Article
Pharmacology & Pharmacy
Lena Wucherpfennig, Felix Wuennemann, Monika Eichinger, Angelika Seitz, Ingo Baumann, Mirjam Stahl, Simon Y. Graeber, Shengkai Zhao, Jaehi Chung, Jens-Peter Schenk, Abdulsattar Alrajab, Hans-Ulrich Kauczor, Marcus A. Mall, Olaf Sommerburg, Mark O. Wielpuetz
Summary: Chronic rhinosinusitis (CRS) in cystic fibrosis (CF) can cause nasal congestion, rhinorrhea, and anosmia, affecting the quality of life. Previous studies using MRI showed early onset and progression of CRS in CF patients from infancy to school age, as well as mid-term improvements in preschool and school-age CF children with lumacaftor/ivacaftor treatment. However, there is a lack of long-term data on the treatment effects on paranasal sinus abnormalities in CF children.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Respiratory System
Lena Wucherpfennig, Felix Wuennemann, Monika Eichinger, Niclas Schmitt, Angelika Seitz, Ingo Baumann, Mirjam Stahl, Simon Y. Graeber, Jaehi Chung, Jens-Peter Schenk, Abdulsattar Alrajab, Hans-Ulrich Kauczor, Marcus A. Mall, Olaf Sommerburg, Mark O. Wielputz
Summary: This study longitudinally evaluated chronic rhinosinusitis (CRS) in children with cystic fibrosis (CF) using paranasal sinus magnetic resonance imaging (MRI). The results showed that CRS starts early in infancy and progresses in severity until school age. The study also found that lumacaftor/ivacaftor therapy can improve CRS in children with CF.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2023)
Article
Respiratory System
Lena Wucherpfennig, Simon M. F. Triphan, Sabine Wege, Hans-Ulrich Kauczor, Claus P. Heussel, Niclas Schmitt, Felix Wuennemann, Victoria L. Mayer, Olaf Sommerburg, Marcus A. Mall, Monika Eichinger, Mark O. Wielpuetz
Summary: This study found that therapy with Elexacaftor/Tezacaftor/Ivacaftor can improve chest and sinus abnormalities in adult cystic fibrosis patients, indicating the reversibility of structural lung and sinus abnormalities in patients with established disease.
JOURNAL OF CYSTIC FIBROSIS
(2022)
Article
Chemistry, Multidisciplinary
Dan Zhao, Dong Li, Xueliang Cheng, Zheng Zou, Xuesi Chen, Chaoliang He
Summary: In this study, cationic nanogels were synthesized through ionic cross-linking and showed potential as a mucolytic agent for the treatment of asthma and other muco-obstructive diseases. The nanogels effectively prevented the formation of large aggregates of mucin and exhibited antibacterial and anti-inflammatory effects.
Article
Critical Care Medicine
Miranda Kirby, Benjamin M. Smith
Summary: This article provides an overview of methodologic considerations for implementing quantitative CT scan airway analyses and reviews the scientific literature on quantitative CT scan airway measurements used in clinical trials and observational studies. While observational studies have shown associations between CT scan airway measurements and important clinical outcomes, few such measurements are applied in clinical practice. More research is needed to evaluate the clinical benefit of quantitative CT scan imaging in the clinical setting.
Article
Oncology
Fanny Pinot, David Bourhis, Vincent Bourbonne, Romain Floch, Maelle Mauguen, Frederique Blanc-Beguin, Ulrike Schick, Mohamed Hamya, Ronan Abgral, Gregoire Le Gal, Pierre-Yves Salaun, Francois Lucia, Pierre-Yves Le Roux
Summary: This study aimed to develop and evaluate an automated threshold method based on total lung function for the delineation of lung functional volumes using Gallium-68 MAA lung PET/CT imaging. The results showed that the WLF threshold method provided more reliable and consistent functional volumes, especially in patients with normal PFTs, as compared to the pmax method. This new approach, relatively unaffected by the presence of hot spots, is clinically meaningful for clinicians.
