Review
Immunology
Irma Husain, Xunrong Luo
Summary: The therapeutic potential of using apoptotic cells in preventing and treating graft versus host disease, transplant rejection, and inducing donor-specific tolerance in solid organ transplantation has been explored in recent years. However, challenges and limitations exist in this apoptotic cell-based therapy, and further research and improvements are needed to overcome them.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Ludmilla Le Berre, Melanie Chesneau, Richard Danger, Florian Dubois, Damien Chaussabel, Mathieu Garand, Sophie Brouard
Summary: BANK1 transcript is upregulated in tolerant patients after kidney transplantation, and it plays a role in regulating effector T cell proliferation through Bregs expressing granzyme B. Despite being decreased in GZMB(+) Bregs, BANK1 is also down-regulated in other subtypes of Bregs and activated/differentiated B cells. Through analyzing transcriptomic studies and literature, a link between BANK1, tolerance, and Bregs was established, suggesting two different roles for BANK1 in B cells and Bregs.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Surgery
Hui-Yun Cheng, Chih-Fan Lin, Madonna Rica Anggelia, Ping-Chin Lai, Ling-Yi Shih, Shiao-Chin Liu, Fu-Chan Wei, Cheng-Hung Lin
Summary: This study evaluated the outcome of VCA surgery on reciprocal rodent donor-recipient combinations and found that the same immunosuppression regimen produced different results in different donor-recipient combinations. Modification of the model and immunosuppression regimen is needed based on the results.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2023)
Article
Multidisciplinary Sciences
Hiroaki Takeya, Shun Itai, Hiroo Kimura, Yuta Kurashina, Tsuyoshi Amemiya, Narihito Nagoshi, Takuji Iwamoto, Kazuki Sato, Shinsuke Shibata, Morio Matsumoto, Hiroaki Onoe, Masaya Nakamura
Summary: This study investigated the nerve regeneration effect of a Schwann cell-encapsulated chitosan-collagen hydrogel nerve conduit (CCN) in a rat model of sciatic nerve defect. The results showed that the CCN group with Schwann cell encapsulation had better motor functional recovery, axonal regrowth, and myelination compared to the CCN group without Schwann cells and the silicone tube group. Therefore, the Schwann cell-encapsulated CCN is a promising approach for peripheral nerve regeneration.
SCIENTIFIC REPORTS
(2023)
Review
Immunology
Min Hu, Natasha M. Rogers, Jennifer Li, Geoff Y. Zhang, Yuan Min Wang, Karli Shaw, Philip J. O'Connell, Stephen Alexander
Summary: Tregs play a crucial role in kidney transplantation by limiting immune activation and potentially reducing the need for immunosuppression. Studies have shown their importance in improving allo-specific Treg function in both animal and human models.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Surgery
Maureen Beederman, Chad M. Teven, Lawrence J. Gottlieb
Summary: This article discusses the ethical implications of living donor vascularized composite allotransplantation.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2022)
Article
Agronomy
Yan Chen, Dawei Wang, Ning Li, Deng Wang, Xiao-Hui Liu, Ying Song
Summary: This study found that rodent species living in arid areas exhibit elevated tolerance to anti-vitamin K rodenticides (AVKs). Through analyzing the DNA sequences of certain genes, researchers discovered an accelerated evolution rate in these genes among desert rodent species, indicating genetic preadaptation to AVKs.
