Article
Biochemistry & Molecular Biology
Se Jeong Kwon, Dohee Ahn, Hyun-Mo Yang, Hyo Jin Kang, Sang J. Chung
Summary: Natural product Polyphyllin D selectively inhibits SHP2, while echinocystic acid and oleanolic acid inhibit both SHP1 and SHP2. Polyphyllin D shows cytotoxicity in acute lymphoma leukemia cells and decreases p-ERK levels. Knockdown of PTPN6 and PTPN11 recovers p-ERK levels in Jurkat cells.
Article
Oncology
Zhihan Li, Jinchuan Xi, Baokun Li, Youqiang Liu, Guiying Wang, Bin Yu, Hongqing Ma, Zhilin Li, Zhenya Zhang
Summary: This study found that low expression of SHP-2 may regulate M2 polarization of tumor-associated macrophages (TAMs) and exosome release through the PI3K/AKT pathway, thereby enhancing the migration and invasion ability of colorectal cancer (CRC) cells.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Natasha S. Clayton, Millie Fox, Jose J. Vicente-Garcia, Courtney M. Schroeder, Trevor D. Littlewood, Jonathon Wilde, Kadalmani Krishnan, Murray J. B. Brown, Claire Crafter, Helen R. Mott, Darerca Owen
Summary: Activated Cdc42-associated kinase (ACK) phosphorylates PI3K regulatory subunits, promoting cell proliferation. ACK interacts with p85 alpha in nuclear-enriched cell fractions, facilitating dimerization of the regulatory subunits.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Veterinary Sciences
Ning Han, Ying Su, Mi Guo, Li Yu
Summary: Diabetic retinopathy is a common complication of diabetes that can lead to blindness. In this study, the role of protein tyrosine phosphatase 2 (SHP2) in diabetic retinopathy was investigated, and it was found that inhibiting SHP2 can alleviate retinal pathological changes and reduce inflammation and oxidative stress in rats with diabetic retinopathy.
EXPERIMENTAL ANIMALS
(2022)
Article
Cell Biology
Zhe Qian, Dongyan Song, Jonathan J. Ipsaro, Carmelita Bautista, Leemor Joshua-Tor, Johannes T. -H. Yeh, Nicholas K. Tonks
Summary: In this study, the researchers generated a novel monoclonal antibody, RD-43, which targeted the ectodomain of PTPRD to inhibit its function and promote its degradation. Treatment with RD-43 was found to suppress SRC signaling required for breast cancer cell invasion. These findings suggest that antibodies targeting extracellular segments of receptor protein tyrosine phosphatases may have therapeutic potential.
GENES & DEVELOPMENT
(2023)
Review
Cell Biology
Michel L. Tremblay
Summary: In this study, a monoclonal antibody targeting PTPRD was identified, which induced dimerization and inhibition of the phosphatase activities of PTPRD and led to its proteolysis by intracellular degradation pathways. This finding opens up a new framework for the clinical manipulation of PTPRD and its closely related family members.
GENES & DEVELOPMENT
(2023)
Article
Orthopedics
Ziying Sun, Xingquan Xu, Zhongyang Lv, Jiawei Li, Tianshu Shi, Heng Sun, Kuoyang Sun, Guihua Tan, Wenqiang Yan, Yannick Xiaofan Yang, Rui Wu, Jia Xu, Hu Guo, Qing Jiang, Dongquan Shi
Summary: This study demonstrates that the SHP2 inhibitor SHP099 promotes chondrogenesis and the repair of cartilage defects, suggesting its potential as a therapeutic drug for cartilage repair.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2022)
Article
Oncology
Shu Li, Jialing Qu, Xiaotong Wang, Qin Zou, Chunli Li
Summary: This study assessed the impact of SHP2 on solid tumors and found that SHP2 expression levels were increased in various tumor tissues and associated with tumor progression and prognosis. Furthermore, SHP2 expression was positively correlated with OS and DFS in kidney renal clear cell carcinoma, but negatively correlated with OS and DFS in urothelial carcinoma and cervical and endocervical cancer types. In addition, SHP2 expression was associated with the tumor microenvironment of different tumor types and may serve as a potential biological target for cancer therapy.
Article
Chemistry, Organic
Lijie Yu, Bo Feng, Zhijia Wang, Lixin Gao, Chun Zhang, Satheeshkumar Rajendran, Jia Li, Yubo Zhou, Wenlong Wang
Summary: SHP1 is a potential target for drug development in cancer treatment due to its role as a convergent node for oncogenic cell-signaling cascades. A new type of SHP1 inhibitor with 5-phenyl-1,3,4-thiadiazole scaffold, such as compound 5b, demonstrated promising inhibitory activity and selectivity, offering a novel scaffold for developing new SHP1 inhibitors.
