Review
Gastroenterology & Hepatology
Brian T. Lee, M. Isabel Fiel, Thomas D. Schiano
Summary: Antibody-mediated rejection after liver transplantation is a lesser recognized cause of allograft injury, with challenges in timely diagnosis and treatment, highlighting the need for further research and development in this area.
JOURNAL OF HEPATOLOGY
(2021)
Article
Medicine, General & Internal
Hoa Le Mai, Nicolas Degauque, Sabine Le Bot, Marie Rimbert, Karine Renaudin, Richard Danger, Florent Le Borgne, Clarisse Kerleau, Gaelle Tilly, Anais Vivet, Florent Delbos, Alexandre Walencik, Magali Giral, Sophie Brouard
Summary: The study found that the percentage and absolute number of CD28-CD8+ T cells were significantly increased in kidney transplant patients with antibody-mediated rejection (ABMR). Moreover, CD28-CD8+ T cells from patients with ABMR showed a more rigorous response to stimulation compared to their CD28+ counterparts. These findings suggest that differentiated CD28-CD8+ T cells, with increased frequency, number, and function, may play a role in the pathobiology of ABMR.
Article
Immunology
Konstantin Doberer, Johannes Klaeger, Guido A. Gualdoni, Katharina A. Mayer, Farsad Eskandary, Evan A. Farkash, Hermine Agis, Thomas Reiter, Roman Reindl-Schwaighofer, Markus Wahrmann, Gerald Cohen, Helmuth Haslacher, Gregor Bond, Ingrid Simonitsch-Klupp, Philip F. Halloran, Georg A. Boehmig
Summary: The study highlights the potential of targeting CD38 for plasma cell and NK cell depletion in treating AMR. The use of daratumumab in a kidney allograft recipient with chronic active AMR led to significant improvements in immune cell counts, donor-specific antibody levels, and rejection-related gene expression patterns. This innovative treatment concept shows promise for future trials in organ transplantation research.
Article
Medicine, Research & Experimental
Xin Li, Ruoying Li, Bingqing Ji, Lili Zhao, Junpeng Wang, Tianzhong Yan
Summary: This study investigated the metagenomic and metabolic patterns of gut microbiota in patients with antibody-mediated rejection (AMR) after kidney transplantation. The findings provide a comprehensive understanding of the correlation between AMR and gut microbiota, which is important for the etiological and diagnostic study of AMR after kidney transplantation.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Chang Liu, Pengpeng Yan, Xiaoyu Xu, Wenhui Zhou, Dhayakumar Rajan Prakash, Shuqi Wang, Junnian Zhou, Rending Wang, Hongfeng Huang, Jianghua Chen, Hongbo Zhang, Jia Shen
Summary: By utilizing a site-specific nanovehicle, this study presents a novel approach for treating ABMR. The nanovehicle is capable of targeting the affected allograft kidney endothelium under ABMR and releasing an anti-inflammatory drug upon laser irradiation to promote endothelial recovery. This strategy holds potential for future clinical applications.
Review
Pharmacology & Pharmacy
Min Young Kim, Daniel C. Brennan
Summary: Significant progress has been made in the pathophysiology, diagnosis, and treatment of antibody-mediated rejection (ABMR) in recent decades, but effective treatment for chronic ABMR remains a challenge. Chronic ABMR has a distinct phenotype from active ABMR and is mainly caused by de novo donor specific antibodies (DSA), leading to progressive graft injury.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pathology
James B. Maurice, Akudo Nwaogu, Mahmoud Gouda, Olivia Shaw, Alberto Sanchez-Fueyo, Yoh Zen
Summary: This study aimed to examine the clinical utility and impact of the 2016 Banff criteria for acute antibody-mediated rejection (acute AMR) in patients with liver transplantation. The results showed that only a small percentage of DSA-positive patients met the Banff criteria for acute AMR, and combined acute AMR/TCMR cases were more common than isolated acute AMR.
Editorial Material
Biochemistry & Molecular Biology
Nissrin Alachkar, Nada Alachkar
Summary: Diagnosing kidney allograft rejection is complex and subjective, but an automated Banff classification could make assessment easier and improve accuracy.
