Review
Clinical Neurology
Zhuo Wang, Munan Zhao, Sujun Gao
Summary: The incidence of epileptic seizures after allogeneic hematopoietic stem cell transplantation has raised concerns among clinicians for its impact on patient survival and quality of life. This review aims to elucidate the incidence, etiologies, mechanisms, clinical manifestations, therapeutic schedule, and prognosis of post-transplantation seizures to improve doctors' understanding and management of this complication for better patient outcomes.
FRONTIERS IN NEUROLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Aryan Shiari, Mo'ath Nassar, Ayman O. Soubani
Summary: Hematopoietic stem cell transplantation (HSCT) is used for treating both malignant and nonmalignant disorders, but patients remain at risk for post-transplant complications. Pulmonary complications, including infectious and non-infectious, highlight the importance of early identification and treatment of infections, as well as the toxicities related to chemoradiation and immunosuppressive drugs. This report serves as a guide for pulmonologists caring for these patients.
RESPIRATORY MEDICINE
(2021)
Article
Immunology
Lilli Leimi, Jessica R. Koski, Outi Kilpivaara, Kim Vettenranta, A. Inkeri Lokki, Seppo Meri
Summary: This study investigated genetic complement system variants in patients with documented endotheliopathy and found that variants in complement genes may be related to endotheliopathy and poor prognosis in these patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Hyewon Shin, Mi-Sun Yum, Min-Jee Kim, Jin Kyung Suh, Ho Joon Im, Hyery Kim, Kyung-Nam Koh, Tae-Sung Ko
Summary: Most children with neurologic complications and neuroimaging abnormalities during HSCT had recovered. However, children with neurologic complications associated with infectious causes, malignant disease or severe brain MRI abnormalities should be more carefully monitored during HSCT.
Article
Multidisciplinary Sciences
Laura Breda, Tyler E. Papp, Michael P. Triebwasser, Amir Yadegari, Megan T. Fedorky, Naoto Tanaka, Osheiza Abdulmalik, Giulia Pavani, Yongping Wang, Stephan A. Grupp, Stella T. Chou, Houping Ni, Barbara L. Mui, Ying K. Tam, Drew Weissman, Stefano Rivella, Hamideh Parhiz
Summary: This study developed a nanoparticle system that can target hematopoietic stem cells in vivo and achieved correction of diseased cells through mRNA delivery. Furthermore, this system enables non-genotoxic conditioning for stem cells, providing a new approach for HSCT.
Article
Pharmacology & Pharmacy
D. Iskender, M. Ibanoglu, S. Secilmis, N. A. Baysal, M. K. Cakar, M. S. Dal, B. U. Ulu, S. Y. Ergani, A. Kaymak, T. T. Ilhan, S. Basci, T. N. Yigenoglu, C. Iskender, F. Altuntas
Summary: This study retrospectively investigated the pregnancy outcomes of patients who underwent stem cell transplantation (SCT) and determined the reasons for avoiding pregnancy. The results showed that patients who became pregnant after SCT had a higher rate of pregnancy complications, but achieved similar live birth rates as the healthy population. Many patients have concerns about pregnancy and should be counseled appropriately.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Review
Cell & Tissue Engineering
Davod Pashoutan Sarvar, Hosein Effatpanah, Parvin Akbarzadehlaleh, Karim Shamsasenjan
Summary: The study highlights the important role of MSC-derived extracellular vesicles (MSC-EVs) in hematopoietic regulation and immune response after transplantation. MSC-EVs directly fuse with hematopoietic stem cell membranes, affecting their fate, and regulate the proliferation and differentiation of hematopoietic stem cells through the release of various bioactive factors.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Immunology
Tirthankar Sen, Rajkumar P. Thummer
Summary: The human microbiota plays a significant role in organ transplantation outcomes and rejection risk, with complex interactions existing between different microbiotas and the human body.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Soheila Montazersaheb, Ali Ehsani, Ezzatollah Fathi, Raheleh Farahzadi, Ilja Vietor
