Article
Infectious Diseases
Guirong Wang, Ruixia Liang, Qing Sun, Xinlei Liao, Chenqian Wang, Hairong Huang
Summary: This study evaluated different methods for diagnosing central nervous system (CNS) involvement in patients with military tuberculosis (TB). The results showed that MRI had superior sensitivity and could be used as an initial diagnostic approach.
BMC INFECTIOUS DISEASES
(2022)
Article
Biotechnology & Applied Microbiology
Ying Liu, Weiwei Zhu, Mengfan Jiao, Wenhu Guo, Yonggang Luo
Summary: The clinical value of metagenomic next-generation sequencing (mNGS) in central nervous system (CNS) infections was evaluated in this study. mNGS and routine examination of cerebrospinal fluid (CSF) samples were retrospectively analyzed and compared with clinical diagnosis. The results showed that mNGS had a higher detection rate and identified additional pathogens compared to conventional methods. The sensitivity and specificity of mNGS in the diagnosis of CNS infections were 89.5% and 44%, respectively.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Medical Laboratory Technology
Yao Hu, Jin Xiang, Xiao Luo, Meijuan Lu, Dongwen Xu, Bobin Chen, Ming Guan
Summary: This study assessed the potential application of CSF FLC ratios in diagnosing PCNSL and monitoring treatment efficacy, and found that CSF FLC is a novel biomarker for diagnosis and chemotherapy efficacy monitoring in PCNSL.
CLINICA CHIMICA ACTA
(2022)
Article
Clinical Neurology
Finja Schweitzer, Yasemin Goereci, Christiana Franke, Steffi Silling, Fabian Bosl, Franziska Maier, Eva Heger, Birgit Deiman, Harald Pruss, Oezguer A. Onur, Florian Klein, Gereon R. Fink, Veronica Di Cristanziano, Clemens Warnke
Summary: The study found no evidence of SARS-CoV-2 in cerebrospinal fluid, and intrathecally produced anti-SARS-CoV-2 antibodies were not detected in post-COVID-19 syndrome patients. This suggests that a persistent central nervous system infection is unlikely to be the cause of neurological or neuropsychiatric post-COVID-19 syndrome.
ANNALS OF NEUROLOGY
(2022)
Article
Medicine, General & Internal
Annamaria D'Alessandro, Domenico Ciavardelli, Anna Pastore, Germana Giannone, Giada Del Baldo, Andrea Carai, Angela Mastronuzzi, Andrea Onetti Muda, Ottavia Porzio
Summary: This study evaluated the suitability of an analytical method certified for use on serum and/or amniotic fluid for quantifying hCG and AFP in cerebrospinal fluid. The results showed that the automated immunochemical method can accurately quantify hCG and AFP in CSF for selective and specific diagnosis of secreting germ cell tumors.
Article
Oncology
Yuki Yamagishi, Nobuyoshi Sasaki, Yoshiko Nakano, Yuko Matushita, Takaki Omura, Saki Shimizu, Kuniaki Saito, Keiichi Kobayashi, Yoshitaka Narita, Akihide Kondo, Yoshiaki Shiokawa, Motoo Nagane, Koichi Ichimura
Summary: The current standard for diagnosing CNS lymphoma is stereotactic biopsy, but it carries risks of complications. This study established a protocol for detecting MYD88 mutations in the CSF, showing that liquid biopsy with cfDNA is more accurate and efficient compared to cellular DNA. Digital PCR in cfDNA can effectively detect MYD88 L265P mutation, highlighting its importance in diagnosing CNS lymphoma.
Review
Medicine, General & Internal
Inga Zerr
Summary: The diagnosis of Creutzfeldt-Jakob disease has evolved to include the detection of 14-3-3 protein and abnormally folded prion protein in cerebrospinal fluid, with nearly 100% sensitivity and specificity.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Giulia Menculini, Elena Chipi, Federico Paolini Paoletti, Lorenzo Gaetani, Pasquale Nigro, Simone Simoni, Andrea Mancini, Nicola Tambasco, Massimiliano Di Filippo, Alfonso Tortorella, Lucilla Parnetti
Summary: Psychiatric symptoms are common in neurological diseases and can often be the first clinical manifestations, emphasizing the importance of a coordinated diagnostic approach between neurologists and psychiatrists.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Emergency Medicine
Ping Wang, Li-Ying Lin, Yuan-Qiang Lu
Summary: This article reports a case of diquat poisoning and highlights the importance of being aware of the development of pulmonary symptoms and neurological complications in patients. Interestingly, the study also found a correlation between the concentration of diquat in the cerebrospinal fluid and both the intracranial pressure and the severity of cerebral edema.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Pharmacology & Pharmacy
Yaqian Li, Wenpeng Lu, Xuecheng Zheng, Linhui Zhang, Weichong Dong, Xiaoxiao Zhao, Zongmao Zhao, Zhiqing Zhang
Summary: This study demonstrates that combined intravenous and intrathecal administration can significantly shorten the treatment time of MRSA ventriculitis and increase the exposure of the drug in cerebrospinal fluid without an increased risk of adverse reactions.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Clinical Neurology
Fereshte Sheybani, Diederik van de Beek, Matthijs C. Brouwer
Summary: Half of the patients with suspected CNS infections are diagnosed with a CNS infection, and this was not related to CD4 counts. The best predictor for CNS infections was the CSF leukocyte count.
