Article
Respiratory System
Kevin L. Winthrop, Patrick A. Flume, Rachel Thomson, Kevin C. Mange, Dayton W. Yuen, Monika Ciesielska, Kozo Morimoto, Stephen J. Ruoss, Luigi R. Codecasa, Jae-Joon Yim, Theodore K. Marras, Jakko van Ingen, Richard J. Wallace, Barbara A. Brown-Elliott, Chris Coulter, David E. Griffith
Summary: This study evaluated the safety, tolerability, and efficacy of ALIS combined with GBT in patients with refractory MAC lung disease for 12 months. The results showed that respiratory treatment-emergent adverse events were common, nephrotoxicity and hearing decline were infrequent, and culture conversion continued beyond 6 months of therapy.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2021)
Article
Critical Care Medicine
David E. Griffith, Rachel Thomson, Patrick A. Flume, Timothy R. Aksamit, Stephen K. Field, Doreen J. Addrizzo-Harris, Kozo Morimoto, Wouter Hoefsloot, Kevin C. Mange, Dayton W. Yuen, Monika Ciesielska, Richard J. Wallace, Jakko van Ingen, Barbara A. Brown-Elliott, Chris Coulter, Kevin L. Winthrop
Summary: In the CONVERT study, adding ALIS to GBT treatment can help more patients with treatment-refractory disease achieve sustained and durable culture conversion, with lower relapse rates at 3 months after treatment, and no new safety signals were observed after 12 months of treatment.
Article
Infectious Diseases
Atsuho Morita, Ho Namkoong, Kazuma Yagi, Takanori Asakura, Makoto Hosoya, Hiromu Tanaka, Ho Lee, Takunori Ogawa, Tatsuya Kusumoto, Shuhei Azekawa, Kensuke Nakagawara, Hirofumi Kamata, Makoto Ishii, Koichi Fukunaga, Hiroyuki Ozawa, Naoki Hasegawa
Summary: ALIS therapy may be a treatment option for patients with refractory MAC infection with long disease duration and a poor response to guideline-based therapy.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Critical Care Medicine
Noeul Kang, Kyeongman Jeon, Hojoong Kim, O. Jung Kwon, Hee Jae Huh, Nam Yong Lee, Charles L. Daley, Won-Jung Koh, Byung Woo Jhun
Summary: Treatment with inhaled amikacin-containing regimens shows favorable outcomes in patients with M massiliense-PD, while more effective treatments are needed for those with M abscessus-PD. Overall, 65% of treatment-naive patients achieved cure after 12 months of treatment initiation, with significantly greater improvement observed in patients with M massiliense-PD.
Article
Immunology
Raphael Chiron, Wouter Hoefsloot, Jakko Van Ingen, Helene Marchandin, Laurent Kremer, Helene Morisse-Pradier, Jeremy Charriot, Jean-Pierre Mallet, Jean-Louis Herrmann, Davide Caimmi, Johan Moreau, Yann Dumont, Sylvain Godreuil, Anne Bergeron, Margot Drevait, Elodie Bouzat-Rossigneux, Nicolas Terrail, Claire Andrejak, Nicolas Veziris, Dominique Grenet, Alexandre Coudrat, Emilie Catherinot
Summary: This study investigated the safety and efficacy of ALIS as an adjunct treatment for M abscessus lung infection. Among 26 patients with long-term follow-up data, a sputum culture conversion rate of 54% was achieved, and there was a significant association between patient treatment compliance and culture conversion and clinical outcomes.
OPEN FORUM INFECTIOUS DISEASES
(2022)
Article
Critical Care Medicine
Sarah A. R. Siegel, David E. Griffith, Julie V. Philley, Barbara A. Brown-Elliott, Amanda E. Brunton, Peter E. Sullivan, Cristina Fuss, Luke Strnad, Richard J. Wallace Jr, Kevin L. Winthrop
Summary: ALIS can lead to sputum culture conversion in half of the patients with macrolide-resistant M abscessus. However, the emergence of mutational amikacin resistance is common and associated with clofazimine monotherapy.
