Article
Multidisciplinary Sciences
Sujin Kang, Jaekyung Kim, Areum Park, Minsoo Koh, Wonji Shin, Gayoung Park, Taeyun A. Lee, Hyung Jin Kim, Heonjong Han, Yongbo Kim, Myung Kyung Choi, Jae Hyung Park, Eunhye Lee, Hyun-Soo Cho, Hyun Woo Park, Jae Hee Cheon, Sungwook Lee, Boyoun Park
Summary: The authors found that TRIM40, an E3 ligase, disrupts cortical actin formation and leads to loss of epithelial barrier integrity. Genetic loss of TRIM40 is protective against experimental colitis in male mice.
NATURE COMMUNICATIONS
(2023)
Article
Fisheries
Yu Han, Yu Tang, Shuge Sun, Tongchol Kim, Kwangjin Ju, Sanghyok Ri, Xueying Du, Weishang Zhou, Wei Shi, Shiguo Li, Guangxu Liu
Summary: This study demonstrates the important role of CaM in immune modulation and hemocyte phagocytosis in bivalve species. Inhibition of CaM significantly decreases phagocytic activity of hemocytes, affects intracellular Ca2+ elevation, actin cytoskeleton assembly, and immune-related pathways. The findings suggest potential pathways through which CaM modulates phagocytosis in bivalves.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Daniel Brandhorst, Heide Brandhorst, Samuel Acreman, Paul R. Johnson
Summary: Islet cells, especially from NHBD, showed greater benefits from hypoxic preconditioning (HP), including increased cell yields, viability, and in vitro function, and decreased apoptosis and reactive oxygen species generation. HP also decreased pro-apoptotic gene expression and increased HIF-1 and VEGF expression.
SCIENTIFIC REPORTS
(2022)
Review
Cardiac & Cardiovascular Systems
Shuji Okahara, Bronwyn Levvey, Mark McDonald, Rohit D'Costa, Helen Opdam, David Pilcher, Gregory I. Snell
Summary: This retrospective study reviewed lung donor referrals between 2014 and 2018, finding main reasons for refusal to be lung quality issues, general medical issues, and organizational issues. Despite indications, the actual number of retrievable lungs through EVLP was limited.
ANNALS OF THORACIC SURGERY
(2021)
Article
Biochemistry & Molecular Biology
Huijie Zhao, Jian Sun, Christine Insinna, Quanlong Lu, Ziqiu Wang, Kunio Nagashima, Jimmy Stauffer, Thorkell Andresson, Suzanne Specht, Sumeth Perera, Ira O. Daar, Christopher J. Westlake
Summary: Ccdc108 is crucial for the formation and function of motile cilia, and it cooperates with the IFT-B complex to regulate the migration and docking of cilia, as well as the establishment of the apical actin network.
Article
Cardiac & Cardiovascular Systems
Michelle Mendiola Pla, Silvia Berrettoni, Franklin H. H. Lee, Giacomo Rozzi, Federica Marrano, Ryan T. T. Gross, Amy Evans, David C. C. Wendell, Paul Lezberg, Margherita Burattini, Francesco Paolo lo Muzio, Lorenzo Fassina, Carmelo A. A. Milano, Marie-Louise Bang, Dawn E. E. Bowles, Michele Miragoli
Summary: A video algorithm was used to assess the viability of donor hearts undergoing ex vivo perfusion, demonstrating that the hearts maintain steady kinematic measurements throughout the preservation period.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Xuejun He, Yimin Huang, Yuan Liu, Xincheng Zhang, Quanji Wang, Yanchao Liu, Xiaopeng Ma, Xiaobing Long, Yang Ruan, Hongxia Lei, Chao Gan, Xiaochuan Wang, Xin Zou, Bo Xiong, Kai Shu, Ting Lei, Huaqiu Zhang
Summary: This study revealed that an exosomal long non-coding RNA from astrocytes attenuates microglial activation after traumatic brain injury by up-regulating Smad7, providing a potential therapeutic target.
Review
Biology
Yongrong Liao, Izabela Sumara, Evanthia Pangou
Summary: This review examines the important roles of non-proteolytic ubiquitylation in cellular signaling and diseases. It provides insights into the functions of non-proteolytic ubiquitylation in cellular processes and its association with the development of human diseases.
COMMUNICATIONS BIOLOGY
(2022)
Article
Cell Biology
Jorge Ibanez-Vega, Felipe Del Valle, Juan Jose Saez, Fanny Guzman, Jheimmy Diaz, Andrea Soza, Maria Isabel Yuseff
Summary: The study reveals that the asymmetric distribution of the proteasome, mediated by Ecm29, coordinates actin dynamics at the centrosome and the IS in B cells, promoting lysosome recruitment and cell spreading.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Immunology
Romina Ulloa, Oreste Corrales, Fernanda Cabrera-Reyes, Jorge Jara-Wilde, Juan Jose Saez, Christopher Rivas, Jonathan Lagos, Steffen Haertel, Clara Quiroga, Maria-Isabel Yuseff, Jheimmy Diaz-Munoz
Summary: This study reveals that changes in nuclear morphology and positioning are critical for the formation of immune synapse and efficient antigen extraction in B cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Wenfa Li, Cailing Jiao, Dengxiang Lai, Di Wu, Zuyuan You, Lin Feng, Xiaoping Wu, Jianrong Zhang
Summary: Perfusion of papaverine via the aortic root before heart rebeating during valve replacement surgery showed positive effects in reducing myocardial injury, inflammatory response, and NF-kappa B expression levels, leading to shorter mechanical ventilation time, ICU and in-hospital stay.
