoma, regardless of Milan-criteria, had comparable outcomes and cost-effectiveness. Extended criteria donor grafts were favored for patients outside the Milan-criteria with low labMELD.
Article
Oncology
Paolo Borghetti, Jessica Imbrescia, Giulia Volpi, Vieri Scotti, Michele Aquilano, Alessio Bruni, Davide Franceschini, Stefano Ursino, Patrizia Ciammella, Gaia Piperno, Maria Taraborrelli, Stefano Maria Magrini
Summary: This article describes the pattern of relapse, progression-free survival (PFS), and overall survival (OS) in patients treated with radio-chemotherapy and durvalumab for loco-regional relapse after surgical resection of non-small-cell lung cancer (NSCLC). The results suggest that this treatment strategy may prolong post recurrence survival in patients with good performance status experiencing loco-regional relapse after surgery.
RADIATION ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Nieun Seo, Dong Jin Joo, Mi-Suk Park, Seung-seob Kim, Hye Jung Shin, Yong Eun Chung, Jin-Young Choi, Myoung Soo Kim, Myeong-Jin Kim
Summary: The study aimed to investigate the optimal radiologic method for determining Milan criteria (MC) in predicting post-liver transplantation (LT) recurrence in hepatocellular carcinoma (HCC) patients. The findings showed that MRI with mRECIST was the optimal method in predicting recurrence, with higher accuracy and sensitivity compared to CT with LI-RADS TRA or MRI with mRECIST.
EUROPEAN RADIOLOGY
(2023)
Article
Oncology
Fredrik Landstrom, Elin Aspenblad, Johan Reizenstein, Stefan Kristiansson
Summary: The study found that the majority of recurrences of oral tongue cancer were detected during routine follow-up visits, and patient-initiated detection did not lead to increased survival rates.
ANTICANCER RESEARCH
(2021)
Article
Oncology
Huimin Yu, Hongtao Zhang, Zhen Gao, Xiaoli Liu, Lijuan Zhang, Xuemin Di, Zeyang Wang, Zezhou Liu, Aixia Sui, Juan Wang, Gaofeng Shi
Summary: This study evaluated the feasibility and efficacy of I-125 seed brachytherapy as salvage treatment for recurrence from non-anaplastic thyroid cancer refractory to other modalities. The results showed that I-125 seed brachytherapy is a feasible and effective treatment option for refractory local recurrence from non-anaplastic thyroid cancer.
FRONTIERS IN ONCOLOGY
(2022)
Review
Surgery
Gonzalo Sapisochin, Tommy Ivanics, Vijay Subramanian, Majella Doyle, Julie K. Heimbach, Johnny C. Hong
INTERNATIONAL JOURNAL OF SURGERY
(2020)
Review
Oncology
Joohyun Kim, Michael A. Zimmerman, Johnny C. Hong
JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2020)
Article
Surgery
Povilas Ignatavicius, Christian E. Oberkofler, William C. Chapman, Ronald P. DeMatteo, Bryan M. Clary, Michael D'Angelica, Kenneth K. Tanabe, Johnny C. Hong, Thomas A. Aloia, Timothy M. Pawlik, Roberto Hernandez-Alejandro, Shimul A. Shah, Jean-Nicolas Vauthey, Guido Torzilli, Hauke Lang, Pal-Dag Line, Olivier Soubrane, Hugo Pinto-Marques, Ricardo Robles-Campos, Karim Boudjema, Peter Lodge, Rene Adam, Christian Toso, Alejandro Serrablo, Luca Aldrighetti, Michelle L. DeOliveira, Philipp Dutkowski, Henrik Petrowsky, Michael Linecker, Cacilia S. Reiner, Julia Braun, Ruslan Alikhanov, Giedrius Barauskas, Albert C. Y. Chan, Jiahong Dong, Norihiro Kokudo, Masakazu Yamamoto, Koo Jeong Kang, Yuman Fong, Mohamed Rela, Xabier De Aretxabala, Eduardo De Santibanes, Miguel Angel Mercado, Oscar C. Andriani, Orlando Jorge M. Torres, Antonio D. Pinna, Pierre-Alain Clavien
Article
