Article
Immunology
S. Bos, L. J. De Sadeleer, J. Yserbyt, L. J. Dupont, L. Godinas, G. M. Verleden, L. J. Ceulemans, B. M. Vanaudenaerde, R. Vos
Summary: Among the lung transplant recipients included in this study, 13% received mTORi treatment, mostly due to renal insufficiency and malignancy. However, half of the patients discontinued mTORi therapy after experiencing adverse events or drug toxicity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Mohamed Rela, Jesus Quintero, Mureo Kasahara, Paolo Muiesan, Francisco Hernandez-Oliveros, Rajesh Rajalingam, Sadhana Shankar, Blayne Amir Sayed, Diego di Sabato, Ashwin Rammohan, John Fung, Itxarone Bilbao
Summary: The incidence and distribution of cancers in children are different from adults. Nonhepatic cancers should be considered in pediatric liver transplantation. With longer post-transplant survival and increased risk of new cancers, guidelines and best practices are needed for nonhepatic cancers in pediatric liver transplantation.
Review
Oncology
Letizia Todeschini, Luca Cristin, Alessandro Martinino, Amelia Mattia, Salvatore Agnes, Francesco Giovinazzo
Summary: Liver transplantation is an effective treatment option for nonresectable patients with early-stage HCC, especially when they meet the Milan criteria. However, the use of CNIs for immunosuppression increases the risk of tumor regrowth. mTOR inhibitors have emerged as an alternative immunosuppressive approach that can address both immunosuppression and cancer control. This review summarizes the roles of mTOR inhibitors in managing HCC patients undergoing LT and proposes strategies to overcome common adverse effects.
Review
Oncology
Alessandra Ruenger, Dirk Schadendorf, Axel Hauschild, Christoffer Gebhardt
Summary: Clinical trials studying immune checkpoint inhibitors (ICIs) have excluded immunocompromised patients. This study reviewed the existing literature and analyzed treatment outcomes of 144 patients. The findings suggest that effective immunotherapy with retained transplant was achieved in approximately 30.8% of patients. The overall response rates of immunotherapy were similar to non-immunocompromised cancer patients, but publication bias may overestimate positive outcomes.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Medicine, General & Internal
Rabea Asleh, Darko Vucicevic, Tanya M. Petterson, Walter K. Kremers, Naveen L. Pereira, Richard C. Daly, Brooks S. Edwards, D. Eric Steidley, Robert L. Scott, Sudhir S. Kushwaha
Summary: This study found that the use of sirolimus (SRL)-based immunosuppression after heart transplantation is associated with a lower risk of post-transplant lymphoproliferative disorder (PTLD) compared to calcineurin inhibitor (CNI)-based regimen.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Simona Granata, Gianpaolo Tessari, Giovanni Stallone, Gianluigi Zaza
Summary: In the last two decades, advancements in organ preservation, surgical techniques, and personalised immunosuppression have reduced the occurrence of acute rejections and early post-transplant complications. However, long-term graft survival rates have remained stagnant, possibly due to chronic calcineurin inhibitor toxicity. Skin cancer, particularly non-melanoma skin cancer (squamous cell carcinoma and basal cell carcinoma), is the most common malignancy among Caucasian solid organ transplant recipients. Various factors, including immunosuppression, contribute to the susceptibility to skin cancers, which have higher mortality rates compared to the general population. Early identification and treatment, along with patient education on sun protection and self-diagnosis, are crucial preventive measures. Collaboration between transplant clinicians, dermatologists, and surgeons is essential for effective management of these complications.
FRONTIERS IN MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Rabea Asleh, Hilmi Alnsasra, Thomas M. Habermann, Alexandros Briasoulis, Sudhir S. Kushwaha
Summary: Post-transplant lymphoproliferative disorder (PTLD) is a spectrum of lymphoid conditions associated with Epstein Barr Virus (EBV) and immunosuppressive drugs. It remains a major cause of morbidity and mortality after heart transplantation. EBV is a key driver in many PTLD cases, with B-cell proliferation and impaired T-cell immune surveillance playing a crucial role. This article reviews the pathogenesis, recent advances, and potential therapeutic targets to reduce the burden of PTLD after heart transplantation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Surgery
Lissa Pipeleers, Daniel Abramowicz, Nilufer Broeders, Alain Lemoine, Patrick Peeters, Steven Van Laecke, Laurent E. Weekers, Jacques Sennesael, Karl M. Wissing, Caroline Geers, Jean-Louis Bosmans
Summary: Withdrawal of steroids or switching to everolimus instead of cyclosporine are two effective strategies to reduce treatment-related side effects and improve long-term outcomes of kidney transplantation. Both regimens provide similar 5-year patient survival and death-censored graft survival, but the everolimus group showed higher (51)CrEDTA clearance at 1 and 5 years post-transplantation.