FRONTIERS IN NEUROLOGY
(2021)
Review
Medicine, General & Internal
Xue Chen, Min Huang, Zhenyuan Zhang, Huilan Jing, Yueli Zou, Hui Bu
Summary: This article reports a rare case of primary meningeal central nervous system lymphoma. The patient presented with progressive lower extremity motor dysfunction and blurred vision. Diagnosis was confirmed through cytology, immunohistochemistry, and flow cytometry of the cerebrospinal fluid. After treatment, the patient showed significant improvement and could walk and take care of herself after a 2-year follow-up.
Article
Microbiology
Yunqi Zhu, Wenxuan Zhao, Xihong Yang, Yuanyuan Zhang, Xiaoling Lin, Xing Weng, Yali Wang, Cong Cheng, Yun Chi, Hongxia Wei, Zhihang Peng, Zhiliang Hu
Summary: This study found that mNGS has a high sensitivity for detecting common opportunistic CNS pathogens in HIV-infected patients, although its performance in CNS tuberculosis is unsatisfactory. EBV and CMV are commonly detected by CSF mNGS, but the threshold for clinically significant detection still needs to be defined.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Maria Thastrup, Hanne Vibeke Marquart, Kjeld Schmiegelow
Summary: Despite the good prognosis of acute lymphoblastic lymphoma in children and adolescents, involvement of the central nervous system (CNS) remains a therapeutic challenge. The current method for detecting CNS involvement has low sensitivity, while flow cytometric analysis of cerebrospinal fluid (CSF) offers a novel and sensitive approach. Prospective studies have shown that flow cytometry detects CNS involvement at a higher rate than conventional methods and is particularly sensitive in detecting low-level CNS disease. Flow cytometry-detected CNS involvement is linked to a higher risk of relapse and poor outcomes in childhood ALL.
Article
Oncology
Jiayan Gu, Xin Huang, Yi Zhang, Chenhui Bao, Ziyang Zhou, Hongyan Tong, Jie Jin
Summary: This study evaluated the correlation between cerebrospinal fluid (CSF) cytokine levels and central nervous system (CNS) involvement in adult acute myeloid leukemia (AML). The results showed that CSF IL-6 is a promising marker for the diagnosis of adult AML with CNS involvement and is also associated with therapeutic response.
FRONTIERS IN ONCOLOGY
(2022)
Article
Infectious Diseases
Le Hong Van, Phan Trieu Phu, Dao Nguyen Vinh, Vo Thanh Son, Nguyen Thi Hanh, Le Thanh Hoang Nhat, Nguyen Huu Lan, Truong Van Vinh, Nguyen Thi Mai Trang, Dang Thi Minh Ha, Guy E. Thwaites, Nguyen Thuy Thuong Thuong
BMC INFECTIOUS DISEASES
(2020)
Letter
Infectious Diseases
Nguyen Thi Thu Hong, Ho Dang Trung Nghia, Tran Tan Thanh, Nguyen Phu Huong Lan, Nguyen Thi Han Ny, Nghiem My Ngoc, Vu Thi Ty Hang, Le Thi My Chau, Van Xuan Quynh, Le Thi Diem, Bui Thi Bich Hanh, Nguyen Ho Hong Hanh, Du Trong Duc, Dinh Nguyen Huy Man, James Campbell, Pham Kieu Nguyet Oanh, Jeremy Day, Nguyen Hoan Phu, Nguyen Van Vinh Chau, Guy Thwaites, Le Van Tan
JOURNAL OF INFECTION
(2020)
Article
Virology
Tu Thi Kha Nguyen, Tue Tri Ngo, Phuc My Tran, Tam Thi Thanh Pham, Hang Thi Ty Vu, Ny Thi Han Nguyen, Guy Thwaites, Anna-Maija K. Virtala, Olli Vapalahti, Stephen Baker, Tan Le Van
JOURNAL OF MEDICAL VIROLOGY
(2020)
Article
Infectious Diseases
