Article
Biochemistry & Molecular Biology
Yunchao Su, Weihong Han, Anita Kovacs-Kasa, Alexander D. Verin, Laszlo Kovacs
Summary: The study shows that HDAC6 expression is upregulated in patients with COPD and in a COPD animal model. Cigarette smoke extract, PDGF, and IL-6 increase protein levels and activation of HDAC6 in bronchial and pulmonary smooth muscle cells, leading to collagen synthesis and cell proliferation. Pharmacological inhibition of HDAC6 prevents airway and vascular remodeling in COPD.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2021)
Article
Critical Care Medicine
James D. Sargent, Michael Halenar, Alexander W. Steinberg, Jenny Ozga, Zhiqun Tang, Cassandra A. Stanton, Laura M. Paulin
Summary: This study confirms the association between childhood smoking and the risk of COPD, with childhood smokers having a higher risk of developing COPD.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Critical Care Medicine
Sandeep Bodduluri, Abhilash Kizhakke Puliyakote, Arie Nakhmani, Jean-Paul Charbonnier, Joseph M. Reinhardt, Surya P. Bhatt
Summary: The study analyzed airway remodeling in COPD patients by examining the ratio of airway luminal surface area to volume, which indicates airway narrowing and loss. The results showed that airway SA/V is associated with disease severity, lung function decline, respiratory quality, and survival in COPD patients.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Review
Medicine, General & Internal
Klara Szalontai, Nikolett Gemes, Jozsef Furak, Tunde Varga, Patricia Neuperger, Jozsef A. Balog, Laszlo G. Puskas, Gabor J. Szebeni
Summary: COPD is a frequently fatal pathology of the respiratory tract, often caused by chronic inflammatory response to irritants such as tobacco smoke. Early diagnosis, smoking cessation, and global abandonment of biomass fuels are crucial in alleviating the major health problems associated with COPD.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Stanislav Kotlyarov
Summary: Tobacco smoking is a major risk factor for both COPD and ASCVD, and they have common pathogenesis and mutual influence on clinical presentation and prognosis. Smoking-induced systemic inflammation, impaired endothelial function, and oxidative stress play crucial roles in the development and progression of both diseases. Components present in tobacco smoke have adverse effects on various cellular functions, and smoking may also impair the innate immune system and promote oxidative stress in respiratory and vascular systems. This review discusses the importance of smoking in the mechanisms underlying the comorbidity of COPD and ASCVD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Caspar Schiffers, Cheryl van de Wetering, Robert A. Bauer, Aida Habibovic, Milena Hristova, Christopher M. Dustin, Sara Lambrichts, Pamela M. Vacek, Emiel F. M. Wouters, Niki L. Reynaert, Albert van der Vliet
Summary: The downregulation of DUOX1 in the airways of patients with Chronic Obstructive Pulmonary Disease (COPD) may contribute to the pathogenesis of COPD, leading to airway remodeling and emphysema. Animal studies also demonstrate that Duox1 deficiency exacerbates lung pathology induced by smoke exposure.
Review
Immunology
Yafei Rao, Yanqing Le, Jing Xiong, Yuqiang Pei, Yongchang Sun
Summary: COPD is a prevalent chronic airway disease with acute exacerbations as the main cause of morbidity and mortality. NK cells are thought to play important roles in the pathogenesis of COPD but the specific mechanisms remain largely unknown. Further in-depth studies are needed to elucidate these mechanisms.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Respiratory System
Yuan Zhan, Jinkun Chen, Jixing Wu, Yiya Gu, Qian Huang, Zhesong Deng, Shanshan Chen, Xiaojie Wu, Yongman Lv, Zhilin Zeng, Jungang Xie
Summary: The study found that HE4 is significantly upregulated in COPD patients, and is negatively correlated with lung function in these patients. HE4 expression is increased in CSE-induced HBE and CS-exposed mice, but not in HPF. HE4 promotes IL-6 release in HBE through regulating NF kappa B-p65 phosphorylation, and promotes fibroblast-myofibroblast transition and proliferation in HPF.
