Review
Biochemistry & Molecular Biology
Marco Heestermans, Geraldine Poenou, Anne-Claire Duchez, Hind Hamzeh-Cognasse, Laurent Bertoletti, Fabrice Cognasse
Summary: This review outlines the role of platelets in venous thrombosis, highlighting their involvement in disease initiation, leukocyte recruitment, coagulation, fibrinolysis, and resolution. Conventional antiplatelet therapy can prevent venous thrombosis and impact (recurrent) VTE in humans.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Lisa Repsold, Anna Margaretha Joubert
Summary: Platelets play a crucial role in homeostasis, thrombosis, inflammation, cancer progression, and metastasis by releasing pro-inflammatory factors to regulate immune function and inflammatory processes. Despite our understanding of platelets in these processes, the complete interrelation and extent of these processes are still not fully understood.
Review
Dermatology
Zhijia Fan, Li Wang, Haoqin Jiang, Yong Lin, Zhicheng Wang
Summary: This study aims to review the abnormal platelet function in psoriasis and explain the crucial role of platelets in the pathogenic mechanism of psoriasis, in order to identify new targets for comprehensive medical treatment.
Review
Pharmacology & Pharmacy
Raayma Iffah, Felicity N. E. Gavins
Summary: The pathophysiology of COVID-19 is complex, with multiple systems contributing to thrombosis and inflammation. Understanding the role of the immune system in different patient cohorts is crucial for developing novel therapeutic targets and drug repurposing strategies.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Cell Biology
Yiming Feng, Yue Zhang, Jialan Shi
Summary: Classical myeloproliferative neoplasm (MPN) is a clonal disease characterized by abnormal expansion of hematopoietic stem cells. MPN patients are more susceptible to thrombotic events, but antiplatelet therapies may cause bleeding. Platelets play a critical role in the pathogenesis of MPN and optimizing antithrombotic treatment strategies by adjusting the administration of antiplatelet drugs may achieve simultaneous control of thrombosis and bleeding.
Article
Chemistry, Analytical
Xiaoying Wang, Tao Gao, Jin Zhu, Shipeng Long, Songyan Zhao, Li Yuan, Zhaoxia Wang
Summary: Hematogenous metastasis is the main cause of cancer-related deaths, and platelets play a crucial role in promoting this process. A new channeled and conductive 3D electrode was constructed to capture and detect platelet interacted circulating tumor cells (CTCs). The modified antibody allowed for the capture of platelet-interacted CTC hybrids, while the conductive layer facilitated electron transfer for sensitive electrochemical detection. This work provides an efficient method for simultaneous capture and detection of invasive CTCs, with the potential to monitor hematogenous metastasis accurately.
ANALYTICAL CHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Daphne N. Pariser, Zachary T. Hilt, Sara K. Ture, Sara K. Blick-Nitko, Mark R. Looney, Simon J. Cleary, Estheany Roman-Pagan, Jerry Saunders, Steve N. Georas, Janelle Veazey, Ferralita Madere, Laura Tesoro Santos, Allison Arne, Nguyen P. T. Huynh, Alison C. Livada, Selena M. Guerrero-Martin, Claire Lyons, Kelly A. Metcalf-Pate, Kathleen E. McGrath, James Palis, Craig N. Morrell
Summary: Platelets, previously known as cellular mediators of thrombosis, are also immune cells that interact with immune cells, impacting their activation and differentiation. Lung megakaryocytes (Mk(L)) have gene expression patterns similar to antigen-presenting cells, and have key immune regulatory roles influenced by the tissue environment. This indicates the plasticity of the immune phenotype of Mk(L) and their ability to induce T cell activation.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Cell Biology
Danielle M. Coenen, Alexandra C. A. Heinzmann, Silvia Oggero, Hugo J. Albers, Magdolna Nagy, Perrine Hague, Marijke J. E. Kuijpers, Jean-Marie Vanderwinden, Andries D. van der Meer, Mauro Perretti, Rory R. Koenen, Judith M. E. M. Cosemans
Summary: This study demonstrated previously unrecognized roles for platelet PDE3A and platelet PDE5 in platelet procoagulant and proinflammatory responses. Cilostazol delayed platelet-dependent fibrin formation under whole blood flow and reduced the release of phosphatidylserine-positive extracellular vesicles from human platelets, while both cilostazol and tadalafil reduced platelet interactions with inflamed endothelium and the release of chemokines. Additionally, cilostazol, but not tadalafil, reduced monocyte recruitment and platelet-monocyte interaction in vitro.