Article
Immunology
Claire Tinel, Baptiste Lamarthee, Jasper Callemeyn, Elisabet Van Loon, Virginia Sauvaget, Lise Morin, Laila Aouni, Marion Rabant, Wilfried Gwinner, Pierre Marquet, Maarten Naesens, Dany Anglicheau
Summary: miRNAs play key roles in antibody-mediated rejection in solid-organ transplantation by regulating cellular functions, such as endothelial cells, epithelial cells, and immune cells, impacting the development of microvascular inflammation as well as renal immune response and electrolyte homeostasis.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Medicine, General & Internal
Elena Yukie Uebayashi, Hideaki Okajima, Miki Yamamoto, Eri Ogawa, Tatsuya Okamoto, Hironori Haga, Etsurou Hatano
Summary: Antibody-mediated rejection (AMR) of liver allograft transplantation has gained clinical awareness as a potential cause of chronic liver injury and graft failure. The accurate incidence, diagnostic criteria, and treatment protocols of chronic AMR in pediatric patients remain unclear and further research is needed.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Urology & Nephrology
Anil Dangi, Irma Husain, Collin Z. Jordan, Shuangjin Yu, Naveen Natesh, Xiling Shen, Jean Kwun, Xunrong Luo
Summary: This study found that resident macrophages in the donor kidney rapidly expanded during the early stages of kidney transplantation and were induced to express high levels of Ccl8. This led to the infiltration of recipient monocytes, their differentiation into resident macrophages, and subsequent expression of Ccl8. Enhanced infiltration of recipient T cells followed. Targeting the CCL8-CCR8 axis shows promise for reducing early kidney allograft inflammation.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Nanoscience & Nanotechnology
Jinwen Lin, Junhao Lv, Xianping Yu, Xing Xue, Shiping Yu, Huiping Wang, Jianghua Chen
Summary: A genetic engineered membrane-coated nanoparticle called DSA trapper, inspired by the affinity of bacterial proteins for antibodies, is able to efficiently adsorb and clear alloreactive antibodies, restoring single-cell transcriptional heterogeneity. DSA trappers absorbed antibodies through heterophagic clearance, reducing IgG deposition and complement activation, providing an immune tolerant niche for restoration of single-cell genetic architecture. In allogeneic transplantation mice, DSA trapper improved glomerular filtration rate and prolonged survival. Overall, DSA trapper offers a promising approach for treating alloantibody-mediated immune injury.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Medicine, General & Internal
Farah Abuazzam, Casey Dubrawka, Tarek Abdulhadi, Gwendolyn Amurao, Louai Alrata, Dema Yaseen Alsabbagh, Omar Alomar, Tarek Alhamad
Summary: Despite advances in immunosuppressive medications, antibody-mediated rejection (AMR) remains a major cause of kidney allograft failure. Recent developments in understanding the pathophysiology of AMR and new therapeutic options have emerged. Surveillance protocols using donor-derived cell-free DNA and gene profile testing have allowed for early detection of AMR. Ongoing clinical trials offer opportunities for improving outcomes in kidney transplant recipients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Kaiyin Wu, Danilo Schmidt, Covadonga Lopez del Moral, Bilgin Osmanodja, Nils Lachmann, Qiang Zhang, Fabian Halleck, Mira Choi, Friederike Bachmann, Simon Ronicke, Wiebke Duettmann, Marcel G. Naik, Eva Schrezenmeier, Birgit Rudolph, Klemens Budde
Summary: The study retrospectively investigated renal allograft function and long-term outcomes in patients with chronic antibody-mediated rejection (cAMR), and found that patients who received antihumoral therapy had more concomitant T-cell-mediated rejection and a higher decline in renal function, with lower graft survival rates.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cell Biology
Fei Han, Qipeng Sun, Zhengyu Huang, Heng Li, Maolin Ma, Tao Liao, Zihuang Luo, Lingling Zheng, Nana Zhang, Nan Chen, Liangqing Hong, Ning Na, Qiquan Sun
Summary: The study reveals that donor plasma mitochondrial DNA (dmtDNA) levels are correlated with the occurrence of antibody-mediated rejection (ABMR) in renal allograft recipients. Higher dmtDNA levels are associated with acute rejection and ABMR, presenting dmtDNA as a potential predictive marker for ABMR in organ evaluation.
