Editorial Material
Orthopedics
Andy Williams
Summary: Lateral extra-articular tenodesis (LET) reduces the risk of ACL graft rerupture in high-risk patients. Ilio-tibial band (ITB)-related LET is believed to effectively restrain anterolateral rotatory instability (ALRI) in ACL-injured and reconstructed knees. However, there is a potential for conflict between a modified Lemaire LET femoral tunnel and an ACL femoral tunnel, which may lead to iatrogenic ACL graft damage or compromised fixation.
ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY
(2022)
Article
Orthopedics
Alberto Grassi, Luca Macchiarola, Gian Andrea Lucidi, Annamaria Silvestri, Giacomo Dal Fabbro, Maurilio Marcacci, Stefano Zaffagnini
Summary: The study examined long-term outcomes and predictors of success or failure after ACL reconstruction, finding that most patients achieved satisfactory function, symptoms, and quality of life after 10 years. Female sex and severity of chondropathy were identified as predictors of poorer outcomes in patients' recovery and quality of life.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2021)
Article
Medicine, General & Internal
Marc Dauty, Vincent Crenn, Bastien Louguet, Jerome Grondin, Pierre Menu, Alban Fouasson-Chailloux
Summary: This study identified age, body mass index, knee laxity, knee strength, and passive knee alignment as risk factors for non-contact ACL injuries. Among these factors, age, passive knee extension, and weak hamstring strength were associated with a higher risk, while passive knee valgus was specifically identified as a risk factor for women. These findings suggest that hamstring strengthening exercises could be beneficial in preventing ACL injuries in young male athletes or individuals with knee laxity.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Orthopedics
Ahmed Mahmoud, Stephen Torbey, Conor Honeywill, Peter Myers
Summary: The study found that patients undergoing combined anterior cruciate ligament reconstruction and lateral extra-articular tenodesis showed good graft survival and patient-reported outcome measures (PROMS), suggesting that lateral extra-articular tenodesis is an effective technique in restoring joint stability for knees with additional risk factors.
ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY
(2022)
Editorial Material
Orthopedics
Andrew G. Geeslin, Jorge Chahla, Robert F. LaPrade
Summary: The anterolateral complex (ALC) of the knee has regained attention due to its potential role in ACL tear biomechanics and surgical outcomes. The precise anatomical locations and biomechanical relevance of the ALC structures are still debated, but studies have shown that the ALC contributes to restraining tibial rotation and anterior translation.
ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY
(2022)
Article
Medicine, General & Internal
Dawid Szwedowski, Lukasz Paczesny, Jan Zabrzynski, Maciej Gagat, Marcin Domzalski, Gazi Huri, Wojciech Widuchowski
Summary: The study compared the stability and function after ACL primary repair with single-bundle ACLR, showing a significant decrease in anterior tibial translation in the ACL repair group. Functional outcomes after ACL repair with internal bracing were comparable to ACLR, but two complications were noted. This supports further development of ACL repair techniques.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Orthopedics
Yong-Beom Park, Han-Jun Lee, Hyung-Chul Cho, Nicolas Pujol, Seong Hwan Kim
Summary: The purpose of this study was to compare the outcomes of isolated anterior cruciate ligament (ACL) reconstruction, combined lateral extraarticular tenodesis (LET), and anterolateral ligament reconstruction (ALLR) using a network meta-analysis. The results showed that ACL + ALLR had significantly better knee rotational stability and graft failure rate compared to isolated ACL reconstruction, but the clinical outcomes were uncertain after a minimum 12 months follow-up. Therefore, ACL + ALLR was considered the most preferred technique for patients with ACL injury.
ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY
(2023)
Article
Orthopedics
Simone Perelli, Giuseppe Gianluca Costa, Veronica Montiel Terron, Mario Formagnana, Corrado Bait, Joao Espregueira-Mendes, Juan Carlos Monllau
Summary: This study showed that adding LET to ACL reconstruction in pediatric patients significantly improves anteroposterior and rotational stability, reduces failure rates, but does not result in significant differences in patient-reported outcomes or return-to-sports activity.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Toan Nguyen, Shamrez Haider, David Tietze, Yin Xi, Uma Thakur, Jay Shah, Avneesh Chhabra
Summary: ACL reconstruction tunnel location is an important predictor for outcomes after surgery. This study established 3D and 2D MRI radiological measurements to provide information for pre-operative planning for anatomical graft placement. The measurements were also correlated in a subset of patients on arthroscopy. The results showed both 2D and 3D MRI had good inter-reader reliability with small inter-modality mean differences in the measurements.
