Review
Immunology
Solaf Al-Awadhi, Marc Raynaud, Kevin Louis, Antoine Bouquegneau, Jean-Luc Taupin, Olivier Aubert, Alexandre Loupy, Carmen Lefaucheur
Summary: In this systematic review, meta-analysis, and critical appraisal, the impact of complement-activating anti-HLA DSAs on solid organ transplant outcomes was investigated. The study found that complement-activating anti-HLA DSAs were associated with an increased risk of allograft loss and rejection. These findings demonstrate the significant deleterious impact and independent prognostic value of circulating complement-activating anti-HLA DSAs.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Elisabet Van Loon, Baptiste Lamarthee, Thomas Barba, Sandra Claes, Maarten Coemans, Henriette de Loor, Marie-Paule Emonds, Priyanka Koshy, Dirk Kuypers, Paul Proost, Aleksandar Senev, Ben Sprangers, Claire Tinel, Olivier Thaunat, Amaryllis H. Van Craenenbroeck, Dominique Schols, Maarten Naesens
Summary: Through multiplex assay, we found that kidney transplant patients with donor-specific anti-human leukocyte antigen antibodies and histological rejection have increased levels of pro-inflammatory cytokines in blood. Even in patients without histological rejection, elevated pro-inflammatory cytokine levels can be observed. These findings challenge the concept of histology as the gold standard for identifying ongoing allo-immune activation after transplantation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Justin C. Quon, Kelli Kaneta, Nicholas Fotiadis, Jondavid Menteer, Rachel M. Lestz, Molly Weisert, Lee Ann Baxter-Lowe
Summary: This study investigated the prevalence and potential impact of unrepresented HLA proteins in different ethnic populations, and found a higher number of unrepresented HLA alleles in non-European populations.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pediatrics
Ryoichi Goto, Yasutomo Fukasaku, Yoshikazu Ganchiku, Norio Kawamura, Masaaki Watanabe, Takuji Ota, Kanako C. Hatanaka, Tomomi Suzuki, Tsuyoshi Shimamura, Akinobu Taketomi
Summary: This study aimed to identify the risks of post-transplant anti-HLA donor specific antibody (DSA) for graft fibrosis progression in pediatric living donor liver transplantation (LDLT). The results showed that pediatric cases with a high DSA-MFI and specific risk factors should undergo histological examination to determine the appropriate treatment for post-transplant DSA.
FRONTIERS IN PEDIATRICS
(2023)
Article
Medicine, General & Internal
Covadonga Lopez del Moral, Kaiyin Wu, Marcel Naik, Bilgin Osmanodja, Aylin Akifova, Nils Lachmann, Diana Stauch, Sabine Hergovits, Mira Choi, Friederike Bachmann, Fabian Halleck, Eva Schrezenmeier, Danilo Schmidt, Klemens Budde
Summary: This study provides a comprehensive analysis of the natural course of dnDSA after kidney transplantation, demonstrates the impact of MFI evolution on graft outcomes, and identifies a subgroup of patients with a stable disappearance of dnDSA associated with better allograft survival.
FRONTIERS IN MEDICINE
(2022)
Review
Immunology
Scott M. Krummey, Alison J. Gareau
Summary: Advances in hematopoietic stem cell transplant have led to changes in donor selection approach, including the use of haploidentical donors or permissive HLA mismatches. However, this may increase the risk of donor-specific HLA antibodies, which can limit engraftment. Desensitization treatments can effectively reduce HLA antibodies and improve transplant outcomes. The consideration and management of HLA antibodies in donor selection are increasingly important in HSCT.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Safak Guel-Klein, Henriette Hegermann, Robert Roehle, Moritz Schmelzle, Frank Tacke, Wenzel Schoening, Robert Oellinger, Tomasz Dziodzio, Patrick Maier, Julius M. Plewe, David Horst, Igor Maximilian Sauer, Johann Pratschke, Nils Lachmann, Dennis Eurich
Summary: Donor-specific antibodies against donor human leukocyte antigen are associated with histological and biochemical graft inflammation after liver transplantation, while fibrosis seems to be unaffected.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Review
Surgery
Wei Liu, Zheng-Lu Wang, Zhong-Yu Kang, Yan-Li Xiao, Chun Liu, Dai-Hong Li
Summary: This study explored the association between different risk levels of newly developed donor-specific anti-human leukocyte antigen antibodies (dnDSAs) and liver graft injury after pediatric liver transplantation. The results showed significant differences in liver function indices among different risk groups, as well as in the cumulative incidences of antibody-mediated rejection and T cell-mediated rejection. The level of dnDSAs in the low risk group should not be disregarded, and routine detection of dnDSAs can provide noninvasive risk stratification for this population.