Summary: Autophagy is a fundamental process that helps cells adapt to metabolic stress by degrading and recycling intracellular components. It plays a crucial role in various aspects of allogeneic hematopoietic stem cell transplantation (HSCT), including the survival and function of hematopoietic stem cells, T-cell differentiation, antigen presentation, and responsiveness to cytokine stimulation. However, the overall role of autophagy in HSCT remains unclear, highlighting the need for further understanding to improve transplant outcomes.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Immunology
Ashley M. Nelson, Alexandra A. Erdmann, Christopher L. Coe, Mark B. Juckett, Keayra Morris, Jennifer M. Knight, Peiman Hematti, Erin S. Costanzo
Summary: Increased synthesis and release of inflammatory signalling proteins are common among individuals with hematologic malignancies undergoing hematopoietic cell transplantation (HCT). This study examined the relationship between markers of inflammatory activity and depression symptoms following HCT. The results showed that patients with elevated levels of IL-6 and IL-10 reported more severe depression symptoms post-HCT, especially in terms of neurovegetative symptoms.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Immunology
Rebecca Isabel Wurm-Kuczera, Judith Buentzel, Julia Felicitas Leni Koenig, Tobias Legler, Jan-Jakob Valk, Justin Hasenkamp, Wolfram Jung, Jan-Gerd Rademacher, Peter Korsten, Gerald Georg Wulf
Summary: Sarcoidosis is a disease characterized by altered immune response and inflammatory granulomatous tissue infiltration. It may occur during immune reconstitution after HSCT, with glucocorticoid treatment resolving symptoms effectively. The HLA allele association reflects that observed in the general population.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Xiaofeng Zhou, Bethany B. Moore
Summary: Pulmonary infections are a major concern for hematopoietic cell transplantation recipients, with mouse models playing a key role in understanding the impacts of these infections. Studies have shown that post-transplant infectious complications adversely affect innate immunity, and previous infections may contribute to noninfectious pulmonary issues post-HCT.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cell Biology
Yan Man, Xiangmei Yao, Tonghua Yang, Yajie Wang
Summary: The self-renewal and differentiation of hematopoietic stem cells are tightly controlled by various cells and cytokines in the bone marrow microenvironment. Changes in the niche composition can lead to hematological malignancies, and processes like homing, proliferation, and differentiation of HSCs are crucial for the success of hematopoietic stem cell transplantation. Single-cell sequencing and in vivo imaging are powerful tools for studying the bone marrow microenvironment in diseases like leukemia and after transplantation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Medicine, General & Internal
Xiaoqi Wang, Ruihao Huang, Xiaohui Zhang, Xi Zhang
Summary: Hematopoietic stem cell transplantation is an effective medical procedure for treating hematological malignancies. China has made significant contributions to the global process of HSCT, with the haploid HSCT technology in the Beijing Protocol becoming the dominant choice in China. The development and refinement of HSCT techniques in China have had a global impact.
CHINESE MEDICAL JOURNAL
(2022)
Article
Immunology
Elisa B. Margolis, Gabriela Maron Alfaro, Yilun Sun, Ronald H. Dallas, Kim J. Allison, Jose Ferrolino, Hailey S. Ross, Amy E. Davis, Qidong Jia, Paige Turner, Victoria Mackay, Cara E. Morin, Brandon M. Triplett, Eileen J. Klein, Janet A. Englund, Li Tang, Randall T. Hayden
Summary: This study explores the correlation between gut microbiota and infection risk in pediatric allogeneic hematopoietic cell transplantation (allo-HCT). It finds that disruptions in the gut microbiome are related to infection risk in pediatric allo-HCT, and different microbiota patterns are associated with different infections. The ratios of specific bacteria types in the gut can predict the risk of bacteremia, bacterial infections, and viral enterocolitis.
JOURNAL OF INFECTIOUS DISEASES
(2023)
