Review
Oncology
Jialun Wang, Yu Chen, Xihan Li, Xiaoping Zou
Summary: Perineural invasion is a complex process that occurs in many malignant tumors, including gastric carcinoma, biliary tract tumor, and pancreatic cancer. It is associated with poor survival and decreased quality of life in pancreatic cancer patients. Studies have revealed subtle molecule regulatory mechanisms during perineural invasion and its potential causal link with pancreatic cancer-associated pain.
Article
Multidisciplinary Sciences
Ekaterina Khristenko, Igor Shrainer, Galia Setdikova, Oxana Palkina, Valentin Sinitsyn, Vladimir Lyadov
Summary: This study aimed to evaluate the diagnostic accuracy of CT in detecting EPNI in resectable PDAC, finding a sensitivity of 93.1% and specificity of 64.7%. CT could provide sufficient diagnostic information for detecting PPC-II invasion in patients with resectable PDAC.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Andrea R. Marcadis, Elizabeth Kao, Qi Wang, Chun-Hao Chen, Laxmi Gusain, Ann Powers, Richard L. Bakst, Sylvie Deborde, Richard J. Wong
Summary: The invasion of nerves by cancer cells, or perineural invasion (PNI), is influenced by the nerve microenvironment and is associated with negative clinical outcomes. However, the specific characteristics of cancer cells that enable PNI have not been well defined. Through serial passaging of pancreatic cancer cells in a murine sciatic nerve model of PNI, we generated cell lines enriched for a rapid neuroinvasive phenotype. These leading neuroinvasive cells exhibited upregulation of proteins involving the plasma membrane, cell leading edge, and cell movement. They also underwent phenotypic changes from a mesenchymal to an amoeboid phenotype, and acquired increased migration ability and affinity for dorsal root ganglia. Inhibition of ROCK reversed these changes and reduced PNI in a murine sciatic nerve model. This study highlights the plasticity of cancer migration mode in facilitating rapid nerve invasion.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Oncology
Wunai Zhang, Rui He, Wenbin Yang, Yan Zhang, Qinggong Yuan, Jixin Wang, Yang Liu, Shuo Chen, Simei Zhang, Weifan Zhang, Zeen Zhu, Jing Zhang, Zheng Wang, Junhui Li
Summary: Autophagy and perineural invasion (PNI) in pancreatic cancer have negative effects on prognosis. Schwann cells (SCs) in PNI are activated through NGF-mediated autophagy, promoting PNI by enhancing migration and axon guidance towards cancer cells and increasing chemoattraction. Targeting NGF and autophagy for PNI treatment can block nerve infiltration.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tiezhu Ren, Wenjuan Zhang, Shenglin Li, Liangna Deng, Caiqiang Xue, Zhengxiao Li, Suwei Liu, Jiachen Sun, Junlin Zhou
Summary: The study investigates the use of combining clinical and spectral computed tomography (CT) parameters for the preoperative evaluation of lymphovascular invasion (LVI) and perineural invasion (PNI) in gastric cancers (GCs). The combination of clinical and spectral-CT parameters effectively predicts LVI and PNI in GCs.
DIAGNOSTIC AND INTERVENTIONAL IMAGING
(2022)
Article
Oncology
Tao Qin, Jie Li, Ying Xiao, Xueni Wang, Mengyuan Gong, Qiqi Wang, Zeen Zhu, Simei Zhang, Wunai Zhang, Fang Cao, Liang Han, Zheng Wang, Qingyong Ma, Huanchen Sha
Summary: The study showed that HNK can inhibit the invasion and migration of pancreatic cancer cells, as well as the PNI of pancreatic cancer, partially through inhibition of SMAD2/3 phosphorylation. In vivo, HNK was found to suppress EMT in pancreatic cancer, inhibit cancer cell migration along the nerve, reduce damage to the sciatic nerve caused by tumor cells, and protect the function of the sciatic nerve.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Mei Zhang, Hong-chun Xian, Li Dai, Ya-ling Tang, Xin-hua Liang
Summary: Perineural invasion (PNI) is a common clinical feature in malignant tumors that can lead to postoperative recurrence and metastasis. Recent studies have shown that miRNA plays a crucial role in regulating PNI, offering potential new biomarkers and therapeutic targets for cancer treatment.