Review
Medicine, General & Internal
Hussam A. S. Murad, Misbahuddin M. Rafeeq, Thamer M. A. Alqurashi
Summary: Atherosclerosis, a leading cause of mortality and morbidity globally, involves the complex interplay of chemokines and their receptors, particularly CXCL12 and its receptors CXCR4 and ACKR3. The CXCL12/CXCR4/ACKR3 axis in atherosclerosis has a dual role in promoting and protecting against atherosclerosis in various cell types. Due to the functional heterogeneity and cross talk of CXCR4 and ACKR3 at receptor level and downstream pathways, targeted modulation of CXCL12, CXCR4, and ACKR3 with specific spatial and temporal factors is a potential area for further exploration in atherosclerosis research.
ANNALS OF MEDICINE
(2021)
Review
Immunology
Subhadip Choudhuri, Nisha J. Garg
Summary: Chagas disease is a major health problem in the Americas and an emerging health problem in Europe and other nonendemic countries. The persistence of Trypanosoma cruzi and oxidative and inflammatory stress are significant factors in the pathogenesis of the disease. Cardiac thrombi, arrhythmias, and cardiomyopathy are major clinical features. During T. cruzi infection, parasite-released factors induce endothelial dysfunction and activation of platelets and immune cells.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Review
Physiology
M. Sauter, H. F. Langer
Summary: This article investigates the contribution of innate immune mechanisms to atherosclerosis and their interaction with molecules of cholesterol homeostasis. Recent research has identified potential roles of previously overlooked cell types, such as platelets and dendritic cells, in this chronic disease. However, specific therapeutic approaches targeting these immune mechanisms have not yet been successfully introduced into everyday clinical practice.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Critical Care Medicine
George A. Alba, Andriy O. Samokhin, Rui-Sheng Wang, Ying-Yi Zhang, Bradley M. Wertheim, Elena Arons, Edward A. Greenfield, Martina H. Lundberg Slingsby, Julia R. Ceglowski, Kathleen J. Haley, Frederick P. Bowman, Yen-Rei Yu, John C. Haney, George Eng, Richard N. Mitchell, Anthony Sheets, Sara O. Vargas, Sachiko Seo, Richard N. Channick, Peter J. Leary, Sudarshan Rajagopal, Joseph Loscalzo, Elisabeth M. Battinelli, Bradley A. Maron
Summary: The study identified the modifiable protein-protein interaction between NEDD9 and P-selectin as a potential target to inhibit platelet-pulmonary endothelial adhesion and thromboembolic vascular remodeling under hypoxia conditions. Custom anti-NEDD9 antibody effectively inhibited platelet adhesion to pulmonary artery endothelial cells and reduced chronic pulmonary thromboembolic remodeling in vivo.Therefore, the NEDD9-P-selectin interaction may have therapeutic implications for patients with disorders characterized by increased hypoxia signaling pathways, such as CTEPH.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Cell Biology
Nishant Ranjan Chauhan, Soumya Kundu, Ramyasing Bal, Diya Chattopadhyay, Rinku Sahu, Subhash Mehto, Rina Yadav, Sivaram Krishna, Kautilya Kumar Jena, Sameekshya Satapathy, Anusha Pv, Krushna C. Murmu, Bharati Singh, Srinivas Patnaik, Sarita Jena, Krishnan H. Harshan, Gulam Hussain Syed, Mohammed M. Idris, Punit Prasad, Santosh Chauhan
Summary: Interferon Type I (IFN-I) response plays a crucial role in host defense against SARS-CoV-2 infection. Through mouse models, it has been found that a high level of IFN-I response can protect against lethal SARS-CoV-2 infection, while a dampened IFN-I response may lead to severe infection and immune inflammation.
