Article
Medicine, Research & Experimental
Johannes Geilen, Matthias Kainz, Bernhard Zapletal, Silvana Geleff, Wilfried Wisser, Barbara Bohle, Thomas Schweiger, Marcus J. Schultz, Edda Tschernko
Summary: This study developed a method of creating a unilateral acute lung injury model in pigs and evaluated the key parameters. The experiment confirmed the successful induction of unilateral lung injury in pigs using this model, reducing the number of animals required for experiments while obtaining valid conclusions. The results of the study suggest that this model has good clinical application value.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Critical Care Medicine
Haruka Hashimoto, Takeshi Yoshida, Andi Muhammad Fadlillah Firstiogusran, Hiroki Taenaka, Ryota Nukiwa, Yukiko Koyama, Akinori Uchiyama, Yuji Fujino
Summary: Patient-ventilator asynchrony during mechanical ventilation may lead to lung and diaphragm injury. Breath stacking has a more detrimental effect on oxygenation, lung compliance, and lung injury compared to assist control, while reverse triggering predominantly causes diaphragm injury. Therefore, careful monitoring and management of patient-ventilator asynchrony is crucial in minimizing lung and diaphragm injury in ARDS patients.
CRITICAL CARE MEDICINE
(2023)
Article
Multidisciplinary Sciences
Alessandra F. Thompson, Lillian Moraes, Nazareth N. Rocha, Marcos V. S. Fernandes, Mariana A. Antunes, Soraia C. Abreu, Cintia L. Santos, Vera L. Capelozzi, Cynthia S. Samary, Marcelo G. de Abreu, Felipe Saddy, Paolo Pelosi, Pedro L. Silva, Patricia R. M. Rocco
Summary: The study found that adjusting the frequency of controlled breaths and the level of pressure support can mitigate lung and diaphragm damage in an animal model of acute respiratory distress syndrome. Increasing pressure support can improve lung mechanics and reduce lung injury, while partitioning inspiratory effort and pressure in spontaneous breathing can minimize lung and diaphragm damage.
Article
Critical Care Medicine
Jose Dianti, Samira Fard, Jenna Wong, Timothy C. Y. Chan, Lorenzo Del Sorbo, Eddy Fan, Marcelo B. Passos Amato, John Granton, Lisa Burry, W. Darlene Reid, Binghao Zhang, Damian Ratano, Shaf Keshavjee, Arthur S. Slutsky, Laurent J. Brochard, Niall D. Ferguson, Ewan C. Goligher
Summary: This study aimed to optimize respiratory effort in patients with acute hypoxemic respiratory failure (AHRF) to achieve lung- and diaphragm-protective (LDP) targets. Titrating ventilation and sedation could optimize respiratory effort for lung and diaphragm protection in most patients, and the use of veno-venous extracorporeal membrane oxygenation (VV-ECMO) facilitated the delivery of a LDP strategy. Partial neuromuscular blockade (pNMBA) treatment was effective for patients with excessive respiratory effort.
Article
Physiology
Gabriel C. Motta-Ribeiro, Tilo Winkler, Eduardo L. V. Costa, Nicolas de Prost, Mauro R. Tucci, Marcos F. Vidal Melo
Summary: Lung perfusion redistribution is associated with increased inflammation, nondependent capillary obliteration, and lung derecruitment susceptibility depending on endotoxemia level and ventilation strategy during pre-ARDS protective ventilation in animals.
JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ana Beatriz Farias de Souza, Natalia Alves de Matos, Thalles de Freitas Castro, Guilherme de Paula Costa, Laser Antonio Machado Oliveira, Katiane de Oliveira Pinto Coelho Nogueira, Iara Mariana Lellis Ribeiro, Andre Talvani, Silvia Dantas Cangussu, Rodrigo Cunha Alvim de Menezes, Frank Silva Bezerra
Summary: Hesperidin can protect the lungs of mice submitted to mechanical ventilation by reducing the inflammatory response and oxidative damage, and may act to prevent mechanical ventilation-induced injuries.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Immunology
Shuqing Jin, Xibing Ding, Chenxuan Yang, Wenbo Li, Meihong Deng, Hong Liao, Xin Lv, Bruce R. Pitt, Timothy R. Billiar, Li-Ming Zhang, Quan Li
Summary: The study showed that moderate tidal volume ventilation (MTV) may exacerbate preexisting lung injury by increasing intestinal permeability and causing endotoxemia, leading to acute lung injury (ALI). This effect is associated with the gut-lung axis influencing non-canonical and canonical inflammasome activation and pyroptosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Wei Hong, Fang Xiang Zhi, Tu Han Kun, Feng Jie Hua, Li Huan Ling, Fang Fang, Chen Wen, Wang Jie, Li Chao Yang
Summary: The study found that pre-treatment with 6-gingerol significantly improved histological changes and pulmonary oedema, inhibited neutrophil accumulation and the release of early pro-inflammatory cytokines and MPO, and reduced oxidative stress reactions after high mechanical ventilation. Additionally, 6-gingerol treatment also increased PPAR gamma expression and decreased NF-kappa B activation in rats subjected to high mechanical ventilation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Physiology
Charalampos Pierrakos, Marry R. Smit, Luigi Pisani, Frederique Paulus, Marcus J. Schultz, Jean-Michel Constantin, Davide Chiumello, Francesco Mojoli, Silvia Mongodi, Lieuwe D. J. Bos
Summary: The study assessed the accuracy of LUS methods for classifying lung morphology in ARDS patients under mechanical ventilation. Results showed that the Amsterdam and Lombardy methods had high sensitivity and specificity for focal lung morphology, while the Piedmont method also showed good sensitivity and specificity. The anterior LUS regions were found to be the most discriminant between focal and non-focal lung morphology.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Immunology
Laura Chavez, Julia Meguro, Shaoyi Chen, Vanessa Nunes de Paiva, Ronald Zambrano, Julia M. Eterno, Rahul Kumar, Matthew R. Duncan, Merline Benny, Karen C. Young, W. Dalton Dietrich, Roberta Brambilla, Shu Wu, Augusto F. Schmidt
Summary: Mechanical ventilation in preterm newborns can cause lung and brain inflammation, as well as activate pyroptosis pathways. Circulating extracellular vesicles (EVs) isolated from neonatal rats with ventilation-induced lung injury can lead to neuroinflammation and activation of caspase-1 and gasdermin D in the brain, mimicking the effects of mechanical ventilation.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Physiology
Thijs A. Lilien, David M. P. Van Meenen, Marcus J. Schultz, Lieuwe D. J. Bos, Reinout A. Bem
Summary: The interest in oxygen toxicity has led to numerous studies, but there is still no consensus on the clinical impact of hyperoxia and hyperoxemia. This article explores the importance of hyperoxia-induced lung injury in current critical care practice, suggesting that it may be less important than other ventilator-related factors in patients with acute respiratory distress syndrome.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2023)
Article
Physiology
Martin Scharffenberg, Jakob Wittenstein, Xi Ran, Yingying Zhang, Anja Braune, Raphael Theilen, Lorenzo Maiello, Giulia Benzi, Thomas Bluth, Thomas Kiss, Paolo Pelosi, Patricia R. M. Rocco, Marcus J. Schultz, Joerg Kotzerke, Marcelo Gama de Abreu, Robert Huhle
Summary: In this study, pulmonary neutrophilic inflammation evaluated by PET/CT increased after 24 hours of mechanical ventilation, and correlated with mechanical power.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Physiology
Nada Ismaiel, Sara Whynot, Laurette Geldenhuys, Zhaolin Xu, Arthur S. Slutsky, Valerie Chappe, Dietrich Henzler
Summary: The study found that low tidal volume ventilation reduces mechanical damage to the lung and attenuates ventilator-associated lung injury (VALI), while hypercapnia reduces inflammation and biochemical mechanisms of injury to attenuate VALI. Both lung-protective ventilation and hypercapnia may have a synergistic effect in preventing VALI.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Medicine, General & Internal
Mariyam Humayun, Lavienraj Premraj, Vishank Shah, Sung-Min Cho
Summary: Acute respiratory distress syndrome (ARDS) is commonly seen in patients with acute brain injury (ABI), and lung injury in ABI occurs secondary to catecholamine surge and neuro-inflammatory processes. Lung protective ventilation strategies that benefit ARDS patients may interfere with neurological recovery in ABI patients. Hypoxia leads to poor outcomes in ABI, hence a lower PO2 target may not be the best practice in patients with concomitant ARDS and severe ABI.
FRONTIERS IN MEDICINE
(2022)
Article
Anesthesiology
Jakob Wittenstein, Robert Huhle, Mark Leiderman, Marius Moebius, Anja Braune, Sebastian Tauer, Paul Herzog, Giulio Barana, Alessandra de Ferrari, Andrea Corona, Thomas Bluth, Thomas Kiss, Andreas Gueldner, Marcus J. Schultz, Patricia R. M. Rocco, Paolo Pelosi, Marcelo Gama de Abreu, Martin Scharffenberg
Summary: The study found that subject-ventilator asynchrony during spontaneous breathing did not exacerbate lung or diaphragm injury and dysfunction in experimental porcine ARDS.
BRITISH JOURNAL OF ANAESTHESIA
(2021)