Article
Medicine, General & Internal
Min-Kuang Tsai, Wayne Gao, Kuo-Liong Chien, Chih-Cheng Hsu, Chi-Pang Wen
Summary: A study found that sustained leisure-time physical activity, particularly with vigorous intensity, significantly lowered the risk of ESRD, even among individuals with comorbidities such as diabetes or hyperlipidemia.
MAYO CLINIC PROCEEDINGS
(2022)
Article
Biochemistry & Molecular Biology
Kuo-Hua Lee, Yuan-Chia Chu, Ming-Tsun Tsai, Wei-Cheng Tseng, Yao-Ping Lin, Shuo-Ming Ou, Der-Cherng Tarng
Summary: This study used machine learning to predict the risk of end-stage renal disease (ESRD) in sepsis survivors. The researchers found that estimated glomerular filtration rates, hemoglobin, and proteinuria were important predictors of ESRD development.
Article
Multidisciplinary Sciences
Jae-Seung Yun, Yong-Moon Park, Kyungdo Han, Hyung-Wook Kim, Seon-Ah Cha, Yu-Bae Ahn, Seung-Hyun Ko
Summary: The study showed a significant association between the number of severe hypoglycemia episodes and the development of end-stage renal disease (ESRD) in patients with type 2 diabetes, with those experiencing three or more episodes having nearly double the risk of developing ESRD.
SCIENTIFIC REPORTS
(2021)
Article
Gastroenterology & Hepatology
Mark Sulkowski, Laura E. Telep, Massimo Colombo, Francois Durand, K. Rajender Reddy, Eric Lawitz, Marc Bourliere, Nelson Cheinquer, Stacey Scherbakovsky, Liyun Ni, Lindsey Force, Heribert Ramroth, Anuj Gaggar, Anand P. Chokkalingam, Meghan E. Sise
Summary: In clinical trials, patients with chronic kidney disease did not experience worsening of estimated glomerular filtration rate during treatment with sofosbuvir, and sofosbuvir was not associated with an increased risk of end-stage renal disease in patients with CKD in a nationally-representative administrative claims database.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Infectious Diseases
Jose Molto, Fredzzia Graterol, Adrian Curran, Natalia Ramos, Arkaitz Imaz, Diego Sandoval, Francisco Perez, Lucia Bailon, Saye Khoo, Laura Else, Roger Paredes
Summary: This study evaluated the effect of haemodialysis on doravirine concentrations in people living with HIV (PLWH) undergoing routine haemodialysis. The results showed that despite moderate removal of doravirine by haemodialysis, trough doravirine concentrations in plasma after the haemodialysis sessions remained in excess of the protein-binding-adjusted EC50 (5 ng/mL). Therefore, doravirine dosage adjustments are unnecessary in PLWH undergoing intermittent haemodialysis.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Ziad M. El-Zaatari, Luan D. Truong
Summary: Renal cell carcinoma (RCC) occurring in the setting of end-stage renal disease (ESRD) shows unique clinicopathological characteristics, with acquired cystic kidney disease-associated renal cell carcinoma (ACKD-RCC) and clear-cell papillary renal cell carcinoma (ccpRCC) being the most frequent types. Other types of RCC also occur in ESRD, albeit with different frequencies from the non-ESRD general population. While the histological features of RCC do not vary in the setting of ESRD vs. non-ESRD, other findings, such as multifocality and multiple tumor types, are more frequent in ESRD. Studies have generated novel and important knowledge of the etiology, epidemiology, diagnosis, treatment, immunophenotype, and molecular characteristics of ESRD-associated RCC.
Article
Multidisciplinary Sciences
Yu-Kang Chang, Hueng-Chuen Fan, Chi-Chien Lin, Yuan-Hung Wang, Wan-Ni Tsai, Paik-Seong Lim
Summary: This study evaluated the risk of developing end-stage renal disease (ESRD) in diabetes mellitus (DM) patients with and without atrial fibrillation (AF). The results showed that DM patients with AF had an increased risk of ESRD compared to those without AF, and DM patients with hypertension, chronic kidney disease (CKD), or higher Charlson Comorbidity Index scores also had significantly increased ESRD risks.
Article
Endocrinology & Metabolism
Rodolfo J. Galindo, Francisco J. Pasquel, Priyathama Vellanki, Cesar Zambrano, Bonnie Albury, Citlalli Perez-Guzman, Zheng Ziduo, Guillermo E. Umpierrez
Summary: This study revealed significant metabolic differences among DKA patients with different levels of renal function, with beta-hydroxybutyrate levels potentially assisting in confirming the diagnosis of DKA in ESKD patients.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Medicine, General & Internal
Sang Heon Suh, Jin Hyung Jung, Tae Ryom Oh, Eun Mi Yang, Hong Sang Choi, Chang Seong Kim, Eun Hui Bae, Seong Kwon Ma, Kyung-Do Han, Soo Wan Kim
Summary: This study aimed to investigate the association between rheumatoid arthritis (RA) and the risk of end-stage renal disease (ESRD). The results showed that patients with RA had an increased risk of ESRD compared to those without RA, and the risk was higher in relatively young and healthy individuals. Therefore, kidney-protective treatment, such as biologic agents, should be preferred for these patients with RA.