CHINESE JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Cell Biology
Antonio Rodriguez-Blazquez, Arturo Carabias, Alba Moran-Vaquero, Sergio de Cima, Juan R. Luque-Ortega, Carlos Alfonso, Peter Schuck, Jose Antonio Manso, Sandra Macedo-Ribeiro, Carmen Guerrero, Jose M. de Pereda
Summary: C3G activation is regulated by phosphorylation and interaction with Crk adaptor proteins, revealing a two-factor mechanism for tight control of its activity.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Multidisciplinary Sciences
Long Zhao, Hao Luo, Yu Ma, Shengze Zhu, Yongjiang Wu, Muxing Lu, Xiaojun Yao, Xin Liu, Gang Chen
Summary: The lack of effective and safe analgesics for chronic pain management has long been a health issue. Analgesic peptides, without opioid-related adverse effects, have recently shown promise for pain treatment. This study discovers that the peptide H-20 binds to PD-1, reduces nociceptive signals, and displays effective analgesia in preclinical pain models, making it a promising candidate drug for chronic pain treatment.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Immunology
Xu Ding, Fei-Fei Liao, Li Su, Xi Yang, Wei Yang, Qing-Hua Ren, Jin-Zhe Zhang, Huan-Min Wang
Summary: Sciatic nerve block can alleviate pain hypersensitivity and microglial activation in rats subjected to neonatal and adult incision. Decreased activation of spinal microglia contributes to the beneficial effects of sciatic nerve block on the exaggerated incisional pain induced by neonatal incision.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Cell Biology
Alessia Varone, Chiara Amoruso, Marcello Monti, Manpreet Patheja, Adelaide Greco, Luigi Auletta, Antonella Zannetti, Daniela Corda
Summary: The research demonstrated that Shp1 plays a crucial role in invadopodia formation by promoting the dephosphorylation of cortactin, thereby reducing melanoma cancer cells' ability to degrade the extracellular matrix. Additionally, the study showed that Shp1 can be considered as a regulator of melanoma cell invasiveness and a potential target for antimetastatic drugs. Glycerophosphoinositol was found to facilitate the localization of Shp1 at invadopodia, leading to impaired invadopodia function and decreased tumor dissemination both in vitro and in an in vivo model of melanomas.
CELL COMMUNICATION AND SIGNALING
(2021)
Review
Biochemistry & Molecular Biology
Awa Diop, Daniele Santorelli, Francesca Malagrino, Caterina Nardella, Valeria Pennacchietti, Livia Pagano, Lucia Marcocci, Paola Pietrangeli, Stefano Gianni, Angelo Toto
Summary: This review summarizes the latest research on the structure, function, pathogenic role, and regulation of SH2 domains. The findings suggest that pharmacological interest in SH2 domains and a deeper understanding of their binding properties are crucial.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ming-Fo Hsu, Yoshihiro Ito, Maryam Afkarian, Fawaz G. Haj
Summary: Shp2 contributes significantly to podocyte function under hyperglycemia, and its deficiency can protect podocyte function from high glucose damage. Its deficiency alters insulin signaling and reduces hyperglycemia-induced endoplasmic reticulum stress, inflammation, and fibrosis.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Guoying Yu, Argyris Tzouvelekis, Rong Wang, Jose D. Herazo-Maya, Gabriel H. Ibarra, Anup Srivastava, Joao Pedro Werneck de Castro, Giuseppe DeIuliis, Farida Ahangari, Tony Woolard, Nachelle Aurelien, Rafael Arrojo e Drigo, Ye Gan, Morven Graham, Xinran Liu, Robert J. Homer, Thomas S. Scanlan, Praveen Mannam, Patty J. Lee, Erica L. Herzog, Antonio C. Bianco, Naftali Kaminski
Editorial Material
Cardiac & Cardiovascular Systems
David J. Hur, Lindsey M. Prescher, Judith L. Meadows, Steven E. Pfau, Robert J. Homer, George Tellides, James J. Yun
ANNALS OF THORACIC SURGERY
(2019)
Editorial Material
Cardiac & Cardiovascular Systems
Kelly Brown, Robert Homer, Marina Baine, Justin D. Blasberg
