Review
Nutrition & Dietetics
Louise Pitsillides, Gianluca Pellino, Paris Tekkis, Christos Kontovounisios
Summary: Probiotics may help lower the rates of infectious and non-infectious complications, reduce bacterial translocation, maintain intestinal mucosal permeability, and provide a better balance of beneficial to pathogenic microorganisms in CRC patients during the perioperative period.
Article
Food Science & Technology
Fabiana Helen Santos, Sandeep K. Panda, Danielle Cristine Mota Ferreira, Gargi Dey, Gustavo Molina, Franciele Maria Pelissari
Summary: Recently, there has been growing interest in nutraceutical compounds for the development of anti-infective and anti-inflammatory nutritional formulations. Various bio-based delivery vehicles, such as micro and nano particles, nano-emulsions, and liposome-based models, have shown potential in enhancing the bioaccessibility and bioavailability of these compounds. This review aims to provide recent information on effective nutraceuticals and suitable delivery vehicles for combating infections and inflammatory conditions.
Review
Gastroenterology & Hepatology
Michael W. Dougherty, Christian Jobin
Summary: The development of colorectal cancer is influenced by the presence of bacterial communities in the gastrointestinal tract. These microorganisms obtain essential nutrients from indigestible compounds and play a role in molecular signaling pathways that are necessary for normal tissue and immune function. Several bacterial species, such as Fusobacterium nucleatum, Enterotoxigenic Bacteroides fragilis, and pks(+) E. coli, have been identified to potentially increase the risk of colorectal cancer. Recent research has expanded on this topic to include host mutational status, microbial heterogeneity within tumors, transient infections, and the cumulative effects of multiple carcinogenic bacteria. This review provides an updated overview of how host-bacteria interactions influence colorectal cancer development, potential applications in diagnosis or prevention, and the impact of the gut microbiome on colorectal cancer treatment efficacy.
Review
Nutrition & Dietetics
Yifan Wu, Gongsheng Zhang, Yucong Wang, Xin Wei, Huanhuan Liu, Lili Zhang, Lanwei Zhang
Summary: Allergic diseases are prevalent in infants worldwide and are closely related to maternal and infant flora composition and metabolism. The mother's flora, including breast milk, intestinal, and vaginal flora, affects the infant's immune system development during pregnancy and lactation. Changes in maternal flora composition and function are associated with infant allergic diseases. The infant's own flora, especially the intestinal flora, plays a role in the development and regulation of allergic diseases, and is affected by allergic diseases.
Review
Cell Biology
Ling Wang, Ke-Chun Yu, Yun-qing Hou, Min Guo, Fan Yao, Zhen-Xia Chen
Summary: Colorectal cancer (CRC) is the most common malignant tumor in the digestive system, and the gut microbiome plays a crucial role in its development and treatment. This review discusses the effects of gut microbiome dysbiosis on CRC and explores the mechanisms behind it. The modulation of gut microbiome is a novel strategy for preventing and treating CRC. Probiotics can protect the intestinal barrier, inhibit cancer cell growth, resist oxidative stress, and enhance the host's immune system to antagonize CRC tumorigenesis. Clinical applications of the gut microbiome, such as biomarker screening and prediction, as well as microbe modulation for CRC prevention, treatment enhancement, and reduction of side effects, are also highlighted.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Naoki Sugimura, Qing Li, Eagle Siu Hong Chu, Harry Cheuk Hay Lau, Winnie Fong, Weixin Liu, Cong Liang, Geicho Nakatsu, Anthony Chin Yang Su, Olabisi Oluwabukola Coker, William Ka Kei Wu, Francis Ka Leung Chan, Jun Yu
Summary: In this study, we found that L. gallinarum significantly reduced intestinal tumor number and size in murine models, by producing protective metabolites that promote apoptosis of colorectal cancer cells, thus protecting against intestinal tumorigenesis.
Article
Biochemistry & Molecular Biology
Ifeoma Julieth Dikeocha, Abdelkodose Mohammed Al-Kabsi, Hsien-Tai Chiu, Mohammed Abdullah Alshawsh
Summary: This study demonstrated the potential role of F. prausnitzii in the prevention and management of colorectal cancer, showing its anti-tumorigenic and antiproliferative effects, as well as its modulation of gut microbiota diversity in rats.