Public, Environmental & Occupational Health
Jack Keegan, Blake W. Buchan, Nathan A. Ledeboer, Zhipeng Zhou, Johnny C. Hong, Mary Beth Graham, L. Silvia Munoz-Price
Summary: The study revealed an association between Clostridioides difficile colonization and CDI in solid-organ transplant patients, although the overall incidence of CDI was low. Only C. difficile colonization, age, and hospital days were independently associated with CDI.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2021)
Article
Surgery
Leigh Anne Dageforde, Neeta Vachharajani, Parissa Tabrizian, Vatche Agopian, Karim Halazun, Erin Maynard, Kristopher Croome, David Nagorney, Johnny C. Hong, David Lee, Cristina Ferrone, Erin Baker, William Jarnagin, Alan Hemming, Gabriel Schnickel, Shoko Kimura, Ronald Busuttil, Jessica Lindemann, Sander Florman, Matthew L. Holzner, Rami Srouji, Marc Najjar, Lavanya Yohanathan, Jane Cheng, Hiral Amin, Charles A. Rickert, Ju Dong Yang, Joohyun Kim, Jennifer Pasko, William C. Chapman, Maria B. Majella Doyle
Summary: Through a multicenter collaboration study, liver transplantation for cHCC-CCA within Milan criteria showed similar overall survival to HCC, with a higher chance of cure.
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2021)
Article
Gastroenterology & Hepatology
Nia Adeniji, Vinodhini Arjunan, Vijay Prabhakar, Ajitha Mannalithara, Tara Ghaziani, Aijaz Ahmed, Paul Kwo, Mindie Nguyen, Marc L. Melcher, Ronald W. Busuttil, Sander S. Florman, Brandy Haydel, Richard M. Ruiz, Goran B. Klintmalm, David D. Lee, C. Burcin Taner, Maarouf A. Hoteit, Elizabeth C. Verna, Karim J. Halazun, Amit D. Tevar, Abhinav Humar, William C. Chapman, Neeta Vachharajani, Federico Aucejo, Trevor L. Nydam, James F. Markmann, Constance Mobley, Mark Ghobrial, Alan N. Langnas, Carol A. Carney, Jennifer Berumen, Gabriel T. Schnickel, Debra L. Sudan, Johnny C. Hong, Abbas Rana, Christopher M. Jones, Thomas M. Fishbein, Vatche Agopian, Renumathy Dhanasekaran
Summary: The incidence of hepatocellular carcinoma (HCC) is increasing in the elderly population in the United States, leading to a rise in transplant surgeries for this demographic. However, advanced age has been shown to be an independent predictor of overall survival posttransplantation, with every 5-year increase in age older than 50 years resulting in an 8.3% increase in mortality rate. Older patients also experience higher rates of non-HCC-related mortality, highlighting the importance of closer surveillance for de novo cancers in this population.
LIVER TRANSPLANTATION
(2021)
Article
Cardiac & Cardiovascular Systems
Stylianos Voulgarelis, Johnny C. Hong, Michael A. Zimmerman, Joohyun Kim, John P. Scott
Summary: This case describes the challenging perioperative course of a 55-year-old patient with hepatic failure requiring liver transplantation, where different modalities of extracorporeal device were successfully used to optimize various parameters. The patient was weaned off the device at the end of the case and discharged home.
Article
Immunology
Francisco A. Durazo, Allyssa A. Nicholas, Jennifer J. Mahaffey, Shannon Sova, John J. Evans, Juan Pablo Trivella, Veronica Loy, Joohyun Kim, Michael A. Zimmerman, Johnny C. Hong
Summary: Liver injury is a nonpulmonary manifestation of COVID-19, with post-COVID-19 cholangiopathy being a special entity that can progress to end-stage liver disease. This case report demonstrates successful treatment of post-COVID-19 cholangiopathy with liver transplantation.
