Article
Biochemistry & Molecular Biology
Teppei Okabe, Yosuke Kamiya, Takeshi Kikuchi, Hisashi Goto, Masayuki Umemura, Yuki Suzuki, Yoshihiko Sugita, Yoshikazu Naiki, Yoshiaki Hasegawa, Jun-ichiro Hayashi, Shotaro Kawamura, Noritaka Sawada, Yuhei Takayanagi, Takeki Fujimura, Naoya Higuchi, Akio Mitani
Summary: This study found that the culture supernatant of Porphyromonas gingivalis accelerated inflammation in the lungs of Streptococcus pneumoniae-infected mice, and increased inflammatory cell infiltration. Compared to S. pneumoniae infection alone, PgSup synergistically increased TNF-alpha and IL-17 expression/production.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Kat Franklin, Brenda Kwambana-Adams, Fernanda C. Lessa, Heidi M. Soeters, Laura Cooper, Matthew E. Coldiron, Jason Mwenda, Martin Antonio, Tomoka Nakamura, Ryan Novak, Adam L. Cohen
Summary: The study reviewed and analyzed 10 potential pneumococcal meningitis outbreaks in Africa between 2000 and 2018. These outbreaks showed lower peak attack rates than meningococcal meningitis outbreaks and were characterized by a predominance of serotype 1. Patients with pneumococcal meningitis tended to be older and had a higher case fatality rate compared to meningococcal meningitis cases. Improved laboratory testing for S. pneumoniae is essential for early outbreak identification.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Biology
Philip H. C. Kremer, Bart Ferwerda, Hester J. Bootsma, Nienke Y. Rots, Alienke J. Wijmenga-Monsuur, Elisabeth A. M. Sanders, Krzysztof Trzcinski, Anne L. Wyllie, Paul Turner, Arie van der Ende, Matthijs C. Brouwer, Stephen D. Bentley, Diederik van de Beek, John A. Lees
Summary: This study identified genetic variations in pneumococcal carriage that differ between infants and adults. Serotypes and genetic background were found to explain a proportion of the heritability in carriage. The findings support the proposal for adaptive vaccination strategies targeting dominant circulating serotypes and tailored to the composition of the pathogen populations.
Review
Infectious Diseases
Fereshte Sheybani, Matthijs C. Brouwer, Diederik van de Beek
Summary: Bacterial meningitis in patients with multiple myeloma is rare but severe, with high rates of unfavorable outcomes. These patients often present with a lower cerebrospinal fluid leukocyte count compared to those without multiple myeloma. Physicians should have a low threshold for performing lumbar puncture and initiating antibiotic treatment in these patients.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Editorial Material
Microbiology
Marco Rinaldo Oggioni, Uwe Koedel
Summary: Researchers have found a link between impaired glymphatic system functionality and neurological sequelae caused by Streptococcus pneumoniae meningitis. This study provides an important initial step in evaluating the potential impact of glymphatic system functionality on disease severity and sequelae in meningitis.
Article
Microbiology
Tomoko Sumitomo, Masanobu Nakata, Satoshi Nagase, Yuki Takahara, Mariko Honda-Ogawa, Yasushi Mori, Yukako Akamatsu, Masaya Yamaguchi, Shigefumi Okamoto, Shigetada Kawabata
Summary: Influenza A virus infection increases susceptibility to secondary bacterial pneumonia, with GP96 on infected cell surfaces mediating interactions with Streptococcus pneumoniae, leading to increased bacterial adherence and translocation. Inhibition of GP96 enhances pneumococcal clearance and reduces lung pathology in infected mice, suggesting a potential therapeutic target for inhibiting bacterial colonization in an IAV-infected respiratory tract.
Article
Infectious Diseases
Hideo Kato, Mao Hagihara, Yoshihiko Morikawa, Nobuhiro Asai, Hiroshige Mikamo, Takuya Iwamoto
Summary: This study retrospectively evaluated the effectiveness and safety of ceftriaxone administered twice daily with a dosage of 1 g versus ceftriaxone administered once daily with a dosage of 2 g for the treatment of aspiration pneumonia. The results showed that the once daily administration of 2 g ceftriaxone had significantly improved clinical responses compared to the twice daily administration of 1 g. The incidence of choleliths during ceftriaxone therapy was also found to be lower in the once daily administration group.
Article
Pediatrics
Dongdong Wang, Jianshe Zhao, Ran Zhang, Qinghu Yan, Lu Zhou, Xiaoyu Han, Yafei Qi, Dexin Yu
Summary: This study investigated the value of CT radiomics in differentiating mycoplasma pneumoniae pneumonia (MPP) from streptococcus pneumoniae pneumonia (SPP) in children under 5 years old. The random forest (RF) model was found to have the best classification efficiency in identifying MPP from SPP.
