Article
Pharmacology & Pharmacy
Brandon W. Lewis, Maria L. Ford, Aiman Q. Khan, Joshua Walum, Rodney D. Britt
Summary: Type 2-high severe asthma is a distinct subtype characterized by Th2 inflammation, high eosinophil lung infiltration, impaired lung function, and reduced corticosteroid sensitivity. Acute and chronic allergen models induce type 2 inflammation, but the differences in corticosteroid sensitivity remain unclear. This study found that chronic allergen exposure is associated with more persistent type 2 immune responses and corticosteroid insensitivity.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Respiratory System
Cassandra Spector, Camden M. De Sanctis, Reynold A. Panettieri Jr, Cynthia J. Koziol-White
Summary: Rhinovirus infections can lead to airway remodeling, which is characterized by irreversible airway obstruction and diminished responsiveness to bronchodilators. Structural cells of the airways, including epithelial cells, smooth muscles, fibroblasts, myofibroblasts, and lung vascular endothelial cells, play a role in this process by producing various mediators and components that contribute to airway remodeling. Rhinovirus exposure can induce airway hyperresponsiveness and remodeling phenotypes such as mucus hypersecretion, epithelial-mesenchymal transition, and fibroblast-myofibroblast transdifferentiation. Different cellular responses to rhinovirus infection can lead to persistent airway remodeling in asthmatic individuals, including exaggerated type 2 inflammation, increased extracellular matrix deposition, and enhanced production of pro-angiogenic mediators.
RESPIRATORY RESEARCH
(2023)
Article
Multidisciplinary Sciences
Sophie Mainguy-Seers, Roxane Boivin, Sheila Pourali Dogaheh, Francis Beaudry, Pierre Helie, Alvaro G. Bonilla, James G. Martin, Jean-Pierre Lavoie
Summary: Adding azithromycin to ICS can improve the quality of life and exacerbation rate in neutrophilic asthma, but its effects on lung function, airway inflammation, and bronchial remodeling are not fully understood.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, Research & Experimental
Jinmei Zhang, Zhengcan Wu, Fenfang Yu, Liang Ye, Wei Gu, Yan Tan, Li Wang, Ying Shi
Summary: The research found that LXRs can increase airway inflammation and hyperresponsiveness, as well as promote airway remodeling, suggesting that inhibiting LXRs may be a potential method for treating allergic asthma.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Multidisciplinary Sciences
Ruping Wang, Yinna Wang, Guoning Liao, Bohao Chen, Reynold A. Panettieri, Raymond B. Penn, Dale D. Tang
Summary: Asthma is a complex pulmonary disorder with multiple pathological mechanisms. A key pathological feature is airway remodeling, which is largely caused by the abnormal proliferation of airway smooth muscle cells. An adapter protein called Abi1 has been identified as a molecular switch that regulates the activation of certain proteins and contributes to the progression of asthma.
Article
Cardiac & Cardiovascular Systems
Yijun Yang, Justin Kurian, Giana Schena, Jaslyn Johnson, Hajime Kubo, Joshua G. Travers, Chunya Kang, Anna Maria Lucchese, Deborah M. Eaton, Maoting Lv, Na Li, Lorianna G. Leynes, Daohai Yu, Fengzhen Yang, Timothy A. McKinsey, Raj Kishore, Mohsin Khan, Sadia Mohsin, Steven R. Houser
Summary: The study suggests that metabolic syndrome in obese pregnant women may lead to pathological cardiac remodeling, increasing the risk of chronic heart disorders.
Letter
Respiratory System
Aleksandra Rybka-Fraczek, Marta Dabrowska, Elzbieta M. Grabczak, Katarzyna Bialek-Gosk, Karolina Klimowicz, Olga Truba, Rafal Krenke
Summary: Bronchial hyperresponsiveness may be considered as a predictor of cough variant asthma in non-smoking adults with chronic cough, showing a high positive predictive value in this population. Cough severity and cough related quality of life were not related to the severity of bronchial hyperresponsiveness in CVA patients.