Joseph Donovan, Do Dang Anh Thu, Nguyen Hoan Phu, Vu Thi Mong Dung, Tran Phu Quang, Ho Dang Trung Nghia, Pham Kieu Nguyet Oanh, Tran Bao Nhu, Nguyen Van Vinh Chau, Vu Thi Ngoc Ha, Vu Thi Ty Hang, Dong Huu Khanh Trinh, Ronald B. Geskus, Le Van Tan, Nguyen Thuy Thuong Thuong, Guy E. Thwaites
LANCET INFECTIOUS DISEASES
(2020)
Editorial Material
Medicine, General & Internal
Guy Thwaites, Payam Nahid
NEW ENGLAND JOURNAL OF MEDICINE
(2020)
Article
Pediatrics
Julie Huynh, Guy Thwaites, Ben J. Marais, H. Simon Schaaf
PAEDIATRIC RESPIRATORY REVIEWS
(2020)
Article
Immunology
Nguyen Thi Thu Hong, Nguyen To Anh, Nguyen Thi Hoang Mai, Ho Dang Trung Nghia, Le Nguyen Truc Nhu, Tran Tan Thanh, Nguyen Hoan Phu, Xutao Deng, H. Rogier van Doorn, Nguyen Van Vinh Chau, Eric Delwart, Guy Thwaites, Le Van Tan
OPEN FORUM INFECTIOUS DISEASES
(2020)
Review
Microbiology
Ursula Theuretzbacher, Karen Bush, Stephan Harbarth, Mical Paul, John H. Rex, Evelina Tacconelli, Guy E. Thwaites
NATURE REVIEWS MICROBIOLOGY
(2020)
Article
Multidisciplinary Sciences
Lara Harris, Julia Griem, Alison Gummery, Laura Marsh, Sylviane Defres, Maneesh Bhojak, Kumar Das, Ava Easton, Tom Solomon, Michael Kopelman
Article
Medicine, Research & Experimental
Leanne McCabe, Ian R. White, Nguyen Van Vinh Chau, Eleanor Barnes, Sarah L. Pett, Graham S. Cooke, A. Sarah Walker
Article
Public, Environmental & Occupational Health
Nhung Nguyen Thi, Yen Nguyen Thi Phuong, Cuong Nguyen, Kiet Bach Tuan, Hien Vo Be, James Campbell, Guy Thwaites, Stephen Baker, Ronald Geskus, Philip Ashton, Juan Carrique-Mas
ZOONOSES AND PUBLIC HEALTH
(2020)
Article
Microbiology
Lu Lu, Gail Robertson, Jordan Ashworth, Anh Pham Hong, Ting Shi, Alasdair Ivens, Guy Thwaites, Stephen Baker, Mark Woolhouse
FRONTIERS IN MICROBIOLOGY
(2020)
Article
Infectious Diseases
T. T. Thanh, C. Casals-Pascual, N. T. H. Ny, N. M. Ngoc, R. Geskus, L. N. T. Nhu, N. T. T. Hong, D. T. Duc, D. D. A. Thu, P. N. Uyen, V. B. Ngoc, L. T. M. Chau, V. X. Quynh, N. H. H. Hanh, N. T. T. Thuong, L. T. Diem, B. T. B. Hanh, V. T. T. Hang, P. K. N. Oanh, R. Fischer, N. H. Phu, H. D. T. Nghia, N. V. V. Chau, N. T. Hoa, B. M. Kessler, G. Thwaites, L. Tan
Summary: The study identified Lipocalin 2 (LCN2) as a sensitive and specific biomarker for discriminating bacterial meningitis from other CNS infections. LCN2 outperformed other CSF markers commonly used in routine care and in combination with CSF leukocytes, glucose, protein, and lactate, it showed the highest diagnostic performance for bacterial meningitis.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Review
Infectious Diseases
Joseph Donovan, Guy E. Thwaites, Julie Huynh
CURRENT OPINION IN INFECTIOUS DISEASES
(2020)
Article
Biology
Laura Whitworth, Jacob Coxon, Arjan van Laarhoven, Nguyen Thuy Thuong Thuong, Sofiati Dian, Bachti Alisjahbana, Ahmad Rizal Ganiem, Reinout van Crevel, Guy E. Thwaites, Mark Troll, Paul H. Edelstein, Roger Sewell, Lalita Ramakrishnan
Summary: Tuberculous meningitis has high mortality linked to excessive inflammation, and adjunctive anti-inflammatory corticosteroids reduce mortality by only 30%. The LTA4H TT genotype confers survival benefit, particularly in individuals with hyper-inflammatory responses, but this benefit is nullified in the most severe cases with high early mortality.