Article
Multidisciplinary Sciences
Katherine R. Martin, Katherine L. Mansfield, Anna E. Savage
Summary: Characterizing MHC genes' polymorphism is crucial for understanding vertebrates' immune response to disease. This study explores the immunogenetic variation in sea turtles afflicted by fibropapillomatosis, a global infectious tumour disease. Extensive variation and trans-species polymorphism were recovered in MHC class I genes among green and loggerhead sea turtles. Supertyping analysis identified three functional MHC supertypes corresponding to well-supported clades in the phylogeny. Positive selection at seven amino acid sites in the class I exon was observed. One allele weakly associated with a specific tumour texture was found, suggesting a potential link between MHC diversity and disease outcome. This study highlights the importance of evaluating genetic predictors of disease, including MHC and other functional markers, in sea turtles.
ROYAL SOCIETY OPEN SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Yuying Sun, Fang Yuan, Ling Wang, Dongfa Dai, Zhijian Zhang, Fei Liang, Nan Liu, Juan Long, Xiao Zhao, Yongzhi Xi
Summary: This study generated fine-scale maps of MHC recombination and de novo mutations in Han Chinese families, revealing recombination hotspots and Han-specific breakpoints. The MHC de novo mutation rate was found to be higher than the genome-wide de novo mutation rate, and the polymorphisms generated by mutation and recombination were located within and outside linkage disequilibrium regions of the MHC, respectively. The evolution of the MHC locus was mainly controlled by positive selection.
JOURNAL OF GENETICS AND GENOMICS
(2022)
Article
Pharmacology & Pharmacy
Natsumi Mizuno, Yoshiki Yanagawa
Summary: In this study, it was found that tofacitinib enhanced IFN-gamma-induced MHC II expression in macrophages by transcriptional regulation through induction of CIITA, while decreasing the expression of CD86.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Review
Genetics & Heredity
Erick Velastegui, Edwin Vera, Wim Vanden Berghe, Mindy S. Munoz, Andrea Orellana-Manzano
Summary: HLA-C, located within the major histocompatibility complex, has become a prominent target in biomedical research due to its involvement in various diseases. The interaction between HLA-C and KIR is crucial for immune responses, particularly in viral infections. This review provides an overview of the structure, origin, function, and pathological implications of HLA-C, highlighting its genetic variations and susceptibility to epigenetic modifications.
FRONTIERS IN GENETICS
(2023)
Article
Biology
Sarah L. Jennings, Brian A. Hoover, Simon Yung Wa Sin, Susan E. Ebeler
Summary: This study found that volatile compounds from bird feathers can encode information about the MHC genes and play a role in mate choice. Individual MHC diversity, related to sex and breeding status, is reflected in feather chemicals, and similarity in MHC genotype is correlated with similarity in chemical profiles within female-female and male-female dyads.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2022)
Article
Genetics & Heredity
Ales Knoll, Jan Wijacki, Martin Plasil, Pamela A. Burger, Petr Horin
Summary: In this study, we identified and characterized 11 polymorphic microsatellite markers suitable for routine testing in dromedaries and Bactrian camels. These markers can be used to study the adaptive genetic diversity of the MHC region in Old World camels.
FRONTIERS IN GENETICS
(2022)
Article
Genetics & Heredity
Dong Chen, Yanjuan Li
Summary: The major histocompatibility complex (MHC) is a crucial locus on vertebrate DNA encoding cell surface proteins that play a key role in the adaptive immune system. An effective predictor called PredMHC was developed to identify MHC from protein sequences using a combination of features and classifiers. Experimental results demonstrated the accuracy and effectiveness of PredMHC in predicting MHC.
FRONTIERS IN GENETICS
(2022)
Article
Immunology
Ping Xia, Yu-Quan Shao, Cong-Cong Yu, Yu Xie, Zhi-Jie Zhou
Summary: This study found that the NLRP3 inflammasome plays an important role in the pathogenesis of polymyositis (PM). Inhibiting NLRP3 activation may hold promise for the treatment of PM.