PEST MANAGEMENT SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Nina Pilat, Romy Steiner, Jonathan Sprent
Summary: The limited success of solid organ transplantation is influenced by the insufficiency of immunosuppressive regimens to control chronic rejection and late graft loss. However, regulatory T cells (Tregs) have shown potential in inducing allograft tolerance and prolonging graft survival. The first Treg-based clinical trials have yielded promising results, demonstrating the feasibility and safety of Treg therapy in organ transplantation. Nevertheless, there are still unresolved questions regarding Treg phenotype, dosage, antigen-specificity, adjunct immunosuppressants, and efficacy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Filip Cvetkovski, J. Mark Hexham, Erik Berglund
Summary: Liver transplant recipients require lifelong immunosuppression therapy to preserve allograft function, which may lead to increased risks of malignancy, infection, renal impairment, and other toxicities. Although rare cases may achieve operational tolerance, predicting successful withdrawal of immunosuppression is difficult and requires long-term study.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Romy Steiner, Nina Pilat
Summary: Since the discovery of regulatory T cells (Tregs) as crucial regulators of immune tolerance, they have become a promising tool for inducing donor-specific tolerance in transplantation medicine. Various approaches, such as adoptive transfer, ex vivo expansion, and in vivo stimulation, have been explored to enhance Treg therapy. Furthermore, next generation concepts, such as CARs, TRUCKs, and BARs, are being investigated for improving Treg function. Clinical trials have shown promise, but long-term results and efficacy remain limited, and challenges for clinical translation remain open.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2023)
Book Review
Biochemistry & Molecular Biology
Graziela P. F. Dantas, Fausto S. Ferraz, Lidia M. Andrade, Guilherme M. J. Costa
Summary: The use of nanoscale materials for biomedical applications has raised concerns about their toxic effects on human health. This systematic review focuses on the reproductive toxicity of different types of inorganic nanoparticles in male rodents. The findings indicate that these nanoparticles can cause structural and functional alterations in testicular cells, leading to oxidative stress, apoptosis, and/or necrosis. However, the lack of standardized protocols in the studies results in highly variable outcomes.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Review
Immunology
Jason Cheung, Beata Zahorowska, Michael Suranyi, Jeffrey K. W. Wong, Jason Diep, Stephen T. T. Spicer, Nirupama D. D. Verma, Suzanne J. Hodgkinson, Bruce M. M. Hall
Summary: The immune response to an allograft can activate lymphocytes that cause rejection. The activation of T regulatory cells can reduce allograft rejection and induce immune tolerance. Activated T regulatory cells can be distinguished by various markers. A more detailed characterization of these cells may help reduce non-specific immunosuppression.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Casey O. Lightbourn, Dietlinde Wolf, Sabrina N. Copsel, Ying Wang, Brent J. Pfeiffer, Henry Barreras, Cameron S. Bader, Krishna V. Komanduri, Victor L. Perez, Robert B. Levy
Summary: Cyclophosphamide administered post hematopoietic stem cell transplantation may prolong survival of solid organ transplants by deleting or suppressing allo-reactive T cells, potentially reducing rejection responses. The timing of post-transplant cyclophosphamide administration is critical for the success of corneal transplants.
FRONTIERS IN IMMUNOLOGY
(2021)
Editorial Material
Cell Biology
Shifan Wang, Huijuan Guo, Feng Ge, Yucheng Sun
Summary: Apoptosis and autophagy are two important processes for host intracellular immunity against virus infection. A study on tomato yellow leaf curl virus (TYLCV) infected whiteflies revealed that the virus hijacks a master regulator called PEBP4 to activate apoptosis and autophagy simultaneously. The viral coat protein (CP) captures membrane-localized PEBP4, stabilizing its association with RAF1. This triple complex blocks a MAPK phosphorylation cascade and triggers apoptosis. At the same time, the CP competes for PEBP4 binding, promoting the disassociation of PEBP4 from ATG8 and initiating autophagy. Apoptosis increases the viral load, while autophagy degrades the virus. Only a balanced immune response involving both apoptosis and autophagy allows long-term coexistence between vectors and arboviruses.
Article
Cell & Tissue Engineering
Lisa M. McGinley, Matthew S. Willsey, Osama N. Kashlan, Kevin S. Chen, John M. Hayes, Ingrid L. Bergin, Shayna N. Mason, Aaron W. Stebbins, Jacquelin F. Kwentus, Crystal Pacut, Jennifer Kollmer, Stacey A. Sakowski, Caleb B. Bell, Cynthia A. Chestek, Geoffrey G. Murphy, Parag G. Patil, Eva L. Feldman
Summary: Research evaluated a novel MRI contrast agent for tracking stem cells post intracranial transplantation in vivo. Results demonstrated that the contrast agent does not impact cell viability and provides robust MRI contrast in animal brains. Linear correlations suggest the contrast agent aids in determining graft survival or rejection.
