Article
Medicine, General & Internal
Jin Liu, Xiaorui Yin, Hreedi Dev, Xianfu Luo, Jon D. D. Blumenfeld, Hanna Rennert, Martin R. R. Prince
Summary: This study investigates the association between autosomal dominant polycystic kidney disease (ADPKD) and pleural effusion. Pleural effusions were observed in 21% of ADPKD subjects compared to 8% in controls. In a subpopulation controlling for renal function, 25% of ADPKD subjects had pleural effusions compared to 5% of controls.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Ahsan Alam, Emilie Cornec-Le Gall, Ronald D. Perrone
Summary: This article describes autosomal dominant polycystic kidney disease, its signs and symptoms, diagnosis, and treatment options.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Urology & Nephrology
Kyongtae T. Bae, Cheng Tao, Robert Feldman, Alan S. L. Yu, Vicente E. Torres, Ronald D. Perrone, Arlene B. Chapman, Godela Brosnahan, Theodore I. Steinman, William E. Braun, Michal Mrug, William M. Bennett, Peter C. Harris, Avantika Srivastava, Douglas P. Landsittel, Kaleab Z. Abebe
Summary: This study aimed to evaluate the associations of polycystic liver progression with other disease progression variables and classify liver progression on the basis of patient's age, height-adjusted liver cystic volume, and height-adjusted liver volume. The use of height-adjusted liver cystic volume showed greater separations in volumetric progression of polycystic liver disease.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Chenglin Zhu, Hreedi Dev, Arman Sharbatdaran, Xinzi He, Daniil Shimonov, James M. Chevalier, Jon D. Blumenfeld, Yi Wang, Kurt Teichman, George Shih, Akshay Goel, Martin R. Prince
Summary: Total kidney volume measured on MRI is an important biomarker for assessing the progression of autosomal dominant polycystic kidney disease and response to treatment. In this study, we examined the variability of kidney volume measurements among five commonly acquired MRI pulse sequences in abdominal MRI exams in 105 patients with ADPKD.
Review
Nutrition & Dietetics
Lauren Pickel, Ioan-Andrei Iliuta, James Scholey, York Pei, Hoon-Ki Sung
Summary: Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressive growth of renal cysts and loss of functional nephrons. Evidence suggests that dietary interventions such as caloric restriction, intermittent fasting, and ketogenic diets have the potential to slow disease progression and confer metabolic benefits.
ADVANCES IN NUTRITION
(2022)
Review
Biochemistry & Molecular Biology
Claudio Ponticelli, Gabriella Moroni, Francesco Reggiani
Summary: Autosomal-Dominant Polycystic Kidney Disease (ADPKD) is a genetic disorder caused by mutations in PKD1 or PKD2 genes. The involvement of autophagy in ADPKD remains a subject of investigation, with potential implications on cyst formation and fibrosis. Autophagy inducers have shown promising results in preclinical studies and may provide a potential avenue for future investigations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Anish Raj, Fabian Tollens, Laura Hansen, Alena-Kathrin Golla, Lothar R. Schad, Dominik Noerenberg, Frank G. Zoellner
Summary: This study aims to improve TKV estimation based on U-Net by incorporating attention mechanisms, cosine loss function, and sharpness aware minimization technique, enhancing the accuracy of kidney segmentation. Experimental results demonstrate significant performance improvements using these methods with only 100 MRI datasets.
Review
Pharmacology & Pharmacy
Guangying Shao, Shuai Zhu, Baoxue Yang
Summary: ADPKD is a common hereditary kidney disease characterized by progressively enlarged cysts that destroy renal function, potentially leading to ESRD. Herbal medicines have shown potential in inhibiting cyst development and ADPKD progression, providing new insights for clinical therapeutic strategies.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biology
Maria Rombolotti, Fabio Sangalli, Domenico Cerullo, Andrea Remuzzi, Ettore Lanzarone
Summary: This study proposes a method for kidney and cyst segmentation in micro-CT images of mice with Autosomal Dominant Polycystic Kidney Disease and normal mice using fully convolutional networks. Different network architectures are compared and evaluated based on Intersection over Union and Dice coefficients. The results show that the U-Net with a batch normalization layer after each pair of 3 x 3 convolutions, and the U-Net with convolutional layers replaced by inception blocks perform the best.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Medicine, General & Internal
Larina A. Karner, Sita Arjune, Polina Todorova, David Maintz, Franziska Grundmann, Thorsten Persigehl, Roman-Ulrich Mueller
Summary: Autosomal dominant polycystic kidney disease (ADPKD) is a common genetic kidney disease. The glomerular filtration rate (GFR) is not a reliable indicator of disease progression until decline begins. Kidney volumetry is often used to assess disease severity, but additional imaging markers are needed. This study examined cyst fraction as a potential marker and found that it correlated with eGFR and showed higher predictive accuracy than total kidney volume. Future clinical trials are encouraged to explore the predictive value of cyst fraction in combination with other biomarkers.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Jin Liu, Kana Fujikura, Hreedi Dev, Sadjad Riyahi, Jon Blumenfeld, Jiwon Kim, Hanna Rennert, Martin R. Prince
Summary: This study investigated the potential association of pericardial effusion with autosomal dominant polycystic kidney disease (ADPKD). The results showed that pericardial effusion was more prevalent in ADPKD subjects compared to controls. Pericardial effusion thickness was associated with female gender patients and pleural effusion thickness. Although no clinical significance was identified in this retrospective cross-sectional study, further investigations may help to understand the role of pericardial effusion in ADPKD.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Urology & Nephrology
Youngwoo Kim, Cheng Tao, Hyungchan Kim, Geum-Yoon Oh, Jeongbeom Ko, Kyongtae T. Bae
Summary: A fully automated segmentation method was developed to measure TKV in ADPKD patients. This method accurately segments the kidney regions while excluding exophytic cysts and has a similar accuracy to that of manual methods.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Urology & Nephrology
Jessica T. T. Camargo, Camilo A. Gonzalez, Lina Herrera, Nancy Yomayusa-Gonzalez, Milciades Ibanez, Ana M. M. Valbuena-Garcia, Lizbeth Acuna-Merchan
Summary: This study investigated the prevalence, geographical location, and ethnic groups of ADPKD patients undergoing dialysis or kidney transplant in Colombia between 2015 and 2019. The prevalence of ADPKD was lower compared to Europe and the US, and further genetic prevalence studies may be needed in some states with higher prevalence.
