Article
Medicine, General & Internal
Xiaodan Fu, Jing Dong, Hongyan Wang, Dayuan Lou, Xin Li, Jiajie Mei, Zheng Sui, Qian Yang, Nan Niu, Peng Qu
Summary: The study found that the expression of endothelial microparticles is related to renal function and the occurrence of contrast-induced nephropathy. In patients with CIN, plasma EMPs were significantly increased after coronary angiography.
Review
Health Care Sciences & Services
Marijn M. Speeckaert, Jesse Seegmiller, Griet Glorieux, Norbert Lameire, Wim Van Biesen, Raymond Vanholder, Joris R. Delanghe
Summary: Inulin clearance is no longer considered the gold standard for measuring glomerular filtration rates due to limitations in accuracy and safety, with non-radioactive and radioactive markers now being preferred. However, standardization and regulatory issues remain challenges in the use of alternative mGFR methods.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Medicine, General & Internal
Zhiqiang Nie, Yong Liu, Chao Wang, Guoli Sun, Guo Chen, Zuxun Lu
Summary: The study found that the contrast volume-to-chronic kidney disease epidemiology collaboration (CV/CKD-EPI) ratio of >= 1.78 was significantly associated with contrast-induced nephropathy (CIN) in patients undergoing coronary angiography (CAG) or percutaneous coronary intervention (PCI). The CV/CKD-EPI showed the best performance in predicting CIN and could be a reliable and convenient predictor for intraprocedural preventive measures.
FRONTIERS IN MEDICINE
(2021)
Article
Medicine, General & Internal
Chin-Chou Huang, Chia-Min Chung, Chih-Yu Yang, Hsin-Bang Leu, Po-Hsun Huang, Liang-Yu Lin, Tao-Cheng Wu, Shing-Jong Lin, Wen-Harn Pan, Jaw-Wen Chen
Summary: This study found an association between SLC12A3 gene polymorphisms and renal function in patients with hypertension.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Andrzej Konieczny, Piotr Donizy, Tomasz Golebiowski, Andrzej Tukiendorf, Agnieszka Halon, Mariusz Kusztal, Hanna Augustyniak-Bartosik, Magdalena Krajewska
Summary: This study analyzed clinical and histopathological data from 80 patients with IgA nephropathy, and found that endocapillary hypercellularity and interstitial fibrosis were predictors of eGFR decline, while serum albumin concentration had a protective impact on eGFR deterioration. The presence of endocapillary hypercellularity and extent of interstitial fibrosis also negatively correlated with the reduction in proteinuria below 1.0 g/24 h.
Editorial Material
Urology & Nephrology
Sho Hasegawa, Masaomi Nangaku
Summary: This study suggests that SGLT2 inhibitors, such as dapagliflozin, may reduce the risk of abrupt declines in kidney function in patients with chronic kidney disease.
KIDNEY INTERNATIONAL
(2022)
Editorial Material
Urology & Nephrology
Maurice Laville
Summary: Nephroprotective treatments may lead to a drop in glomerular filtration rate, which could be related to the intensity of baseline glomerular anomalies and potential treatment benefits. The study by Oshima et al. further confirms this relationship in diabetic patients with chronic kidney disease under sodium-glucose cotransporter 2 inhibition.
KIDNEY INTERNATIONAL
(2021)
Article
Medical Laboratory Technology
Pierre Delanaye, Francois Gaillard, Jessica van der Weijden, Geir Mjoen, Ingela Ferhman-Ekholm, Laurence Dubourg, Natalie Ebert, Elke Schaeffner, Torbjorn Akerfeldt, Karolien Goffin, Lionel Couzi, Cyril Garrouste, Lionel Rostaing, Marie Courbebaisse, Christophe Legendre, Maryvonne Hourmant, Nassim Kamar, Etienne Cavalier, Laurent Weekers, Antoine Bouquegneau, Martin H. de Borst, Christophe Mariat, Hans Pottel, Marco van Londen
Summary: This study calculated GFR percentiles from donors under 65 years old and successfully extrapolated and validated them in donors and healthy subjects over 65 years old, showing that younger donors have higher mGFR than elderly donors. This model may aid in decision-making for elderly donors.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2022)
Review
Medicine, General & Internal
Hernan Trimarchi, Mark Haas, Rosanna Coppo
Summary: IgA nephropathy is a progressive disease with great variability in clinical course. Crescents, a distinct pathological feature, have been considered as a prognostic indicator of poor outcomes. However, recent guidelines suggest that crescents should not be used to determine disease progression or guide immunosuppression.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Baiyu Feng, Yu Lu, Lin Ye, Lijun Yin, Yingjun Zhou, Anqun Chen
Summary: This study used Mendelian randomization analysis to determine the causal relationship between cystatin C and diabetic nephropathy. The study found that cystatin C is an independent risk factor for diabetic nephropathy in patients with diabetes, regardless of BMI and SBP.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Sam O. Kleeman, Mattia Cordioli, Paul R. H. J. Timmers, Atlas Khan, Pinkus Tober-Lau, Florian Kurth, Vadim Demichev, Hannah Meyer, James F. Wilson, Markus Ralser, Krzysztof Kiryluk, Andrea Ganna, Kenneth Baillie, Tobias Janowitz
Summary: This study found a significant association between cystatin C production and the severity and mortality of COVID-19 in patients, suggesting its potential use in stratifying patients and its functional role in the host response to COVID-19.