TRANSPLANT INTERNATIONAL
(2021)
Article
Transplantation
Rachel Hellemans, Daniel Abramowicz
Summary: CMV-related complications after kidney transplantation present a significant challenge. Tailoring preventive strategies based on individual patient risk levels can improve outcomes. CMV-specific T-cell assays can help predict CMV risk pre-transplantation. Immunosuppressive regimens including mammalian target of rapamycin inhibitors can reduce CMV risk. New antiviral agents and adoptive T-cell therapy hold promise for future treatment options.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Review
Biochemistry & Molecular Biology
Antonino Glaviano, Aaron S. C. Foo, Hiu Y. Lam, Kenneth C. H. Yap, William Jacot, Robert H. Jones, Huiyan Eng, Madhumathy G. Nair, Pooyan Makvandi, Birgit Geoerger, Matthew H. Kulke, Richard D. Baird, Jyothi S. Prabhu, Daniela Carbone, Camilla Pecoraro, Daniel B. L. Teh, Gautam Sethi, Vincenzo Cavalieri, Kevin H. Lin, Nathalie R. Javidi-Sharifi, Eneda Toska, Matthew S. Davids, Jennifer R. Brown, Patrizia Diana, Justin Stebbing, David A. Fruman, Alan P. Kumar
Summary: The PI3K/AKT/mTOR (PAM) signaling pathway plays a crucial role in cell survival, growth, and cell cycle progression. Dysregulation of this pathway is associated with cancer development and resistance to therapy. This review focuses on the major dysregulations in the PAM signaling pathway in cancer and discusses strategies for overcoming treatment resistance. The role of PAM signaling in immunology and immunotherapies is also discussed.
Article
Dentistry, Oral Surgery & Medicine
Tobias Moest, Rainer Lutz, Arne Eric Jahn, Katharina Heller, Mario Schiffer, Werner Adler, James Deschner, Manuel Weber, Marco Rainer Kesting
Summary: This retrospective clinical study evaluates the necessity for intraoral surgical intervention and/or conservative treatment in candidates awaiting organ re-transplantation. Results showed that the majority of patients needed conservative and/or surgical treatment, especially in cases of residual root remnants and unclear mucosal changes.
Article
Cardiac & Cardiovascular Systems
Polydoros N. Kampaktsis, Ilias P. Doulamis, Rabea Asleh, Elpiniki Makri, Ilias Kalamaras, Christoforos Papastergiopoulos, Maria Emfietzoglou, Anastasis Drosou, Hilmi Alnsasra, Ernesto Ruiz Duque, Alexandros Briasoulis
Summary: The use of mTOR inhibitors in heart transplant recipients within the first 2 years is relatively low, but they are noninferior to contemporary immunosuppression regimens in terms of all-cause mortality, infection, malignancy, or renal transplantation, and are associated with rejection risk.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Medicine, General & Internal
Alice Bedin, Marie Carbonnel, Renaud Snanoudj, Antoine Roux, Sarah Vanlieferinghen, Claire Marchiori, Alexandre Hertig, Catherine Racowsky, Jean-Marc Ayoubi
Summary: A retrospective study on women under 40 who underwent solid organ transplantation showed that pregnancies after transplantation are feasible, but with increased risks of pre-eclampsia and premature birth, requiring close monitoring.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Isabella Pirozzolo, Zhipeng Li, Martin Sepulveda, Maria-Luisa Alegre
Summary: The microbiome plays a crucial role in shaping immune responses in transplantation, affecting various aspects such as cell modulation, immune response phases, and drug metabolism. The complex interactions between the microbiota and the host have significant implications for transplant outcomes and alloimmunity.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2021)
Article
Public, Environmental & Occupational Health
Andre Karch, Daniela Schindler, Andrea Kuehn-Steven, Rainer Blaser, Klaus A. Kuhn, Lisa Sandmann, Claudia Sommerer, Markus Guba, Uwe Heemann, Jens Stroehaker, Stephan Gloeckner, Rafael Mikolajczyk, Dirk H. Busch, Thomas F. Schulz
Summary: The DZIF Transplant Cohort is a multicentre prospective cohort study focusing on infectious complications after solid organ and stem cell transplantation. It aims to understand the risk factors associated with infections, collect detailed data and biosamples to facilitate studies in infectious diseases and transplant medicine. The study has collected baseline data and biosamples from approximately 1400 patients as of January 2020, with plans to recruit 3500 patients by 2023 and continue follow-up visits and documentation of infectious events until at least 2025.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Surgery
Palmina Petruzzo, Stephane Luong, Jean Kanitakis, Claudia Sardu, Patrick Feugier, Fabrice Danjou, Aram Gazarian, Lionel Badet, Emmanuel Morelon
Summary: This study demonstrated a significant increase in IMT in an UET recipient who developed GV. There was a difference in IMT values between recipient and grafted arteries, except for patient #2.