RESPIRATORY RESEARCH
(2022)
Article
Medicine, General & Internal
Tingting Di, Yue Yang, Congli Fu, Zixiao Zhang, Chu Qin, Xiaoyan Sai, Jiaxin Liu, Caixia Hu, Mingfeng Zheng, Yan Wu, Tao Bian
Summary: This study observed decreased let-7 expression but increased IL-6 levels in COPD patients, CS-exposed mice, and CSE-treated human bronchial epithelial cells. Let-7 was shown to regulate myofibroblast differentiation and ECM deposition by targeting and silencing IL-6 through binding to its 3' UTR.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Medicine, General & Internal
Chiwook Chung, Kyu Na Lee, Kyungdo Han, Dong Wook Shin, Sei Won Lee
Summary: Smoking increases the risk of developing COPD in young individuals, with higher risks for current and heavy smokers. Female smokers are more susceptible to developing COPD than male smokers.
FRONTIERS IN MEDICINE
(2023)
Article
Medicine, Research & Experimental
Rosalia Gagliardo, Fabio Bucchieri, Angela Marina Montalbano, Giusy Daniela Albano, Delphine Gras, Alberto Fucarino, Roberto Marchese, Giulia Anzalone, Chiara Lo Nigro, Pascal Chanez, Mirella Profita
Summary: The airway epithelium plays a critical role in the pathophysiology of COPD, with dysregulation of Oct4, CD146, and CD105 expression induced by cigarette smoke exposure potentially exacerbating airway epithelial dysfunction and contributing to disease progression.
Article
Public, Environmental & Occupational Health
Yong Liu, Susan A. Carlson, Kathleen B. Watson, Fang Xu, Kurt J. Greenlund
Summary: Chronic obstructive pulmonary disease (COPD) is a leading cause of death in the United States. The overall COPD prevalence did not change significantly from 2011 to 2021, but there were significant changes in prevalence among different age groups and smoking status. More attention and tailored strategies are needed to reduce COPD prevalence, especially among adults disproportionately affected.
MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT
(2023)
Article
Immunology
Li Che, Zhefan Xie, Guangshu Chen, Wei Zhang, Tingting Xia, Jiaxin Lin, Wenzhi Luo, Li Chen, Wenguang Yin, Xingdong Cai, Shengming Liu
Summary: This study found that the expression of RELM beta and autophagy genes is significantly increased in the lung tissue of COPD patients. RELM beta promotes airway inflammation in COPD by activating autophagy and increasing the expression of inflammatory cytokines. Furthermore, RELM beta mediates signal transduction by binding to the cell membrane receptor TLR4.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Medicine, General & Internal
Yueying Wu, Hui Meng, Bo Qiao, Ning Li, Qiang Zhang, Wenqing Jia, Haijing Xing, Yuqing Li, Jiali Yuan, Zhongshan Yang
Summary: In this study, the Yifei Sanjie Formula was found to have therapeutic effects on COPD by remodeling lung microbes and inhibiting inflammation signal pathways. This intervention may serve as a potential therapeutic strategy for COPD by positively influencing beneficial lung bacteria and negatively affecting pathogenic bacteria.
FRONTIERS IN MEDICINE
(2022)
Article
Respiratory System
Rui Zhang, Hu Shan, Yuer Li, Yuefeng Ma, Shiyuan Liu, Xiaohuan Liu, Xia Yang, Jie Zhang, Ming Zhang
Summary: Airway epithelial mitochondrial injury is an important factor in the pathogenesis of COPD. CypD, a component of the mitochondrial permeability transition pore, is related to mitochondrial damage. However, the role of CypD in airway epithelial mitochondrial injury and COPD pathogenesis remains unclear.
Review
Rheumatology
Yehya Al-Adwi, Johanna Westra, Harry van Goor, Janette K. Burgess, Christopher P. Denton, Douwe J. Mulder
Summary: SSc is a multiphase autoimmune disease characterized by vasculopathy, inflammation, and fibrosis. Macrophages play a crucial role in the pathogenesis of SSc, as they can initiate chronic inflammation and secrete fibrotic factors.
Letter
Critical Care Medicine
Senani N. H. Rathnayake, Benedikt Ditz, Brigitte W. M. Willemse, Wim Timens, Wierd Kooistra, Irene H. Heijink, Brian G. G. Oliver, Maarten van den Berge, Alen Faiz
Article
Biology
Chantal Donovan, Xu Bai, Yik Lung Chan, Min Feng, Kin-Fai Ho, Hai Guo, Hui Chen, Brian G. Oliver
Summary: TNC expression is increased during lung development, in offspring following maternal PM exposure, asthma, COPD, and lung cancer tissues. Therefore, targeting TNC may provide a novel therapeutic target for lung diseases.