AMERICAN JOURNAL OF SURGERY
(2023)
Article
Immunology
Nicholas G. Larkins, Lloyd D'Orsogna, Anne Taverniti, Ankit Sharma, Aron Chakera, Doris Chan, Anoushka Krishnan, Germaine Wong, Wai H. Lim
Summary: High resolution HLA typing is crucial for eplet compatibility and specificity of DSA. NGS and LD typing show high concordance but significant differences. Inaccurate DSA assignment from LD typing may inappropriately exclude candidates.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Julien Subburayalu, Sebastian Dolff, Shilei Xu, Ming Sun, Monika Lindemann, Andreas Heinold, Falko M. Heinemann, Jan Willem Cohen Tervaert, Ute Eisenberger, Johannes Korth, Alexandra Brinkhoff, Andreas Kribben, Oliver Witzke, Benjamin Wilde
Summary: TFH cells and TFR cells play important roles in the formation of dnDSA after renal transplant. Activation of TFH cells is associated with the development of dnDSA, while TFR cells have an inhibitory effect on TFH cells.
CLINICAL IMMUNOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Brian D. Cone, Jennifer Q. Zhang, Rebecca A. Sosa, Fiorella Calabrese, Elaine F. Reed, Gregory A. Fishbein
Summary: This study revealed a positive correlation between de novo DSA and p-S6RP expression in pneumocytes and macrophages using IHC. p-S6RP was found to be relatively sensitive, specific, and had superior inter-rater reliability compared to C4d.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2021)
Article
Immunology
Maria Meneghini, Elena Crespo, Matthias Niemann, Alba Torija, Nuria Lloberas, Vincent Pernin, Pere Fontova, Edoardo Melilli, Alexandre Fava, Nuria Montero, Anna Manonelles, Josep Maria Cruzado, Eduard Palou, Jaume Martorell, Josep Maria Grinyo, Oriol Bestard
Summary: Molecular HLA mismatches between donors and recipients may impact the development of posttransplant T-cell alloimmunity and subsequent donor-specific cellular and humoral alloimmune activation. These immune responses are influenced by the degree of HLA molecular incompatibility between donors and recipients, as well as the pretransplant cellular immune status of the patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cell Biology
Jonathan Visentin, Lionel Couzi, Jean-Luc Taupin
Summary: This review highlights the unique characteristics of HLA-C and its clinical relevance in solid organ transplantation. Despite lower expression levels, HLA-C antigens are still immunogenic and preformed anti-HLA-C DSA can impact graft outcomes. The inclusion of HLA-C in transplant allocation systems is recommended to address this issue.
Article
Immunology
Shengli Song, Miriam Manook, Jean Kwun, Annette M. Jackson, Stuart J. Knechtle, Garnett Kelsoe
Summary: Antibody-mediated allograft rejection is a major cause of kidney transplant failure, with research focusing on identifying antibodies and optimizing therapies. New reagents and techniques have been used to measure MHC sensitization and isolate HLA-specific B cells from sensitized patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Dalia Raich-Regue, Javier Gimeno, Laura Llinas-Mallol, Silvia Menendez, David Benito, Dolores Redondo, M. Jose Perez-Saez, Marta Riera, Elaine F. Reed, Julio Pascual, Marta Crespo
Summary: Antibody-mediated rejection (ABMR) plays a significant role in allograft loss after kidney transplantation. This study investigates the activation of the mTOR pathway and its modulation by mTOR inhibitors in ABMR with donor-specific HLA-antibodies (DSA). The findings suggest different mechanisms of endothelial damage in ABMR + DSA+ and ABMR + DSA-.
FRONTIERS IN MEDICINE
(2022)
Article
Surgery
Nattawat Klomjit, Mireille El Ters, Benjamin A. Adam, Priya Sampathkumar, Raymund R. Razonable, Sandra J. Taler, Timucin Taner, Mariam Priya Alexander
Summary: Neutralizing monoclonal antibodies like bamlanivimab show promise in treating COVID-19 in kidney transplant recipients, but their impact on kidney allograft histology is unclear. A case study reported diffuse peritubular capillary C4d staining following bamlanivimab treatment in a kidney transplant recipient with stable kidney function at 6 months post-biopsy.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Immunology
Kristopher P. Croome, Amit K. Mathur, Bashar Aqel, Liu Yang, Timucin Taner, Julie K. Heimbach, Charles B. Rosen, Ricardo Paz-Fumagalli, C. Burcin Taner
Summary: This study provides a detailed analysis of the natural history and clinical course of IC, showing that IC can be classified into 4 distinct patterns with different clinical courses.
Article
Medicine, General & Internal
Xiomara Benavides, Richard T. Rogers, Ek Khoon Tan, Massini A. Merzkani, Sorkko Thirunavukkarasu, Furkan Yigitbilek, Byron H. Smith, Andrew D. Rule, Aleksandra Kukla, George K. Chow, Julie K. Heimbach, Timucin Taner, Patrick G. Dean, Mikel Prieto, Mark D. Stegall
Summary: Most major complications of HALLDN occur after discharge, suggesting the need for close follow-up and indicating that the current literature may underestimate the true incidence.