Review
Biochemistry & Molecular Biology
Elias Rawish, Harald F. Langer
Summary: P2X receptors are a family of cation channel proteins that respond to extracellular ATP. Recent research suggests that targeting purinergic receptors may provide a novel therapeutic approach for neurological diseases. This review explores the role of platelets and purinergic signaling in these conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Maria Amparo Blanch-Ruiz, Raquel Ortega-Luna, Maria Angeles Martinez-Cuesta, Angeles Alvarez
Summary: Cardiovascular diseases are a leading cause of death, with blood-cell interactions and endothelial dysfunction playing a key role in thrombus formation. Neutrophil extracellular vesicles (EVs) and neutrophil extracellular traps (NETs) have been reported to contribute to thrombosis through various mechanisms, requiring exhaustive analysis of their structure and composition to clarify their role in pathological thrombus formation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Carolina A. Moraes, Eugenio D. Hottz, Debora Dos Santos Ornellas, Daniel Adesse, Carolina T. de Azevedo, Joana C. D'Avila, Camila Zaverucha-do-Valle, Tatiana Maron-Gutierrez, Helene Santos Barbosa, Patricia Torres Bozza, Fernando Augusto Bozza
Summary: This study investigated the role of the NLRP3 inflammasome in microglial activation and synaptic loss related to sepsis. The results showed increased expression of NLRP3 inflammasome in the brains of septic mice, specifically in microglial cells. In vitro experiments also revealed that LPS-stimulated microglia produced mitochondrial reactive oxygen species, recruited NLRP3 complex, and released IL-1β. Inhibition of NLRP3, caspase-1, and mitochondrial ROS decreased IL-1β secretion by microglial cells.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Critical Care Medicine
Bruno Goncalves, Carla Rynkowski, Ricardo Turon, Nestor Charris, Fabio Miranda, Vanessa de Caro, Marco Prazeres, Thayana Santos, David M. Greer, Tarek Sharshar, Turc Guillaume, Fernando A. Bozza, Cassia Righy, Pedro Kurtz
Summary: This study aimed to evaluate the clinical characteristics and treatment practices of patients with aneurysmal subarachnoid hemorrhage (SAH) in Brazil, a middle-income country, and assess their long-term outcomes. The study found significant differences in SAH management in Brazil compared to other countries, and suggested that earlier aneurysm occlusion and increased use of endovascular therapy could potentially improve functional outcomes in SAH patients.
NEUROCRITICAL CARE
(2023)
Article
Engineering, Biomedical
Neel Shah, Bing Xue, Ziqi Xu, Hanqing Yang, Eva Marwali, Heidi Dalton, Philip P. R. Payne, Chenyang S. Lu, Ahmed Said
Summary: In this study, several ECMO mortality prediction and severity of illness scores were validated for a large COVID-19 V-V ECMO cohort. The results showed inconsistent discrimination and calibration of these scores, highlighting the need for better clinically applicable decision support tools.