Article
Endocrinology & Metabolism
Lucas M. Wiggenhauser, Lena Metzger, Katrin Bennewitz, Silas Soleymani, Mike Boger, Christoph T. Tabler, Ingrid Hausser, Carsten Sticht, Paulus Wohlfart, Nadine Volk, Elena Heidenreich, Michael Buettner, Hans-Peter Hammes, Jens Kroll
Summary: This study identified the pdx1 mutant as a novel model for the study of DKD, showing signs of the early disease progression already in the larval stage and several selective features of later DKD in adult mutants.
Article
Medicine, General & Internal
H. Pottel, J. Bjork, A. D. Rule, N. Ebert, B. O. Eriksen, L. Dubourg, E. Vidal-Petiot, A. Grubb, M. Hansson, E. J. Lamb, K. Littmann, C. Mariat, T. Melsom, E. Schaeffner, P. -O. Sundin, A. Akesson, A. Larsson, E. Cavalier, J. B. Bukabau, E. K. Sumaili, E. Yayo, D. Monnet, M. Flamant, U. Nyman, P. Delanaye
Summary: The study developed a cystatin C-based equation (EKFC eGFRcys) to estimate glomerular filtration rate (GFR). This equation had similar accuracy to a creatinine-based equation (EKFC eGFRcr) and outperformed other commonly used equations. Furthermore, taking the arithmetic mean of EKFC eGFRcr and EKFC eGFRcys further improved the accuracy of GFR estimation.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Peripheral Vascular Disease
Lingyan Fei, Minze Xu, Honghong Wang, Cheng Zhong, Shan Jiang, Falk-Bach Lichtenberger, Cem Erdogan, Han Wang, Julia S. Bonk, En Yin Lai, Pontus B. Persson, Richard Kovacs, Zhihua Zheng, Andreas Patzak, Pratik H. Khedkar
Summary: Acute hyperglycemia is a risk factor for acute kidney injury, and our study suggests that hyperglycemia-induced hyperosmolarity facilitates vasodilation through Piezo1-mediated eNOS activation. Our findings indicate that inhibiting Piezo1 and CaMKII can prevent the vasodilation induced by hyperglycemia and hyperosmotic mannitol solution.
Editorial Material
Urology & Nephrology
Lesley A. Inker, Andrew S. Levey
Summary: Developing and validating equations for estimating glomerular filtration rate in diverse populations, including different age groups, races, and clinical conditions, is essential. Two newly developed equations for children and young adults showed better performance than recommended equations, but require further evaluation for generalizability in diverse populations.
KIDNEY INTERNATIONAL
(2021)
Article
Orthopedics
Noam Ben-Eliezer, Jose G. Raya, James S. Babb, Thomas Youm, Daniel K. Sodickson, Riccardo Lattanzi
Summary: A new study proposed a normalized T2-index method to evaluate cartilage in FAI patients, showing high accuracy in detecting cartilage lesions. Normalizing T2 values was found to be important to address interpatient variability, and the T2-index may be a promising biomarker for cartilage lesion detection in FAI. Further research is needed to explore the combination of T2-index with morphologic MRI and other quantitative biomarkers to improve cartilage assessment in FAI.
Article
Radiology, Nuclear Medicine & Medical Imaging
Sahar Semaan, Naik Vietti Violi, Sara Lewis, Manjil Chatterji, Christopher Song, Cecilia Besa, James S. Babb, M. Isabel Fiel, Myron Schwartz, Swan Thung, Claude B. Sirlin, Bachir Taouli
EUROPEAN RADIOLOGY
(2020)
Article
Neurosciences
Faye McKenna, James Babb, Laura Miles, Donald Goff, Mariana Lazar
Article
Geriatrics & Gerontology
Jian W. Dong, Ileana O. Jelescu, Benjamin Ades-Aron, Dmitry S. Novikov, Kent Friedman, James S. Babb, Ricardo S. Osorio, James E. Galvin, Timothy M. Shepherd, Els Fieremans
NEUROBIOLOGY OF AGING
(2020)
Article
Orthopedics
Dana J. Lin, Christopher J. Burke, Benjamin Abiri, James S. Babb, Ronald S. Adler
SKELETAL RADIOLOGY
(2020)
Article
Oncology
Sushma Gaddam, Samantha L. Heller, James S. Babb, Yiming Gao
Summary: Breast cancer screening recommendations vary widely among high-risk men, with most undergoing clinical breast examination and only a minority undergoing mammography screening.