Article
Gastroenterology & Hepatology
Zhao Shan, Xiaodong Liu, Yuan Chen, Meng Wang, Yue Rachel Gao, Liangguo Xu, Wasim A. Dar, Chun Geun Lee, Jack Angel Elias, Pavel Davizon Castillo, Jorge Di Paola, Cynthia Ju
Article
Surgery
Kyle Freischlag, Paul M. Schroder, Brian Ezekian, Morgan L. Cox, Michael S. Mulvihill, Matthew G. Hartwig, Stuart J. Knechtle
JOURNAL OF SURGICAL RESEARCH
(2018)
Review
Immunology
Brian Ezekian, Paul M. Schroder, Kyle Freischlag, Janghoon Yoon, Jean Kwun, Stuart J. Knechtle
Article
Immunology
Miriam Manook, Jean Kwun, Steven Sacks, Anthony Dorling, Nizam Mamode, Stuart Knechtle
TRANSPLANTATION REVIEWS
(2018)
Review
Gastroenterology & Hepatology
Wasim A. Dar, Elise Sullivan, John S. Bynon, Holger Eltzschig, Cynthia Ju
LIVER INTERNATIONAL
(2019)
Article
Immunology
Mohanad Al-Obaidi, Rodrigo Hasbun, Karen J. Vigil, Angelina R. Edwards, Violeta Chavez, David R. Hall, Wasim A. Dar, Aleksandra De Golovine, Luis Ostrosky-Zeichner, John S. Bynon, Masayuki Nigo
OPEN FORUM INFECTIOUS DISEASES
(2019)
Article
Oncology
Kishore Polireddy, Kanchan Singh, Melissa Pruski, Neal C. Jones, Naveen V. Manisundaram, Pavani Ponnela, Michel Ouellette, George Van Buren, Mamoun Younes, John S. Bynon, Wasim A. Dar, Jennifer M. Bailey
Article
Surgery
Gloria Chen, Cynthia S. Bell, Penelope Loughhead, Bashar Ibeche, John S. Bynon, David R. Hall, Aleksandra De Golovine, Angelina Edwards, Wasim A. Dar
PROGRESS IN TRANSPLANTATION
(2019)
Article
Biochemistry & Molecular Biology
Kanchan Singh, Melissa A. Pruski, Kishore Polireddy, Neal C. Jones, Qingzheng Chen, Jun Yao, Wasim A. Dar, Florencia McAllister, Cynthia Ju, Holger K. Eltzschig, Mamoun Younes, Cesar Moran, Harry Karmouty-Quintana, Haoqiang Ying, Jennifer M. Bailey
Article
Multidisciplinary Sciences
Kun Jiang, Mohammad K. Mohammad, Wasim A. Dar, Jun Kong, Alton B. Farris
Article
Gastroenterology & Hepatology
Lindsey Kennedy, Vik Meadows, Amelia Sybenga, Jennifer Demieville, Lixian Chen, Laura Hargrove, Burcin Ekser, Wasim Dar, Ludovica Ceci, Debjyoti Kundu, Konstantina Kyritsi, Linh Pham, Tianhao Zhou, Shannon Glaser, Fanyin Meng, Gianfranco Alpini, Heather Francis
Summary: The study found that mast cells promote the progression of NAFLD/NASH and inhibiting mast cell activation may be a potential therapeutic strategy for NAFLD/NASH by controlling the miR-144-3p/ALDH1A3 signaling pathway.
Article
Cell Biology
Yaochun Wang, Yang Yang, Meng Wang, Shuhong Wang, Jong-Min Jeong, Long Xu, Yankai Wen, Christoph Emontzpohl, Constance Lynn Atkins, Kevin Duong, Nicolas F. Moreno, Xiaoyi Yuan, David R. Hall, Wasim Dar, Dechun Feng, Bin Gao, Yong Xu, Zoltan Czigany, Sean P. Colgan, J. Steve Bynon, Shizuo Akira, Jared M. Brown, Holger K. Eltzschig, Elizabeth A. Jacobsen, Cynthia Ju
Summary: Eosinophils rapidly accumulate in human liver grafts after transplantation, playing a critical role in reducing liver injury caused by ischemia and reperfusion. Targeting the ST2-dependent production of interleukin-13 by eosinophils may provide a potential therapeutic strategy to improve outcomes in liver transplantation patients.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Lixian Chen, Nan Wu, Lindsey Kennedy, Heather Francis, Ludovica Ceci, Tianhao Zhou, Niharika Samala, Konstantina Kyritsi, Chaodong Wu, Amelia Sybenga, Burcin Ekser, Wasim Dar, Constance Atkins, Vik Meadows, Shannon Glaser, Gianfranco Alpini
Summary: The study evaluated the impact of disrupting biliary SCT/SCTR/miR-125b signaling on NAFLD/NASH. Findings showed that biliary/hepatocyte senescence, ductular reaction, and liver angiogenesis were affected in mouse and human samples.
Article
Medicine, Research & Experimental
Cynthia Ju, Meng Wang, Eunyoung Tak, Boyun Kim, Christoph Emontzpohl, Yang Yang, Xiaoyi Yuan, Huban Kutay, Yafen Liang, David R. Hall, Wasim A. Dar, J. Steve Bynon, Peter Carmeliet, Kalpana Ghoshal, Holger K. Eltzschig
Summary: miRNA miR122 plays a crucial role in hepatic ischemia and reperfusion injury by regulating HIF1 alpha and PHD1 to enhance liver protection. Pharmacologic interventions targeting miR122 show potential benefits in attenuating liver injury, as demonstrated in patient studies undergoing liver transplantation.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Anesthesiology
Srikanth Sridhar, Sara Guzman-Reyes, Sam D. Gumbert, Semhar J. Ghebremichael, Angelina R. Edwards, Mark J. Hobeika, Wasim A. Dar, Evan G. Pivalizza
SEMINARS IN CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2018)