期刊
AMERICAN JOURNAL OF THERAPEUTICS
卷 16, 期 3, 页码 274-278出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MJT.0b013e3181822564
关键词
sinus node dysfunction; chronic lithium use; cardiovascular effects
Lithium is derived from the Greek word lithia which means stone. Since its discovery by the Swedish chemist Arfedsson in the year 1817, it has been used for treatment of gout, hypertension, uremia, and rheumatism. Currently, lithium is the treatment of choice for the long-term control of mania and to prevent relapse in bipolar disorder. It has a narrow therapeutic :index (0.6-1.2 mEq/L). Lithium overdose has been associated with a wide range of cardiovascular complications including cardiac arrhythmias and interstitial myocarditis. We present a review of published cases relevant to lithium-related cardiotoxicity.
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