期刊
AMERICAN JOURNAL OF TRANSPLANTATION
卷 10, 期 10, 页码 2305-2312出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1600-6143.2010.03232.x
关键词
Addiction; alcohol; psychological functioning
资金
- National Institute of Alcohol Abuse and Alcoholism [K23 AA0257]
- National Institute of Digestive Disorders and Kidney Diseases Rockville, MD, USA [R01 DK066266]
Any use of alcohol in the years following liver transplantation (LTX) approaches 50% of patients transplanted for alcoholic liver disease (ALD). We collected detailed prospective data on alcohol consumption following LTX for ALD to investigate ongoing patterns of use. Using trajectory modeling we identified four distinct alcohol use trajectories. One group had minimal use over time. Two other groups developed early onset moderate-to-heavy consumption and one group developed late onset moderate use. These trajectories demonstrate that alcohol use varies based on timing of onset, quantity and duration. Using discriminant function analysis, we examine characteristics of recipient's pre-LTX alcohol histories and early post-LTX psychological stressors to identify the profile of those at risk for these specific trajectories. We discuss the relevance of these findings to clinical care and preliminarily to outcomes.
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