CLINICAL BREAST CANCER
(2021)
Article
Clinical Neurology
Simona Schiavi, Maria Petracca, Peng Sun, Lazar Fleysher, Sirio Cocozza, Mohamed Mounir El Mendili, Alessio Signori, James S. Babb, Kornelius Podranski, Sheng-Kwei Song, Matilde Inglese
Summary: This study investigated the feasibility of diffusion basis spectrum imaging in multiple sclerosis at 7 T, identifying significant differences in various diffusion metrics between different types of lesions and normal appearing white matter. The study also found associations between certain diffusion metrics and clinical measures, suggesting the potential clinical relevance of diffusion basis spectrum imaging in monitoring disease progression and treatment response in multiple sclerosis.
Article
Radiology, Nuclear Medicine & Medical Imaging
Christopher J. Burke, Mohammad Samim, Hamza Alizai, Julien Sanchez, Dallas Kingsbury, James S. Babb, William R. Walter
Summary: This study evaluated the utility of a 2D dynamic HASTE sequence in assessing cervical spine flexion-extension, specifically comparing dynamic spondylolisthesis to radiographs and assessing dynamic contact or deformity of the cord. The results showed good agreement in evaluating dynamic spondylolisthesis and cord deformity using the dynamic HASTE sequence.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lea Azour, William H. Moore, Thomas O'Donnell, Mylene T. Truong, James Babb, Bowen Niu, Andreas Wimmer, Saman Kiumehr, Jane P. Ko
Summary: This study evaluated the inter-observer consistency of radiomic features for subsolid pulmonary nodules. The results showed that some features had high consistency among observers, and nodule morphology influenced both feature consistency and segmentation accuracy.
ACADEMIC RADIOLOGY
(2022)
Article
Geriatrics & Gerontology
Ivan I. Kirov, Marc Sollberger, Matthew S. Davitz, Lidia Glodzik, Brian J. Soher, James S. Babb, Andreas U. Monsch, Achim Gass, Oded Gonen
Summary: In a study involving older and younger adults, MRI scans showed that while brain tissue atrophy was present with age, neuronal integrity, as reflected by WBNAA, did not remain preserved in normal aging. Women showed less brain atrophy compared to men across all age groups.
NEUROBIOLOGY OF AGING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Anastasia Plaunova, Samantha L. Heller, James S. Babb, Cathleen C. Heffernan
Summary: The COVID-19 pandemic has disproportionately affected female academic radiologists by increasing their household responsibilities and reducing their work productivity.
Female academic radiologists with young children reported a significant decrease in productivity, while male counterparts reported having more time for productivity.
ACADEMIC RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lea Azour, Sharon Steinberger, Danielle Toussie, Ruwanthi Titano, Nina Kukar, James Babb, Adam Jacobi
Summary: In this study, the distribution of Agatston score severity categories differed in codominant versus right- or left-dominant patients, but there was no significant difference in Agatston score based on coronary dominance pattern in the cohort.
Article
Clinical Neurology
Teresa Gerhalter, Anna M. Chen, Seena Dehkharghani, Rosemary Peralta, Fatemeh Adlparvar, James S. Babb, Tamara Bushnik, Jonathan M. Silver, Brian S. Im, Stephen P. Wall, Ryan Brown, Steven H. Baete, Ivan I. Kirov, Guillaume Madelin
Summary: The study found that while there were significant differences in sodium concentration and anisotropy in specific regions, overall patients had lower sodium concentrations compared to controls. Linear regression analysis showed significantly lower global sodium concentrations in patients, with the strongest correlation found between global grey matter sodium concentration and patient outcomes. This suggests that sodium imaging may be a non-invasive and sensitive method for assessing outcomes in mild traumatic brain injury.
BRAIN COMMUNICATIONS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Samantha L. Heller, Melanie Wegener, James S. Babb, Yiming Gao
Summary: The study evaluated the impact of an artificial intelligence support system on breast ultrasound diagnostic accuracy. Artificial intelligence was found to be more accurate in assessing irregular shape lesions and improved diagnostic accuracy for low-confidence lesions rated by readers.
ULTRASOUND QUARTERLY
(2021)
Article
Computer Science, Artificial Intelligence
Tatiane Cantarelli Rodrigues, Cem M. Deniz, Erin F. Alaia, Natalia Gorelik, James S. Babb, Jared Dublin, Soterios Gyftopoulos
RADIOLOGY-ARTIFICIAL INTELLIGENCE
(2020)