FRONTIERS IN PEDIATRICS
(2022)
Article
Immunology
Eileen M. Dunne, Yinglei Hua, Rasheed Salaudeen, Ilias Hossain, Malick Ndiaye, Belinda D. Ortika, E. Kim Mulholland, Jason Hinds, Sam Manna, Grant A. Mackenzie, Catherine Satzke
Summary: We investigated the pathogenesis of pneumococcal pneumonia using clinical samples. Results demonstrated that pneumococci in the lung originated from the nasopharynx and suggested that changes in pneumococcal gene expression in the lung are a feature of pneumococcal pneumonia.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Clinical Neurology
Stefanie Voelk, Markus Pfirrmann, Uwe Koedel, Hans-Walter Pfister, Thomas Lang, Franziska Scheibe, Farid Salih, Julia Herzig-Nichtweiss, Julian Zimmermann, Angelika Alonso, Matthias Wittstock, Andreas Totzeck, Patrick Schramm, Ingo Schirotzek, Oezguer A. Onur, Johann Otto Pelz, Caroline Ottomeyer, Sebastian Luger, Kristian Barlinn, Tobias Binder, Gabriele Woebker, Gernot Reimann, Christian Urbanek, Jan Heckelmann, Piergiorgio Lochner, Martin Berghoff, Silvia Schoenenberger, Bernhard Neumann, Wolf-Dirk Niesen, Christian Dohmen, Hagen B. Huttner, Albrecht Guenther, Matthias Klein
Summary: This study demonstrates a decrease in the number of patients with bacterial and viral meningitis as well as otolaryngological infections during the COVID-19 pandemic, suggesting a possible correlation with hygiene measures.
JOURNAL OF NEUROLOGY
(2022)
Article
Public, Environmental & Occupational Health
Kai Zheng, Liang Zhu, Yiwei Ding, Xixi Zhang, Ning Chen, Gang Liu, Qiushui He
Summary: The study revealed significant changes in serum pro-inflammatory and anti-inflammatory cytokines in pediatric patients with pneumococcal meningitis. IL-10 levels were significantly higher, while IL-12p40, IL-17A, and IL-1 beta levels were significantly lower in patients compared to healthy controls. Additionally, there was a negative correlation between blood neutrophil percentages and IL-10 concentrations, and lower levels of IL-12p40 and CXCL-1 were observed in patients with sepsis.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2021)
Article
Multidisciplinary Sciences
Bin Chang, Kosuke Tamura, Hiroyuki Fujikura, Hiroshi Watanabe, Yoshinari Tanabe, Koji Kuronuma, Jiro Fujita, Kengo Oshima, Takaya Maruyama, Shuichi Abe, Kei Kasahara, Junichiro Nishi, Tetsuya Kubota, Yuki Kinjo, Yusuke Serizawa, Reiko Shimbashi, Munehisa Fukusumi, Tomoe Shimada, Tomimasa Sunagawa, Motoi Suzuki, Kazunori Oishi
Summary: This study assessed the impact of pediatric 13-valent pneumococcal conjugate vaccine (PCV13) on pneumococcal meningitis in adults in Japan from 2014 to 2018. Results showed that younger age and lower case fatality rate were associated with meningitis in adult patients. Factors such as splenic dysfunction, specific serotypes, and age influenced the occurrence of meningitis. PCV13 had an indirect effect on non-meningitis cases, but its impact on meningitis was limited due to an increase in non-PCV13 serotypes.
SCIENTIFIC REPORTS
(2022)
Article
Health Care Sciences & Services
Christopher C. Blyth, Kathryn J. Britton, Cattram D. Nguyen, Joycelyn Sapura, John Kave, Birunu Nivio, Jocelyn Chan, Catherine Satzke, Rebecca Ford, Wendy Kirarock, Deborah Lehmann, William Pomat, Fiona M. Russell
Summary: This study evaluates the effectiveness of the 13-valent pneumococcal conjugate vaccine (13vPCV) in reducing hypoxic pneumonia and hospitalization in children in Eastern Highlands Province, Papua New Guinea (PNG).
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2022)
Article
Immunology
Flavia Rayssa Braga Martins, Maycon Douglas de Oliveira, Jessica Amanda Marques Souza, Celso Martins Queiroz-Junior, Francisco Pereira Lobo, Mauro Martins Teixeira, Nathalia Luisa Malacco, Frederico Marianetti Soriani
Summary: This study aimed to investigate the inflammatory mechanisms involved in pneumococcal pneumonia associated with chronic ethanol exposure. The results showed that alcohol-fed mice produced higher levels of nitric oxide and CXCL1 during pneumonia, exhibited reduced leukocyte infiltration and less severe lung inflammation, but no changes in survival after infection.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Sunil Palani, Md Bashir Uddin, Michael McKelvey, Shengjun Shao, Keer Sun
Summary: The susceptibility of B6 mice to pneumococcal pneumonia after mild IAV infection is primarily attributed to the type 1 immune predisposition. IFN-γ signaling inhibits neutrophil recruitment and bacterial clearance in B6 mice, leading to lethal coinfection.
FRONTIERS IN IMMUNOLOGY
(2023)