Letter
Critical Care Medicine
Pedro Kurtz, Leonardo S. L. T. Bastos, Otavio Ranzani, Marcio Soares, Fernando Zampieri, Silvio Hamacher, Jorge A. Salluh, Fernando Bozza, DP EFFECT BRAZIL investigators
INTENSIVE CARE MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Christiana Kartsonaki, J. Kenneth Baillie, Noelia Garcia Barrio, Joaquin Baruch, Abigail Beane, Lucille Blumberg, Fernando Bozza, Tessa Broadley, Aidan Burrell, Gail Carson, Barbara Wanjiru Citarella, Andrew Dagens, Emmanuelle A. Dankwa, Christl A. Donnelly, Jake Dunning, Loubna Elotmani, Martina Escher, Nataly Farshait, Jean-Christophe Goffard, Bronner P. Goncalves, Matthew Hall, Madiha Hashmi, Benedict Sim Lim Heng, Antonia Ho, Waasila Jassat, Miguel Pedrera Jimenez, Cedric Laouenan, Samantha Lissauer, Ignacio Martin-Loeches, France Mentre, Laura Merson, Ben Morton, Daniel Munblit, Nikita A. Nekliudov, Alistair D. Nichol, Budha Charan Singh Oinam, David Ong, Prasan Kumar Panda, Michele Petrovic, Mark G. Pritchard, Nagarajan Ramakrishnan, Grazielle Viana Ramos, Claire Roger, Oana Sandulescu, Malcolm G. Semple, Pratima Sharma, Louise Sigfrid, Emily C. Somers, Anca Streinu-Cercel, Fabio Taccone, Pavan Kumar Vecham, Bharath Kumar Tirupakuzhi Vijayaraghavan, Jia Wei, Evert-Jan Wils, Xin Ci Wong, Peter Horby, Amanda Rojek, Piero L. Olliaro, Ali Abbas
Summary: This study analyzed demographic features, treatments, and clinical outcomes of hospitalized COVID-19 patients in 52 countries from January 2020 to January 2022. Age and male sex were associated with a higher risk of death. Symptoms, co-morbidities, and treatments were associated with clinical outcomes. This comprehensive international study provides valuable information for prioritizing treatment for COVID-19 patients at higher risk of death.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Urology & Nephrology
Henrique Palomba, Daniel Cubos, Fernando Bozza, Fernando Godinho Zampieri, Thiago Gomes Romano
Summary: The study aimed to develop a prognostic score for predicting the development of Acute Kidney Injury (AKI) in COVID-19 patients. A retrospective observational study of 2334 COVID-19 patients admitted to 23 different hospitals in Brazil was conducted, and common clinical variables were found to accurately predict the development of AKI in these patients.
Article
Immunology
Andre C. Ferreira, Carolina Q. Sacramento, Filipe S. Pereira-Dutra, Natalia Fintelman-Rodrigues, Priscila P. Silva, Mayara Mattos, Caroline S. de Freitas, Andressa Marttorelli, Gabrielle R. de Melo, Mariana M. Campos, Isaclaudia G. Azevedo-Quintanilha, Aluana S. Carlos, Joao Vitor Emidio, Cristiana C. Garcia, Patricia T. Bozza, Fernando A. Bozza, Thiago M. L. Souza
Summary: This study found that influenza virus infection can induce inflammatory programmed cell death in macrophages, and inhibiting inflammatory cell death can reduce inflammation and lung injury. This study identified an additional mechanism involved in severe influenza and proposed a clinically available method for treatment.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Public, Environmental & Occupational Health
Horacio N. Hastenreiter Filho, Igor T. Peres, Lucas G. Maddalena, Fernanda A. Baiao, Otavio T. Ranzani, Silvio Hamacher, Paula M. Macaira, Fernando A. Bozza
Summary: This article provides a narrative review of COVID-19 vaccination impact studies, discussing their characteristics and analyzing their similarities and differences. The review includes 18 studies evaluating the vaccine impact in different countries.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Amanda de Araujo Batista-da-Silva, Camila Barros Moraes, Helena Rodrigues Bozza, Leonardo dos Santos Lourenco Bastos, Otavio T. Ranzani, Silvio Hamacher, Fernando Augusto Bozza, Comite Gestor Conexao Saude
Summary: This study analyzed the impact of a multicomponent intervention on COVID-19 case detection and mortality rates in a vulnerable community in Rio de Janeiro, Brazil. The intervention included community engagement, mobile surveillance, massive testing, and telehealth. The findings suggest that this integrated intervention can reduce COVID-19 mortality and increase case detection.
Article
Urology & Nephrology
Marina Wainstein, Nicholas Spyrison, Danyang Dai, Moji Ghadimi, Jonathan S. Chavez-Iniguez, Lilia Rizo-Topete, Barbara Wanjiru Citarella, Laura Merson, Jason D. Pole, Rolando Claure-Del Granado, David W. Johnson, S. Shrapnel
Summary: There is a lack of research on the relationship between COVID-19 and acute kidney injury (AKI) in low- and low-middle income countries. This study found that AKI incidence was highest in LLMIC, with lower rates of dialysis and poorer patient outcomes.