Article
Physiology
Maunick Lefin Koloko Ngassie, Maaike De Vries, Theo Borghuis, Wim Timens, Don D. Sin, David Nickle, Philippe Joubert, Peter Horvatovich, Gyorgy Marko-Varga, Jacob J. Teske, Judith M. Vonk, Reinoud Gosens, Y. S. Prakash, Janette K. Burgess, Corry-Anke Brandsma
Summary: This study investigated age-associated extracellular matrix (ECM) differences in human lungs using transcriptomic, proteomic, and immunohistochemical analyses. Seven ECM proteins were found to be higher in expression with age, and these differences may contribute to the development of chronic lung diseases.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Vyoma K. Patel, Sukriti Vishwas, Rajan Kumar, Gabriele De Rubis, Shakti D. Shukla, Keshav Raj Paudel, Bikash Manandhar, Thakur Gurjeet Singh, Dinesh Kumar Chellappan, Monica Gulati, Indu Pal Kaur, Venkata Sita Rama Raju Allam, Philip M. Hansbro, Brian G. Oliver, Ronan MacLoughlin, Sachin Kumar Singh, Kamal Dua
Summary: Asthma is a chronic inflammatory airway disease that presents a huge burden worldwide. Overproduction of pro-inflammatory cytokines triggers an uncontrolled inflammatory response known as 'cytokine storm', leading to disease progression and fatal consequences. Targeting cytokine overproduction and signaling may provide a promising approach for asthma treatment. This review discusses pharmacological strategies, drug delivery systems, and clinical trial findings that may overcome the limitations of current therapies.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Vinod Kumar Kannaujiya, Gabriele De Rubis, Keshav Raj Paudel, Bikash Manandhar, Dinesh Kumar Chellappan, Sachin Kumar Singh, Ronan MacLoughlin, Gaurav Gupta, Dikaia Xenaki, Pradeep Kumar, Philip Michael Hansbro, Brian Gregory George Oliver, Peter Richard Wich, Kamal Dua
Summary: Non-small cell lung cancer (NSCLC) is a leading cause of cancer-related deaths worldwide, and current treatment options are limited. Inhibition of NF kappa B, a master regulator of NSCLC, shows promise as an innovative therapeutic strategy. This study demonstrates the encapsulation of a hydrophilic NF kappa B decoy ODN into a dextran-based nanoparticle system, which effectively inhibits NF kappa B activity and exhibits promising anticancer activity against NSCLC.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Virology
Xinhui Cai, Tian Lan, Pengyao Ping, Brian Oliver, Jinyan Li
Summary: This study presents a computational method to identify co-existing strains of the SARS-CoV-2 virus from RNA-sequencing data. Multiple strains were found in both the viral and wastewater samples. The method is also capable of identifying within-host diversity in foot-and-mouth disease virus.
Article
Respiratory System
Rosa K. Kortekaas, Kerstin E. Geillinger-Kastle, Theo Borghuis, Kaoutar Belharch, Megan Webster, Wim Timens, Janette K. Burgess, Reinoud Gosens
Summary: IL-11 is found to be related to the pathogenesis of IPF, as it induces myofibroblast differentiation and stimulates excessive collagen deposition in the lung. This study reveals that IL-11 disrupts alveolar epithelial regeneration and inhibits the formation of mature alveolar epithelial cells. The distribution of IL-11 and IL-11 receptor in human lungs further supports these findings.