ARCHIVES OF MEDICAL RESEARCH
(2021)
Article
Immunology
Margaret K. Seeley-Fallen, Michelle Lazzaro, Chaohong Liu, Quan-Zhen Li, Arpita Upadhyaya, Wenxia Song
Summary: Actin-mediated B-cell contraction negatively regulates B-cell receptor (BCR) signaling, while non-muscle myosin II (NMII) participates in B-cell development and antibody responses by regulating B-cell membrane contraction and antigen clustering. Inhibition of NMII enhances BCR signaling, reduces antibody affinity, and increases levels of autoantibodies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Joseph W. Hawkins, Madeleine C. McNeill, Reza Ebrahimighaei, Harry H. Mellor, Andrew C. Newby, Mark Bond
Summary: cAMP inhibits NF-kB activity by increasing nuclear actin monomer levels, leading to immunosuppressive and anti-inflammatory effects.
Article
Biochemistry & Molecular Biology
Elizabeta Georgieva, Stefan L. Leber, Cora Wex, Christoph Garbers
Summary: The study reveals that perturbation of the actin cytoskeleton is not sufficient to induce NF-kappa B activation and IL-6 secretion, but it reduces IL-6-induced activation of STAT3 in Hep3B cells. Additionally, IL-6 receptor proteolysis by ADAM10 is not dependent on the integrity of the actin cytoskeleton.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Chun-Hao Chang, Yun-Li Lin, Yeu-Sheng Tyan, Yun-Hsuan Chiu, Ya-Han Liang, Chie-Pein Chen, Jiahn-Chun Wu, Hwai-Shi Wang
Summary: Human umbilical cord Wharton's jelly derived mesenchymal stem cells (hUCMSCs) have the ability to migrate to damaged sites in response to signals. IL-1 beta induces the expression of MMP-3 in hUCMSCs, which is related to cell migration. Additionally, ERK1/2, JNK, p38 MAPK and Akt signaling pathways are involved in IL-1 beta-induced hUCMSCs migration through MMP-3 expression.
Editorial Material
Cardiac & Cardiovascular Systems
Thomas M. Egan
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2019)
Letter
Surgery
Thomas M. Egan, John Jacob Requard
AMERICAN JOURNAL OF TRANSPLANTATION
(2019)
Editorial Material
Cardiac & Cardiovascular Systems
Thomas M. Egan, John Ikonomidis
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2020)
Editorial Material
Cardiac & Cardiovascular Systems
Thomas M. Egan
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2020)
Review
Chemistry, Multidisciplinary
Libertario Demi, Thomas Egan, Marie Muller
APPLIED SCIENCES-BASEL
(2020)
Letter
Surgery
Thomas M. Egan, John J. Requard
AMERICAN JOURNAL OF TRANSPLANTATION
(2020)
Letter
Surgery
Thomas M. Egan, Stephen Wall, Lewis Goldfrank, John J. Requard
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Acoustics
Theresa H. Lye, Roshan Roshankhah, Yasamin Karbalaeisadegh, Stephanie A. Montgomery, Thomas M. Egan, Marie Muller, Jonathan Mamou
Summary: Quantitative ultrasound methods were used to quantify lung properties in vivo, finding that multiple BSC and envelope statistical parameters provide contrast between healthy and diseased lungs, and are significantly correlated with the severity of pulmonary fibrosis.
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
(2021)
Article
Acoustics
Roshan Roshankhah, John Blackwell, Mir H. Ali, Behrooz Masuodi, Thomas Egan, Marie Muller
Summary: This study proposes a method for detecting and localizing pulmonary nodules by mapping the multiple scattering contribution inside highly scattering lung. The feasibility of the method was demonstrated in ex-vivo lungs, with 95% of nodules being detected.
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
(2021)
Review
Respiratory System
Thomas M. Egan, Benjamin E. Haithcock, Jason Lobo, Gita Mody, Robert B. Love, John Jacob I. I. I. I. I. I. Requard, John Espey, Mir Hasnain Ali
Summary: Lung transplantation has historically faced a shortage of suitable donors, but the introduction of brain death donors has provided a new source of organs. This could potentially increase the number of lung transplants performed in the future.
JOURNAL OF THORACIC DISEASE
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Aurelie Merlo, Thomas M. Egan
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Article
Chemistry, Multidisciplinary
Parth Chansoria, John Blackwell, Emma L. Etter, Emily E. Bonacquisti, Natalie Jasiewicz, Taylor Neal, Sarah Alhajli Kamal, Jiaul Hoque, Shyni Varghese, Thomas Egan, Juliane Nguyen
Summary: This study presents a new bilayered hydrogel-based patch platform that can conform to the complex mechanics of dynamic organs. Through computational and experimental studies, design rules are established and validated, and hole-filling auxetic patches are developed to reduce pulmonary air leakage. This is the first rational patch design framework that features anisotropic and auxetic properties, paving the way for future clinical development of biomimetic patches.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Letter
Critical Care Medicine
Thomas M. Egan, John Jacob Requard III
Article
Medicine, Research & Experimental
Kalene Morozumi, Tanha Patel, Paul Kerr, Mary Beth Cassely, Timothy Carey, John Buse, Andrea Carnegie, Tom Egan, Gaurav Dave
Summary: Pilot programs are crucial for advancing research at CTSA hubs. NC TraCS conducted an evaluation case study to describe their pilot program structure and assess its impact, providing a framework for other institutions. Data analysis showed that the program successfully met the diverse needs of researchers and had positive impacts on research outcomes.
JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE
(2021)
Article
Acoustics
Kaustav Mohanty, Yasamin Karbalaeisadegh, John William Blackwell, Mir Hasnain Ali, Behrooz Masuodi, Thomas Egan, Marie Muller
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2020)