Article
Microbiology
Amer El Ghali, Taylor Morrisette, Sara Alosaimy, Kristen Lucas, Maria G. Tupayachi-Ortiz, Raaga Vemula, Carly Wadle, Julie V. Philley, Carlos Mejia-Chew, Yasir Hamad, Ryan W. Stevens, John D. Zeuli, Andrew J. Webb, Christina T. Fiske, Anahit Simonyan, Christo L. Cimino, Mehriban Mammadova, Virginia E. Umana, Rodrigo Hasbun, Saira Butt, Kyle C. Molina, Michael Thomas, Emily A. Kaip, Jeannette Bouchard, Tristan W. Gore, Catessa Howard, M. Gabriela Cabanilla, Dana J. Holger, Jeremy J. Frens, Melissa Barger, Aaron Ong, Keira A. Cohen, Michael J. Rybak
Summary: This multicenter retrospective study examined the long-term clinical success, safety, and tolerability of Omadacycline (OMC) for nontuberculous mycobacteria (NTM) infections. The study found that 80.0% of patients achieved clinical success after 3 months of treatment, but 32.0% experienced adverse events related to OMC.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Microbiology
Jin Lee, Nicole Ammerman, Anusha Agarwal, Maram Naji, Si-Yang Li, Eric Nuermberger
Summary: This study assessed the in vitro bactericidal activity of single drugs against Mycobacterium abscessus populations and found that the combination of bedaquiline and rifabutin had potential bactericidal activity against nutrient-starved M. abscessus, further enhanced by the addition of amikacin.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Critical Care Medicine
Joong-Yub Kim, Jiwon Park, Yunhee Choi, Taek Soo Kim, Nakwon Kwak, Jae-Joon Yim
Summary: This study found that achieving microbiological cure at the end of treatment is associated with longer survival in patients with nontuberculous mycobacterial pulmonary disease.
Article
Immunology
Rebekah M. Dedrick, Bailey E. Smith, Madison Cristinziano, Krista G. Freeman, Deborah Jacobs-Sera, Yvonne Belessis, A. Whitney Brown, Keira A. Cohen, Rebecca M. Davidson, David van Duin, Andrew Gainey, Cristina Berastegui Garcia, C. R. Robert George, Ghady Haidar, Winnie Ip, Jonathan Iredell, Ameneh Khatami, Jessica S. Little, Kirsi Malmivaara, Brendan J. McMullan, David E. Michalik, Andrea Moscatelli, Jerry A. Nick, Maria G. Tupayachi Ortiz, Hari M. Polenakovik, Paul D. Robinson, Mikael Skurnik, Daniel A. Solomon, James Soothill, Helen Spencer, Peter Wark, Austen Worth, Robert T. Schooley, Constance A. Benson, Graham F. Hatfull
Summary: Bacteriophage therapy shows potential as an adjunctive treatment for nontuberculous Mycobacterium infections. This study observed no adverse reactions, favorable outcomes in at least 50% of patients, and no evidence of phage resistance.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Vincent Le Moigne, Sabine Blouquit-Laye, Aurore Desquesnes, Fabienne Girard-Misguich, Jean-Louis Herrmann
Summary: This study evaluated the colocalization of an inhaled liposomal amikacin suspension (ALIS) with intracellular Mabs, and measured its intracellular anti-Mabs activity. The results showed that ALIS can colocalize with Mabs inside cells and has antibacterial activity against intracellular Mabs, suggesting its potential use for treating Mabs pulmonary infections.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Infectious Diseases
Yu He, Jun-Li Wang, Yan-An Zhang, Mao-Shui Wang
Summary: This study analyzed the prevalence of NTM disease and the occurrence of tuberculosis (TB) in patients with positive mycobacterial cultures. The results showed that 8.0% of patients with NTM disease were also diagnosed with TB. Therefore, caution should be taken during the treatment of NTM disease.
