Article
Dermatology
Jack Lee, Vernon J. Forrester, Wendy M. Novicoff, Darren J. Guffey, Mark A. Russell
Summary: In a retrospective analysis of SCCs and basal cell carcinomas treated with Mohs surgery at a single institution, the study identified an association between surgical delays and tumor growth for higher-grade SCCs, suggesting potential clinical significance.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Review
Dermatology
Stephanie Clements, Amor Khachemoune
Summary: The incidence of NMSC is increasing in the US, with a significant proportion being upstaged during surgery. Biopsy sampling error and variability in reporting contribute to discrepancies. More comprehensive treatment modalities may be necessary for high-risk tumors.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2021)
Article
Oncology
Peter R. Jermain, Tyler W. Iorizzo, Mary Maloney, Bassel Mahmoud, Anna N. Yaroslavsky
Summary: This study developed and tested a novel handheld optical polarization imaging (OPI) system for the rapid and noninvasive detection of basal cell carcinoma (BCC) margins. The results showed that OPI could be a valuable tool for optimizing surgical treatment of skin cancer.
Article
Dermatology
Jonas A. Adalsteinsson, Sonal Muzumdar, Reid Waldman, Chaoran Hu, Rong Wu, Desiree Ratner, Hao Feng, Jonathan Ungar, Jonathan Silverberg, Gudridur H. Olafsdottir, Arni Kjalar Kristjansson, Laufey Tryggvadottir, Jon Gunnlaugur Jonasson
Summary: A study conducted in the Icelandic population demonstrated that statin exposure is associated with an increased risk of SCC, but not BCC. Additionally, the association of statins with SCC was significant in patients over 60, but not in those under 60.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2022)
Review
Dermatology
Ajay Nair Sharma, Samantha Shwe, Natasha Atanaskova Mesinkovska
Summary: This study provides a quantitative review of the success of machine learning techniques in non-melanoma skin cancer (NMSC) screening, showing high sensitivity and specificity in the diagnosis of NMSC. Further subgroup analysis was conducted on algorithm type, data set source, etc., but there is currently insufficient evidence to suggest that ML algorithms are superior to dermatologists trained in dermoscopy for NMSC screening.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2022)
Review
Dermatology
Tomasz Krzysztofiak, Grazyna Kaminska-Winciorek, Aleksandra Pilsniak, Piotr Wojcieszek
Summary: This study reviewed English medical full-text papers to evaluate the efficacy and safety of high dose rate (HDR) brachytherapy (BT) as a treatment option for nonmelanoma skin cancers (NMSCs). The results showed that HDR BT has good local control and cosmetic outcomes. Compared to other treatment methods, HDR BT is considered a potentially noninferior treatment option.
DERMATOLOGIC THERAPY
(2022)
Article
Dermatology
Pushkar Aggarwal, Peter Knabel, Alan B. Fleischer
Summary: This study evaluated the burden of skin cancer in the US from 1990 to 2019, finding that incidence and prevalence rates of melanoma and non-melanoma skin cancer have increased, while mortality rates have remained stable. Males have had higher incidence and mortality rates since 1990, and melanoma incidence was relatively higher in the northern half of the US.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Tuba M. Ansary, M. D. Razib Hossain, Mayumi Komine, Mamitaro Ohtsuki
Summary: Melanoma and squamous cell carcinoma (SCC) are the most common neoplasms in white people, with increasing incidence rates. SCC, the most prevalent malignancy among nonmelanoma skin cancers, is influenced by factors such as extreme ultraviolet radiation, hereditary predisposition, and immunosuppression. SCC tumors have a high tumor mutational burden and expression of immune checkpoints, making them highly responsive to immunotherapies. However, challenges such as resistance to immunotherapy and difficulty in patient selection exist. This review explores the genetic alterations related to SCC, factors contributing to the benefits of immunotherapy, and challenges associated with this treatment regime.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Enrico Zelin, Iris Zalaudek, Marina Agozzino, Caterina Dianzani, Arianna Dri, Nicola Di Meo, Roberta Giuffrida, Giovanni Francesco Marangi, Nicoleta Neagu, Paolo Persichetti, Ludovica Toffoli, Claudio Conforti
Summary: Newly introduced systemic therapies for locally advanced and metastatic non-melanoma skin cancers are opening up the possibility of neoadjuvant approaches. Targeted therapy with sonic hedgehog pathway inhibitors has shown effectiveness in certain types of NMSCs, while immunotherapy with immune checkpoint inhibitors holds promise for others. Both targeted therapy and immunotherapy represent the leading edge of NMSC therapeutic management, with recent studies showing positive results.
CURRENT TREATMENT OPTIONS IN ONCOLOGY
(2021)
Article
Dermatology
Efrat Solomon-Cohen, Shiran Reiss-Huss, Emmilia Hodak, Batya Davidovici
Summary: Low-dose acitretin treatment in SOTRs has shown to significantly reduce the number of new keratinocyte carcinomas, including both SCC and basal cell carcinoma, indicating its positive effect as a chemoprevention method in this population.
Review
Dermatology
Palak V. Patel, Jessica N. Pixley, Hannah S. Dibble, Steven R. Feldman
Summary: This article discusses the cost consideration in the treatment of basal cell carcinoma (BCC) and presents a cost-conscious algorithm based on different scenarios. For superficial BCC smaller than 0.5 cm, curettage and electrodesiccation or cryosurgery are recommended as the first-line treatment. For nodular BCC ranging from 1.1 to 2 cm, curettage and electrodesiccation, cryosurgery, or 5-fluorouracil are prioritized. For giant BCC, superficial radiation therapy is identified as the first-line treatment option.
DERMATOLOGY AND THERAPY
(2023)
Article
Medicine, General & Internal
Ming-Jun Wu, Yu-Chun Chen, Xiao-Li Cui, Qian Yang, Qing-Liang Xue
Summary: This case study demonstrates the positive effect of the PD-1 immunosuppressant tislelizumab in treating basal cell carcinoma.
Article
Oncology
Pablo Garcia-Montero, Maria Victoria de Galvez-Aranda, Nuria Blazquez-Sanchez, Francisco Rivas-Ruiz, Jose Francisco Millan-Cayetano, Cristina Garcia Harana, Magdalena de Troya Martin
Summary: Non-melanoma skin cancer is the most common neoplasm worldwide, with patients' quality of life improving following treatment but with variations among individuals. Factors influencing the degree of improvement include sex, education, marital status, history of anxiety or depression, tumor type, treatment received, and VAS score.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Medicine, General & Internal
Philip Surmanowicz, Arunima Sivanand, Amy X. Du, Muhammad N. Mahmood, Robert Gniadecki
Summary: The muffin technique micrographic surgery (MTMS) is a superior alternative to Mohs micrographic surgery (MMS) in providing full margin control and residual tumor mapping for high-risk facial non-melanoma skin cancer. Preliminary results from its implementation in an academic dermatology center show a high success rate, no observed tumor recurrence or major adverse events in 69 patients.
FRONTIERS IN MEDICINE
(2021)
Review
Oncology
Marianela Zambrano-Roman, Jorge R. Padilla-Gutierrez, Yeminia Valle, Jose F. Munoz-Valle, Emmanuel Valdes-Alvarado
Summary: This review provides an update on the genetic features of non-melanoma skin cancer (NMSC), candidate genes, and new therapies, considering diverse perspectives of skin carcinogenesis. It also offers innovative approaches to overcome the difficulties in the current clinical dynamics, especially in the diagnosis and treatment of patients with cancer.