FRONTIERS IN MEDICINE
(2023)
Article
Immunology
Benoit Brilland, Charlotte Boud'hors, Marie-Christine Copin, Pierre Jourdain, Nicolas Henry, Samuel Wacrenier, Assia Djema, Clement Samoreau, Jean-Philippe Coindre, Maud Cousin, Jeremie Riou, Anne Croue, Jean-Paul Saint-Andre, Jean-Francois Subra, Giorgina Barbara Piccoli, Jean-Francois Augusto
Summary: This study analyzed the value of Renal Risk Score (RRS) and histopathological classification in predicting the risk of end-stage kidney disease (ESKD) in ANCA-associated glomerulonephritis (ANCA-GN). It also found that eGFR at ANCA-GN diagnosis was the main determinant of eGFR variation within the first 2 years.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Zaipul I. Md Dom, Eiichiro Satake, Jan Skupien, Bozena Krolewski, Kristina O'Neil, Jill A. Willency, Simon T. Dillon, Jonathan M. Wilson, Hiroki Kobayashi, Katsuhito Ihara, Towia A. Libermann, Marlon Pragnell, Kevin L. Duffin, Andrzej S. Krolewski
Summary: This study identified three elevated plasma proteins associated with protection against progressive renal decline and progression to endstage renal disease in individuals with diabetes. These protective proteins may serve as biomarkers for stratifying diabetic individuals by their risk of developing ESRD, and could be explored as potential therapeutics to delay or prevent ESRD onset.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Yinghui Wang, Lu Gao
Summary: Chronic kidney disease and cardiac insufficiency often co-exist, especially in uremic patients on hemodialysis. Impaired renal function is often indicative of poor prognosis in patients with cardiac insufficiency. Inflammation plays a significant role in the development of cardiovascular complications in patients with chronic kidney disease and is indicative of prognosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Lorry Aitkens, Jennifer L. Waller, Stephanie L. Baer, Azeem Mohammed, Sarah Tran, Budder Siddiqui, Sandeep Padala, Lufei Young, Mufaddal Kheda, Wendy B. Bollag
Summary: This study found that psoriasis is protective against pneumonia in patients with end-stage renal disease, with other factors such as the Charlson Comorbidity Index (CCI) and tobacco use being more strongly associated with increased risk for pneumonia.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2022)
Article
Clinical Neurology
Chang Min Heo, Won Ho Lee, Bong Soo Park, Yoo Jin Lee, Sihyung Park, Yang Wook Kim, Dong Ah Lee, Byeong Cheol Yoo, Kang Min Park
Summary: This study compares glymphatic dysfunction between patients with end-stage renal disease (ESRD) and healthy controls, and reveals the presence of glymphatic dysfunction in patients with ESRD as demonstrated by the DTI-ALPS index. Additionally, a significant positive correlation is found between the DTI-ALPS index and serum parathyroid hormone levels in ESRD patients.
FRONTIERS IN NEUROLOGY
(2022)
Article
Endocrinology & Metabolism
Lijun Zhao, Yutong Zou, Yucheng Wu, Linli Cai, Yuancheng Zhao, Yiting Wang, Xiang Xiao, Qing Yang, Jia Yang, Honghong Ren, Nanwei Tong, Fang Liu
Summary: This study investigated the pathological characteristics and the independent or mutual relations of obesity and metabolic abnormalities with end-stage kidney disease (ESKD) in patients with type 2 diabetes and associated diabetic kidney disease (DKD). The study found that obesity was associated with Kimmelstiel-Wilson nodules and severe mesangial expansion, while metabolic abnormalities were associated with severe interstitial fibrosis and tubular atrophy. Obesity itself was insignificantly associated with ESKD, but adding a metabolically unhealthy status to obesity increased the risk for progression to ESKD in T2D and biopsy-proven DKD patients.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Surgery
C. F. Bryan, W. S. Cherikh, D. A. Sesok-Pizzini
AMERICAN JOURNAL OF TRANSPLANTATION
(2016)
Letter
Medicine, General & Internal
Mandeep R. Mehra, John A. Jarcho, Wida Cherikh, Muthiah Vaduganathan, Rebecca R. Lehman, Jacqueline Smits, Josef Stehlik
NEW ENGLAND JOURNAL OF MEDICINE
(2018)
Article
Surgery
Wida S. Cherikh, Linda C. Cendales, Christopher L. Wholley, Jennifer Wainrigh, Vijay S. Gorantla, David K. Klassen, Sue McDiarmid, Lawrence Scott Levin
AMERICAN JOURNAL OF TRANSPLANTATION
(2019)
Article
Cardiac & Cardiovascular Systems
Daniel C. Chambers, Wida S. Cherikh, Michael O. Harhay, Don Hayes, Eileen Hsich, Kiran K. Khush, Bruno Meiser, Luciano Potena, Joseph W. Rossano, Alice E. Toll, Tajinder P. Singh, Aparna Sadavarte, Andreas Zuckermann, Josef Stehlik
