Review
Gastroenterology & Hepatology
Takashi Murakami, Taro Kurosawa, Hirofumi Fukushima, Tomoyoshi Shibuya, Takashi Yao, Akihito Nagahara
Summary: The term sessile serrated lesion (SSL) was introduced in the 2019 WHO Classification of Tumours of the Digestive System as an early precursor lesion in the serrated neoplasia pathway. These lesions can quickly progress into dysplastic or invasive carcinomas with high lymphatic invasion potential.
DIGESTIVE ENDOSCOPY
(2022)
Review
Pathology
Kenneth P. Batts, Birtukan Cinnor, Adam Kim, Emily Stickney, Lawrence J. Burgart
Summary: This study aimed to explore the relative percentages and significance of subtypes of sessile serrated adenomas with dysplasia (SSADs) in the colon. The results showed that while some trends exist, morphologically subclassifying SSADs is probably not justified in routine clinical practice. Loss of MLH1 indicates an increased burden of sessile serrated adenomas in the background colon.
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
(2022)
Article
Gastroenterology & Hepatology
Mehul Trivedi, Suha Godil, Joshua Demb, Ashley Earles, Ranier Bustamante, Olga Patterson, Andrew J. Gawron, Tonya Kaltenbach, Sumana Mahata, Lin Liu, Samir Gupta
Summary: This study aimed to investigate the clinical characteristics and long-term outcomes associated with traditional serrated adenomas (TSAs). The results showed that TSA patients have an increased risk for colorectal cancer (CRC) and a risk of developing other high-risk neoplasia during follow-up surveillance colonoscopy.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Jooyoung Lee, Jung Ho Bae, Su Jin Chung, Hae Yeon Kang, Seung Joo Kang, Min-Sun Kwak, Ji Yeon Seo, Ji Hyun Song, Sun Young Yang, Jong In Yang, Seon Hee Lim, Jeong Yoon Yim, Joo Hyun Lim, Goh Eun Chung, Eun Hyo Jin, Ji Min Choi, Yoo Min Han, Joo Sung Kim
Summary: Comprehensive optical diagnosis training with WASP classification significantly increased the overall SDR of expert endoscopists, while it did not have a significant impact on ADR.
DIGESTIVE ENDOSCOPY
(2022)
Review
Cell Biology
Iris D. Nagtegaal, Dale C. Snover
Summary: The precursor lesion for around 30% of colon carcinomas, known as sessile serrated adenoma, remains controversial and has sparked debates over alternative names. Despite the term sessile serrated lesion being adopted by the World Health Organization in 2019, universal acceptance is still lacking.
Article
Pathology
Filippo Cappello, Valentina Angerilli, Luca Dal Santo, Giada Munari, Marianna Sabbadin, Marcello Lo Mele, Gianmaria Pennelli, Claudio Luchini, Paola Parente, Stefano Lazzi, Matteo Fassan
Summary: Adenomatous dysplasia may develop in sessile serrated lesions (SSL) as part of the serrated lesion. However, some of these lesions may represent collisions between a serrated polyp and a conventional adenoma. Based on mutational analysis and MMR status, we found that adenomatous dysplasia in SSL may develop as part of the serrated lesion, while polyps morphologically classified as mixed lesions are more likely to be collision lesions.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Oncology
Jung Ho Kim, Jeong Hoon Hong, Yoon-La Choi, Ji Ae Lee, Mi-kyoung Seo, Mi-Sook Lee, Sung Bin An, Min Jung Sung, Nam-Yun Cho, Sung-Su Kim, Young Kee Shin, Sangwoo Kim, Gyeong Hoon Kang
Summary: The study revealed that NTRK-rearranged colorectal tumors develop exclusively through the serrated neoplasia pathway and can be initiated from non-dysplastic SSLs without BRAF/KRAS mutations prior to full occurrence of MSI-high/CIMP-high.