Article
Immunology
Yun Mao, Sonika Patial, Yogesh Saini
Summary: This study investigated the role of airway epithelium-specific HMGB1 in the pathogenesis of muco-obstructive lung disease in Tg+ mice. The deficiency of HMGB1 in airway epithelial cells in Tg+ mice resulted in increased inflammation and impaired bacterial clearance.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Nina Hoglund, Petteri Nieminen, Anne-Mari Mustonen, Reijo Kakela, Sylvain Tollis, Ninna Koho, Minna Holopainen, Hanna Ruhanen, Anna Mykkanen
Summary: This study investigates how the respiratory fatty acid (FA) profile reflects airway inflammatory status. The results show that the FA composition differs in samples with different diagnoses, but it is insufficient to predict the health status of uncategorized samples. Specifically, in severe EA horses, the proportion of 16:0 decreases and the proportion of 20:5n-3 increases, while all sample types of asthmatic horses have elevated proportions of 20:3n-6. The study suggests a potential role for extracellular vesicles (EVs) as vehicles for lipid mediators in asthma pathogenesis and EV lipid manifestations can offer translational targets for studying asthma pathophysiology and treatment options.
SCIENTIFIC REPORTS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yuwei Bao, Ying Pang, Ziyan Sun, Qian Li, Dazhong Tang, Liming Xia
Summary: The study found that IVIM parameters f and D* can quantitatively evaluate the higher perfusion in AP compared to NP. Additionally, IVIM may be a useful functional diagnostic technique for predicting placenta accreta.
EUROPEAN RADIOLOGY
(2021)
Article
Multidisciplinary Sciences
Preetish Kadur Lakshminarasimha Murthy, Vishwaraj Sontake, Aleksandra Tata, Yoshihiko Kobayashi, Lauren Macadlo, Kenichi Okuda, Ansley S. Conchola, Satoko Nakano, Simon Gregory, Lisa A. Miller, Jason R. Spence, John F. Engelhardt, Richard C. Boucher, Jason R. Rock, Scott H. Randell, Purushothama Rao Tata
Summary: This study identifies previously unknown cell types in the human distal airways and reveals their roles in lung development and regeneration. These findings are important for understanding the mechanisms underlying respiratory diseases.
Article
Veterinary Sciences
Roxane Westerfeld, Flavie Payette, Valerie Dubuc, Estelle Manguin, Khristine Picotte, Guy Beauchamp, Christian Bedard, Mathilde Leclere
Summary: Soaked hay can help control airway obstruction in horses with severe asthma. However, the strict protocol for soaking and discarding dried-out hay used in this study may be considered inconvenient by horse owners.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Efe Ilicak, Greta Thater, Safa Ozdemir, Jascha Zapp, Lothar R. Schad, Stefan O. Schoenberg, Frank G. Zoellner, Meike Weis
Summary: This study investigated the feasibility of non-contrast-enhanced functional lung imaging in 2-year-old children after congenital diaphragmatic hernia repair. The results showed that this method successfully generated ventilation and perfusion maps, and the results were consistent with dynamic contrast-enhanced MRI. This method provides a new option for lung imaging in CDH patients without the need for ionizing radiation or contrast agents.
EUROPEAN RADIOLOGY
(2023)
Article
Critical Care Medicine
Yunus Colak, Shoaib Afzal, Borge G. Nordestgaard, Peter Lange, Jorgen Vestbo
Summary: This study suggests that it is possible to identify individuals who may develop chronic obstructive pulmonary disease (COPD) at an early age. Smoking exposure is an important factor associated with the development of COPD, with smokers having a higher risk compared to non-smokers.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Computer Science, Information Systems
Chang Sheng Lee, Yaolong Lou, Minghui Li, Qammer H. Abbasi, Muhammad Ali Imran
Summary: This study presents a new and effective method for assessing lung function using acoustic imaging, which links acoustic lung images with pathologic changes. It also analyzes the practicality and extreme design of the acoustic imaging system on the resolution of the located nidus. The research may be used to offer recommendations for acoustic imaging system design and assess the number of sensors in current systems.
Article
Respiratory System
Eduardo Genofre, Donna Carstens, Wilfried DeBacker, Patrick Muchmore, Reynold A. Panettieri Jr, Kirsty Rhodes, Vivian H. Shih, Frank Trudo
Summary: The BURAN study aims to use FRI to assess changes in lung structure and function in patients with SEA treated with benralizumab. The study will contribute to the understanding of how benralizumab improves lung function and asthma control.
RESPIRATORY RESEARCH
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lena Wucherpfennig, Simon M. F. Triphan, Oliver Weinheimer, Monika Eichinger, Sabine Wege, Ralf Eberhardt, Michael U. Puderbach, Hans-Ulrich Kauczor, Claus P. Heussel, Gudula Heussel, Mark O. Wielpuetz
Summary: The study demonstrates that MRA provides high-quality diagnostic images in patients with COPD and CF, and its image quality and reproducibility are not dependent on disease severity.