Review
Genetics & Heredity
Martin Plasil, Jan Futas, April Jelinek, Pamela A. Burger, Petr Horin
Summary: This review provides a summary of the current knowledge on the major histocompatibility complex (MHC) in the family Felidae. Despite the potential for studying the biological functions of MHC genes in disease mechanisms and adaptation, our understanding of the MHC in the Felidae is fragmentary and based mainly on studies of the domestic cat and selected big cats. The structure and conservation of the MHC region in felids show similarities to those of other mammals, but there are some differences in gene contents. Further research is needed to explore the functional significance of felid MHC genes, particularly in relation to disease and conservation.
FRONTIERS IN GENETICS
(2022)
Article
Pediatrics
Ramesh Radhika, Milind S. Tullu, Sunil Karande, Umair Ahmed Bargir
Summary: Major Histocompatibility Complex (MHC) Class II deficiency is a rare autosomal recessive primary immunodeficiency caused by mutations in regulatory genes of MHC Class II proteins. This case report describes a 9-month-old girl presenting with repeated pneumonia, lymphocytopenia, and absence of HLA-DR expression on B cells, which led to the diagnosis of MHC Class II deficiency. Genetic analysis identified a homozygous mutation in the RFX-5 gene. Despite the patient's unfortunate outcome, the importance of prenatal diagnosis was emphasized to the parents.
INDIAN JOURNAL OF PEDIATRICS
(2023)
Article
Multidisciplinary Sciences
Ewa Pikus, Radoslaw Wlodarczyk, Jan Jedlikowski, Piotr Minias
Summary: The study found significant differentiation at the MHC class II gene between the old urban population and other populations. There was also moderate but significant divergence at the MHC between the new urban population and rural populations. The total number of MHC alleles and private alleles was lower in old urban populations compared to rural ones.
Article
Dermatology
Wencheng Fan, Zhuo Li, Yirui Wang, Chang Zhang, Hao Liu, Daiyue Wang, Yuanming Bai, Sihan Luo, Yuanyuan Li, Qin Qin, Weiwei Chen, Liang Yong, Qi Zhen, Yafen Yu, Huiyao Ge, Yiwen Mao, Lu Cao, Ruixue Zhang, Xia Hu, Yanxia Yu, Bao Li, Liangdan Sun
Summary: The study found no significant genetic correlation between bullous pemphigoid and dermatomyositis, but proved that the major histocompatibility complex region was significantly associated with both diseases separately.
JOURNAL OF DERMATOLOGY
(2022)
Article
Immunology
Luca D. Bertzbach, Clive A. Tregaskes, Rebecca J. Martin, Undine-Sophie Deumer, Lan Huynh, Ahmed M. Kheimar, Andele M. Conradie, Jakob Trimpert, Jim Kaufman, Benedikt B. Kaufer
Summary: The major histocompatibility complex (MHC) is crucial for appropriate immune responses against invading pathogens in chickens. VALO specific pathogen free (SPF) chickens possess MHC haplotypes that include B9, B9:02, B15, B19, and B21 at various frequencies. The study found that B15 homozygotes had the lowest tumor incidence while B21 homozygotes had the lowest number of organs with tumors. The data have immediate implications for the use of VALO SPF chickens and eggs in the life sciences.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemical Research Methods
Li Huang, Li Zhang, Xing Chen
Summary: MicroRNAs (miRNAs) are important gene regulators in the pathogenesis of complex diseases and have potential applications in diagnosis and therapy. Accurate discovery of miRNA-disease associations (MDAs) is crucial for effective miRNA therapy. This review revisits miRNA biogenesis, detection techniques, and functions, summarizes recent experimental findings related to common miRNA-associated diseases, introduces updates of relevant databases and web servers, and discusses the contribution of diverse data sources to accurate MDA prediction.