CELL AND BIOSCIENCE
(2021)
Article
Oncology
Jun-Feng Zhang, Ling-Ye Tao, Min-Wei Yang, Da-Peng Xu, Shu-Heng Jiang, Xue-Liang Fu, De-Jun Liu, Yan-Miao Huo, Wei Liu, Jian-Yu Yang, Rong Hua, Ping Lu, Yong-Wei Sun
Summary: The study revealed that the expression level of CD74 in pancreatic ductal adenocarcinoma is an independent predictor of PNI and poor prognosis, with CD74 enhancing migration and invasion capabilities of PDAC by promoting GDNF production to facilitate neuroplasticity in the microenvironment.
Article
Pharmacology & Pharmacy
Fengjiao Li, Chong He, Hanming Yao, Yue Zhao, Xijiu Ye, Shurui Zhou, Jinmao Zou, Yaqing Li, Jiajia Li, Shaojie Chen, Fanghai Han, Kaihong Huang, Guoda Lian, Shangxiang Chen
Summary: This study found that glutamate released from nerve cells promotes glycolysis in PDAC cells and ultimately promotes PNI through the NMDAR2B and downstream Ca2+ dependent CaMKII/ERK-MAPK pathway. Additionally, synthesized dual targeting nanoparticles were verified to effectively block PNI in PDAC.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jing Li, Shuning Xu, Yi Wang, Mengjie Fang, Fei Ma, Chunmiao Xu, Li Hailiang
Summary: This study developed and validated a spectral CT-based nomogram for preoperatively predicting perineural invasion in locally advanced gastric cancer. The nomogram, based on clinical and CT parameters, showed good predictive performance and potential clinical utility in guiding post-surgical treatment strategy.
EUROPEAN RADIOLOGY
(2023)
Article
Medicine, General & Internal
Matthaus Felsenstein, Flora Lindhammer, Mathilde Feist, Karl Herbert Hillebrandt, Lea Timmermann, Christian Benzing, Brigitta Globke, Dario Zocholl, Mengwen Hu, Uli Fehrenbach, Bruno Valentin Sinn, Uwe Pelzer, Igor Maximillian Sauer, Johann Pratschke, Thomas Malinka
Summary: This study confirms the improvement in long-term survival of PDAC-resected cancer patients with Pn0, and highlights the significant impact of perineural invasion on the long-term survival of formally curative patients. These findings provide new insights into risk stratification and multimodal treatment strategies for pancreatic cancer patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Peng-Chao Zhan, Pei-jie Lyu, Zhen Li, Xing Liu, Hui-Xia Wang, Na-Na Liu, Yuyuan Zhang, Wenpeng Huang, Yan Chen, Jian-bo Gao
Summary: This study aimed to develop and evaluate a CT-based radiomics model for noninvasive prediction of perineural invasion (PNI) in patients with perihilar cholangiocarcinoma (pCCA) before surgery. The radiomics model showed better predictive performance than the clinical model and the combined model, with good consistency and clinical utility. The study highlights the potential of radiomics in preoperative assessment of PNI in pCCA.
FRONTIERS IN ONCOLOGY
(2022)
Article
Gastroenterology & Hepatology
Xiaofan Guo, Song Gao, Jie Yu, Yizhang Zhou, Chuntao Gao, Jihui Hao
Summary: The study found that measuring the minimum distance between the tumor boundary and arteries is an effective imaging indicator for diagnosing EPNI; iPNI is an independent risk factor for DFS and OS; the novel typing method based on potentially invaded PLX may have guiding significance for surgical dissection.
Review
Pharmacology & Pharmacy
Rong-jia Shi, Bo-wen Ke, Ya-ling Tang, Xin-hua Liang
Summary: Perineural invasion (PNI) is the process of tumor invasion and interaction with nerves, causing dynamic changes and disturbing symptoms. PNI-related cancer pain in neuro-rich tumors is closely related to nerve invasion in the tumor microenvironment, and can indicate the occurrence of PNI, guide treatment strategies, and predict tumor resectability and the need for palliative care.