MAYO CLINIC PROCEEDINGS
(2022)
Editorial Material
Immunology
Julie K. Heimbach, Timucin Taner
Review
Immunology
Timucin Taner, Julia Bruner, Juliet Emamaullee, Eliano Bonaccorsi-Riani, Ali Zarrinpar
Summary: Immunosuppression is crucial for preventing allograft rejection after liver transplantation. However, current methods for monitoring rejection have limitations, calling for the development of noninvasive techniques to improve understanding and diagnosis of rejection.
Article
Cell Biology
Qizhi Tang, Joey Leung, Yani Peng, Alberto Sanchez-Fueyo, Juan-Jose Lozano, Alice Lam, Karim Lee, John R. Greenland, Marc Hellerstein, Mark Fitch, Kelvin W. Li, Jonathan H. Esensten, Amy L. Putnam, Angela Lares, Vinh Nguyen, Weihong Liu, Nancy D. Bridges, Jonah Odim, Anthony J. Demetris, Josh Levitsky, Timucin Taner, Sandy Feng
Summary: Promoting immune tolerance to transplanted organs can reduce the amount of immunosuppressive drugs needed, lowering risks. Testing showed the potential of autologous donor alloantigen-reactive T-reg therapy in inducing transplantation tolerance.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Immunology
Furkan Yigitbilek, Elif Ozdogan, Nitin Abrol, Walter D. Park, Michael J. Hansen, Surendra Dasari, Mark D. Stegall, Timucin Taner
Summary: Liver-resident mesenchymal stem cells (L-MSCs) are more potent inhibitors of NK cell functions compared to their counterparts, contributing to the tolerogenic liver microenvironment and liver-induced systemic tolerance.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Urology & Nephrology
Naba Farooqui, Mark Zaidi, Lisa Vaughan, Trevor D. McKee, Eram Ahsan, Kevin D. Pavelko, Jose C. Villasboas, Svetomir Markovic, Timucin Taner, Nelson Leung, Haidong Dong, Mariam P. Alexander, Sandra M. Herrmann
Summary: This study found that immune checkpoint inhibitors (ICIs) therapy may lead to acute kidney injury (AKI) and there are no biomarkers currently available to distinguish AKI caused by ICIs from other causes. The urine levels of cytokines such as TNF-a, IL-2, and IL-10 were significantly higher in AKI-ICI patients. Therefore, these T-cell responses and their respective cytokines may be helpful in differentiating AKI-ICI from AKI-other.
KIDNEY INTERNATIONAL REPORTS
(2023)
Article
Transplantation
Kathryn T. del Valle, Michael J. Krowka, Julie K. Heimbach, Timucin Taner, Hilary M. DuBrock
Summary: The study analyzed data from 2006 to 2019 and found that 504 patients received POPH MELD exceptions during this period. Over time, there was an increase in patient age and severity of liver disease. Posttreatment hemodynamic values showed improvement, while the use of parenteral therapy and monotherapy regimens decreased. However, there were no significant changes in waitlist or liver transplant mortality outcomes.
TRANSPLANTATION DIRECT
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Tiffany Wu, Omar Y. Mousa, Tasha Kulai, Cori Larson, Amy Olofson, Patrick S. Kamath, Vijay Shah, Timucin Taner, William Sanchez, Douglas A. Simonetto
Meeting Abstract
Gastroenterology & Hepatology
Furkan Yigitbilek, Elif Ozdogan, Nitin Abrol, Walter D. Park, Michael Hansen, Surendra Dasari, Mark D. Stegall, Timucin Taner
Meeting Abstract
Gastroenterology & Hepatology
Navine Nasser-Ghodsi, Charles B. Rosen, Christopher Welle, Sudhakar K. Venkatesh, Isabella Zaniletti, Walter Kremers, Julie Heimbach, Timucin Taner, Sumera I. Ilyas, Gregory J. Gores, John E. Eaton
Meeting Abstract
Surgery
L. A. Mercado, H. K. Bhangu, K. R. Musto, K. D. Watt, B. Taner, C. B. Rosen, T. Taner, L. Yang, D. M. Harnois, J. D. LeGout, K. P. Croome
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Meeting Abstract
Immunology
S. M. Hosseiniasl, T. Taner, J. K. Hemibach, T. S. Diwan, S. L. Nyberg, C. B. Rosen
Article
Gastroenterology & Hepatology
Nidhi Jalan-Sakrikar, Thiago M. De Assuncao, Amaia Navarro-Corcuera, Feda H. Hamdan, Lorena Loarca, Lindsey A. Kirkeby, Zachary T. Resch, Steven P. O'Hara, Brian D. Juran, Konstantinos N. Lazaridis, Charles B. Rosen, Julie K. Heimbach, Timucin Taner, Vijay H. Shah, Nicholas F. LaRusso, Robert C. Huebert
Summary: The research team successfully generated specific cholangiocytes and biliary organoids from patients with PSC, revealing an intrinsic predisposition to cellular senescence in PSC cholangiocytes.
HEPATOLOGY COMMUNICATIONS
(2022)