Review
Gastroenterology & Hepatology
Monika Kvakova, Anna Kamlarova, Jana Stofilova, Veronika Benetinova, Izabela Bertkova
Summary: Colorectal cancer is a major cause of death worldwide. Conventional anticancer therapy is not always effective, leading to growing interest in drug-free cancer treatments or interventions that improve the efficacy of established therapy. Supplementing patient treatment with probiotics, next-generation probiotics, or postbiotics can restore gut microbiota composition and/or signaling to the host, providing an effective and accessible complementary anticancer strategy.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Food Science & Technology
Xiaoran Song, Yanan Liu, Xin Zhang, Peifang Weng, Ruilin Zhang, Zufang Wu
Summary: Accumulating evidence suggests that probiotics in the gastrointestinal tract play an important role in regulating host metabolism, particularly in the treatment of lipid metabolism diseases. However, the relationship between probiotics and abnormal lipid metabolism remains unclear, and the mechanisms of action are the focus of microbiome research. This article explores the connection between intestinal probiotics and lipid metabolism, discusses the underlying mechanisms, and provides therapeutic strategies for abnormal lipid metabolism. It serves as a reference for the utilization of probiotics in functional foods and benefits the clinical diagnosis and treatment of lipid metabolism diseases.
FOOD SCIENCE AND HUMAN WELLNESS
(2023)
Review
Gastroenterology & Hepatology
Ramesh Pothuraju, Sanjib Chaudhary, Satyanarayana Rachagani, Sukhwinder Kaur, Hemant K. Roy, Michael Bouvet, Surinder K. Batra
Summary: An imbalance in the crosstalk between host and gut microbiota can lead to inflammatory diseases and colorectal cancer, with dietary patterns playing a crucial role in regulating gut microbiota composition and maintaining mucin expression. Proper communication between host and gut microbiota through different dietary patterns is essential for maintaining mucus composition and regulation in health and disease.
Article
Nutrition & Dietetics
Emmanouil Benioudakis, Eleni Karlafti, Alexandra Bekiaridou, Triantafyllos Didangelos, Theodossis S. Papavramidis
Summary: Diabetes mellitus patients have increased surgical and post-surgical risks, and the gut microbiota seems to play a crucial role in glucose homeostasis and insulin resistance. The use of probiotics can enhance gut microbiota homeostasis and promote healing and anti-inflammatory effects in diabetic patients undergoing surgery.
Review
Microbiology
Zhenyu Dong, Ruixian Shi, Pengda Li, Xiaobiao Song, Fan Dong, Jianmin Zhu, Riga Wu, Zhi Liang, Mingyue Du, Jijun Wang, Zhigang Yang
Summary: This article reviews the literature to summarize the research progress on the correlation between the occurrence of colorectal tumors after cholecystectomy, aiming to provide help for the prevention and treatment of colorectal tumors.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Microbiology
Christina Thoda, Maria Touraki
Summary: Colorectal cancer (CRC) is a global disease with high morbidity and mortality rates. Drug resistance and side effects of chemotherapy have led to the need for alternative anticancer agents, such as probiotic-derived bioactive compounds. These compounds, including bacteriocins, short-chain fatty acids, and bacterial peptides, exhibit anti-inflammatory and antiproliferative properties. This review summarizes the classification and biological role of postbiotics, as well as their interaction with the gut microbiota and their potential for CRC prevention and treatment.
Review
Food Science & Technology
Hadi Feizi, Andrey Plotnikov, Mohammad Ahangarzadeh Rezaee, Khudaverdi Ganbarov, Fadhil S. Kamounah, Sergei Nikitin, Hiva Kadkhoda, Pourya Gholizadeh, Pasquale Pagliano, Hossein Samadi Kafil
Summary: The mechanisms and applications of probiotics and postbiotics in preventing and treating early-onset colorectal cancer are of significant importance but are still subject to debate. Probiotics exert anticancer features through immune system regulation, inhibition of cancer cell propagation, and other mechanisms, while postbiotics restore eubiosis against EOCRC through modulation of gut microbiota composition, regulation of microbial metabolites, and improvement of intestinal barrier function.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Nutrition & Dietetics
Shaowei Bai, Guangyun Zhang, Yaqin Han, Jianwei Ma, Bing Bai, Jingjie Gao, Zuoming Zhang
Summary: The active components of ginseng, such as ginsenosides and polysaccharides, have high therapeutic value in treating cancer, decreasing obesity, and enhancing immunity. However, simple primary ginseng treatment cannot maximize this medicinal potential. Therefore, in this study, Panax ginseng was co-fermented with multi-enzyme-coupling probiotics to obtain a fermentation broth with higher levels of ginsenosides, polysaccharides, and probiotics. The results reveal that the P. ginseng fermentation broth treated with multi-enzyme-coupling probiotics could significantly improve the immune function of immunosuppressive mice and restore intestinal flora stability, providing a novel strategy for promoting the application of ginseng and the relief of immunosuppression.