EUROPEAN RADIOLOGY
(2022)
Article
Orthopedics
Stefano Di Paolo, Alberto Grassi, Nicola Pizza, Gian Andrea Lucidi, Giacomo Dal Fabbro, Luca Macchiarola, Stefano Zaffagnini
Summary: The use of lateral plasty in ACL reconstruction reduced anterior-posterior knee laxity caused by medial meniscectomy. In ACL-deficient status, combined medial meniscectomy led to significantly increased knee laxity, without differences between surgical techniques.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2022)
Review
Orthopedics
James Randolph Onggo, Hari Krishnan Rasaratnam, Mithun Nambiar, Jason Derry Onggo, Vishal Pai, Iswadi Damasena, Arash Riazi, Sina Babazadeh
Summary: This meta-analysis found that LEAT in combination with ACLR improved anterolateral knee stability, had better clinical outcomes, and reduced graft rerupture rate compared to ACLR alone. Although statistically significant, the clinical significance of improved Lysholm and IKDC scores in the LEAT group may be limited, and further studies are needed to identify patient populations that would benefit the most from LEAT.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2022)
Review
Orthopedics
Eoghan T. Hurley, Amit K. Manjunath, Eric J. Strauss, Laith M. Jazrawi, Michael J. Alaia
Summary: The study systematically reviewed evidence on return to play rates after ACLR with extra-articular augmentation (EA) and found that EA resulted in high levels of return to play, especially for primary ACLR patients. However, revision ACLR patients had lower return rates. Comparative studies showed similar return rates for primary ACLR with or without EA.
ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY
(2021)
Article
Orthopedics
Daniel W. Green, Sofia Hidalgo Perea, Christopher M. Brusalis, Danielle E. Chipman, Lori A. Asaro, Frank A. Cordasco
Summary: This study evaluated the 2-year clinical outcomes of ACL reconstruction with soft tissue quadriceps tendon autograft performed with a concomitant lateral extra-articular tenodesis in skeletally immature patients. The results showed that this technique is safe and effective compared to isolated ACL reconstruction and has a positive impact on reducing the risk of ACL retear.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2023)
Article
Orthopedics
Sunil Sheshrao Nikose, Devashree Nikose, Shashank Jain, Aditya Kekatpure, Kiran Saoji, Rahul Chaudhary, Gajanan Pisulkar
Summary: The study aimed to analyze the fate of hamstring tendons in ACL reconstruction, finding that weaknesses in the transplanted ST and G contribute to flexion deficit in the operated limb.
INTERNATIONAL ORTHOPAEDICS
(2021)
Review
Cell Biology
Zirong Huang, Jiaming Cui, Mingjin Zhong, Zhenhan Deng, Kang Chen, Weimin Zhu
Summary: Anterior cruciate ligament injury is the most common sports injury, affecting knee joint function and exercise. Surgical reconstruction is the preferred treatment, but can lead to articular cartilage injury and osteoarthritis. This review explores the factors influencing cartilage lesions after anterior cruciate ligament reconstruction, providing insights for delaying and preventing osteoarthritis progression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Anesthesiology
Emanuele M. Giusti, Marco Lacerenza, Samantha Gabrielli, Gian Mauro Manzoni, Chiara Manna, Federico D'Amario, Maurilio Marcacci, Gianluca Castelnuovo
Summary: Central sensitization was found to be a predictor of pain trajectories and pain interference, while emotional distress and cognitive flexibility were also associated with pain intensity and interference, respectively.
Article
Orthopedics
Tommaso Bonanzinga, Alberto Grassi, Daniele Altomare, Nicolo Danilo Vitale, Stefano Zaffagnini, Maurilio Marcacci
Summary: The study found that young professional athletes undergoing Meniscal Allograft Transplantation (MAT) surgery can successfully return to their pre-injury sports level in most cases, but nearly 50% of patients require reoperation, with Lysholm score results being rated as good or fair.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2022)
Article
Orthopedics
Tommaso Bonanzinga, Alberto Grassi, Daniele Altomare, Gian Andrea Lucidi, Luca Macchiarola, Stefano Zaffagnini, Maurilio Marcacci
Summary: This study aimed to analyze the return to play and the career of professional footballers who underwent ACL reconstruction with hamstrings. The results showed that most patients were able to successfully return to competitive play and had good clinical outcomes after surgery. However, some patients required reoperation on the contralateral knee.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2022)
Article
Biology
Francesca Veronesi, Milena Fini, Lucia Martini, Paolo Berardinelli, Valentina Russo, Giuseppe Filardo, Berardo Di Matteo, Maurilio Marcacci, Elizaveta Kon
Summary: Early treatment of osteoarthritis (OA) is crucial for restoring daily and sport activities. This study compared the effects of three orthobiological treatments on OA and found that adipose-derived mesenchymal stromal cells (ADSCs) and amniotic epithelial stem cells (AECs) showed superior results in cartilage regeneration and inflammation reduction.
Article
Orthopedics
Balint Zsidai, Ian D. Engler, Oriol Pujol, Gian Andrea Lucidi, Andrew J. Curley, Stefano Zaffagnini, Volker Musahl
Summary: Revision anterior cruciate ligament reconstruction (ACL-R) often faces challenges such as rotatory instability, tunnel malpositioning and widening, and limited autograft options. Lateral extra-articular tenodesis (LET), alternative tunnel routing, and the use of allograft tissue can be used to manage these challenges. This Technical Note describes a method of revision ACL-R using the over-the-top (OTT) technique with Achilles tendon allograft with concomitant LET, providing a versatile approach for managing failed ACL-R and addressing rotatory instability.