INFECTION AND DRUG RESISTANCE
(2022)
Review
Critical Care Medicine
Marie Yan, Sarah K. Brode, Theodore K. Marras
Summary: Slowly growing nontuberculous mycobacteria (NTM) are a diverse group of environmental organisms, many of which are important human pathogens. This review focuses on less common, but notable, species of slowly growing NTM with respect to lung disease. The specific organisms highlighted include Mycobacterium kansasii, Mycobacterium xenopi, Mycobacterium malmoense, Mycobacterium simiae, and Mycobacterium szulgai. The diagnosis and management of NTM pulmonary disease require a nuanced approach that takes into consideration the unique characteristics of each species.
Article
Multidisciplinary Sciences
Kimberly J. Alexander, Jennifer L. Furlong, Julianne L. Baron, John D. Rihs, Dominic Stephenson, John D. Perry, Janet E. Stout
Summary: The study investigated the use of highly selective Rapidly Growing Mycobacteria (RGM) medium for culturing non-tuberculous mycobacteria (NTM) from environmental water samples, and found that direct culturing on RGM medium provided sensitivity comparable to that of acid-pre-treated 7H10 and 7H11 medium, with significantly less overgrowth and interference from other organisms on RGM medium.
Article
Infectious Diseases
Jodie A. Schildkraut, Jordy P. M. Coolen, Carolien Ruesen, Jeroen J. M. W. van den Heuvel, Laura Edo Acena, Heiman F. L. Wertheim, Robert S. Jansen, Jan B. Koenderink, Lindsey H. M. te Brake, Jakko van Ingen
Summary: The study found that Mycobacterium avium (M. avium) has ABC transporters related to antibiotic efflux, which plays an important role in antibiotic resistance. It was found that ABC transporters are sensitive to certain antibiotics, but only specific ones. In addition, M. avium cannot modify amikacin, which is of significant importance to its activity.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2023)
Review
Hematology
Marianne Goualou, Steve Noumegni, Claire de Moreuil, Mathilde Le Guillou, Gabrielle De Coninck, Clement Hoffmann, Sara Robin, Karine Morcel, Emmanuelle Le Moigne, Christophe Tremouilhac, Philippe Merviel, Raphael Le Mao, Christophe Leroyer, Sarah Bouee, Francis Couturaud, Cecile Tromeur
Summary: Hormonal exposure increases the risk of venous thromboembolism (VTE), but the association between assisted reproductive technology (ART) and VTE is unclear. A systematic review of 14 studies found that the overall frequency of VTE associated with ART was 0.23%. Women undergoing ART had a two-to threefold increased risk of VTE compared to spontaneous pregnancy. The risk of VTE specifically related to ovarian hyperstimulation syndrome (OHSS) was very low. Risk factors for VTE associated with ART included the in vitro fertilization procedure, hyperhomocysteinemia, polycystic ovarian syndrome (PCOS), and successful ART leading to pregnancy. Further research is needed to optimize thromboprophylaxis in women undergoing ART.
THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Hematology
Alexander G. G. Turpie, Alfredo E. Farjat, Sylvia Haas, Walter Ageno, Jeffrey Weitz, Samuel Z. Goldhaber, Shinya Goto, Pantep Angchaisuksiri, Gloria Kayani, Renato D. Lopes, Chern-En Chiang, Harry Gibbs, Eric Tse, Peter Verhamme, Hugo ten Cate, Juan Muntaner, Sebastian Schellong, Henri Bounameaux, Paolo Prandoni, Uma Maheshwari, Ajay K. Kakkar
Summary: GARFIELD-VTE is an observational study that aims to collect clinical data of patients with deep vein thrombosis and pulmonary embolism worldwide. The study found that the highest accumulation of events occurred within the first 12 months after diagnosis, which may help identify treatment gaps and improve patient outcomes.
THROMBOSIS RESEARCH
(2023)
Article
Microbiology
Jodie A. Schildkraut, Jordy P. M. Coolen, Heleen Severin, Ellen Koenraad, Nicole Aalders, Willem J. G. Melchers, Wouter Hoefsloot, Heiman F. L. Wertheim, Jakko van Ingen
Summary: We introduce a new sequencing technique that can identify nontuberculous mycobacteria (NTM) to (sub)species level based on whole-genome extracted from enriched shotgun metagenomic data. This technique can be used to study the association between genotypes and clinical manifestations and pave the way for personalized healthcare.