ANNALS OF THORACIC SURGERY
(2019)
Editorial Material
Medicine, Research & Experimental
Benjamin L. Mazer, Robert J. Homer, David L. Rimm
LABORATORY INVESTIGATION
(2019)
Article
Multidisciplinary Sciences
Eriko Kudo, Eric Song, Laura J. Yockey, Tasfia Rakib, Patrick W. Wong, Robert J. Homer, Akiko Iwasaki
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Oncology
Deborah Ayeni, Braden Miller, Alexandra Kuhlmann, Ping-Chih Ho, Camila Robles-Oteiza, Mmaserame Gaefele, Stellar Levy, Fernando J. de Miguel, Curtis Perry, Tianxia Guan, Gerald Krystal, William Lockwood, Daniel Zelterman, Robert Homer, Zongzhi Liu, Susan Kaech, Katerina Politi
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2019)
Article
Oncology
Jessie Torgersen, Tamar H. Taddei, Lesley S. Park, Dena M. Carbonari, Michael J. Kallan, Kisha Mitchell Richards, Xuchen Zhang, Darshana Jhala, Norbert Br Au, Robert Homer, Kathryn D'Addeo, Rajni Mehta, Melissa Skanderson, Farah Kidwai-Khan, Amy C. Justice, Vincent Lo Re
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2020)
Article
Pathology
Marina K. Baine, John H. Sinard, Guoping Cai, Robert J. Homer
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
(2020)
Article
Immunology
Benjamin Israelow, Eric Song, Tianyang Mao, Peiwen Lu, Amit Meir, Feimei Liu, Mia Madel Alfajaro, Jin Wei, Huiping Dong, Robert J. Homer, Aaron Ring, Craig B. Wilen, Akiko Iwasaki
JOURNAL OF EXPERIMENTAL MEDICINE
(2020)
Article
Multidisciplinary Sciences
Ruoyi Jiang, Kenneth B. Hoehn, Casey S. Lee, Minh C. Pham, Robert J. Homer, Frank C. Detterbeck, Inmaculada Aban, Leslie Jacobson, Angela Vincent, Richard J. Nowak, Henry J. Kaminski, Steven H. Kleinstein, Kevin C. O'Connor
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Multidisciplinary Sciences
Tianyang Mao, Benjamin Israelow, Mario A. Pena-Hernandez, Alexandra Suberi, Liqun Zhou, Sophia Luyten, Melanie Reschke, Huiping Dong, Robert J. Homer, W. Mark Saltzman, Akiko Iwasaki
Summary: This study developed a vaccine strategy called prime and spike, which activates mucosal immune memory within the respiratory tract and induces strong immune responses. It enhances both systemic and local immunity against SARS-CoV-2, and provides full protection against lethal infection in partially immune mice.
Article
Multidisciplinary Sciences
Ilianna Barbayianni, Paraskevi Kanellopoulou, Dionysios Fanidis, Dimitris Nastos, Eleftheria-Dimitra Ntouskou, Apostolos Galaris, Vaggelis Harokopos, Pantelis Hatzis, Eliza Tsitoura, Robert Homer, Naftali Kaminski, Katerina M. Antoniou, Bruno Crestani, Argyrios Tzouvelekis, Vassilis Aidinis
Summary: This study found that the formation of podosomes in lung fibroblasts is closely associated with extracellular matrix invasion in patients with idiopathic pulmonary fibrosis and mouse models. Targeting podosome formation or organization may be a potential therapeutic option for pulmonary fibrosis.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, Research & Experimental
John E. McDonough, Farida Ahangari, Qin Li, Siddhartha Jain, Stijn E. Verleden, Jose Herazo-Maya, Milica Vukmirovic, Giuseppe DeIuliis, Argyrios Tzouvelekis, Naoya Tanabe, Fanny Chu, Xiting Yan, Johny Verschakelen, Robert J. Homer, Dimitris Manatakis, Junke Zhang, Jun Ding, Karen Maes, Laurens De Sadeleer, Robin Vos, Arne Neyrinck, Panayiotis Benos, Ziv Bar-Joseph, Dean Tantin, James C. Hogg, Bart M. Vanaudenaerde, Wim A. Wuyts, Naftali Kaminski
Meeting Abstract
Critical Care Medicine
M. Vukmirovic, A. Fabre, X. Yan, G. Deluliis, T. Woolard, B. Hu, A. Mihaljinec, R. Homer, J. H. Maya, F. Ahangari, D. Smart, F. Conforti, B. Marshall, A. Alzetani, D. E. Davies, L. Richeldi, N. Kaminski, M. Jones
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2018)
Meeting Abstract
Critical Care Medicine
Z. Chen, S. Oh, P. Fang, Q. Li, F. Zhang, H. Tang, R. Homer, X. Zhang, N. Kaminski, T. Zheng, Z. Zhu
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2018)