STEM CELLS TRANSLATIONAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Catherine E. Kling, James D. Perkins, Jorge D. Reyes, Martin I. Montenovo
LIVER TRANSPLANTATION
(2019)
Article
Pediatrics
Martin Montenovo, Kiran Bambha, Jorge Reyes, Andre Dick, James Perkins, Patrick Healey
PEDIATRIC TRANSPLANTATION
(2019)
Meeting Abstract
Oncology
Amir A. Rahnemai-Azar, Sean Ronnekleiv-Kelly, Daniel Abbott, Cecilia Grace Ethun, George A. Poultsides, Thuy Tran, Ryan Fields, Bradley Aaron Krasnick, Robert C. G. Martin, Charles Raben Scoggins, Kamran Idrees, Chelsea A. Isom, Ioannis Hatzaras, Rivfka Shenoy, Perry Shen, James D. Perkins, Timothy M. Pawlik, Shishir K. Maithel, Sharon M. Weber
JOURNAL OF CLINICAL ONCOLOGY
(2019)
Article
Multidisciplinary Sciences
Catherine R. Butler, James D. Perkins, Christopher K. Johnson, Christopher D. Blosser, Ramasamy Bakthavatsalam, Nicolae Leca, Lena Sibulesky
Article
Surgery
Catherine E. Kling, James D. Perkins, Scott W. Biggins, Christopher K. Johnson, Ajit P. Limaye, Lena Sibulesky
Meeting Abstract
Surgery
Andre A. Dick, Niviann Blondet, Patrick J. Healey, Jorge Reyes, James Perkins
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2019)
Article
Surgery
Jorge D. Reyes, Andre A. Dick, James B. Hendele, James D. Perkins, Evelyn K. Hsu
CLINICAL TRANSPLANTATION
(2020)
Article
Surgery
Ioannis A. Ziogas, Sophoclis P. Alexopoulos, Lea K. Matsuoka, Sunil K. Geevarghese, Lee D. Gorden, Seth J. Karp, James D. Perkins, Martin I. Montenovo
CLINICAL TRANSPLANTATION
(2020)
Letter
Gastroenterology & Hepatology
James B. Hendele, James D. Perkins, Lena Sibulesky
LIVER TRANSPLANTATION
(2020)
Article
Education, Scientific Disciplines
Danielle L. Sobol, Kathleen S. Berfield, Sherene Shalhub, Roger P. Tatum, Laura A. Yale, James D. Perkins, Kristine E. Calhoun
Summary: General surgery remains a male-dominated specialty, with fewer female professors. Despite the existence of subjective grading bias against women during medical school clerkships, women have achieved more clinical and final clerkship honors than men over the past decade, with similar exam grades, indicating that the gender imbalance is not related to clerkship evaluations.
JOURNAL OF SURGICAL EDUCATION
(2022)
Article
Immunology
J. B. Hendele, J. D. Perkins, N. Leca, S. W. Biggins, L. Sibulesky
Summary: This study analyzed a database of simultaneous liver-kidney transplant recipients and identified factors associated with poor post-transplant survival. Older age, higher liver disease severity, diabetes, dialysis prior to transplant, and ICU admission were all associated with lower survival rates. Similarly, receiving organs from older donors with poorer kidney function profiles also resulted in lower survival rates.
TRANSPLANTATION PROCEEDINGS
(2022)
Article
Surgery
William Christian Crannell, James D. Perkins, Nicolae Leca, Catherine E. Kling
Summary: The kidney donor risk index (KDRI) and kidney donor profile index (KDPI) provide continuous measures of donor quality. Through studying the impact of high KDPI labeling, it was found that the high KDPI label is associated with lower kidney utilization and increased discard rates.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Surgery
Lena Sibulesky, Nicolae Leca, Ramasamy Bakthavatsalam, James D. Perkins
Summary: Patients aged 70 and above achieve satisfactory outcomes following kidney retransplantation, highlighting that age should not preclude this medically complex population from this life-saving procedure. Improvement in functional status and timely retransplantation are the key factors to successful outcomes.
CLINICAL TRANSPLANTATION
(2023)
Meeting Abstract
Surgery
Kathryn Shaw, James Perkins, Sharon Bartosh, Patrick Healey, Jodi Smith, Andre Dick
AMERICAN JOURNAL OF TRANSPLANTATION
(2019)
Meeting Abstract
Surgery
Kathryn Shaw, James Perkins, Niviann Blondet, Patrick Healey, Simon Horslen, Andre Dick
AMERICAN JOURNAL OF TRANSPLANTATION
(2019)