BRIEFINGS IN BIOINFORMATICS
(2022)
Article
Biology
W. Huang, J. M. Pemberton
Summary: By studying parent-offspring trios of MHCII genes in a wild population of sheep, it was found that there may not be strong post-copulatory selection at the diplotype level, but there were signs of transmission ratio distortion in certain haplotypes.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2021)
Article
Immunology
Mengkai Shieh, Nilesh Chitnis, Peter Clark, F. Brad Johnson, Malek Kamoun, Dimitri Monos
Article
Biotechnology & Applied Microbiology
Juliette Hordeaux, Yuan Yuan, Peter M. Clark, Qiang Wang, R. Alexander Martino, Joshua J. Sims, Peter Bell, Angela Raymond, William L. Stanford, James M. Wilson
Article
Biotechnology & Applied Microbiology
Camilo Breton, Peter M. Clark, Lili Wang, Jenny A. Greig, James M. Wilson
Article
Biochemical Research Methods
Pushkala Jayaraman, Timothy Mosbruger, Taishan Hu, Nikolaos G. Tairis, Chao Wu, Peter M. Clark, Monica D'Arcy, Deborah Ferriola, Katarzyna Mackiewicz, Xiaowu Gai, Dimitrios Monos, Mahdi Sarmady
Meeting Abstract
Biotechnology & Applied Microbiology
Jenny A. Greig, Cassandra Gorsuch, Joanna K. Chorazeczewski, Melanie K. Smith, Thomas Furmanak, Alexa N. Avitto, Scott N. Ashley, Wendy Sharer, Hui Li, Jeff Smith, Peter Clark, Camilo Breton, Derek Jantz, James M. Wilson
Meeting Abstract
Biotechnology & Applied Microbiology
Lili Wang, Claude Warzecha, Camilo Breton, Zhenning He, John White, Peter Bell, Elizabeth L. Buza, Peter M. Clark, Hanying Yan, Alexei Saveliev, Kirsten A. Copren, Derek Jantz, James M. Wilson
Meeting Abstract
Biotechnology & Applied Microbiology
L. Wang, I. Muthuramu, W. Sharer, J. Smith, V. Bartsevich, P. Clark, Z. He, H. Zhang, A. Saveliev, D. Jantz, J. M. Wilson
HUMAN GENE THERAPY
(2019)
Meeting Abstract
Biotechnology & Applied Microbiology
K. Nambiar, Q. Wang, P. Bell, P. Clark, J. M. Wilson
HUMAN GENE THERAPY
(2019)
Meeting Abstract
Biotechnology & Applied Microbiology
Jenny A. Greig, Camilo Breton, Gary Owens, Roshni Davey, Melanie K. Smith, Thomas Furmanak, Janel Lape, Peter Bell, Peter Clark, Jeff Smith, Derek Jantz, James M. Wilson
Meeting Abstract
Biotechnology & Applied Microbiology
Jenny A. Greig, Scott N. Ashley, Cassandra Gorsuch, Joanna Chorazeczewski, Thomas Furmanak, Yanqing Zhu, Peter Bell, Wendy Sharer, Hui Li, Jeff Smith, Peter Clark, Camilo Breton, James M. Wilson
Meeting Abstract
Biotechnology & Applied Microbiology
Qiang Wang, Gui Hu, Jia Zhang, Alexei Saveliev, Peter Clark, Claudia Lee, James M. Wilson
Meeting Abstract
Biotechnology & Applied Microbiology
Yuan Yuan, Juliette Hordeaux, Peter Clark, Qiang Wang, R. Alexander Martino, Joshua Sims, Peter Bell, Angela Raymond, William Stanford, Jams M. WIlson
Meeting Abstract
Biotechnology & Applied Microbiology
Camilo Breton, Thomas Furmanak, Peter Clark, Jenny A. Greig, James M. Wilson
Meeting Abstract
Biotechnology & Applied Microbiology
Lili Wang, Jeff Smith, Camilo Breton, Peter M. Clark, Jia Zhang, Lei Ying, Yan Che, Janel Lape, Peter Bell, Robert Calcedo, Elizabeth L. Buza, Alexei Saveliev, Victor V. Bartsevich, Zhenning He, John White, Minyao Li, Derek Jantz, James M. Wilson
Meeting Abstract
Biotechnology & Applied Microbiology
Kalyani Nambiar, Peter Clark, James M. Wilson