Review
Immunology
M. Fodor, S. Salcher, H. Gottschling, A. Mair, M. Blumer, S. Sopper, S. Ebner, A. Pircher, R. Oberhuber, D. Wolf, S. Schneeberger, T. Hautz
Summary: The liver has a large repertoire of resident immune cells that play a critical role in maintaining immune balance and responding to inflammation. Machine perfusion (MP) has been used to preserve and evaluate the quality of organs, including livers, prior to transplantation. However, the impact of MP on the liver's immune cell repertoire and its role in inflammation during MP is not well understood. This review discusses the role of hepatic immune cells in inflammatory conditions and ischemia reperfusion injury in liver transplantation, and highlights the potential impact of MP on immune cell modification and future immune modulation of the liver.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Zhangliu Jin, Meng Dou, Weihui Peng, Boen Xiao, Jinjin Liu, Wen Meng, Wei Liu
Summary: This study aimed to analyze alterations in gene expression, immune infiltration components, and potential biomarkers in liver ischemia-reperfusion injury (IRI) following liver transplantation (LT). The study identified differentially expressed genes associated with inflammation, apoptosis, cell proliferation, immune disorders, and cellular response, as well as various immune cell types infiltrating the IRI. The study also identified potential biological biomarkers, which may contribute to the diagnosis and prognosis of IRI post-transplant.
Review
Cell Biology
Qiao Tang, Chong Dong, Qian Sun
Summary: This review summarizes the similarities and differences in the immune response associated with IRI during diverse organ transplantation, including both innate and adaptive immunity.
INFLAMMATION RESEARCH
(2022)
Article
Cell Biology
Yuanbang Lin, Mingwei Sheng, Hua Qin, Peng Zhang, Chunli Wang, Wei Fu, Xiangjun Meng, Duowei Wang, Yachao Hou
Summary: This study reveals the important regulatory role of Caspase 6 in liver sterile inflammatory injury. Overexpression of Caspase 6 is associated with more severe liver injury and inflammation in human liver tissues. Caspase 6 is mainly elevated in macrophages rather than hepatocytes. In mouse models, Caspase 6 deficiency protects the liver from IR injury.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Oncology
Zhiyong Guo, Jinghong Xu, Shanzhou Huang, Meixian Yin, Qiang Zhao, Weiqiang Ju, Dongping Wang, Ningxin Gao, Changjun Huang, Lu Yang, Maogen Chen, Zhiheng Zhang, Zebin Zhu, Linhe Wang, Caihui Zhu, Yixi Zhang, Yunhua Tang, Haitian Chen, Kunpeng Liu, Yuting Lu, Yi Ma, Anbin Hu, Yinghua Chen, Xiaofeng Zhu, Xiaoshun He
Summary: Ischemia-free liver transplantation can avoid graft ischemia-reperfusion injury and has the potential to improve transplant outcomes and organ utilization.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Review
Medicine, Research & Experimental
Fatemeh Sabet Sarvestani, Negar Azarpira, Ismail H. Al-Abdullah, Ali-Mohammad Tamaddon
Summary: Ischemia reperfusion injury can lead to tissue damage, especially during organ transplantation. By manipulating miRNAs level, they can be used as a biomarker for early diagnosis of IRI or suggestive to be therapeutic agents in clinical situation in future.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Gastroenterology & Hepatology
Jiang Liu, Kwan Man
Summary: Ischemia/reperfusion injury is an inevitable process during liver transplantation, leading to high rates of dysfunction and failure. The mechanism involves microcirculation dysfunction, hypoxia, oxidative stress, and cell death. The immune response also plays a crucial role. Studies on living donor liver transplantation have identified specific mitochondrial and metabolic dysfunction in certain types of graft injury. These findings have paved the way for new biomarkers and potential therapeutics, but further validation and clinical trials are needed. This review emphasizes the importance of the spatiotemporal microenvironment resulting from various factors in liver ischemia/reperfusion injury.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Asa Noren, Mihai Oltean, Styrbjorn Friman, Antonio Molinaro, Johan Molne, Carina Sihlbom, Gustaf Herlenius, Annika Thorsell