CLINICAL TRANSPLANTATION
(2021)
Article
Dermatology
Jean Kanitakis
Summary: Circumscribed palmoplantar hypokeratosis is a rare acquired dermatosis mainly affecting middle-aged or elderly women, presenting clinically with sharply limited, annular erythematous plaques. Despite its characteristic clinical and microscopic features, the pathogenesis and treatment of the disease remain unclear.
CLINICS IN DERMATOLOGY
(2021)
Article
Rheumatology
Nadege Cordel, Celine Derambure, Sophie Coutant, Xavier Mariette, Denis Jullien, Sebastien Debarbieux, Olivier Chosidow, Alain Meyer, Didier Bessis, Pascal Joly, Alexis Mathian, Herve Levesque, Jean-Christophe Sabourin, Isabelle Tournier, Olivier Boyer
Summary: This study deep sequenced the TRIM33 gene in tumours from patients with cancer-associated anti-TIF1 gamma autoantibody-positive DM, identifying potential somatic variants. The results support the hypothesis of a role of TRIM33 gene mutations in the pathophysiology of anti-TIF1 gamma autoantibody-positive DM, consistent with previous reports.
Letter
Surgery
Jean Kanitakis
ANNALS OF PLASTIC SURGERY
(2022)
Review
Dermatology
Uwe Wollina, Jean Kanitakis, Robert Baran
Summary: This narrative review discusses the impact of COVID-19 on the nail organ, as well as symptoms induced by personal protective measures and SARS-CoV-2 vaccination, while also exploring available treatment options.
DERMATOLOGIC THERAPY
(2021)
Letter
Dermatology
C. Lesort, J. Kanitakis, L. Donzier, D. Jullien
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Article
Surgery
Marion Patras, Evelyne Decullier, Celeste Lebbe, Julie Delyon, Jacques Dantal, Christophe Legendre, Manal Mazloum, Aurelie Du Thanh, Feriel Boukari, Emmanuel Morelon, Denis Jullien, Jean Kanitakis, Emilie Ducroux
Summary: This study assessed melanoma recurrence-free survival after pretransplant melanoma (PTM), showing reassuring results for in situ and stage IA PTM. Waiting time for transplantation is not mandatory for these patients, but caution is needed for those with higher stage melanomas.
TRANSPLANT INTERNATIONAL
(2021)
Review
Dermatology
M. Chastagner, J. Shourik, M. Jachiet, M. Battistella, G. Lefevre, J-B Gibier, H. Aubert, M. Musquer, V Descamps, L. Deschamps, O. Chosidow, N. Ortonne, M. Groh, M. Bernier, D. Jullien, F. Chasset, D. Staumont-Salle, J-D Bouaziz, J. Kanitakis, A. P. Villani
Summary: This study investigated the underlying diseases, treatments, and outcomes of patients with eosinophilic annular erythema (EAE). The results showed that topical or systemic corticosteroids, hydroxychloroquine, and dapsone were the most common and efficient treatments. In refractory patients, a combination of systemic corticosteroids with hydroxychloroquine achieved a high complete clinical response rate.