BIOCHEMICAL PHARMACOLOGY
(2023)
Review
Oncology
Federico Selvaggi, Eugenia Melchiorre, Ilaria Casari, Sebastiano Cinalli, Massimiliano Cinalli, Gitana Maria Aceto, Roberto Cotellese, Ingrid Garajova, Marco Falasca
Summary: Pancreatic ductal adenocarcinoma is highly threatening and characterized by perineural invasion (PNI), which is associated with recurrence, poor prognosis, and pain. Researchers are currently seeking more effective therapies to inhibit the nerve invasion promoted by pancreatic ductal adenocarcinoma.
Article
Chemistry, Multidisciplinary
Rammohan Devulapally, Narayana M. Sekar, Thillai V. Sekar, Kira Foygel, Tarik F. Massoud, Juergen K. Willmann, Ramasamy Paulmurugan
Article
Radiology, Nuclear Medicine & Medical Imaging
Kesav Raghavan, R. Brooke Jeffrey, Bhavik N. Patel, Michael A. DiMaio, Juergen K. Willmann, Eric W. Olcott
AMERICAN JOURNAL OF ROENTGENOLOGY
(2015)
Article
Oncology
Sunitha V. Bachawal, Kristin C. Jensen, Katheryne E. Wilson, Lu Tian, Amelie M. Lutz, Juergen K. Willmann
Article
Radiology, Nuclear Medicine & Medical Imaging
Lotfi Abou-Elkacem, Sunitha V. Bachawal, Juergen K. Willmann
EUROPEAN JOURNAL OF RADIOLOGY
(2015)
Article
Radiology, Nuclear Medicine & Medical Imaging
Huaijun Wang, Osamu F. Kaneko, Lu Tian, Dimitre Hristov, Juergen K. Willmann
INVESTIGATIVE RADIOLOGY
(2015)
Article
Chemistry, Multidisciplinary
Tzu-Yin Wang, Jung Woo Choe, Kanyi Pu, Rammohan Devulapally, Sunitha Bachawal, Steven Machtaler, Sayan Mullick Chowdhury, Richard Luong, Lu Tian, Butrus Khuri-Yakub, Jianghong Rao, Ramasamy Paulmurugan, Juergen K. Willmann
JOURNAL OF CONTROLLED RELEASE
(2015)
Article
Acoustics
Aya Kamaya, Ali M. Tahvildari, Bhavik N. Patel, Juergen K. Willmann, R. Brooke Jeffrey, Terry S. Desser
JOURNAL OF ULTRASOUND IN MEDICINE
(2015)
Article
Radiology, Nuclear Medicine & Medical Imaging
Huaijun Wang, Dimitre Hristov, Jiale Qin, Lu Tian, Juergen K. Willmann
Review
Radiology, Nuclear Medicine & Medical Imaging
Paul F. Laeseke, Ru Chen, R. Brooke Jeffrey, Teresa A. Brentnall, Juergen K. Willmann
Article
Radiology, Nuclear Medicine & Medical Imaging
Marybeth A. Pysz, Steven B. Machtaler, E. Scott Seeley, John J. Lee, Teresa A. Brentnall, Jarrett Rosenberg, Francois Tranquart, Juergen K. Willmann
Article
Radiology, Nuclear Medicine & Medical Imaging
Huaijun Wang, Stephen A. Felt, Steven Machtaler, Ismayil Guracar, Richard Luong, Thierry Bettinger, Lu Tian, Amelie M. Lutz, Juergen K. Willmann
Article
Medicine, Research & Experimental
Steven Machtaler, Ferdinand Knieling, Richard Luong, Lu Tian, Juergen K. Willmann
Article
Radiology, Nuclear Medicine & Medical Imaging
Stephanie T. Chang, R. Brooke Jeffrey, Bhavik N. Patel, Michael A. DiMaio, Jarrett Rosenberg, Juergen K. Willmann, Eric W. Olcott
Article
Radiology, Nuclear Medicine & Medical Imaging
Krista E. Weiss, Juergen K. Willmann, R. Brooke Jeffrey, Terry S. Desser
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2016)
Review
Radiology, Nuclear Medicine & Medical Imaging
Keerthi S. Valluru, Juergen K. Willmann