Article
Medicine, General & Internal
Alexander R. Chang, Bryn S. Moore, Jonathan Z. Luo, Gino Sartori, Brian Fang, Steven Jacobs, Yoosif Abdalla, Mohammed Taher, David J. Carey, William J. Triffo, Gurmukteshwar Singh, Tooraj Mirshahi
Summary: This study reveals substantial genetic and phenotypic variability in autosomal dominant polycystic kidney disease (ADPKD) among patients within a regional health system in the US. In addition to PKD1 and PKD2, LOF variants in IFT140, GANAB, and HNF1B were associated with ADPKD diagnosis. Patients with a family history of ADPKD had a higher yield for genetic determinants of the disease.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Article
Multidisciplinary Sciences
Katharina Hopp, Victoria A. Catenacci, Nidhi Dwivedi, Timothy L. Kline, Wei Wang, Zhiying You, Dustin T. Nguyen, Kristen Bing, Bhavya Poudyal, Ginger C. Johnson, Matthew R. Jackman, Marsha Miller, Cortney N. Steele, Natalie J. Serkova, Paul S. MacLean, Raphael A. Nemenoff, Berenice Gitomer, Michel Chonchol, Kristen L. Nowak
Summary: This study demonstrates that both daily caloric restriction (DCR) and intermittent fasting (IMF) can lead to significant weight loss and slow cyst growth in ADPKD patients. DCR has better efficacy in weight loss compared to IMF, and patients showed higher adherence and tolerability to DCR.
Article
Orthopedics
Noam Ben-Eliezer, Jose G. Raya, James S. Babb, Thomas Youm, Daniel K. Sodickson, Riccardo Lattanzi
Summary: A new study proposed a normalized T2-index method to evaluate cartilage in FAI patients, showing high accuracy in detecting cartilage lesions. Normalizing T2 values was found to be important to address interpatient variability, and the T2-index may be a promising biomarker for cartilage lesion detection in FAI. Further research is needed to explore the combination of T2-index with morphologic MRI and other quantitative biomarkers to improve cartilage assessment in FAI.
Article
Radiology, Nuclear Medicine & Medical Imaging
Atul B. Shinagare, Matthew S. Davenport, Hyesun Park, Ivan Pedrosa, Erick M. Remer, Hersh Chandarana, Ankur M. Doshi, Nicola Schieda, Andrew D. Smith, Raghunandan Vikram, Zhen J. Wang, Stuart G. Silverman
Summary: The study aimed to develop a standardized lexicon to describe renal masses at CT and MRI, through a multi-institutional, prospective quality improvement project. The consensus was reached for the inclusion of terms used to describe imaging features of renal masses, improving clarity and consistency in radiology reports and research related to renal masses.
ABDOMINAL RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Gregory Chang, Ankur Doshi, Hersh Chandarana, Michael Recht
Summary: The workflow changes implemented in response to COVID-19 in outpatient imaging facilities of a large healthcare system in New York City led to a significant reduction in patient wait times and overall time on site, as well as an increase in patients using the digital patient portal.