Summary: Acute kidney injury (AKI) is common after liver transplantation (LT) and is related to the later development of chronic kidney disease. This study found that grafts from LT recipients who develop early AKI have distinct proteomic alterations, primarily dominated by an early yet prominent activation of innate immunity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Tong Wu, Cheng Zhang, Tianfeng Shao, Jianzhong Chen, Diyu Chen
Summary: Ischemia-reperfusion injury (IRI) is a crucial factor in liver transplantation, and the activation of hepatic macrophages, especially NLRP3 inflammasome, plays a significant role in the progression of IRI. The NLRP3 inflammasome pathway in hepatic macrophages is highly expressed and may lead to liver IRI, making it a potential therapeutic target.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
J. Zeller, B. Bogner, J. D. McFadyen, J. Kiefer, D. Braig, G. Pietersz, G. Krippner, T. L. Nero, C. J. Morton, K. S. Cheung Tung Shing, M. W. Parker, K. Peter, S. U. Eisenhardt
Summary: C-reactive protein (CRP) is not only a marker of inflammation and predictor of cardiovascular risk, but also a direct pathogenic pro-inflammatory mediator in atherosclerosis and cardiovascular diseases. The different conformations of the CRP system can aggravate tissue injury in pathological conditions, and studying the structural changes of CRP could be a novel therapeutic target for cardiovascular diseases and excessive inflammation.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Surgery
Jinsoo Rhu, Jong Man Kim, Woo Kyoung Jeong, Gyu-Seong Choi, Jae-Won Joh
Summary: This study revealed that venous outflow congestion in the liver after liver transplantation is associated with hepatocellular carcinoma recurrence, with congestion volume being a significant risk factor for recurrence-free survival. No significant relationship was found with overall survival.
TRANSPLANT INTERNATIONAL
(2021)
Review
Biochemistry & Molecular Biology
C. Corbin Frye, Amit I. Bery, Daniel Kreisel, Hrishikesh S. Kulkarni
Summary: Sterile inflammation after organ transplantation, caused by necrotic cell death and release of endogenous ligands, including DAMPs and alarmins, is a significant contributor to graft damage. Understanding the mechanistic basis of sterile inflammation is critical for identifying personalized therapies to prevent or interrupt this vicious cycle and mitigate allograft dysfunction.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Medicine, General & Internal
Laurent Reydellet, Audrey Le Saux, Valery Blasco, Cyril Nafati, Karim Harti-Souab, Romain Armand, Ariane Lannelongue, Emilie Gregoire, Jean Hardwigsen, Jacques Albanese, Sophie Chopinet
Summary: Hyperoxia is common during liver transplantation, but no guidelines support its use. Recent studies have shown the potential harm of hyperoxia in similar ischemia-reperfusion models. Hyperoxia after orthotopic liver transplantation can increase lactate levels and worsen patient outcomes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Wojciech Figiel, Grzegorz Niewinski, Michal Grat, Marek Krawczyk, Jan Stypulkowski, Zbigniew Lewandowski, Maciej Krasnodebski, Waldemar Patkowski, Krzysztof Zieniewicz
Summary: Despite the importance of perioperative hyperoxygenation in preventing postoperative infections, this study found that it should not be used for prophylaxis of infections after liver transplantation due to the lack of efficacy.
Review
Biochemistry & Molecular Biology
Fernando Lucas-Ruiz, Alejandro Penin-Franch, Jose Antonio Pons, Pablo Ramirez, Pablo Pelegrin, Santiago Cuevas, Alberto Baroja-Mazo
Summary: The NLRP3 inflammasome and pyroptosis play important roles in liver transplantation, affecting the progression of liver disease and treatment outcomes. Studying this pathway may lead to new strategies for the future treatment of LT.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)