ANNALES DE DERMATOLOGIE ET DE VENEREOLOGIE
(2022)
Editorial Material
Dermatology
Caroline Andrea, Anne-Laure Breton, Jean Kanitakis
EUROPEAN JOURNAL OF DERMATOLOGY
(2021)
Review
Oncology
Nour Kibbi, Joshua L. Owen, Brandon Worley, Jake X. Wang, Vishnu Harikumar, Malia B. Downing, Sumaira Z. Aasi, Phyu P. Aung, Christopher A. Barker, Diana Bolotin, Jeremy S. Bordeaux, Todd Cartee, Sunandana Chandra, Nancy L. Cho, Jennifer N. Choi, Kee Yang Chung, William A. Cliby, Oliver Dorigo, Daniel B. Eisen, Yasuhiro Fujisawa, Nicholas Golda, Thorvardur R. Halfdanarson, Christos Iavazzo, Shang I. Brian Jiang, Jean Kanitakis, Ashraf Khan, John Y. S. Kim, Timothy M. Kuzel, Naomi Lawrence, Mario M. Leitao, Allan B. MacLean, Ian A. Maher, Bharat B. Mittal, Kishwer S. Nehal, David M. Ozog, Curtis A. Pettaway, Jeffrey S. Ross, Anthony M. Rossi, Sabah Servaes, Michael J. Solomon, Valencia D. Thomas, Maria Tolia, Bryan B. Voelzke, Abigail Waldman, Michael K. Wong, Youwen Zhou, Nobuo Arai, Alexandria Brackett, Sarah A. Ibrahim, Bianca Y. Kang, Emily Poon, Murad Alam
Summary: Extramammary Paget disease is a frequently recurring malignant neoplasm that requires multiple skin biopsies for diagnosis, with surgical resection preferred for intraepidermal and invasive disease. Non-surgical treatments like radiotherapy and medications are options for unresectable cases, with a recommendation for close follow-up for at least 5 years.
Article
Dermatology
C. Ferrandiz-Pulido, A. Gomez-Tomas, B. Llombart, D. Mendoza, J. Marcoval, S. Piaserico, C. Baykal, J. N. Bouwes-Bavinck, E. Racz, J. Kanitakis, C. A. Harwood, P. Cetkovska, A. Geusau, V Del Marmol, E. Masferrer, C. Orte Cano, J. Ricar, W. R. de Oliveira, R. Salido-Vallejo, E. Ducroux, M. A. Gkini, J. A. Lopez-Guerrero, H. Kutzner, W. Kempf, D. Seckin
Summary: The objective of this study was to describe the clinicopathological features of Merkel cell carcinoma (MCC) in solid-organ transplant recipients (SOTR) and identify factors associated with tumor outcomes. The results showed that the proportion of MCC patients with Merkel cell polyomavirus (MCPyV) was low in SOTR, and solid-organ transplantation was associated with an increased incidence of progression, MCC-specific mortality, and overall mortality. In SOTR, MCPyV positivity and switching to an mTOR inhibitor (mTORi) were associated with an increased incidence of progression.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Article
Immunology
Palmina Petruzzo, Jean Kanitakis, Claudia Sardu, Bahar Bassiri Gharb, Emmanuel Morelon, Hatem Amer, Juan Barret, James Burt, Gerald Brandacher, Tomas Gomez, Simon Kay, Dorotha Kaminska, Christina L. Kaufman, Dinesh S. Kumar, Martin Iglesias, Subramania Iyer, Luis Landin, Marco Lanzetta, Patrick Lassus, Scott Levin, Francis Papay, Bohdan Pomahac, Paolo Sassu, Nilesh G. Satbhai, Simon Talbot
Review
Dermatology
Margaux Dubus, Jean Kanitakis
Summary: Cutaneous epithelioid angiomatous nodule is a rare benign vascular tumour of the skin with characteristic microscopic features. There have been 65 reported cases since its initial description in 2004. A new typical case is presented here, along with a comprehensive review of all previously published cases, outlining the salient clinicopathological features of this rare tumor.
Article
Dermatology
Jean Kanitakis
Summary: Acantholysis is a microscopic finding that describes the breakdown of desmosomes and the formation of intraepithelial clefts in keratinocytes. It is commonly observed in actinic keratoses and squamous cell carcinomas, but rarely seen in basal cell carcinomas.
AMERICAN JOURNAL OF DERMATOPATHOLOGY
(2023)
Review
Dermatology
Jean Kanitakis, Nicolas Fournier, Denis Jullien
Summary: Porokeratoma is a rare type of epidermal acanthoma characterized by the presence of cornoid lamellae within a verrucous or keratotic nodule. This study reports a new case of porokeratoma involving hair follicles, which has only been reported in one previous case, and provides a review of all 23 published cases.
AMERICAN JOURNAL OF DERMATOPATHOLOGY
(2022)