Article
Pharmacology & Pharmacy
Bikash Manandhar, Keshav Raj Paudel, Dvya Delilaa Clarence, Gabriele De Rubis, Thiagarajan Madheswaran, Jithendra Panneerselvam, Flavia C. Zacconi, Kylie A. Williams, Lisa G. Pont, Majid Ebrahimi Warkiani, Ronan MacLoughlin, Brian Gregory Oliver, Gaurav Gupta, Sachin Kumar Singh, Dinesh Kumar Chellappan, Philip M. Hansbro, Kamal Dua
Summary: Lung cancer is a common and deadly form of cancer, especially non-small-cell lung cancer (NSCLC). Zerumbone (ZER) is a natural compound with anti-cancer properties, but its effectiveness is hindered by low solubility and poor absorption. This study developed ZER-loaded liquid crystalline nanoparticles (LCNs) and found that they effectively inhibited the growth and migration of NSCLC cells. The underlying mechanisms involved the regulation of tumor suppressor genes and metastasis-associated genes. This research suggests that ZER-LCNs could be a promising treatment strategy for NSCLC.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Toxicology
Gabriele De Rubis, Keshav Raj Paudel, Gang Liu, Vipul Agarwal, Ronan MacLoughlin, Terezinha de Jesus Andreoli Pinto, Sachin Kumar Singh, Jon Adams, Srinivas Nammi, Dinesh Kumar Chellappan, Brian Gregory George Oliver, Philip Michael Hansbro, Kamal Dua
Summary: Airway remodelling, a common phenomenon in chronic respiratory diseases, is characterized by aberrant activation of epithelial repair, excessive extracellular matrix deposition, epithelial-to-mesenchymal transition, and airway obstruction. This study demonstrates the therapeutic efficacy of berberine-loaded liquid crystalline nanoparticles in inhibiting TGF-beta-induced remodelling features in human bronchial epithelial cells, supporting its potential application as a treatment strategy against chronic respiratory diseases.
TOXICOLOGY IN VITRO
(2023)
Article
Engineering, Biomedical
Simon D. Pouwels, Alina Sigaeva, Shanna de Boer, Ilse A. Eichhorn, Lisanne Koll, Jeroen Kuipers, Romana Schirhagl, Irene H. Heijink, Janette K. Burgess, Dirk-Jan Slebos
Summary: Endoscopic implantation of medical devices, such as airway stents and valves, is commonly used to treat lung diseases. However, the interaction between these devices, made from metals like nickel and titanium, and cells in the airways has not been well studied. This research examined the response of lung epithelial cells and fibroblasts to different implant device materials.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
(2023)
Letter
Biology
Juman Mohammed Rasmi Alamil, Dikaia Xenaki, Bikash Manandhar, Keshav Raj Paudel, Philip Michael Hansbro, Brian Gregory Oliver, Dinesh Kumar Chellappan, Kamal Dua
Article
Medicine, General & Internal
Katrina O. Tonga, Brian G. Oliver
Summary: Chronic obstructive pulmonary disease (COPD) is a complex and serious disease with various physical and psychological manifestations. Pulmonary rehabilitation, including exercise, is an effective intervention for COPD. However, the efficacy of non-traditional forms of exercise in alternative medicine remains poorly understood. This study aims to fill this knowledge gap and provide a summary of the clinical evidence for traditional exercise regimens in the pulmonary rehabilitation of COPD patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cell & Tissue Engineering
Erika Pinheiro-Machado, Vasilena E. Getova, Martin C. Harmsen, Janette K. Burgess, Alexandra M. Smink
Summary: The secretome of adipose-derived stromal cells (ASC) is a heterogeneous mixture of components that have a beneficial influence on cellular microenvironments. Pathophysiological conditions can enhance the therapeutic capacity of ASC and the benefits of their secretome. Secretomics, the unbiased analysis of a cell secretome by mass spectrometry, is a powerful tool to understand the composition of ASC secretomes. However, the currently available ASC secretomic studies lack standardization, making it difficult to draw solid conclusions on the therapeutic value of different ASC secretomes.
STEM CELL REVIEWS AND REPORTS
(2023)
Article
Multidisciplinary Sciences
Mehmet Nizamoglu, Maunick Lefin Koloko Ngassie, Rhode A. Meuleman, Martin Banchero, Theo Borghuis, Wim Timens, Martijn C. Nawijn, Barbro N. Melgert, Irene H. Heijink, Corry-Anke Brandsma, Janette K. Burgess
Summary: Abnormal deposition of extracellular matrix (ECM) in lung tissue is a characteristic of idiopathic pulmonary fibrosis (IPF). This study found consistently lower proportions of collagen type XIV in all lung tissue compartments across IPF samples, suggesting its potential implications for the assembly of ECM fibers and progression of fibrosis.
SCIENTIFIC REPORTS
(2023)