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2019)
Article
Cardiac & Cardiovascular Systems
Joseph W. Rossano, Tajinder P. Singh, Wida S. Cherikh, Daniel C. Chambers, Michael O. Harhay, Don Hayes, Eileen Hsich, Kiran K. Khush, Bruno Meiser, Luciano Potena, Alice E. Toll, Aparna Sadavarte, Andreas Zuckermann, Josef Stehlik
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2019)
Article
Cardiac & Cardiovascular Systems
Kiran K. Khush, Wida S. Cherikh, Daniel C. Chambers, Michael O. Harhay, Don Hayes, Eileen Hsich, Bruno Meiser, Luciano Potena, Amanda Robinson, Joseph W. Rossano, Aparna Sadavarte, Tajinder P. Singh, Andreas Zuckermann, Josef Stehlik
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2019)
Editorial Material
Cardiac & Cardiovascular Systems
Daniel C. Chambers, Andreas Zuckermann, Wida S. Cherikh, Michael O. Harhay, Don Hayes, Eileen Hsich, Kiran K. Khush, Luciano Potena, Aparna Sadavarte, Tajinder P. Singh, Josef Stehlik
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2020)
Article
Surgery
Puneet Sood, Wida S. Cherikh, Alice E. Toll, Rajil B. Mehta, Sundaram Hariharan
Summary: The study found diverse rejection management strategies among different centers, including the use of different induction agents, treatment drugs, and diagnostic tools. Treatment methods for TCMR and ABMR also varied, and harmonizing these diverse practices could provide an opportunity to pool data for evaluating clinical outcomes.
CLINICAL TRANSPLANTATION
(2021)
Article
Cardiac & Cardiovascular Systems
Daniel C. Chambers, Michael Perch, Andreas Zuckermann, Wida S. Cherikh, Michael O. Harhay, Don Hayes Jr., Eileen Hsich, Kiran K. Khush, Luciano Potena, Aparna Sadavarte, Kelsi Lindblad, Tajinder P. Singh, Josef Stehlik
Summary: The ISHLT TTX Registry has collected data on adult lung transplant procedures from around the world for over 30 years, focusing on key themes such as donor and recipient age, retransplantation, and early graft failure. The 2020 report specifically looks at changes in recipient factors over the past three decades, aiming to identify important recipient characteristics that may impact post-transplant outcomes.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2021)
Article
Cardiac & Cardiovascular Systems
Michael O. Harhay, Wida S. Cherikh, Alice E. Toll, Jason D. Christie, Josef Stehlik, Daniel Chambers, Don Hayes Jr, Edward Cantu
Summary: Lung retransplantation is a complex surgical decision that represents the only potential treatment option for recipients suffering from lung allograft failure. This study examined the modern landscape of lung retransplantation and found that the duration of time since the primary lung transplant was the strongest prognostic factor for 1-year mortality in retransplant recipients.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Article
Cardiac & Cardiovascular Systems
Tajinder P. Singh, Wida S. Cherikh, Eileen Hsich, Michael O. Harhay, Don Hayes, Michael Perch, Luciano Potena, Aparna Sadavarte, Andreas Zuckermann, Josef Stehlik
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Article
Cardiac & Cardiovascular Systems
Eileen Hsich, Tajinder P. Singh, Wida S. Cherikh, Michael O. Harhay, Don Hayes, Michael Perch, Luciano Potena, Aparna Sadavarte, Kelsi Lindblad, Andreas Zuckermann, Josef Stehlik
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Article
Cardiac & Cardiovascular Systems
Don Hayes, Wida S. Cherikh, Michael O. Harhay, Michael Perch, Eileen Hsich, Luciano Potena, Aparna Sadavarte, Anne Zehner, Tajinder P. Singh, Andreas Zuckermann, Josef Stehlik
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Article
Cardiac & Cardiovascular Systems
Michael Perch, Don Hayes, Wida S. Cherikh, Andreas Zuckermann, Michael O. Harhay, Eileen Hsich, Luciano Potena, Aparna Sadavarte, Kelsi Lindblad, Tajinder P. Singh, Josef Stehlik
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Article
Cardiac & Cardiovascular Systems
Yasbanoo Moayedi, Eduard Rodenas-Alesina, Brigitte Mueller, Chun-Po S. Fan, Wida S. Cherikh, Josef Stehlik, Jeffrey J. Teuteberg, Heather J. Ross, Kiran K. Khush
Summary: European heart transplantation centers are more likely to accept higher-risk donor hearts than North American centers. The acceptance of higher-risk donor hearts is associated with higher survival rates in European centers.
CIRCULATION-HEART FAILURE
(2023)