ARTHROSCOPY TECHNIQUES
(2022)
Review
Medicine, General & Internal
Eugenio Cammisa, Iacopo Sassoli, Matteo La Verde, Stefano Fratini, Vito Gaetano Rinaldi, Giada Lullini, Vittorio Vaccari, Stefano Zaffagnini, Giulio Maria Marcheggiani Muccioli
Summary: This review discusses the outcomes of bilateral knee arthroplasty in patients with windswept deformity (WSD). The results show that knee replacement surgery improves knee function and reduces axial deviation in both valgus and varus knees. Unicompartmental knee arthroplasty (UKA) allows for limited axial correction, while kinematic alignment (KA) provides similar results in both knees. The choice of implant is important for functional outcomes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Marco Zaffagnini, Angelo Boffa, Luca Andriolo, Federico Raggi, Stefano Zaffagnini, Giuseppe Filardo
Summary: The use of orthobiologics as a minimally invasive treatment for hip osteoarthritis is gaining interest. Current evidence suggests its safety and potential efficacy, with treatment success inversely proportional to disease severity. However, further high-level controlled trials are needed to confirm its potential.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Orthopedics
Stefano Zaffagnini, Iacopo Romandini, Giuseppe Filardo, Giacomo Dal Fabbro, Alberto Grassi
Summary: This study aimed to evaluate the clinical and functional outcomes of a salvage surgical approach combining meniscal allograft transplantation (MAT), anterior cruciate ligament reconstruction (ACLR), and high tibial osteotomy (HTO) in patients with complex knee lesions. The patients were evaluated using various scores and tests at short and mid-term follow-ups. The combined procedure showed good and stable results, reducing pain, improving knee function, and slowing down the progression of osteoarthritis, making it a valid treatment option for complex patients.
INTERNATIONAL ORTHOPAEDICS
(2023)
Article
Chemistry, Analytical
Stefano Di Paolo, Giuseppe Barone, Domenico Alesi, Agostino Igor Mirulla, Emanuele Gruppioni, Stefano Zaffagnini, Laura Bragonzoni
Summary: The aim of this case report was to assess the functional improvements in a patient with transfemoral amputation who underwent osseointegration surgery. Gait analysis using wearable sensors was conducted before surgery and at 3-, 6-, and 12-month follow-ups. The results showed improved gait symmetry, step width, hip kinematics, and pelvic motion after osseointegration surgery. Osseointegration surgery could be a viable solution for patients facing issues with traditional socket-type prostheses.
Article
Medicine, General & Internal
Luca De Marziani, Angelo Boffa, Simone Orazi, Luca Andriolo, Alessandro Di Martino, Stefano Zaffagnini, Giuseppe Filardo
Summary: Infrared thermography can be used to evaluate the inflammation in OA knees, but there is limited evidence on its response to physical exercise. Understanding the response to exercise and the influencing variables in OA knees can provide important information for profiling patients with different knee OA patterns.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Matteo Romagnoli, Marco Casali, Marco Zaffagnini, Ilaria Cucurnia, Federico Raggi, Davide Reale, Alberto Grassi, Stefano Zaffagnini
Summary: The aim of this study was to investigate the efficacy of using tricalcium phosphate (TCP) as a bone substitute in treating severe acetabular bone defects in revision total hip arthroplasty (rTHA). A systematic literature review identified eight clinical studies, which showed overall promising results but poor methodology. Further studies with larger sample sizes and long-term follow-up are needed to draw more definitive conclusions on TCP's potential for rTHA treatment.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Luca De Marziani, Angelo Boffa, Lucia Angelelli, Luca Andriolo, Alessandro Di Martino, Stefano Zaffagnini, Giuseppe Filardo
Summary: The aim of this study was to evaluate the relationship between infrared thermography and knee inflammation in osteoarthritis patients. The results showed that the skin temperature of the knee joint was influenced by demographic and clinical characteristics of patients, with higher temperatures in younger male patients with higher BMI and worse knee scores, and lower temperatures in patients affected by neuropathic pain.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
F. TASSO, V. SIMILI, B. DI MATTEO, G. MONTELEONE, F. MARTORELLI, A. DE ANGELIS, T. D'AMATO, M. BOVIO, D. ALTOMARE, G. CAMPOFREDA, M. MARCACCI, M. SCARDINO
Summary: This study describes the outcomes of implementing a rapid recovery protocol in a referral center for hip and knee replacement surgery. The protocol was able to reduce the length of stay, increase the number of joint replacement procedures, and optimize the use of blood products without increasing complications.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Review
Pharmacology & Pharmacy
D. Altomare, G. Fusco, E. Bertolino, R. Ranieri, C. Sconza, M. Lipina, E. Kon, M. Marcacci, L. Bianchini, B. Di Matteo
Summary: This systematic review provides a comprehensive analysis on the treatment of acute lateral ankle sprains. It suggests that conservative treatment should be the first choice, as it has superior functional outcomes and socio-economic impact compared to surgical management. There is inconclusive evidence on the best external support and rehabilitation protocols, highlighting the need for further research.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Letter
Medicine, General & Internal
Berardo Di Matteo, Maurilio Marcacci
NEW ENGLAND JOURNAL OF MEDICINE
(2022)