JOURNAL OF CLINICAL MICROBIOLOGY
(2023)
Article
Respiratory System
Gina Hong, Scott G. Daniel, Jung-Jin Lee, Kyle Bittinger, Laurel Glaser, Lisa M. Mattei, Daniel J. Dorgan, Denis Hadjiliadis, Steven M. Kawut, Ronald G. Collman
Summary: The respiratory tract fungal microbiome in adults with cystic fibrosis is associated with lung function, exacerbation status, medication use, and CFTR modulator use. Further research is necessary to better understand fungal diversity in the CF airway and its impact on lung health.
JOURNAL OF CYSTIC FIBROSIS
(2023)
Article
Allergy
Bo Ding, Stephanie Chen, Divyansh Srivastava, Anna Quinton, William Cook, Alberto Papi, Helen K. Reddel, NOVELTY Scientific Community, NOVELTY Study Investigators
Summary: Using baseline data from the NOVELTY study, we quantified the symptom burden, health status, and productivity in patients with uncontrolled and controlled severe asthma. The results showed that patients with uncontrolled severe asthma had higher symptom burden, poorer health status, and lower productivity compared to those with controlled severe asthma.
JOURNAL OF ASTHMA AND ALLERGY
(2023)
Article
Respiratory System
Michael R. Loebinger, Roald van der Laan, Marko Obradovic, Jakko van Ingen
Summary: This survey aimed to evaluate current testing practices for nontuberculous mycobacteria (NTM) and identify testing triggers. The results showed that bronchiectasis, COPD, and immunosuppressants were the factors most likely to prompt testing among physicians. Radiological findings were the most common reason for considering NTM testing in patients with bronchiectasis and COPD.
Article
Microbiology
Jodie A. Schildkraut, Jelmer Raaijmakers, Rob Aarnoutse, Wouter Hoefsloot, Heiman F. L. Wertheim, Jakko van Ingen
Summary: This study evaluated the efficacy of azithromycin-ethambutol backbone therapy with and without rifampicin for the treatment of Mycobacterium avium complex pulmonary disease. The results showed that the addition of rifampicin did not significantly enhance the antimycobacterial effect or suppress the emergence of resistance. These findings raise questions about the necessity of rifampicin in the current recommended therapy.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Review
Hematology
Milou A. M. Stals, Thomas Moumneh, Fionnuala Ni Ainle, Drahomir Aujesky, Thomas van Bemmel, Laurent Bertoletti, Ingrid M. Bistervels, Celine Chauleur, Francis Couturaud, Yordi P. A. van Dooren, Antoine Elias, Laura M. Faber, Catherine Le Gall, Herman M. A. Hofstee, Tom van der Hulle, Marieke J. H. A. Kruip, Maxime Maignan, Albert T. A. Mairuhu, Saskia Middeldorp, Emmanuelle Le Moigne, Mathilde Nijkeuter, Liselotte M. van der Pol, Helia Robert-Ebadi, Pierre-Marie Roy, Olivier Sanchez, Jeannot Schmidt, Maarten van Smeden, Cecile Tromeur, Marije Ten Wolde, Marc Righini, Gregoire Le Gal, Menno Huisman, Frederikus A. Klok
Summary: This study evaluated the safety and efficiency of noninvasive diagnostic strategies for suspected acute pulmonary embolism in pregnant women. The results showed that the Wells rule, adapted D-dimer thresholds, and the YEARS algorithm can safely rule out acute PE. However, the efficiency was significantly improved when using pretest probability-adapted D-dimer thresholds. The use of bilateral CUS had limited efficiency, especially in patients without symptoms of deep-vein thrombosis.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Medicine, General & Internal
Shin Hye Yoo, Yejin Kim, Wonho Choi, Jeongmi Shin, Min Sun Kim, Hye Yoon Park, Bhumsuk Keam, Jae -Joon Yim
Summary: This study aimed to explore the various ethical issues referred to clinical ethics support after the implementation of new legislation on hospice palliative care and end-of-life decision-making in Korea in 2018. The most frequent ethical issues identified were goals of care/treatment, decision-making, relationship, and end-of-life issues. The findings highlight the importance of further research on ethical issues and the implementation of clinical ethics support in multiple healthcare centers.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Respiratory System
Erin L. Tomaszewski, Mark J. Atkinson, Christer Janson, Niklas Karlsson, Barry Make, David Price, Helen K. Reddel, Claus F. Vogelmeier, Hana Mullerova, Paul W. Jones
Summary: The Chronic Airways Assessment Test (CAAT), a questionnaire adapted for patients with asthma and/or COPD, has been shown to be consistent and accurate in measuring overall health status in these patients.