RESPIRATORY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Chi-Chien Lin, Kai-Cheng Chuang, Shih-Wei Chen, Ya-Hsuan Chao, Chih-Ching Yen, Shang-Hsun Yang, Wei Chen, Kuang-Hsi Chang, Yu-Kang Chang, Chuan-Mu Chen
Summary: Lactoferrin exhibits anti-inflammation and immunoregulation activities in OVA-induced allergic asthma, ameliorating lung injury, decreasing Th2 cytokines and allergen-specific antibodies production, and influencing the functions of dendritic cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Wei Li, Lu Xue, Changsi Peng, Ping Zhao, Yongbo Peng, Weiwei Chen, Wenyi Wang, Jinhua Shen
Summary: PP121 exerts dual anti-contractile and anti-inflammatory effects in asthma treatment by blocking specific ion channels and downregulating inflammatory factors, mucins, and the MAPK/Akt signaling pathway in asthmatic mice, suggesting it as a promising therapeutic compound for asthma therapy.
MOLECULAR MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Jorge Reyes-Garcia, Abril Carbajal-Garcia, Luis M. Montano
Summary: Transient receptor potential (TRP) ion channels, particularly TRPV1, TRPV2, and TRPV4, play critical roles in the development of asthma. These channels contribute to environmental sensitization, airway inflammation, airway hyperresponsiveness, and remodeling, and may serve as novel therapeutic targets for asthma.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Stephanie Bettink, Jan-Christian Reil, Andrey Kazakov, Christina Koerbel, Dominic Millenaar, Ulrich Laufs, Bruno Scheller, Michael Boehm, Stephan H. Schirmer
Summary: TRIF plays a significant role in pressure-overload-induced cardiac hypertrophy. It regulates the release of inflammatory cytokines and accumulation of inflammatory cells, and is involved in the development of cardiac fibrosis.
Article
Biochemistry & Molecular Biology
Agnieszka A. Gorska, Clara Sandmann, Eva Riechert, Christoph Hofmann, Ellen Malovrh, Eshita Varma, Vivien Kmietczyk, Julie Oelschlaeger, Lonny Juergensen, Verena Kamuf-Schenk, Claudia Stroh, Jennifer Furkel, Mathias H. Konstandin, Carsten Sticht, Etienne Boileau, Christoph Dieterich, Norbert Frey, Hugo A. Katus, Shirin Doroudgar, Mirko Voelkers
Summary: The study reveals the role of mTOR in pathological remodeling of the heart, showing that it protects cardiomyocytes by controlling the translation of specific genes, with Cand2 being a mTOR-regulated protective gene.
Article
Allergy
Morten Hvidtfeldt, Asger Sverrild, Alexis Pulga, Laurits Frossing, Alexander Silberbrandt, Morten Hostrup, Martin Thomassen, Caroline Sanden, Carl Magnus Clausson, Premkumar Siddhuraj, Daisy Bornesund, Juan Jose Nieto-Fontarigo, Lena Uller, Jonas Erjefalt, Celeste Porsbjerg
Summary: This study investigated the relationship between airway hyperresponsiveness and infiltrating mast cells, as well as the effectiveness of inhaled corticosteroid treatment. The results showed that inhaled corticosteroid treatment significantly improved airway hyperresponsiveness in both patients with high fractional exhaled nitric oxide (FENO) and patients with low FENO. However, there were differences in mast cell phenotypes and distribution between the two groups.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Cell Biology
Jennifer L. Rodgers, Sahit Vanthenapalli, Siva K. Panguluri
Summary: Clinical reports show high ICU mortality when hyperoxia is used during mechanical ventilation. This study on mice reveals that hyperoxia treatment leads to body weight reduction and increased cardiomyocyte size at 24 hours, followed by arrhythmias and worsened cardiac dysfunction at 48 and 72 hours. Electrical remodeling precedes structural remodeling and worsens with longer hyperoxia exposure.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Jun Luo, Stephen D. D. Farris, Deri Helterline, April Stempien-Otero