Article
Pharmacology & Pharmacy
Jannik Labrenz, Dominic Edelmann, Jonas S. Heitmann, Helmut R. Salih, Annette Kopp-Schneider, Richard F. Schlenk
Summary: Dose-finding designs are crucial for phase-I trials to determine the recommended phase-II dose (RP2D) for further drug development. This study proposes a two-stage design strategy with intra-patient dose escalation followed by a traditional dose-finding design. Simulation studies compare different designs in terms of accuracy, sample size, safety, and therapeutic efficiency. Results show that intra-patient dose escalation generally improves accuracy and therapeutic efficiency when the RP2D is the highest dose, but it increases the risk of overdosing and overestimation of the RP2D when it is below the highest dose.
PHARMACEUTICAL STATISTICS
(2023)
Review
Respiratory System
Marcus A. Mall, Gerard J. Criner, Marc Miravitlles, Steven M. Rowe, Claus F. Vogelmeier, David J. Rowlands, Matthias Schoenberger, Pablo Altman
Summary: CFTR is an important ion channel responsible for the transport of chloride and bicarbonate anions. Dysfunction of CFTR has been observed in both inherited cystic fibrosis and acquired COPD. CFTR dysfunction can contribute to various manifestations and progression of COPD, including airway obstruction, inflammation, and tissue destruction. This review explores the acquired dysfunction of CFTR in COPD and discusses the potential benefits of CFTR potentiation in improving lung function and reducing inflammation.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Respiratory System
Patricia Leutz-Schmidt, Daiva-Elzbieta Optazaite, Olaf Sommerburg, Monika Eichinger, Sabine Wege, Eva Steinke, Simon Y. Graeber, Michael U. Puderbach, Jens-Peter Schenk, Abdulsattar Alrajab, Simon M. F. Triphan, Hans-Ulrich Kauczor, Mirjam Stahl, Marcus A. Mall, Mark O. Wielputz
Summary: This study evaluated the occurrence of bronchial artery dilatation (BAD) in patients with cystic fibrosis (CF) and its association with disease severity using magnetic resonance imaging (MRI). The results showed that the onset of BAD was associated with disease severity, lung function, and chronic Pseudomonas aeruginosa infection. This finding is important for assessing the severity of CF.
Article
Oncology
Ekaterina Nikitina, Amelie Burk-Koerner, Manuel Wiesenfarth, Elizabeth Alwers, Danijela Heide, Claudia Tessmer, Claudia Ernst, Damir Krunic, Petra Schrotz-King, Jenny Chang-Claude, Moritz von Winterfeld, Esther Herpel, Alexander Brobeil, Hermann Brenner, Mathias Heikenwalder, Michael Hoffmeister, Annette Kopp-Schneider, Timo Bund
Summary: This study assessed the expression of bovine milk and meat factors (BMMFs) in large clinical cohorts and found that BMMFs were associated with tumor-adjacent mucosa and tumor tissues of colorectal cancer (CRC) patients, with increased expression in CRC patients compared to healthy controls. The expression of BMMFs might be a marker and early risk factor for CRC, and could be involved in specific inflammatory regulations.
MOLECULAR ONCOLOGY
(2023)
Letter
Pediatrics
Ruth M. Urbantat, Charlotte O. Pioch, Niklas Ziegahn, Miriam S. Stegemann, Mirjam Stahl, Marcus A. Mall, Jobst F. Roehmel
PEDIATRIC PULMONOLOGY
(2023)
Article
Medicine, General & Internal
Sebastian Stricker, Niklas Ziegahn, Martin Karsten, Thomas Boeckel, Heike Stich-Boeckel, Jakob Maske, Evelyn Rugo, Anita Balazs, Pamela Millar Buchner, Chantip Dang-Heine, Valentin Schriever, Roland Eils, Irina Lehmann, Leif E. Sander, Markus Ralser, Victor M. Corman, Marcus A. Mall, Birgit Sawitzki, Jobst Roehmel
Summary: This study aims to characterize age-dependent differences in immune responses to respiratory infections, using SARS-CoV-2 as a model virus, and assess age differences in clinical outcomes, including lung function. The study plans to recruit at least 120 children and 60 adults infected with SARS-CoV-2 and collect specimens for multiomics analysis. The data obtained from this study will be correlated with medical history and clinical data.