KIDNEY INTERNATIONAL REPORTS
(2023)
Article
Endocrinology & Metabolism
Renata Moll-Bernardes, Juliana R. Ferreira, Andrea Silvestre Sousa, Mariana B. Tortelly, Adriana L. Pimentel, Ana Cristina B. S. Figueiredo, Eduardo B. Schaustz, Jose Carlos Pizzolante Secco, Allan Robson Kluser Sales, Flavia V. O. Terzi, Adriana Xavier de Brito, Renee O. Sarmento, Marcia M. Noya-Rabelo, Sergio Fortier, Flavia A. Matos e Silva, Narendra Vera, Luciana Conde, Mauro Jorge Cabral-Castro, Denilson C. Albuquerque, Paulo Rosado de-Castro, Gabriel C. Camargo, Martha V. T. Pinheiro, Olga F. Souza, Fernando A. Bozza, Ronir R. Luiz, Emiliano Medei
Summary: This study aims to investigate the immune signatures of hypertensive patients with obesity and their association with COVID-19 severity. The findings suggest that clinical and immune variables and obesity have a synergistic effect on increasing the risk of COVID-19 progression.
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Article
Multidisciplinary Sciences
Alvaro Rea-Neto, Rafaella Stradiotto Bernardelli, Mirella Cristine de Oliveira, Paula Geraldes David-Joao, Amanda Christina Kozesinski-Nakatani, Antonio Luis Eiras Falcao, Pedro Martins Pereira Kurtz, Helio Afonso Ghizoni Teive, Neurocritical Brazil Study Grp
Summary: Acute neurological emergencies are common in Brazilian ICUs and have a significant impact on patients. This study found that older age, emergency admission, number of secondary injuries, and severity of illness scores are predictors of mortality and poor outcomes in patients with acute neurological diagnoses.
SCIENTIFIC REPORTS
(2023)
Article
Critical Care Medicine
Hugo Boechat Andrade, Ivan Rocha Ferreira da Silva, Rodolfo Espinoza, Mayara Secco Torres da Silva, Pedro Henrique Nascimento Theodoro, Marcel Treptow Ferreira, Jesus Soares, Ermias D. Belay, James J. Sejvar, Fernando Augusto Bozza, Jose Cerbino-Neto, Andre Miguel Japiassu
Summary: This study compared the performance of specialized infectious diseases ICUs with other ICUs in the treatment of community-acquired central nervous system infections (CNSI), and found that CNSI patients had lower mortality and resource use rates when treated in specialized infectious diseases ICUs.
JOURNAL OF INTENSIVE CARE MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Marcos C. C. Gama-Almeida, Gabriela D. A. Pinto, Livia Teixeira, Eugenio D. D. Hottz, Paula Ivens, Hygor Ribeiro, Rafael Garrett, Alexandre G. G. Torres, Talita I. A. Carneiro, Bianca de O. Barbalho, Christian Ludwig, Claudio J. J. Struchiner, Iranaia Assuncao-Miranda, Ana Paula C. Valente, Fernando A. A. Bozza, Patricia T. Bozza, Gilson C. C. dos Santos Jr, Tatiana El-Bacha
Summary: Brazil has the second-highest COVID-19 death rate worldwide, with Rio de Janeiro being one of the states with the highest rate in the country. Despite vaccine coverage, COVID-19 is expected to become an endemic disease. The molecular mechanisms underlying the progression of the disease and the development of long COVID-19 are still not fully understood.
Article
Hematology
Matthew J. Griffee, Patricia T. Bozza, Luis Felipe Reyes, Devin P. Eddington, Dorothea Rosenberger, Laura Merson, Barbara Wanjiru Citarella, Jonathon P. Fanning, Peta M. A. Alexander, John Fraser, Heidi Dalton
Summary: In this study, the frequency of coagulopathy complications in COVID-19 patients from developing countries (LMICs) was compared to those from high-income countries (HICs), and it was found that complications were more frequent in HICs. Complications were more common in patients receiving advanced treatment, and were associated with increased in-hospital mortality. Moreover, the mortality associated with these complications was higher in LMICs. Therefore, further research is needed to explore timely diagnosis and intervention for coagulation derangements in COVID-19, particularly in limited-resource settings.
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS
(2023)