Summary: Cardiomyocytes increase DNA content in response to stress in humans, but this study found that DNA content decreases in unloaded hearts. Changes in DNA content were independent of cell proliferation. The study used a novel imaging flow cytometry methodology to compare human subjects with LVAD implantation or primary transplantation. Results showed that cardiomyocyte size decreased and DNA content per nucleus significantly decreased in unloaded hearts, while cell-cycle markers were not increased.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yutein Chung, Jun Young Hong, Jing Lei, Qiang Chen, J. Kelley Bentley, Marc B. Hershenson
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2015)
Correction
Multidisciplinary Sciences
Paul D. Bozyk, J. Kelley Bentley, Antonia P. Popova, Anuli C. Anyanwu, Marisa D. Linn, Adam M. Goldsmith, Gloria S. Pryhuber, Bethany B. Moore, Marc B. Hershenson
Article
Allergy
Mingyuan Han, Yutein Chung, Jun Young Hong, Charu Rajput, Jing Lei, Joanna L. Hinde, Qiang Chen, Steven P. Weng, J. Kelley Bentley, Marc B. Hershenson
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2016)
Article
Immunology
Tracy X. Cui, Bhargavi Maheshwer, Jun Y. Hong, Adam M. Goldsmith, J. Kelley Bentley, Antonia P. Popova
JOURNAL OF IMMUNOLOGY
(2016)
Article
Immunology
Mingyuan Han, Charu Rajput, Jun Y. Hong, Jing Lei, Joanna L. Hinde, Qian Wu, J. Kelley Bentley, Marc B. Hershenson
JOURNAL OF IMMUNOLOGY
(2017)
Article
Physiology
Antonia P. Popova, J. Kelley Bentley, Anuli C. Anyanwu, Michelle N. Richardson, Marisa J. Linn, Jing Lei, Elizabeth J. Wong, Adam M. Goldsmith, Gloria S. Pryhuber, Marc B. Hershenson
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2012)
Article
Physiology
Dina Schneider, Jun Young Hong, Emily R. Bowman, Yutein Chung, Deepti R. Nagarkar, Christina L. McHenry, Adam M. Goldsmith, J. Kelley Bentley, Toby C. Lewis, Marc B. Hershenson
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2013)
Article
Physiology
Anuli C. Anyanwu, J. Kelley Bentley, Antonia P. Popova, Omar Malas, Husam Alghanem, Adam M. Goldsmith, Marc B. Hershenson, David J. Pinsky
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2014)
Article
Physiology
Antonia P. Popova, J. Kelley Bentley, Tracy X. Cui, Michelle N. Richardson, Marisa J. Linn, Jing Lei, Qiang Chen, Adam M. Goldsmith, Gloria S. Pryhuber, Marc B. Hershenson
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2014)
Article
Biochemistry & Molecular Biology
Thomas G. Saba, Yutein Chung, Jun Young Hong, Uma S. Sajjan, J. Kelley Bentley, Marc B. Hershenson
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2014)
Letter
Allergy
J. Kelley Bentley, Uma S. Sajjan, Marta B. Dzaman, Nizar N. Jarjour, Wai-Ming Lee, James E. Gern, Marc B. Hershenson
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2013)
Article
Allergy
J. Kelley Bentley, Qiang Chen, Jun Young Hong, Antonia P. Popova, Jing Lei, Bethany B. Moore, Marc B. Hershenson
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2014)
Article
Allergy
Jun Young Hong, J. Kelley Bentley, Yutein Chung, Jing Lei, Jessica M. Steenrod, Qiang Chen, Uma S. Sajjan, Marc B. Hershenson
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2014)
Article
Multidisciplinary Sciences
Paul D. Bozyk, J. Kelley Bentley, Antonia P. Popova, Anuli C. Anyanwu, Marisa D. Linn, Adam M. Goldsmith, Gloria S. Pryhuber, Bethany B. Moore, Marc B. Hershenson
Article
Respiratory System
Jun Young Hong, Yutein Chung, Jessica Steenrod, Qiang Chen, Jing Lei, Adam T. Comstock, Adam M. Goldsmith, J. Kelley Bentley, Uma S. Sajjan, Marc B. Hershenson
RESPIRATORY RESEARCH
(2014)