JOURNAL OF PATHOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sangeeta Jaiswal, Bishnu Joshi, Jing Chen, Fa Wang, Michael K. Dame, Jason R. Spence, Gina M. Newsome, Erica L. Katz, Yatrik M. Shah, Sadeesh K. Ramakrishnan, Gaoming Li, Miki Lee, Henry D. Appelman, Rork Kuick, Thomas D. Wang
Summary: The study identified that Prdx1 is overexpressed on the cell surface in the presence of oxidative stress and can serve as an imaging biomarker for in vivo detection of SSAs.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Oncology
Celina N. Santiago, Samara Rifkin, Julia Drewes, Gerard Mullin, Emma Spence, Linda M. Hylind, Joell J. Gills, David Kafonek, David M. Cromwell, Louis La Luna, Francis Giardello, Cynthia L. Sears
Summary: Metabolic risk factors, particularly obesity and diabetes, are positively associated with colon polyps. Obesity and hypertension may increase the incidence of synch polyps, while no association was found between metabolic risk factors and the onset of SSPs.
CANCER PREVENTION RESEARCH
(2021)
Article
Gastroenterology & Hepatology
Yasuhiko Mizuguchi, Yusaku Tanaka, Hourin Cho, Masau Sekiguchi, Hiroyuki Takamaru, Masayoshi Yamada, Taku Sakamoto, Takahisa Matsuda, Taiki Hashimoto, Shigeki Sekine, Yutaka Saito
Summary: The study evaluated the endoscopic features of isolated and TSA-associated SuSAs, finding that they exhibit several characteristic features on white-light and image-enhanced endoscopy, with diminutive lesions overlapping with hyperplastic polyps. However, the endoscopic diagnosis of larger and TSA-associated SuSAs may be feasible.
DIGESTIVE ENDOSCOPY
(2022)
Article
Gastroenterology & Hepatology
Shahzaib Anwar, Charles Cock, Joanne Young, Graeme P. Young, Rosie Meng, Kalindra Simpson, Michelle Coats, Junming Huang, Peter Bampton, Robert Fraser, Erin L. Symonds
Summary: The prevalence of high-risk serrated polyps decreased by one-third at the first follow-up colonoscopy, but the proportion of serrated polyps with high-risk features remained the same. Females were more likely to have high-risk serrated polyps at the index colonoscopy, while those at greatest risk for high-risk serrated polyps at follow-up colonoscopy were aged over 75 years and had an index high-risk serrated polyp.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Oncology
Tamas Micsik, Anna Jakab, Csaba Lehoczki, Arpad V. Patai
Summary: While the majority of laparoscopic cholecystectomy specimens show typical findings, sometimes unusual structures can be found. In our case, a 67-year-old woman underwent routine laparoscopic cholecystectomy and was diagnosed with a rare traditional serrated adenoma of the gallbladder.
PATHOLOGY & ONCOLOGY RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Seung Wook Hong, Jeongseok Kim, Ji Young Lee, Jong-Soo Lee, Hye-Sook Chang, Hye Won Park, Gwang-Un Kim, Jiyoung Yoon, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Jaewon Choe, Dong-Hoon Yang
Summary: This study found that individuals with synchronous SSL did not have a significantly increased risk of metachronous HRA/AA, but did have an increased risk of metachronous SSL compared to those without SSL.
DIGESTIVE ENDOSCOPY
(2022)
Review
Gastroenterology & Hepatology
Paul P. Shao, Changhan R. Shao, Tahmineh Romero, Felix W. Leung
Summary: This study found that water exchange significantly increases the detection rate of sessile serrated adenomas/polyps, and is superior to Endocuff and cap colonoscopy in detecting them.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Multidisciplinary Sciences
Dan Yoon, Hyoun-Joong Kong, Byeong Soo Kim, Woo Sang Cho, Jung Chan Lee, Minwoo Cho, Min Hyuk Lim, Sun Young Yang, Seon Hee Lim, Jooyoung Lee, Ji Hyun Song, Goh Eun Chung, Ji Min Choi, Hae Yeon Kang, Jung Ho Bae, Sungwan Kim
Summary: A polyp detection system utilizing a generative adversarial network (GAN) was proposed to effectively detect easily overlooked polyps, especially sessile serrated lesions. By synthesizing high-resolution endoscopic images, the system showed a significant 17.5% improvement in performance for detecting sessile serrated lesions.
SCIENTIFIC REPORTS
(2022)