RESPIRATORY RESEARCH
(2023)
Article
Respiratory System
Cori L. Daines, Elizabeth Tullis, Stefano Costa, Rachel W. Linnemann, Marcus A. Mall, Edward F. McKone, Deepika Polineni, Bradley S. Quon, Felix C. Ringshausen, Steven M. Rowe, Hiran Selvadurai, Jennifer L. Taylor-Cousar, Nicholas J. Withers, Neil Ahluwalia, Samuel M. Moskowitz, Valentin Prieto-Centurion, Yaoyuan Vincent Tan, Simon Tian, Tanya Weinstock, Fengjuan Xuan, Yaohua Zhang, Bonnie Ramsey, Matthias Griese
Summary: This study assessed the long-term safety and efficacy of ELX/TEZ/IVA in patients with cystic fibrosis (CF) who have at least one F508del allele. The results showed that ELX/TEZ/IVA treatment was generally safe and well tolerated, with sustained improvements in lung function, respiratory symptoms, CF transmembrane conductance regulator function, pulmonary exacerbation rates, and nutritional status. These findings support the favorable safety profile and durable clinical benefits of ELX/TEZ/IVA.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Review
Infectious Diseases
Thomas Maitre, Alain Baulard, Alexandra Aubry, Nicolas Veziris
Summary: Antibiotic-resistant tuberculosis poses a major threat to global tuberculosis control. Recent research has produced promising compounds that have the potential to change the game in treating multi-drug resistant tuberculosis. However, there are still obstacles preventing these molecules from being used as first-line drugs. Alternative strategies are being evaluated to optimize the utilization of existing antituberculosis agents, with a focus on enhancing the effectiveness of antibiotics against bacterial targets.
INFECTIOUS DISEASES NOW
(2024)
Article
Critical Care Medicine
Joong-Yub Kim, Jiwon Park, Yunhee Choi, Taek Soo Kim, Nakwon Kwak, Jae-Joon Yim
Summary: This study found that achieving microbiological cure at the end of treatment is associated with longer survival in patients with nontuberculous mycobacterial pulmonary disease.
Article
Hematology
Claire de Moreuil, Yesim Dargaud, Christophe Nougier, Pierre-Francois Dupr, Christoph Tremouilhac, Delphine Le Joliff, Sylvain Rosec, Sandy Lucier, Ingrid Pabinger, Cihan Ay, Francis Couturaud, Brigitte Pan-Petesch
Summary: This study aimed to characterize the coagulation properties of predelivery plasmas from pregnant women with severe postpartum hemorrhage (PPH). Thrombin generation assay and hemostatic biomarkers were used to measure these properties. The results suggest that predelivery endogenous thrombin generation potential (ETP) levels may have predictive value for severe PPH.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Cell Biology
Ben O. Staar, Jan Hegermann, Bernd Auber, Raphael Ewen, Sandra von Hardenberg, Ruth Olmer, Isabell Pink, Jessica Rademacher, Martin Wetzke, Felix C. Ringshausen
Summary: Whole-exome sequencing has improved the diagnostic work-up of primary ciliary dyskinesia (PCD), but it also reveals many variants of uncertain significance. This study used transmission electron microscopy (TEM) and the PCD Detect software to assess genotype-phenotype correlations in bronchiectasis patients with inconclusive whole-exome sequencing results. The findings provide important insights into PCD.