Association between Source of Infection and Hospital Mortality in Patients Who Have Septic Shock

Recombinant Human Activated Protein C for Adults with Septic Shock. A Randomized Controlled Trial

(2013) Djillali Annane et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Effect of Eritoran, an Antagonist of MD2-TLR4, on Mortality in Patients With Severe Sepsis

(2013) Steven M. Opal et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach

(2013) Richard S Hotchkiss et al.   LANCET INFECTIOUS DISEASES

An alternate pathophysiologic paradigm of sepsis and septic shock

(2013) Anand Kumar   Virulence

Low-dose steroids in adult septic shock: results of the Surviving Sepsis Campaign

(2012) Brian Casserly et al.   INTENSIVE CARE MEDICINE

After Xigris, researchers look to new targets to combat sepsis

(2012) Sarah C P Williams   NATURE MEDICINE

Hydroxyethyl Starch 130/0.42 versus Ringer's Acetate in Severe Sepsis

(2012) Anders Perner et al.   NEW ENGLAND JOURNAL OF MEDICINE

Drotrecogin Alfa (Activated) in Adults with Septic Shock

(2012) V. Marco Ranieri et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nationwide Trends of Severe Sepsis in the 21st Century (2000–2007)

(2011) Gagan Kumar et al.   CHEST

Outcomes in severe sepsis and patients with septic shock: Pathogen species and infection sites are not associated with mortality*

(2011) Jean-Ralph Zahar et al.   CRITICAL CARE MEDICINE

Procalcitonin-guided interventions against infections to increase early appropriate antibiotics and improve survival in the intensive care unit: A randomized trial*

(2011) Jens U. Jensen et al.   CRITICAL CARE MEDICINE

Association between timing of antibiotic administration and mortality from septic shock in patients treated with a quantitative resuscitation protocol*

(2011) Michael A. Puskarich et al.   CRITICAL CARE MEDICINE

Novel Therapies for Septic Shock Over the Past 4 Decades

(2011) Anthony F. Suffredini et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Immunosuppression in Patients Who Die of Sepsis and Multiple Organ Failure

(2011) Jonathan S. Boomer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The Search for Effective Therapy for Sepsis

(2011) Derek C. Angus   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Optimizing Antimicrobial Therapy in Sepsis and Septic Shock

(2011) Anand Kumar   Critical Care Nursing Clinics of North America

Bundled care for septic shock: An analysis of clinical trials*

(2010) Amisha V. Barochia et al.   CRITICAL CARE MEDICINE

Early combination antibiotic therapy yields improved survival compared with monotherapy in septic shock: A propensity-matched analysis*

(2010) Anand Kumar et al.   CRITICAL CARE MEDICINE

The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis

(2010) Mitchell M. Levy et al.   INTENSIVE CARE MEDICINE

The Lingering Consequences of Sepsis

(2010) Derek C. Angus   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Use of procalcitonin to reduce patients' exposure to antibiotics in intensive care units (PRORATA trial): a multicentre randomised controlled trial

(2010) Lila Bouadma et al.   LANCET

Immunotherapy for Sepsis — A New Approach against an Ancient Foe

(2010) Richard S. Hotchkiss et al.   NEW ENGLAND JOURNAL OF MEDICINE

Comparison of Dopamine and Norepinephrine in the Treatment of Shock

(2010) Daniel De Backer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Assessing and reporting heterogeneity in treatment effects in clinical trials: a proposal

(2010) David M Kent et al.   Trials

Effectiveness of Treatments for Severe Sepsis

(2009) Ricard Ferrer et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Intensive insulin therapy and mortality among critically ill patients: a meta-analysis including NICE-SUGAR study data

(2009) D. E. G. Griesdale et al.   CANADIAN MEDICAL ASSOCIATION JOURNAL

Initiation of Inappropriate Antimicrobial Therapy Results in a Fivefold Reduction of Survival in Human Septic Shock

(2009) Anand Kumar et al.   CHEST

The effects of steroids during sepsis depend on dose and severity of illness: an updated meta-analysis

(2009) P.C. Minneci et al.   CLINICAL MICROBIOLOGY AND INFECTION

Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008

(2009) R Phillip Dellinger et al.   CRITICAL CARE MEDICINE

Phase 2 trial of eritoran tetrasodium (E5564), a Toll-like receptor 4 antagonist, in patients with severe sepsis*

(2009) Mark Tidswell et al.   CRITICAL CARE MEDICINE

The sepsis seesaw: tilting toward immunosuppression

(2009) Richard S Hotchkiss et al.   NATURE MEDICINE

The effect of a quantitative resuscitation strategy on mortality in patients with sepsis: A meta-analysis*

(2008) Alan E. Jones et al.   CRITICAL CARE MEDICINE

Hydrocortisone Therapy for Patients with Septic Shock

(2008) Charles L. Sprung et al.   NEW ENGLAND JOURNAL OF MEDICINE

Vasopressin versus Norepinephrine Infusion in Patients with Septic Shock

(2008) James A. Russell et al.   NEW ENGLAND JOURNAL OF MEDICINE