TRANSPLANTATION PROCEEDINGS
(2021)
Article
Biochemical Research Methods
Stylianos Voulgarelis, Faraneh Fathi, Astrid G. Stucke, Kevin D. Daley, Joohyun Kim, Michael A. Zimmerman, Johnny C. Hong, Nicholas Starkey, Kenneth P. Allen, Bing Yu
Summary: This study demonstrates the utility of vis-DRS for real-time measurement of liver tissue saturation after liver transplantation. Through experiments in a swine model, the results show that vis-DRS technology is accurate and reliable.
JOURNAL OF BIOMEDICAL OPTICS
(2021)
Article
Gastroenterology & Hepatology
Takahiro Ito, James R. Butler, Daisuke Noguchi, Minah Ha, Antony Aziz, Vatche G. Agopian, Joseph DiNorcia, Hasan Yersiz, Douglas G. Farmer, Ronald W. Busuttil, Johnny C. Hong, Fady M. Kaldas
Summary: This study analyzed the impact of era, tumor size, and neoadjuvant therapy strategies on the outcomes of liver transplantation for cholangiocarcinoma patients. The results showed that outcomes of LT for CCA seem to have improved over time, and multimodal neoadjuvant therapy is associated with improved survival in both iCCA and hCCA patients, regardless of tumor size.
LIVER TRANSPLANTATION
(2022)
Meeting Abstract
Oncology
Aditya V. Shreenivas, Ben George, James P. Thomas, Lindsay Puckett, Sakti Chakrabarti, Musaddiq Awan, Michael Wayne Straza, William A. Hall, Veronica Loy, William S. Rilling, Johnny Hong, Mandana Kamgar, Susan Tsai, T. Clark Gamblin, Amanda Smolock, Kathleen K. Christians, Kali Dougherty, Natalie Danziger, Francisco Durazo, Jeffrey S. Ross
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Immunology
Stephanie C. Zanowski, Jenessa S. Price, Motaz A. Selim, Vanessa Schumann, Francisco Durazo, Johnny C. Hong
Summary: This study evaluated the utility of having a mental health program embedded in a transplantation center in risk assessment for alcohol relapse after liver transplantation. The results showed that the program provided an accurate risk stratification for alcohol relapse, successful intervention to mitigate recidivism risk, and optimal short-term alcohol relapse-free patient survival.
TRANSPLANTATION PROCEEDINGS
(2022)
Article
Immunology
Jenessa Mayer, Motaz A. Selim, Jennifer J. Mahaffey, Alicia Martin, Johnny C. Hong
Summary: A prospective study found that transplant candidates and recipients have some understanding of physician assistants and nurse practitioners, but are unfamiliar with the term advanced practice providers. Patients showed consistent recognition and comfort with APPs in the entire transplant surgeon-APP team.
TRANSPLANTATION PROCEEDINGS
(2022)
Article
Immunology
Motaz Selim, Eric J. Hohenwalter, William S. Rilling, Johnny C. Hong
Summary: Our study found that the risk of hepatic artery thrombosis (HAT) after liver transplantation (LT) is similar in patients who received pretransplant transarterial chemoembolization (TACE) compared to those who did not. Furthermore, we suggest that a surgical technique combining early vascular control and super-selective vascular intervention radiology approach can reduce the risk of HAT in patients requiring pretransplant TACE.
TRANSPLANTATION PROCEEDINGS
(2023)
Article
Surgery
Ola Ahmed, Neeta Vachharajani, Kris P. Croome, Parissa Tabrizian, Vatche Agopian, Karim Halazun, Johnny C. Hong, Leigh Anne Dageforde, William C. Chapman, Mb Majella Doyle
Summary: This study assessed liver transplantation outcomes for hepatocellular carcinoma (HCC) patients initially presenting beyond the expanded University of California San Francisco (B-eUCSF) criteria. The results showed that patients initially presenting beyond B-eUCSF criteria achieved comparable survival rates to those meeting the criteria (W-eUCSF) after transplantation.
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2022)