Article
Pharmacology & Pharmacy
Lena Wucherpfennig, Felix Wuennemann, Monika Eichinger, Angelika Seitz, Ingo Baumann, Mirjam Stahl, Simon Y. Graeber, Shengkai Zhao, Jaehi Chung, Jens-Peter Schenk, Abdulsattar Alrajab, Hans-Ulrich Kauczor, Marcus A. Mall, Olaf Sommerburg, Mark O. Wielpuetz
Summary: Chronic rhinosinusitis (CRS) in cystic fibrosis (CF) can cause nasal congestion, rhinorrhea, and anosmia, affecting the quality of life. Previous studies using MRI showed early onset and progression of CRS in CF patients from infancy to school age, as well as mid-term improvements in preschool and school-age CF children with lumacaftor/ivacaftor treatment. However, there is a lack of long-term data on the treatment effects on paranasal sinus abnormalities in CF children.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Julian Berges, Simon Y. Graeber, Susanne Haemmerling, Yin Yu, Arne Kruempelmann, Mirjam Stahl, Stephanie Hirtz, Heike Scheuermann, Marcus A. Mall, Olaf Sommerburg
Summary: In this prospective study, the effect of Lumacaftor/ivacaftor on CFTR biomarkers and clinical outcome parameters in CF patients aged 2-11 years was evaluated. The treatment significantly reduced sweat chloride concentration and improved CFTR activity, consistent with previous findings in older CF patients with F508del.
FRONTIERS IN PHARMACOLOGY
(2023)
Editorial Material
Critical Care Medicine
Mark O. Wielpuetz
Letter
Respiratory System
Katie J. Bayfield, Oliver Weinheimer, Christie Boyton, Rachel Fitzpatrick, Anna Middleton, Brendan Kennedy, Anneliese Blaxland, Geshani Jayasuriya, Neil Caplain, Hana Issa, Robert Goetti, Mark O. Wielpuetz, Lifeng Yu, Craig J. Galban, Terry E. Robinson, Brian Bartholmai, Dominic Fitzgerald, Hiran Selvadurai, Paul D. Robinson
EUROPEAN RESPIRATORY JOURNAL
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Simon M. F. Triphan, Grzegorz Bauman, Philip O. Konietzke, Marilisa Konietzke, Mark Wielpuetz
Summary: Lung perfusion, an essential process for oxygenation, is regulated by hypoxic pulmonary vasoconstriction (HPV) in response to obstructive airway diseases. Various MRI techniques have been developed to visualize lung perfusion, and dynamic-contrast enhanced MRI is widely used in clinical assessment. Non-contrast techniques are still being researched and validated. Preliminary data on these techniques in evaluating therapy effects are emerging. Level of Evidence 5, Technical Efficacy Stage 5.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Medicine, General & Internal
Simon Y. Graeber, Marcus A. Mall
Summary: Cystic fibrosis has become a leading candidate for transformative molecular therapy, with the breakthrough in highly effective modulator therapy in 2019 providing unprecedented clinical benefits. This paper reviews the understanding of the molecular mechanisms underlying CFTR dysfunction in cystic fibrosis, the progress in pharmacological approaches to restore CFTR function, and the potential of genetic therapies and gene editing approaches to cure cystic fibrosis.
Article
Pharmacology & Pharmacy
Annette Kopp-Schneider, Manuel Wiesenfarth, Leonhard Held, Silvia Calderazzo
Summary: Borrowing information from historical or external data for inference in current trials is a growing field in precision medicine. This study proposes a procedure to investigate and report the operating characteristics of borrowing methods. The findings suggest that borrowing external data may not improve the power of certain trials.
PHARMACEUTICAL STATISTICS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Alan A. Peters, Oliver Weinheimer, Oyunbileg von Stackelberg, Jonas Kroschke, Lars Piskorski, Manuel Debic, Kai Schlamp, Linn Welzel, Moritz Pohl, Andreas Christe, Lukas Ebner, Hans-Ulrich Kauczor, Claus Peter Heussel, Mark O. Wielpuetz
Summary: Quantitative computed tomography (QCT) of the whole lung and nodule-bearing lobe can be valuable in assessing the malignancy risk of pulmonary nodules. The study shows that nodules in subjects with higher emphysema levels and less fibrosis in the lungs are more likely to be malignant.
EUROPEAN RADIOLOGY
(2023)