ACADEMIC RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Christopher J. Burke, Mohammad Samim, Hamza Alizai, Julien Sanchez, Dallas Kingsbury, James S. Babb, William R. Walter
Summary: This study evaluated the utility of a 2D dynamic HASTE sequence in assessing cervical spine flexion-extension, specifically comparing dynamic spondylolisthesis to radiographs and assessing dynamic contact or deformity of the cord. The results showed good agreement in evaluating dynamic spondylolisthesis and cord deformity using the dynamic HASTE sequence.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Eddy Solomon, David S. Rigie, Thomas Vahle, Jan Paska, Jan Bollenbeck, Daniel K. Sodickson, Fernando E. Boada, Kai Tobias Block, Hersh Chandarana
Summary: This study introduces a novel method for detecting respiratory signals using a Pilot-Tone (PT) signal and creating motion-resolved images based on 3D stack-of-stars imaging under free-breathing conditions. The PT signal, generated by a small RF transmitter placed outside the MR bore, is used to reconstruct motion-resolved images from free-breathing scans, leading to improved image quality and clearer anatomical depiction of the lung and liver compared to traditional methods.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Hersh Chandarana, Krishna Shanbhogue
Article
Radiology, Nuclear Medicine & Medical Imaging
Lea Azour, William H. Moore, Thomas O'Donnell, Mylene T. Truong, James Babb, Bowen Niu, Andreas Wimmer, Saman Kiumehr, Jane P. Ko
Summary: This study evaluated the inter-observer consistency of radiomic features for subsolid pulmonary nodules. The results showed that some features had high consistency among observers, and nodule morphology influenced both feature consistency and segmentation accuracy.
ACADEMIC RADIOLOGY
(2022)
Article
Geriatrics & Gerontology
Ivan I. Kirov, Marc Sollberger, Matthew S. Davitz, Lidia Glodzik, Brian J. Soher, James S. Babb, Andreas U. Monsch, Achim Gass, Oded Gonen
Summary: In a study involving older and younger adults, MRI scans showed that while brain tissue atrophy was present with age, neuronal integrity, as reflected by WBNAA, did not remain preserved in normal aging. Women showed less brain atrophy compared to men across all age groups.
NEUROBIOLOGY OF AGING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ankur M. Doshi, Angela Tong, Matthew S. Davenport, Ahmed M. Khalaf, Rafah Mresh, Henry Rusinek, Nicola Schieda, Atul B. Shinagare, Andrew D. Smith, Rebecca Thornhill, Raghunandan Vikram, Hersh Chandarana
Summary: This study aimed to measure agreement of texture metrics extracted by six software packages. The results indicate common variability in first- and second-order texture features across software configurations, highlighting the need for standardized algorithms and reporting methods for reliable clinical applications.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Krishna Shanbhogue, Angela Tong, Paul Smereka, Dominik Nickel, Simon Arberet, Rebecca Anthopolos, Hersh Chandarana
Summary: Accelerated single-shot T2-weighted MRI of the liver with deep learning-based image reconstruction showed superior image quality compared to the conventional T2-weighted fat-suppressed sequence despite a 4-fold reduction in acquisition time.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Anastasia Plaunova, Samantha L. Heller, James S. Babb, Cathleen C. Heffernan
Summary: The COVID-19 pandemic has disproportionately affected female academic radiologists by increasing their household responsibilities and reducing their work productivity.
Female academic radiologists with young children reported a significant decrease in productivity, while male counterparts reported having more time for productivity.
ACADEMIC RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lea Azour, Sharon Steinberger, Danielle Toussie, Ruwanthi Titano, Nina Kukar, James Babb, Adam Jacobi
Summary: In this study, the distribution of Agatston score severity categories differed in codominant versus right- or left-dominant patients, but there was no significant difference in Agatston score based on coronary dominance pattern in the cohort.
Article
Radiology, Nuclear Medicine & Medical Imaging
Jeong Hee Yoon, Jeong Min Lee, Mi Hye Yu, Bo Yun Hur, Robert Grimm, Steven Sourbron, Hersh Chandarana, Yohan Son, Susmita Basak, Kyoung-Bun Lee, Nam-Joon Yi, Kwang-Woong Lee, Kyung-Suk Suh
Summary: The study demonstrates that liver MRI using GRASP technique can provide sufficient spatial resolution for confident diagnosis and high temporal resolution for pharmacokinetic modeling. Significant differences in MRI-derived portal blood flow were found at different hepatic fibrosis stages.
EUROPEAN RADIOLOGY
(2022)
Article
Clinical Neurology
Teresa Gerhalter, Anna M. Chen, Seena Dehkharghani, Rosemary Peralta, Fatemeh Adlparvar, James S. Babb, Tamara Bushnik, Jonathan M. Silver, Brian S. Im, Stephen P. Wall, Ryan Brown, Steven H. Baete, Ivan I. Kirov, Guillaume Madelin
Summary: The study found that while there were significant differences in sodium concentration and anisotropy in specific regions, overall patients had lower sodium concentrations compared to controls. Linear regression analysis showed significantly lower global sodium concentrations in patients, with the strongest correlation found between global grey matter sodium concentration and patient outcomes. This suggests that sodium imaging may be a non-invasive and sensitive method for assessing outcomes in mild traumatic brain injury.
BRAIN COMMUNICATIONS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Samantha L. Heller, Melanie Wegener, James S. Babb, Yiming Gao
Summary: The study evaluated the impact of an artificial intelligence support system on breast ultrasound diagnostic accuracy. Artificial intelligence was found to be more accurate in assessing irregular shape lesions and improved diagnostic accuracy for low-confidence lesions rated by readers.
ULTRASOUND QUARTERLY
(2021)